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Henricson, Joakim
Publications (10 of 38) Show all publications
Glasin, J., Henricson, J., Lindberg, L.-G. & Björk Wilhelms, D. (2019). Wireless vitals: Proof of concept for wireless patient monitoring in an emergency department setting. Journal of Biophotonics, 12(4), Article ID e201800275.
Open this publication in new window or tab >>Wireless vitals: Proof of concept for wireless patient monitoring in an emergency department setting
2019 (English)In: Journal of Biophotonics, ISSN 1864-063X, E-ISSN 1864-0648, Vol. 12, no 4, article id e201800275Article in journal (Refereed) Published
Abstract [en]

Vital sign assessment is a common task in emergency medicine, but resources for continuous monitoring are restricted, data is often recorded manually, and entangled wires cause frustration. Therefore, we designed a small, wireless photoplethysmographic device capable of continuously assessing pulse, respiratory frequency and oxygen saturation on the sternum and tested the performance and feasibility in an emergency department setting. Fifty (56.3 20.2 years), consenting emergency patients (29 male) were recruited. Heart rate, respiratory rate and oxygen saturation were recorded simultaneously using the device and standard monitoring equipment. Data was compared using Bland-Altman plotting (heart rate, respiratory rate) and mean difference (oxygen saturation). The bias for heart- and respiratory rate was 0.4 (limits of agreements -11.3, 12.2 and -6.1, 7.0). Mean difference for oxygen saturation was -0.21 +/- 2.35%. This may be the first wireless device to use photoplethysmography on the sternum for vital sign assessment. We noted good agreement with standard monitors, but lack of standardization in data processing between monitoring systems may limit the generalizability of these findings. Although further improvements are needed, the feasibility of this approach provides proof of concept for a new paradigm of large scale, wireless patient monitoring.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2019
Keywords
Emergency medicine; physiologic monitoring; Hospital emergency service; emergency medicine; humans; photoplethysmography
National Category
Other Medical Engineering
Identifiers
urn:nbn:se:liu:diva-157243 (URN)10.1002/jbio.201800275 (DOI)000464399800012 ()30306737 (PubMedID)2-s2.0-85058622127 (Scopus ID)
Note

Funding Agencies|Region Ostergotland [LIO-532001, LIO-700271]

Available from: 2019-06-13 Created: 2019-06-13 Last updated: 2019-06-18Bibliographically approved
Toll John, R., Henricson, J., Junker, J., Jonson, C.-O., Nilsson, G., Björk Wilhelms, D. & Anderson, C. D. (2018). A cool response: the influence of ambient temperature on capillary refill time. Journal of Biophotonics, 11(6)
Open this publication in new window or tab >>A cool response: the influence of ambient temperature on capillary refill time
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2018 (English)In: Journal of Biophotonics, ISSN 1864-063X, E-ISSN 1864-0648, Vol. 11, no 6Article in journal (Refereed) Published
Abstract [en]

Objective

To describe the effect of low ambient temperature on skin temperature and capillary refill (CR) time in forehead, sternum and finger pulp.

Methods

An observational, nonrandomized experimental study on 15 healthy subjects (6 females) in a cold room (8°C). Outcome measures were skin temperature and quantified CR test after application of a standardized blanching pressure (9 N/cm2) using digital photographic polarization spectroscopy to generate CR times.

Results

The finger pulp showed marked temperature fall and prolonged CR times (>10 seconds). The CR registrations of the forehead and sternum were more comparable to curves observed in a control material at room temperature, and skin temperature falls were less marked. CR times were not prolonged in forehead measurements. At the sternum, some individuals showed CR times beyond guideline recommendations despite only a marginal reduction in skin temperature.

