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BETA
Heiberg, Einar
Alternative names
Publications (10 of 24) Show all publications
Heiberg, E. (2007). Hur kan höger kammares globala och regionala funktion värderas med magnetresonanstomografi (den bortglömda kammaren Hur och varför skall högerkammarfunktionen bedömas?). In: IX Svenska Kardiovaskulära vårmötet,2007.
Open this publication in new window or tab >>Hur kan höger kammares globala och regionala funktion värderas med magnetresonanstomografi (den bortglömda kammaren Hur och varför skall högerkammarfunktionen bedömas?)
2007 (English)In: IX Svenska Kardiovaskulära vårmötet,2007, 2007Conference paper, Published paper (Other academic)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-40399 (URN)53203 (Local ID)53203 (Archive number)53203 (OAI)
Available from: 2009-10-10 Created: 2009-10-10
Bolger, A. F., Heiberg, E., Karlsson, M., Wigström, L., Engvall, J., Sigfridsson, A., . . . Wranne, B. (2007). Transit of blood flow through thehuman left ventricle mapped by cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance, 9(5), 741-747
Open this publication in new window or tab >>Transit of blood flow through thehuman left ventricle mapped by cardiovascular magnetic resonance
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2007 (English)In: Journal of Cardiovascular Magnetic Resonance, ISSN 1097-6647, E-ISSN 1532-429X, Vol. 9, no 5, p. 741-747Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

The transit of blood through the beating heart is a basic aspect of cardiovascular physiology which remains incompletely studied. Quantification of the components of multidirectional flow in the normal left ventricle (LV) is lacking, making it difficult to put the changes observed with LV dysfunction and cardiac surgery into context.

METHODS:

Three dimensional, three directional, time resolved magnetic resonance phase-contrast velocity mapping was performed at 1.5 Tesla in 17 normal subjects, 6 female, aged 44+/-14 years (mean+/-SD). We visualized and measured the relative volumes of LV flow components and the diastolic changes in inflowing kinetic energy (KE). Of total diastolic inflow volume, 44+/-11% followed a direct, albeit curved route to systolic ejection (videos 1 and 2), in contrast to 11% in a subject with mildly dilated cardiomyopathy (DCM), who was included for preliminary comparison (video 3). In normals, 16+/-8% of the KE of inflow was conserved to the end of diastole, compared with 5% in the DCM patient. Blood following the direct route lost or transferred less of its KE during diastole than blood that was retained until the next beat (1.6+/-1.0 millijoules vs 8.2+/-1.9 millijoules, p<0.05); whereas, in the DCM patient, the reduction in KE of retained inflow was 18-fold greater than that of the blood tracing the direct route.

CONCLUSION:

Multidimensional flow mapping can measure the paths, compartmentalization and kinetic energy changes of blood flowing into the LV, demonstrating differences of KE loss between compartments, and potentially between the flows in normal and dilated left ventricles.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-41889 (URN)10.1080/10976640701544530 (DOI)17891610 (PubMedID)59319 (Local ID)59319 (Archive number)59319 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13Bibliographically approved
Bolger, A. F., Heiberg, E., Dyverfeldt, P., Carlsson, M., Johansson, P., Markenroth, K., . . . Arheden, H. (2007). Tredimensionellt MR-blodflöde och diastolisk kinetisk energi kvantiferat med magnetisk resonanstomografi efter kirurgisk vänsterkammarrekonstruktion. Ny teknik för utvärdering av kammarfunktion.. In: Riksstämman,2007.
Open this publication in new window or tab >>Tredimensionellt MR-blodflöde och diastolisk kinetisk energi kvantiferat med magnetisk resonanstomografi efter kirurgisk vänsterkammarrekonstruktion. Ny teknik för utvärdering av kammarfunktion.
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2007 (Swedish)In: Riksstämman,2007, 2007Conference paper, Published paper (Other academic)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-43140 (URN)71985 (Local ID)71985 (Archive number)71985 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2013-09-03
Svensson (Renner), J., Gårdhagen, R., Heiberg, E., Ebbers, T., Loyd, D., Länne, T. & Karlsson, M. (2006). Feasibility of Patient Specific Aortic Blood Flow CFD Simulation (1ed.). In: Rasmus Larsen, Mads Nielsen, Jon Sporring (Ed.), Rasmus Larsen, Mads Nielsen and Jon Sporring (Ed.), Medical Image Computing and Computer-Assisted Intervention – MICCAI 2006: 9th International Conference, Copenhagen, Denmark, October 1-6, 2006. Proceedings, Part I. Paper presented at The 9th MICCAI Conference, Copenhagen, Denmark, 1-6 October 2006 (pp. 257-263). Springer Berlin/Heidelberg, 4190
Open this publication in new window or tab >>Feasibility of Patient Specific Aortic Blood Flow CFD Simulation
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2006 (English)In: Medical Image Computing and Computer-Assisted Intervention – MICCAI 2006: 9th International Conference, Copenhagen, Denmark, October 1-6, 2006. Proceedings, Part I / [ed] Rasmus Larsen, Mads Nielsen and Jon Sporring, Springer Berlin/Heidelberg, 2006, 1, Vol. 4190, p. 257-263Conference paper, Published paper (Refereed)
Abstract [en]

