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Sjögren, Elaine
Publications (10 of 10) Show all publications
Pössel, P., Mitchell, A. M., Sjögren, E. & Kristenson, M. (2015). Do Depressive Symptoms Mediate the Relationship Between Hopelessness and Diurnal Cortisol Rhythm?. International Journal of Behavioral Medicine, 22(2), 251-257
Open this publication in new window or tab >>Do Depressive Symptoms Mediate the Relationship Between Hopelessness and Diurnal Cortisol Rhythm?
2015 (English)In: International Journal of Behavioral Medicine, ISSN 1070-5503, E-ISSN 1532-7558, Vol. 22, no 2, p. 251-257Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Research has revealed a well-established relationship of depressive symptoms and hopelessness with a variety of physical illnesses that are associated with a dysfunction of the hypothalamic-pituitary-adrenal-axis.

PURPOSE: The purpose of this study was to test if depressive symptoms mediate the relationship between hopelessness and cortisol, a measure of the hypothalamic-pituitary-adrenal-axis.

METHODS: Hopelessness, depressive symptoms, and diurnal cortisol rhythm were measured in 257 adults (128 women and 129 men; age range, 20-74 years) in this cross-sectional study. To test the hypothesis, two linear regression analyses and asymmetrical confidence intervals around the regression weights were conducted. A second set of analyses was calculated to be able to exclude the possibility of hopelessness as a mediator between depressive symptoms and cortisol.

RESULTS: As predicted, after adjusting for age, gender, awakening time, and medication use, more hopelessness predicted more depressive symptoms and more depressive symptoms predicted a flatter diurnal cortisol rhythm. The 95 % confidence intervals revealed that the indirect relationship between hopelessness and diurnal cortisol rhythm was significant. The analyses with hopelessness as a potential mediator revealed that hopelessness does not mediate the association between depressive symptoms and cortisol.

CONCLUSIONS: While the relationship between hopelessness and cortisol was mediated by depressive symptoms in this cross-sectional study, many other risk factors of depression have not been examined. Thus, future longitudinal studies should examine the relationships between those risk factors of depression and the hypothalamic-pituitary-adrenal-axis.

Keywords
Population-based Cross-sectional study Mediation model Hopelessness Depressive symptoms Diurnal cortisol rhythm
National Category
Other Medical Sciences not elsewhere specified
Identifiers
urn:nbn:se:liu:diva-115573 (URN)10.1007/s12529-014-9422-6 (DOI)000351523600011 ()25475609 (PubMedID)
Available from: 2015-03-18 Created: 2015-03-17 Last updated: 2017-12-04
Mitchell, A. M., Poessel, P., Sjögren, E. & Kristenson, M. (2013). HOPELESSNESS THE "ACTIVE INGREDIENT"? ASSOCIATIONS OF HOPELESSNESS AND DEPRESSIVE SYMPTOMS WITH INTERLEUKIN-6. International Journal of Psychiatry in Medicine, 46(1), 109-117
Open this publication in new window or tab >>HOPELESSNESS THE "ACTIVE INGREDIENT"? ASSOCIATIONS OF HOPELESSNESS AND DEPRESSIVE SYMPTOMS WITH INTERLEUKIN-6
2013 (English)In: International Journal of Psychiatry in Medicine, ISSN 0091-2174, E-ISSN 1541-3527, Vol. 46, no 1, p. 109-117Article in journal (Refereed) Published
Abstract [en]

Objective: Previous research has revealed a relationship of depressive symptoms and hopelessness with cardiovascular diseases (CVDs) which are associated with elevated levels of interleukin-6 (IL-6). The objective of this study was to explore whether depressive symptoms and hopelessness are independent predictors of IL-6 levels. Method: Hopelessness, depressive symptoms, and IL-6 were measured in 45 Swedish adults (26 women and 19 men; age range: 31-65 years). Two separated linear regressions were conducted with hopelessness and depressive symptoms serving as individual predictors of IL-6. Another regression analysis examined whether the two predictors predict IL-6 when controlling for each other. The regression coefficients of the models with one predictor and with both predictors were compared. Results: As predicted, after adjusting for age, BMI, illness, smoking, and gender, more depressive symptoms and more hopelessness predicted higher IL-6 levels in independent regressions. When controlling for each other, hopelessness, but not depressive symptoms, predicted IL-6 levels. Finally, when controlling for hopelessness, the regression between depressive symptoms and IL-6 level was significantly reduced; however, there was no significant change in the regression between hopelessness and IL-6 level when controlling for depressive symptoms. Conclusions: Thus, these results suggest that depressive symptoms and hopelessness are not independent predictors of IL-6 levels. Future research should explore the interplay of hopelessness and depressive symptoms on other risk factors of CVDs.