Conclusions

Low ambient temperature is a strong independent factor for CR time at peripheral sites. Reservation about sternum as a site of measurement is warranted since cold provocation produced prolonged CR times in some individuals. We found that the forehead is the most thermostable of the 3 sites and thus the preferred site to avoid ambient temperature artifact in measuring CR time.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2018
National Category
Atom and Molecular Physics and Optics
Identifiers
urn:nbn:se:liu:diva-145527 (URN)10.1002/jbio.201700371 (DOI)000434641700017 ()29384267 (PubMedID)
Note

Funding agencies: Socialstyrelsen; Region Ostergotland

Available from: 2018-03-05 Created: 2018-03-05 Last updated: 2019-04-30Bibliographically approved
Bergkvist, M., Zötterman, J., Henricson, J., Iredahl, F., Tesselaar, E. & Farnebo, S. (2017). Vascular Occlusion in a Porcine Flap Model: Effects on Blood Cell Concentration and Oxygenation.. Plastic and reconstructive surgery. Global open, 5(11), Article ID e1531.
Open this publication in new window or tab >>Vascular Occlusion in a Porcine Flap Model: Effects on Blood Cell Concentration and Oxygenation.
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2017 (English)In: Plastic and reconstructive surgery. Global open, ISSN 2169-7574, Vol. 5, no 11, article id e1531Article in journal (Refereed) Published
Abstract [en]

Background: Venous congestion in skin flaps is difficult to detect. This study evaluated the ability of tissue viability imaging (TiVi) to measure changes in the concentration of red blood cells (CRBC), oxygenation, and heterogeneity during vascular provocations in a porcine fasciocutaneous flap model.

Methods: In 5 pigs, cranial gluteal artery perforator flaps were raised (8 flaps in 5 pigs). The arterial and venous blood flow was monitored with ultrasonic flow probes. CRBC, tissue oxygenation, and heterogeneity in the skin were monitored with TiVi during baseline, 50% and 100% venous occlusion, recovery, 100% arterial occlusion and final recovery, thereby simulating venous and arterial occlusion of a free fasciocutaneous flap. A laser Doppler probe was used as a reference for microvascular perfusion in the flap.

Results: During partial and complete venous occlusion, increases in CRBC were seen in different regions of the flap. They were more pronounced in the distal part. During complete arterial occlusion, CRBC decreased in all but the most distal parts of the flap. There were also increases in tissue oxygenation and heterogeneity during venous occlusion.

Conclusions: TiVi measures regional changes in CRBC in the skin of the flap during arterial and venous occlusion, as well as an increase in oxygenated hemoglobin during venous occlusion that may be the result of reduced metabolism and impaired delivery of oxygen to the tissue. TiVi may provide a promising method for measuring flap viability because it is hand-held, easy to-use, and provides spatial information on venous congestion.

Place, publisher, year, edition, pages
Wolters Kluwer, 2017
National Category
Radiology, Nuclear Medicine and Medical Imaging Surgery
Identifiers
urn:nbn:se:liu:diva-145391 (URN)10.1097/GOX.0000000000001531 (DOI)29263951 (PubMedID)2-s2.0-85038559789 (Scopus ID)
Available from: 2018-02-27 Created: 2018-02-27 Last updated: 2019-07-23Bibliographically approved
Mernelius, S., Carlsson, E., Henricson, J., Löfgren, S., Lindgren, P.-E., Ehricht, R., . . . Anderson, C. (2016). Staphylococcus aureus colonization related to severity of hand eczema. European Journal of Clinical Microbiology and Infectious Diseases, 35(8), 1355-1361
Open this publication in new window or tab >>Staphylococcus aureus colonization related to severity of hand eczema
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2016 (English)In: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 35, no 8, p. 1355-1361Article in journal (Refereed) Published
Abstract [en]

