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Jacobsson, L
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Publications (5 of 5) Show all publications
Eriksson, P., Jacobsson, L., Lindell, A., Nilsson, J.-A. & Skogh, T. (2009). Improved outcome in Wegener's granulomatosis and microscopic polyangiitis? A retrospective analysis of 95 cases in two cohorts.. Journal of internal medicine, 265(4), 496-506
Open this publication in new window or tab >>Improved outcome in Wegener's granulomatosis and microscopic polyangiitis? A retrospective analysis of 95 cases in two cohorts.
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2009 (English)In: Journal of internal medicine, ISSN 1365-2796, Vol. 265, no 4, p. 496-506Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Mortality rates for Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA) have decreased after the introduction of cyclophosphamide. Standardized mortality ratio (SMR) expresses the overall mortality of patients compared with the general population. The aims of this study were to compare survival in an old and a recent cohort of patients with WG and MPA using SMR and to determine predictors for death in both groups combined. DESIGN: Survival analyses were performed by Kaplan-Meier survival curves, SMR and proportional hazards regression models. SETTING: The nephrology and rheumatology clinics at Linköping University Hospital, Sweden. SUBJECTS: All patients diagnosed with WG or MPA in the catchment area during 1978-2005 were divided into two cohorts; patients diagnosed before (n=32, old cohort) and after (n=63, recent cohort) December 31, 1996. RESULTS: The two cohorts differed regarding the proportion of WG (75% vs. 56%, P=0.03) and a tendency for more pronounced kidney involvement in the old cohort: 266 micromol L(-1) (16% dialysis-dependent) vs. 192 micromol L(-1) (5% dialysis-dependent), but were comparable regarding disease severity. SMR at 1 and 5 years were 2.1 (95% CI: 0.43-6.09) and 1.6 (95% CI: 0.6-3.2) in the recent cohort and 5.2 (95% CI: 1.07-15.14) and 2.5 (95% CI: 0.93-5.52) in the old cohort. Five-year survival was 87% and 81%. Serum creatinine, age, end-stage renal disease, diagnosis before 1997 and first relapse were independent predictors for death. CONCLUSION: Patient survival in WG and MPA analysed with SMR may be better than previously believed. Severe renal disease and disease relapse were the major predictors of reduced survival.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-18996 (URN)10.1111/j.1365-2796.2008.02060.x (DOI)19141094 (PubMedID)
Available from: 2009-06-07 Created: 2009-06-07 Last updated: 2015-08-31
Li, W., Hellsten, A., Jacobsson, L., Blomqvist, H., Olsson, A. & Yuan, X. M. (2004). Alpha-tocopherol and astaxanthin decrease macrophage infiltration, apoptosis and vulnerability in atheroma of hyperlipidaemic rabbits. Journal of Molecular and Cellular Cardiology, 37(5), 969-978
Open this publication in new window or tab >>Alpha-tocopherol and astaxanthin decrease macrophage infiltration, apoptosis and vulnerability in atheroma of hyperlipidaemic rabbits
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2004 (English)In: Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, E-ISSN 1095-8584, Vol. 37, no 5, p. 969-978Article in journal (Refereed) Published
Abstract [en]

The composition of atherosclerotic plaques, not just macroscopical lesion size, has been implicated in their susceptibility to rupture and the risk of thrombus formation. By focusing on the quality of lipids, macrophages, apoptosis, collagen, metalloproteinase expression and plaque integrity, we evaluated the possible anti-atherosclerotic effect of the antioxidants α-tocopherol and astaxanthin in Watanabe heritable hyperlipidemic (WHHL) rabbits. Thirty-one WHHL rabbits were divided into three groups and were fed a standard diet, as controls (N =10), or a standard diet with the addition of 500 mg α-tocopherol per kg feed (N =11) or 100 mg astaxanthin per kg feed (N =10) for 24 weeks. We found that both antioxidants, particularly astaxanthin, significantly decreased macrophage infiltration in the plaques although they did not affect lipid accumulation. All lesions in the astaxanthin-treated rabbits were classified as early plaques according to the distribution of collagen and smooth muscle cells. Both antioxidants also improved plaque stability and significantly diminished apoptosis, which mainly occurred in macrophages, matrix metalloproteinase three expressions and plaque ruptures. Although neither antioxidant altered the positive correlations between the lesion size and lipid accumulation, the lesion size and apoptosis were only positively correlated in the control group. Astaxanthin and α-tocopherol may improve plaque stability by decreasing macrophage infiltration and apoptosis in this atherosclerotic setting. Apoptosis reduction by α-tocopherol and astaxanthin may be a new anti-atherogenic property of these antioxidants. © 2004 Elsevier Ltd. All rights reserved.

