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Olsson, Johan D. M.
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Publications (3 of 3) Show all publications
Nilsson, P., Olsson, J., Stabo-Eeg, F., Lindgren, M., Konradsson, P. & Inganäs, O. (2005). Chiral Recognition of a Synthetic Peptide Using Enantiomeric Conjugated Polyelectrolytes and Optical Spectroscopy. Macromolecules, 38, 6813-6821
Open this publication in new window or tab >>Chiral Recognition of a Synthetic Peptide Using Enantiomeric Conjugated Polyelectrolytes and Optical Spectroscopy
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2005 (English)In: Macromolecules, ISSN 0024-9297, E-ISSN 1520-5835, Vol. 38, p. 6813-6821Article in journal (Refereed) Published
National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-30363 (URN)10.1021/ma051188f (DOI)15910 (Local ID)15910 (Archive number)15910 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13
Herland, A., Nilsson, K. P., Olsson, J. D. M., Hammarström, P., Konradsson, P. & Inganäs, O. (2005). Synthesis of a regioregular zwitterionic conjugated oligoelectrolyte, usable as an optical probe for detection of amyloid fibril formation at acidic pH. Journal of the American Chemical Society, 127(7), 2317-2323
Open this publication in new window or tab >>Synthesis of a regioregular zwitterionic conjugated oligoelectrolyte, usable as an optical probe for detection of amyloid fibril formation at acidic pH
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2005 (English)In: Journal of the American Chemical Society, ISSN 0002-7863, E-ISSN 1520-5126, Vol. 127, no 7, p. 2317-2323Article in journal (Refereed) Published
Abstract [en]

Changes of the optical properties of conjugated polyelectrolytes have been utilized to monitor noncovalent interactions between biomolecules and the conjugated polyelectrolytes in sensor applications. A regioregular, zwitterionic conjugated oligoelectrolyte was synthesized in order to create a probe with a defined set of optical properties and hereby facilitate interpretation of biomolecule−oligoelectrolyte interactions. The synthesized oligoelectrolyte was used at acidic pH as a novel optical probe to detect amyloid fibril formation of bovine insulin and chicken lysozyme. Interaction of the probe with formed amyloid fibrils results in changes of the geometry and the electronic structure of the oligoelectrolyte chains, which were monitored with absorption and emission spectroscopy.

National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-14598 (URN)10.1021/ja045835e (DOI)
Available from: 2007-10-12 Created: 2007-10-12 Last updated: 2018-04-25
Nilsson, P., Olsson, J., Konradsson, P. & Inganäs, O. (2004). Enantiomeric substituents determine the chirality of luminescent conjugated polythiophenes. Macromolecules, 37(17), 6316-6321
Open this publication in new window or tab >>Enantiomeric substituents determine the chirality of luminescent conjugated polythiophenes
2004 (English)In: Macromolecules, ISSN 0024-9297, E-ISSN 1520-5835, Vol. 37, no 17, p. 6316-6321Article in journal (Refereed) Published
Abstract [en]

Chiral isomers of 3-substituted polythiophenes with amino acid functiontionalized side chains are compared. The polymers show pH-dependent absorption, emission, and circular dichroism spectra in buffered aqueous solution. At pH equal to pI of the amino acid, the backbones adopt nonplanar helical conformations, and the polymer chains are separated from each other. Increasing pH leads to more planar conformations of the backbones and an aggregation of the polymer chains occurs. A lower pH will also lead to more planar conformation of the backbones, but aggregation of the polymer chains appears to be absent. The nonplanar to planar transition of the polymer backbone and the separation/aggregation of different polymer chains is not affected by stereochemistry of the zwitterionic side chain. The two isomers have almost identical pH-dependent absorption and emission spectra. However, the chirality of the zwitterionic side chain is reflected in the conformation of the polymer backbone, giving rise to a right-handed and left-handed helical form of polythiophene chains since the induced circular dichroism patterns of the two polymers are mirror images.

National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-45660 (URN)10.1021/ma048859e (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13
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