Patient specific modelling of the blood flow through the human aorta is performed using computational fluid dynamics (CFD) and magnetic resonance imaging (MRI). Velocity patterns are compared between computer simulations and measurements. The workflow includes several steps: MRI measurement to obtain both geometry and velocity, an automatic levelset segmentation followed by meshing of the geometrical model and CFD setup to perform the simulations follwed by the actual simulations. The computational results agree well with the measured data.

Place, publisher, year, edition, pages
Springer Berlin/Heidelberg, 2006 Edition: 1
Series
Lecture Notes in Computer Science, ISSN 0302-9743, E-ISSN 1611-3349 ; 4190
National Category
Medical Image Processing
Identifiers
urn:nbn:se:liu:diva-36902 (URN)10.1007/11866565_32 (DOI)000241556300032 ()32988 (Local ID)3-5404-4707-5 (ISBN)978-3-540-44727-6 (ISBN)978-3-540-44707-8 (ISBN)32988 (Archive number)32988 (OAI)
Conference
The 9th MICCAI Conference, Copenhagen, Denmark, 1-6 October 2006
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2018-02-20Bibliographically approved
Carlhall, C., Wigström, L., Heiberg, E., Karlsson, M., Bolger, A. & Nylander, E. (2006). Reply [2]. American Journal of Physiology. Heart and Circulatory Physiology, 291(5)
Open this publication in new window or tab >>Reply [2]
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2006 (English)In: American Journal of Physiology. Heart and Circulatory Physiology, ISSN 0363-6135, E-ISSN 1522-1539, Vol. 291, no 5Other (Other academic)
Abstract [en]

[No abstract available]

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-50070 (URN)10.1152/ajpheart.00618.2006 (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12
Carlhäll, C., Wigström, L., Heiberg, E., Karlsson, M., Bolger, A. F. & Nylander, E. (2006). Reply to article: Misinterpretation About the Contribution of the Left Ventricular Long-Axis Shortening to the Stroke Volume. American Journal of Physiology. Heart and Circulatory Physiology, 291(5), 2551-2552
Open this publication in new window or tab >>Reply to article: Misinterpretation About the Contribution of the Left Ventricular Long-Axis Shortening to the Stroke Volume
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2006 (English)In: American Journal of Physiology. Heart and Circulatory Physiology, ISSN 0363-6135, E-ISSN 1522-1539, Vol. 291, no 5, p. 2551-2552Article in journal, Editorial material (Other academic) Published
Abstract [en]

   

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-36901 (URN)10.1152/ajpheart.00618.2006 (DOI)32987 (Local ID)32987 (Archive number)32987 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Renner, J., Gårdhagen, R., Heiberg, E., Ebbers, T., Länne, T. & Karlsson, M. (2006). Validation of Simulated Velocity of Blood in Patient Specific Aorta. In: VIII Svenska Kardiovaskulära Vårmöte,2006. Linköping, Sweden: Linköpings universitet
Open this publication in new window or tab >>Validation of Simulated Velocity of Blood in Patient Specific Aorta
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2006 (English)In: VIII Svenska Kardiovaskulära Vårmöte,2006, Linköping, Sweden: Linköpings universitet , 2006Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Linköping, Sweden: Linköpings universitet, 2006
National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-36745 (URN)32325 (Local ID)32325 (Archive number)32325 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-03-27
Heiberg, E. (2005). Automated feature detection in multidimensional images. (Doctoral dissertation). Linköping: Linköping University Electronic Press
Open this publication in new window or tab >>Automated feature detection in multidimensional images
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Manual identification of structures and features in multidimensional images is at best time consuming and operator dependent. Feature identification need to be accurate, repeatable and quantitative.