Place, publisher, year, edition, pages
Baywood Publishing, 2013
Keywords
cross-sectional study, hopelessness, depressive symptoms, interleukin-6
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-102794 (URN)10.2190/PM.46.1.g (DOI)000327728000007 ()
Available from: 2014-01-07 Created: 2013-12-26 Last updated: 2017-12-06
Sjögren, E., Uhlin, L., Ragnemalm, E. L., Tingström, P. & Abrandt Dahlgren, M. (2012). Academics reflections on the use of eportfolio documentation of pedagogical skills: a pilot study. The quality of higher education, 9, 98-119
Open this publication in new window or tab >>Academics reflections on the use of eportfolio documentation of pedagogical skills: a pilot study
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2012 (English)In: The quality of higher education, ISSN 1822-1645, Vol. 9, p. 98-119Article in journal (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-89996 (URN)
Available from: 2013-03-13 Created: 2013-03-13 Last updated: 2013-09-03
Ragnemalm, E., Sjögren, E. & Uhlin, L. (2008). Elektronisk portfolio, ett verktyg för lärares meritering?. In: Proceedings NU2008. Paper presented at NU2008,2008. Centre for educational development, Lunds universitet
Open this publication in new window or tab >>Elektronisk portfolio, ett verktyg för lärares meritering?
2008 (Swedish)In: Proceedings NU2008, Centre for educational development, Lunds universitet , 2008Conference paper, Oral presentation only (Refereed)
Place, publisher, year, edition, pages
Centre for educational development, Lunds universitet, 2008
National Category
Computer Sciences Educational Sciences
Identifiers
urn:nbn:se:liu:diva-44815 (URN)77700 (Local ID)978-91-977974-1-2 (ISBN)77700 (Archive number)77700 (OAI)
Conference
NU2008,2008
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2018-01-12
Sjögren, E., Sjögren, E., Kristenson, M., Kristenson, M., Tondel, M. & Ståhlbom, B. (2006). Can gender differences in psychosocial factors be explained by socioeconomic status?. Scandinavian Journal of Public Health, 34, 59-68
Open this publication in new window or tab >>Can gender differences in psychosocial factors be explained by socioeconomic status?
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2006 (English)In: Scandinavian Journal of Public Health, ISSN 1403-4948, E-ISSN 1651-1905, Vol. 34, p. 59-68Article in journal (Refereed) Published
Keywords
Decision latitude, gender, health, psychosocial factors, social integration, socioeconomic status
National Category
Social Sciences
Identifiers
urn:nbn:se:liu:diva-32373 (URN)10.1080/14034940510006049 (DOI)18270 (Local ID)18270 (Archive number)18270 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13
Sjögren, E., Leanderson, P. & Kristenson, M. (2006). Diurnal saliva cortisol levels and relations to psychosocial factors in a population sample of middle-aged Swedish men and women. International Journal of Behavioral Medicine, 13(3), 193-200
Open this publication in new window or tab >>Diurnal saliva cortisol levels and relations to psychosocial factors in a population sample of middle-aged Swedish men and women
2006 (English)In: International Journal of Behavioral Medicine, ISSN 1070-5503, E-ISSN 1532-7558, Vol. 13, no 3, p. 193-200Article in journal (Refereed) Published
Abstract [en]

Whereas psychosocial risk factors increase the risk for disease, psychosocial resources reduce this risk. To examine a possible pathway for these effects, the relations between saliva cortisol levels and psychosocial factors were studied in a random sample of 257 men and women aged 30 to 64 years. Saliva samples were collected at home on waking, 30 min after waking, and in the evening. A flatter diurnal rhythm of cortisol, that is, lower deviations between awakening and evening cortisol levels, was related to high levels of psychosocial risk factors (cynicism, depression, and vital exhaustion), whereas a steeper diurnal rhythm was related to psychosocial resources (social support and coping), general health, and well-being (all p < .05). Our results support earlier suggestions that the capacity of the hypothalamic-pituitary- adrenal-axis to dynamically respond to stress is 1 pathway for observed effects of psychosocial factors regarding risk for disease development. Copyright © 2006 by Lawrence Erlbaum Associates, Inc.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-35727 (URN)28328 (Local ID)28328 (Archive number)28328 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Sjögren, E., Leanderson, P., Kristenson, M. & Ernerudh, J. (2006). Interleukin-6 levels in relation to psychosocial factors: Studies on serum, saliva, and in vitro production by blood mononuclear cells. Brain, behavior, and immunity, 20(3), 270-278
Open this publication in new window or tab >>Interleukin-6 levels in relation to psychosocial factors: Studies on serum, saliva, and in vitro production by blood mononuclear cells
2006 (English)In: Brain, behavior, and immunity, ISSN 0889-1591, E-ISSN 1090-2139, Vol. 20, no 3, p. 270-278Article in journal (Refereed) Published
Abstract [en]