Knowledge on Staphylococcus aureus colonization rates and epidemiology in hand eczema is limited. The aim of this study was to clarify some of these issues. Samples were collected by the "glove juice" method from the hands of 59 patients with chronic hand eczema and 24 healthy individuals. Swab samples were taken from anterior nares and throat from 43 of the 59 patients and all healthy individuals. S. aureus were spa typed and analysed by DNA-microarray-based genotyping. The extent of the eczema was evaluated by the hand eczema extent score (HEES). The colonization rate was higher on the hands of hand eczema patients (69 %) compared to healthy individuals (21 %, p amp;lt; 0.001). This was also seen for bacterial density (p = 0.002). Patients with severe hand eczema (HEES a parts per thousand yen 13) had a significantly higher S. aureus density on their hands compared to those with milder eczema (HEES = 1 to 12, p = 0.004). There was no difference between patients and healthy individuals regarding colonization rates in anterior nares or throat. spa typing and DNA-microarray-based genotyping indicated certain types more prone to colonize eczematous skin. Simultaneous colonization, in one individual, with S. aureus of different types, was identified in 60-85 % of the study subjects. The colonization rate and density indicate a need for effective treatment of eczema and may have an impact on infection control in healthcare.

Place, publisher, year, edition, pages
Springer, 2016
National Category
Surgery
Identifiers
urn:nbn:se:liu:diva-130833 (URN)10.1007/s10096-016-2672-2 (DOI)000380089800017 ()27193891 (PubMedID)
Note

Funding Agencies|Medical Research Council of Southeast Sweden; Futurum - the Academy of Healthcare, County Council, Jonkoping; Medeca Pharma AB, Uppsala

Available from: 2016-08-26 Created: 2016-08-26 Last updated: 2017-11-21Bibliographically approved
Bergkvist, M., Henricson, J., Iredahl, F., Tesselaar, E., Sjöberg, F. & Farnebo, S. (2015). Assessment of microcirculation of the skin using Tissue Viability Imaging: A promising technique for detecting venous stasis in the skin. Microvascular Research, 101, 20-25
Open this publication in new window or tab >>Assessment of microcirculation of the skin using Tissue Viability Imaging: A promising technique for detecting venous stasis in the skin
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2015 (English)In: Microvascular Research, ISSN 0026-2862, E-ISSN 1095-9319, Vol. 101, p. 20-25Article in journal (Refereed) Published
Abstract [en]

Background: : Venous occlusion in the skin is difficult to detect by existing measurement techniques. Our aim was to find out whether Tissue Viability Imaging (TiVi) was better at detecting venous occlusion by comparing it with results of laser Doppler flowmetry (LDF) during graded arterial and venous stasis in human forearm skin. Methods: : Arterial and venous occlusions were simulated in 10 healthy volunteers by inflating a blood pressure cuff around the upper right arm. Changes in the concentration of red blood cells (RBC) were measured using TiVi, while skin perfusion and concentration of moving red blood cells (CMBC) were measured using static indices of LDF during exsanguination and subsequent arterial occlusion, postocclusive reactive hyperaemia, and graded increasing and decreasing venous stasis. Results: : During arterial occlusion there was a significant reduction in the mean concentration of RBC from baseline, as well as in perfusion and CMBC (p less than 0.008). Venous occlusion resulted in a significant 28% increase in the concentration of RBC (p = 0.002), but no significant change in perfusion (mean change -14%) while CMBC decreased significantly by 24% (p = 0.02). With stepwise increasing occlusion pressures there was a significant rise in the TiVi index and reduction in perfusion (p = 0.008), while the reverse was seen when venous flow was gradually restored. Conclusion: : The concentration of RBC measured with TiVi changes rapidly and consistently during both total and partial arterial and venous occlusions, while the changes in perfusion, measured by LDF, were less consistent This suggests that TiVi could be a more useful, non-invasive clinical monitoring tool for detecting venous stasis in the skin than LDF.