This thesis presents novel methods for automated feature detection in multidimensional images that are independent on imaging modality. Feature detection is described at two abstraction levels. At the first low level the image is regionally processed to find local or regional features. In the second medium level results are taken from the low level feature detection and grouped into objects or parts that can be quantified. A key to quantification of cardiac function is delineation of the cardiac walls which is a difficult task. Two different methods are described and evaluated for delineation of the left ventricular wall from anatomical images. The results show that semi-automatic delineation is a huge time saver compared to manual delineation. To obtain a robust results as much a priori and image information as possible should be used in the delineation process. Regional cardiac wall function is further studied by deriving and analyzing strain-rate tensors from velocity encoded images. For flow encoded images novel methods to find regional flow structures such as vortex cores, flow based delineation, and flow quantification are proposed. These methods are applied to study blood flow in the human heart, but the techniques outlined are general and can be applied to a wide array of flow conditions.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2005. p. 70
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 917
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-29497 (URN)14852 (Local ID)91-85297-10-0 (ISBN)14852 (Archive number)14852 (OAI)
Public defence
2005-04-15, Elsa Brändströmsalen, Campus US, Linköpings Universitet, Linköping, 13:00 (English)
Opponent
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2012-12-10Bibliographically approved
Carlhäll, C., Wigström, L., Heiberg, E., Karlsson, M., Bolger, A. F. & Nylander, E. (2004). Contribution of mitral annular excursion and shape dynamics to total left ventricular volume change. American Journal of Physiology. Heart and Circulatory Physiology, 287(4), H1836-H1841
Open this publication in new window or tab >>Contribution of mitral annular excursion and shape dynamics to total left ventricular volume change
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2004 (English)In: American Journal of Physiology. Heart and Circulatory Physiology, ISSN 0363-6135, E-ISSN 1522-1539, Vol. 287, no 4, p. H1836-H1841Article in journal (Refereed) Published
Abstract [en]

The mitral annulus (MA) has a complex shape and motion, and its excursion has been correlated to left ventricular (LV) function. During the cardiac cycle the annulus’ excursion encompasses a volume that is part of the total LV volume change during both filling and emptying. Our objective was to evaluate the contribution of MA excursion and shape variation to total LV volume change. Nine healthy subjects aged 56 ± 11 (means ± SD) years underwent transesophageal echocardiography (TEE). The MA was outlined in all time frames, and a four-dimensional (4-D) Fourier series was fitted to the MA coordinates (3-D+time) and divided into segments. The annular excursion volume (AEV) was calculated based on the temporally integrated product of the segments’ area and their incremental excursion. The 3-D LV volumes were calculated by tracing the endocardial border in six coaxial planes. The AEV (10 ± 2 ml) represented 19 ± 3% of the total LV stroke volume (52 ± 12 ml). The AEV correlated strongly with LV stroke volume (r = 0.73; P < 0.05). Peak MA area occurred during middiastole, and 91 ± 7% of reduction in area from peak to minimum occurred before the onset of LV systole. The excursion of the MA accounts for an important portion of the total LV filling and emptying in humans. These data suggest an atriogenic influence on MA physiology and also a sphincter-like action of the MA that may facilitate ventricular filling and aid competent valve closure. This 4-D TEE method is the first to allow noninvasive measurement of AEV and may be used to investigate the impact of physiological and pathological conditions on this important aspect of LV performance.

Keywords
annular physiology, ventricular long axis function, echocardiography, three dimension, four dimension
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-24050 (URN)10.1152/ajpheart.00103.2004 (DOI)3608 (Local ID)3608 (Archive number)3608 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13Bibliographically approved
Heiberg, E., Ebbers, T., Wigström, L. & Karlsson, M. (2003). Three-dimensional flow characterization using vector pattern matching. IEEE Transactions on Visualization and Computer Graphics, 9(3), 313-319
Open this publication in new window or tab >>Three-dimensional flow characterization using vector pattern matching
2003 (English)In: IEEE Transactions on Visualization and Computer Graphics, ISSN 1077-2626, E-ISSN 1941-0506, Vol. 9, no 3, p. 313-319Article in journal (Refereed) Published
Abstract [en]

This paper describes a novel method for regional characterization of three-dimensional vector fields using a pattern matching approach. Given a three-dimensional vector field, the goal is to automatically locate, identify, and visualize a selected set of classes of structures or features. Rather than analytically defining the properties that must be fulfilled in a region in order to be classified as a specific structure, a set of idealized patterns for each structure type is constructed. Similarity to these patterns is then defined and calculated. Examples of structures of interest include vortices, swirling flow, diverging or converging flow, and parallel flow. Both medical and aerodynamic applications are presented in this paper.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-26709 (URN)10.1109/TVCG.2003.1207439 (DOI)11302 (Local ID)11302 (Archive number)11302 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
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