Psychosocial factors and interleukin-6 (IL-6) levels are both related to risk of morbidity and mortality. The aim of this study was to investigate how a broad range of psychosocial factors related to levels of IL-6 in different media. Fifty-nine men and women aged 30-65 were recruited from a larger study and selected to cover a broad range of psychosocial status. IL-6 levels were analyzed in serum, in saliva collected at home at three different time points during a day, and in the supernatant of cell cultures stimulated in vitro with lipopolysaccharide. After adjustments for age, gender, self-reported health problems, and lifestyle factors, IL-6-levels in serum were negatively correlated with coping and self-esteem, and positively correlated with cynicism, hostile affect, hopelessness, depression, and vital exhaustion. In saliva samples, at all time points, IL-6 levels were positively correlated to cynicism, and IL-6 levels 30 min after awakening were also positively correlated with hopelessness, depression, and vital exhaustion. After adjustment for age and gender, cynicism, depression, and vital exhaustion were negatively correlated to IL-6 levels in the supernatant of cell cultures stimulated in vitro with lipopolysaccharide, but this effect was lost after control for self-reported health problems and lifestyle factors. In conclusion, we found that IL-6 levels in serum and saliva were negatively related to psychosocial resources and positively related to psychosocial risk factors. These data strengthen the argument that IL-6 is involved in mediating the risk for disease development that has been associated with psychosocial factors. © 2005 Elsevier Inc. All rights reserved.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-34798 (URN)10.1016/j.bbi.2005.08.001 (DOI)23296 (Local ID)23296 (Archive number)23296 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Sjögren, E. (2005). Psychosocial factors in adult life - in relation to gender, biological markers of stress and self-rated health. (Doctoral dissertation). Linköping: Linköpings universitet
Open this publication in new window or tab >>Psychosocial factors in adult life - in relation to gender, biological markers of stress and self-rated health
2005 (English)Doctoral thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2005
Series
Linköping Dissertations on Health and Society, ISSN 1651-1646
National Category
Social Sciences
Identifiers
urn:nbn:se:liu:diva-34561 (URN)21830 (Local ID)91-85299-29-4 (ISBN)21830 (Archive number)21830 (OAI)
Public defence
2005-07-01
Note
2005Available from: 2009-10-10 Created: 2009-10-10
Sjögren, E., Leandersson, P., Ernerudh, J. & Kristenson, M. (2004). Interleukin 6 levels in serum, saliva and in vitro production by blood mononuclear cells and their relations to psychosocial factors. In: Eighth International Congress of Behavioral Medicine,2004 (pp. 353). London: Lawrence erlbaum associates publishers London
Open this publication in new window or tab >>Interleukin 6 levels in serum, saliva and in vitro production by blood mononuclear cells and their relations to psychosocial factors
2004 (English)In: Eighth International Congress of Behavioral Medicine,2004, London: Lawrence erlbaum associates publishers London , 2004, p. 353-Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
London: Lawrence erlbaum associates publishers London, 2004
National Category
Social Sciences
Identifiers
urn:nbn:se:liu:diva-22296 (URN)1482 (Local ID)1482 (Archive number)1482 (OAI)
Available from: 2009-10-07 Created: 2009-10-07
Sjögren, E., Leandersson, P., Ernerudh, J. & Kristenson, M. (2004). Psycholsocial factors and biological mechanisms in stress. In: The 26th World Congress of the International Federation of Biomedical Laboratory Science IFBLS,2004 (pp. 74). Stockholm: ABCD Swedish Association of health professionals
Open this publication in new window or tab >>Psycholsocial factors and biological mechanisms in stress
2004 (English)In: The 26th World Congress of the International Federation of Biomedical Laboratory Science IFBLS,2004, Stockholm: ABCD Swedish Association of health professionals , 2004, p. 74-Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
Stockholm: ABCD Swedish Association of health professionals, 2004
National Category
Social Sciences
Identifiers
urn:nbn:se:liu:diva-22292 (URN)1478 (Local ID)1478 (Archive number)1478 (OAI)
Available from: 2009-10-07 Created: 2009-10-07
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