Place, publisher, year, edition, pages
Elsevier, 2015
Keywords
Tissue viability imaging; Laser Doppler flowmetry; Post-occusive hyperaemia; Venous occlusion; Arterial occlusion
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-121302 (URN)10.1016/j.mvr.2015.06.002 (DOI)000360028500004 ()26092681 (PubMedID)
Note

Funding Agencies|County Council of Ostergotland, Sweden [2014JZ0004]

Available from: 2015-09-16 Created: 2015-09-14 Last updated: 2019-07-23Bibliographically approved
ODoherty, J., Henricson, J., Falk, M. & Anderson, C. (2013). Correcting for possible tissue distortion between provocation and assessment in skin testing: The divergent beam UVB photo-test. Skin research and technology, 19(4), 368-374
Open this publication in new window or tab >>Correcting for possible tissue distortion between provocation and assessment in skin testing: The divergent beam UVB photo-test
2013 (English)In: Skin research and technology, ISSN 0909-752X, E-ISSN 1600-0846, Vol. 19, no 4, p. 368-374Article in journal (Refereed) Published
Abstract [en]

BackgroundIn tissue viability imaging (TiVi), an assessment method for skin erythema, correct orientation of skin position from provocation to assessment optimizes data interpretation. Image processing algorithms could compensate for the effects of skin translation, torsion and rotation realigning assessment images to the position of the skin at provocation. less thanbrgreater than less thanbrgreater thanMethodsA reference image of a divergent, UVB phototest was acquired, as well as test images at varying levels of translation, rotation and torsion. Using 12 skin markers, an algorithm was applied to restore the distorted test images to the reference image. less thanbrgreater than less thanbrgreater thanResultsThe algorithm corrected torsion and rotation up to approximately 35 degrees. The radius of the erythemal reaction and average value of the input image closely matched that of the reference images true value. less thanbrgreater than less thanbrgreater thanConclusionThe image de-warping procedure improves the robustness of the response image evaluation in a clinical research setting and opens the possibility of the correction of possibly flawed images performed away from the laboratory setting by the subject/patient themselves. This opportunity may increase the use of photo-testing and, by extension, other late response skin testing where the necessity of a return assessment visit is a disincentive to performance of the test.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2013
Keywords
tissue viability imaging, TiVi, photo-test, spectroscopy, image correction
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-100468 (URN)10.1111/srt.12055 (DOI)000325547300002 ()
Available from: 2013-11-08 Created: 2013-11-08 Last updated: 2017-12-06
Henricson, J., Baiat, Y. & Sjöberg, F. (2011). Local Heating as a Predilatation Method for Measurement of Vasoconstrictor Responses with Laser-Doppler Flowmetry. Microcirculation, 18(3), 214-220
Open this publication in new window or tab >>Local Heating as a Predilatation Method for Measurement of Vasoconstrictor Responses with Laser-Doppler Flowmetry
2011 (English)In: Microcirculation, ISSN 1073-9688, E-ISSN 1549-8719, Vol. 18, no 3, p. 214-220Article in journal (Refereed) Published
Abstract [en]

Studying microvascular responses to iontophoresis of vasoconstricting drugs contributes to a better understanding of the regulatory mechanisms of cutaneous vessels, but measuring these responses with laser-Doppler flowmetry at basal blood flow conditions is technically challenging. This study aimed to investigate whether the measurement of cutaneous vasoconstrictor responses to noradrenaline (NA) and phenylephrine (PE), delivered by iontophoresis, is facilitated by predilatation of the microvascular bed using local heating. We used different drug delivery rates (100 s x 0.12 mA, 200 s x 0.06 mA, 300 s x 0.04 mA) to investigate whether predilatation affects the local drug dynamics by an increased removal of drugs from the skin. In a predilatated vascular bed, iontophoresis of NA and PE resulted in a significant decrease in perfusion from the thermal plateau (p andlt; 0.001). The decrease was 25-33%, depending on drug delivery rate. In unheated skin, a significant vasoconstriction was observed (p andlt; 0.001), with 17% and 14% decrease from baseline for NA and PE, respectively. These results indicate that predilatating the cutaneous vascular bed by local heating facilitates measurement of vasoconstriction with laser-Doppler flowmetry and does not seem to significantly affect the result by an increased removal of drugs from the skin.

