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2022 (English)In: International Journal of Infectious Diseases, ISSN 1201-9712, E-ISSN 1878-3511, Vol. 125, p. 120-131Article, review/survey (Refereed) Published
Abstract [en]
Objectives: To describe the global trends of pulmonary nontuberculous mycobacteria (NTM) infection and disease.
Methods: A systematic review of studies including culture-based NTM data over time. Studies reporting on pulmonary NTM infection and/or disease were included. Information on the use of guideline-based criteria for disease were collected, in which, infection is defined as the absence of symptoms and radiological findings compatible with NTM pulmonary disease. The trends of change for incidence/prevalence were evaluated using linear regressions, and the corresponding pooled estimates were calculated.
Results: Most studies reported increasing pulmonary NTM infection (82.1%) and disease (66.7%) trends. The overall annual rate of change for NTM infection and disease per 100,000 persons/year was 4.0% (95% confidence interval [CI]: 3.2-4.8) and 4.1% (95% CI: 3.2-5.0), respectively. For absolute numbers of NTM infection and disease, the overall annual change was 2.0 (95% CI: 1.6-2.3) and 0.5 (95% CI: 0.3-0.7), respectively. An increasing trend was also seen for Mycobacterium avium complex infection (n = 15/19, 78.9%) and disease (n = 10/12, 83.9%) and for Mycobacterium abscessus complex (n = 15/23, 65.2%) infection (n = 11/17, 64.7%) but less so for disease (n = 2/8, 25.0%).
Conclusion: Our data indicate an overall increase in NTM worldwide for both infection and disease. The explanation to this phenomenon warrants further investigation.
Place, publisher, year, edition, pages
Elsevier, 2022
Keywords
Chronic lung disease; Incidence; Nontuberculous mycobacteria; Respiratory infections; Systematic review
National Category
Infectious Medicine Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:liu:diva-192100 (URN)10.1016/j.ijid.2022.10.013 (DOI)000965649700010 ()36244600 (PubMedID)
Note
Funding: Department of Public Health, Aarhus University; Fonden, Skibsreder Per Henriksen, R. og hustrus fond; Region Midtjyllands Sundhedsvidenskabelige Forskningsfond; Christian Larsen og dommer Ellen Larsens Legat; Helga og Peter Kornings Fond; Beckett-Fonden
2023-03-022023-03-022024-05-05