Keywords
atherosclerosis, antioxidants, apoptosis, celular lipids, macrophages, collagen, WHHL rabbits
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-24172 (URN)10.1016/j.yjmcc.2004.07.009 (DOI)3759 (Local ID)3759 (Archive number)3759 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
Jacobsson, L., Yuan, X. M., Ziedén, B. & Olsson, A. G. (2004). Effects of α-tocopherol and astaxanthin on LDL oxidation and atherosclerosis in WHHL rabbits. Atherosclerosis, 173(2), 231-237
Open this publication in new window or tab >>Effects of α-tocopherol and astaxanthin on LDL oxidation and atherosclerosis in WHHL rabbits
2004 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 173, no 2, p. 231-237Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to evaluate the influence of α-tocopherol and astaxanthin on low-density lipoprotein (LDL) oxidation lag time and atherosclerotic lesion formation in Watanabe heritable hyperlipidemic (WHHL) rabbits. Thirty-one, 3-month-old WHHL rabbits were divided into three experimental groups. One group (n=10) was fed standard rabbit feed alone and served as a control, a second group (n=11) was supplied with the same feed containing 500mg α-tocopherol/kg and a third group (n=10) was given a feed containing 100mg astaxanthin/kg. Plasma lipids, lipoproteins and LDL oxidation lag time were followed for 24 weeks. At the end of the treatment period, the animals were killed and the thoracic aorta was used for evaluation of the degree of atherosclerosis. Colour photographs of the intimal surface of the vessel were taken for determination of the atherosclerotic area. Cross-sections of the thoracic aorta were used for histological examination and for determination of intimal thickening. Specimens of the vessel were used for determination of the tissue cholesterol content. Plasma cholesterol remained at a high level during the time of the experiment and there were no differences between the experimental groups. After 24 weeks, the LDL oxidation lag time was 53.7±1.7min, 109±4min (P<0.001) and 56.4±3.4min (P=0.47) in the control, α-tocopherol and astaxanthin groups, respectively. In the thoracic aorta, the atherosclerotic area was 80.7±5.1%, 67.1±6.7% (P=0.13) and 75.2±5.7% (P=0.49) in the control, α-tocopherol and astaxanthin groups, respectively. The intimal thickening was 45.6±3.2%, 44.0±4.1% (P=0.89) and 40.0±4.5% (P=0.33) in the control, α-tocopherol and astaxanthin groups, respectively. Finally, the cholesterol content was 107±9μmol/g, 95.7±11. 5μmol/g (P=0.31) and 101±5μmol/g (P=0.33) in the control, α-tocopherol and astaxanthin groups, respectively. It can be concluded that α-tocopherol but not astaxanthin prolonged the LDL oxidation lag time. The two antioxidative substances did not prevent atherogenesis in WHHL rabbits in this setting.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-22710 (URN)10.1016/j.atherosclerosis.2004.01.003 (DOI)2007 (Local ID)2007 (Archive number)2007 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
Jacobsson-Strier, M. & Jacobsson, L. (2000). Plasma lipids and atherosclerosis in Watanabe heritable hyperlipidemic rabbits and fat-fed mini-pigs of the Göttingen strain. In: Proceedings of the International XII ICLAS and VII FELASA Joint Meeting,1999: . Paper presented at International XII CLAS and VII Felasa Joint Meeting, 26-28 May 1999, Palma de Mallorca, Spain (pp. 95). London: Laboratory Animals Ltd
Open this publication in new window or tab >>Plasma lipids and atherosclerosis in Watanabe heritable hyperlipidemic rabbits and fat-fed mini-pigs of the Göttingen strain
2000 (English)In: Proceedings of the International XII ICLAS and VII FELASA Joint Meeting,1999, London: Laboratory Animals Ltd , 2000, p. 95-Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
London: Laboratory Animals Ltd, 2000
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-28371 (URN)13507 (Local ID)0-901334-13-8 (ISBN)13507 (Archive number)13507 (OAI)
Conference
International XII CLAS and VII Felasa Joint Meeting, 26-28 May 1999, Palma de Mallorca, Spain
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2015-03-02
Jacobsson, L. S., Persson, K., Aberg, G., Andersson, R. G. G., Karlberg, B. E. & Olsson, A. G. (1994). Antiatherosclerotic Effects of the Angiotensin-Converting Enzyme Inhibitors Captopril and Fosinopril in Hypercholesterolemic Minipigs. Journal of Cardiovascular Pharmacology, 24(4), 670-677
Open this publication in new window or tab >>Antiatherosclerotic Effects of the Angiotensin-Converting Enzyme Inhibitors Captopril and Fosinopril in Hypercholesterolemic Minipigs
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1994 (English)In: Journal of Cardiovascular Pharmacology, ISSN 0160-2446, E-ISSN 1533-4023, Vol. 24, no 4, p. 670-677Article in journal (Refereed) Published
Abstract [en]

We evaluated the two angiotensin-converting enzyme (ACE) inhibitors captopril and fosinopril with regard to possible antiatherosclerotic effects in minipigs. Experimental hypercholesterolemia and atherosclerosis was produced in 33 minipigs of the Gottingen strain by an egg yolk/cholesterol-enriched diet for 1 year. One group (n = 11) was fed the atherogenic diet alone and served as a control. A second group (n = 11) received captopril (80 mg/kg/day) added to the atherogenic diet, and a third group (n = 11) was treated in the same manner but with fosinopril (8 mg/kglday). The drug treatments produced significant reduction in serum ACE activity associated with a reactive increase in plasma renin activity (PRA), but had only minor effects on plasma lipids and lipoproteins. At the end of the treatment period, all animals were killed and examined for degree of atherosclerosis. The percentage of atherosclerotic area in the abdominal aorta was significantly lower in both drug-treated groups as compared with controls. Furthermore, accumulation of cholesterol in the thoracic and abdominal aorta was inhibited by drug treatment. Finally, the percentage of intimal thickening in abdominal aorta was significantly reduced in the drug-treated groups. In conclusion, the ACE inhibitors captopril and fosinopril inhibited development of atherosclerosis in hypercholesterolemic minipigs.

Keywords
Angiotensin, converting enzyme inhibitors, Atherosclerosis, Captopril, Cholesterol, Fosinopril, lntimal thickening, Minipigs
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-79490 (URN)
Available from: 2012-08-06 Created: 2012-08-06 Last updated: 2017-12-07Bibliographically approved
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