Place, publisher, year, edition, pages
John Wiley & Sons, 2011
Keywords
iontophoresis, laser-Doppler, vasoconstriction, local heating, adrenoceptors
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-67553 (URN)10.1111/j.1549-8719.2010.00079.x (DOI)000288759900006 ()21199093 (PubMedID)
Note

Original Publication: Joakim Henricson, Yashma Baiat and Folke Sjöberg, Local Heating as a Predilatation Method for Measurement of Vasoconstrictor Responses with Laser-Doppler Flowmetry, 2011, MICROCIRCULATION, (18), 3, 214-220. http://dx.doi.org/10.1111/j.1549-8719.2010.00079.x Copyright: Wiley http://eu.wiley.com/WileyCDA/Brand/id-35.html

Available from: 2011-04-18 Created: 2011-04-18 Last updated: 2017-12-11Bibliographically approved
O'Doherty, J., Henricson, J., Enfield, J., Nilsson, G. E., Leahy, M. J. & Anderson, C. D. (2011). Tissue viability imaging (TiVi) in the assessment of divergent beam UV-B provocation. Archives of Dermatological Research, 303(2), 79-87
Open this publication in new window or tab >>Tissue viability imaging (TiVi) in the assessment of divergent beam UV-B provocation
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2011 (English)In: Archives of Dermatological Research, ISSN 0340-3696, E-ISSN 1432-069X, Vol. 303, no 2, p. 79-87Article in journal (Refereed) Published
Abstract [en]

In routine clinical phototesting and in basic research, naked eye dermatological assessment is the "gold standard" for determining the patient's minimal erythemal dose (MED). In UV-B testing with a divergent, radially attenuating beam of characterised dosimetry, laser Doppler perfusion imaging has been previously used to give quantitative description of reactivity to doses above the MED in addition to a "single-dose" objective determination of the MED itself. In the present paper, the recently developed tissue viability imaging (TiVi) technology is presented for the first time as a reliable, easily applicable, high-resolution alternative to LDPI in the divergent beam testing concept. Data obtained after provocation with a range of doses was analysed in order to determine the reaction diameter, which can be related to the MED using field dosimetry. The dose-response features of exposure above the MED and the relationship between naked eye readings and the diameter were determined from the image data. TiVi data were obtained faster than LDPI data and at a higher spatial resolution of 100 μm instead of 1 mm. A tool was developed to centre over the erythema area of the acquired image. Response data could be plotted continuously against dose. Thresholding of processed images compared to naked eye "gold standard" readings showed that the normal skin value +4 standard deviations produced a good fit between both methods. A linear fitting method for the dose-response data provided a further method of determination of the reaction diameter (MED). Erythemal "volume under the surface (VUS)" for the reaction provided a new concept for visualising information. TiVi offers advantages over LDPI in the acquisition and analysis of data collected during divergent beam testing. An increased amount of data compared to traditional phototesting is easily and more objectively obtained which increases applicability in the clinical and research environment.

Place, publisher, year, edition, pages
Springer, 2011
Keywords
Photo-testing – Tissue viability imaging – UV-B – Microcirculation – Polarization spectroscopy – Minimal erythemal dose
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-66519 (URN)10.1007/s00403-010-1055-2 (DOI)000287500600002 ()20524004 (PubMedID)
Available from: 2011-03-18 Created: 2011-03-18 Last updated: 2017-12-11
Henricson, J., Lassus, J., Eklund, J., Lassus, S. & Anderson, C. (2010). Avoidance of dermal exposure to preservatives by packaging. In: JOURNAL OF PHARMACY AND PHARMACOLOGY, vol 62, issue 6, pp 802-802. Paper presented at Perspectives in Percutaneous Penetration, 12th International Conference, La Grande Motte, France (pp. 802-802). Pharmaceutical Press, 62(6)
Open this publication in new window or tab >>Avoidance of dermal exposure to preservatives by packaging
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2010 (English)In: JOURNAL OF PHARMACY AND PHARMACOLOGY, vol 62, issue 6, pp 802-802, Pharmaceutical Press , 2010, Vol. 62, no 6, p. 802-802Conference paper, Published paper (Refereed)
Abstract [en]

Dermal exposure to chemicals in cosmetics and hygiene products (e.g. moisturising creams, soaps, shampoos) is increasingly recognized as an important area for risk assessment and regulation. The contents of such products is regulated by classification of exposure types (e.g. stay on/wash off) and regulatory concepts based on toxicological studies and manufacturing or market experience. Positive lists, negative lists or establishment of recommendations on concentration and exposure form a basis for consumer safety. Common problem areas are perfumes, preservatives and the formation of oxidation products after manufacture.

A new patented system, suitable for packages from 100 ml to 5 l, with collapsible plastic bags and unique dosage valves prevents bacteria and air from entering the packaging. Thus the use of preservatives can be avoided.

This may lead to a reduced risk of individual reactions to specific preservatives as well as cross-allergy reactions. The consumer no longer needs to hunt for strange names on small ingredient labels. Also, it could prevent the prospective development of allergy. The avoidance of oxidation products is another advantage.

Place, publisher, year, edition, pages
Pharmaceutical Press, 2010
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-58367 (URN)000278527300066 ()
Conference
Perspectives in Percutaneous Penetration, 12th International Conference, La Grande Motte, France
Available from: 2010-08-13 Created: 2010-08-11 Last updated: 2011-03-22
Farnebo, S., Thorfinn, J., Henricson, J. & Tesselaar, E. (2010). Hyperaemic changes in forearm skin perfusion and RBC concentration after increasing occlusion times. MICROVASCULAR RESEARCH, 80(3), 412-416
Open this publication in new window or tab >>Hyperaemic changes in forearm skin perfusion and RBC concentration after increasing occlusion times
2010 (English)In: MICROVASCULAR RESEARCH, ISSN 0026-2862, Vol. 80, no 3, p. 412-416Article in journal (Refereed) Published
Abstract [en]

Tissue occlusion and the hyperaemic response upon reperfusion can be used as a tool to assess microvascular function in various vascular diseases. Currently, laser Doppler flowmetry (LDF) is applied most often to measure hyperaemic responses. In this study, we have applied tissue viability imaging (TiVi) and LDF to measure the change in red blood cell concentration and perfusion in the skin after occlusions of the forearm with increasing duration. We have found that there is a strong correlation between the changes in perfusion and red blood cell (RBC) concentration during post-occlusive hyperaemia (perfusion: r = 0.80; RBC concentration: r = 0.94). This correlation increases with longer occlusion durations (1, 5 and 10 min). Furthermore, for both perfusion and RBC concentration, the maximum responses (perfusion: r(2) = 0.59; RBC concentration: r(2) = 0.78) and the recovery times (perfusion: r(2) = 0.62; RBC concentration: r(2) = 0.91) increase linearly with the duration of the occlusion. Maximum responses and recovery times were more reproducible for RBC concentration (as measured with TiVi) than for perfusion (as measured with LDF). These results show that perfusion and RBC concentration are related during post-occlusive hyperaemia and that TiVi can be used as a tool in the assessment of hyperaemic responses that has advantages in terms of reproducibility, sensitivity and ease of use.

Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam, 2010
Keywords
Occlusion, Hyperaemia, Laser Doppler, Tissue viability imaging, Perfusion, Red blood cell concentration, Polarisation light spectroscopy, Ischemia, Reperfusion
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-63383 (URN)10.1016/j.mvr.2010.07.008 (DOI)000284678300016 ()
Note
Original Publication: Simon Farnebo, Johan Thorfinn, Joakim Henricson and Erik Tesselaar, Hyperaemic changes in forearm skin perfusion and RBC concentration after increasing occlusion times, 2010, MICROVASCULAR RESEARCH, (80), 3, 412-416. http://dx.doi.org/10.1016/j.mvr.2010.07.008 Copyright: Elsevier Science B.V., Amsterdam http://www.elsevier.com/ Available from: 2010-12-17 Created: 2010-12-17 Last updated: 2010-12-22
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