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BETA
Bergerheim, Ulf
Publications (7 of 7) Show all publications
Lapointe, J., Li, C., Higgins, J. P., van de Rijn, M., Bair, E., Montgomery, K., . . . Pollack, J. R. (2004). Gene expression profiling identifies clinically relevant subtypes of prostate cancer. Proceedings of the National Academy of Sciences of the United States of America, 101(3), 811-816
Open this publication in new window or tab >>Gene expression profiling identifies clinically relevant subtypes of prostate cancer
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2004 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 101, no 3, p. 811-816Article in journal (Refereed) Published
Abstract [en]

Prostate cancer, a leading cause of cancer death, displays a broad range of clinical behavior from relatively indolent to aggressive metastatic disease. To explore potential molecular variation underlying this clinical heterogeneity, we profiled gene expression in 62 primary prostate tumors, as well as 41 normal prostate specimens and nine lymph node metastases, using cDNA microarrays containing ≈26,000 genes. Unsupervised hierarchical clustering readily distinguished tumors from normal samples, and further identified three subclasses of prostate tumors based on distinct patterns of gene expression. High-grade and advanced stage tumors, as well as tumors associated with recurrence, were disproportionately represented among two of the three subtypes, one of which also included most lymph node metastases. To further characterize the clinical relevance of tumor subtypes, we evaluated as surrogate markers two genes differentially expressed among tumor subgroups by using immunohistochemistry on tissue microarrays representing an independent set of 225 prostate tumors. Positive staining for MUC1, a gene highly expressed in the subgroups with "aggressive" clinicopathological features, was associated with an elevated risk of recurrence (P = 0.003), whereas strong staining for AZGP1, a gene highly expressed in the other subgroup, was associated with a decreased risk of recurrence (P = 0.0008). In multivariate analysis, MUC1 and AZGP1 staining were strong predictors of tumor recurrence independent of tumor grade, stage, and preoperative prostate-specific antigen levels. Our results suggest that prostate tumors can be usefully classified according to their gene expression patterns, and these tumor subtypes may provide a basis for improved prognostication and treatment stratification.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-28162 (URN)10.1073/pnas.0304146101 (DOI)12977 (Local ID)12977 (Archive number)12977 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
Alimov, A., Sundelin, B., Wang, N., Larsson, C. & Bergerheim, U. (2004). Loss of 14q31-q32.2 in renal cell carcinoma is associated with high malignancy grade and poor survival. International Journal of Oncology, 25, 179-185
Open this publication in new window or tab >>Loss of 14q31-q32.2 in renal cell carcinoma is associated with high malignancy grade and poor survival
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2004 (English)In: International Journal of Oncology, ISSN 1019-6439, Vol. 25, p. 179-185Article in journal (Refereed) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-28161 (URN)12976 (Local ID)12976 (Archive number)12976 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
Alimov, A., Sundelin, B., Bergerheim, U., Pavlenko, M., Pisa, P., Zetterberg, A., . . . Lagercrantz, S. (2004). Molecular cytogenetic characterization shows higher genetic homogeneity in conventional renal cell carcinoma compared to other kidney cancers. International Journal of Oncology, 25, 955-960
Open this publication in new window or tab >>Molecular cytogenetic characterization shows higher genetic homogeneity in conventional renal cell carcinoma compared to other kidney cancers
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2004 (English)In: International Journal of Oncology, ISSN 1019-6439, Vol. 25, p. 955-960Article in journal (Refereed) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-28167 (URN)12983 (Local ID)12983 (Archive number)12983 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
Matsuyama, H., Pan, Y., Oba, K., Tsukamoto, M., Nagao, K., Yamaguchi, S., . . . Naito, K. (2003). Analysis of genomic alterations on urological malignancies by fluorescence in situ hybridization. Bulletin of the Yamaguchi Medical School, 50, 11-18
Open this publication in new window or tab >>Analysis of genomic alterations on urological malignancies by fluorescence in situ hybridization
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2003 (English)In: Bulletin of the Yamaguchi Medical School, ISSN 0513-1812, Vol. 50, p. 11-18Article in journal (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-24385 (URN)6478 (Local ID)6478 (Archive number)6478 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2011-01-13
Matsuyama, H., Pan, Y., Yoshihiro, S., Kudren, D., Naito, K., Bergerheim, U. & Ekman, P. (2003). Clinical significance of chromosome 8p, 10q, and 16q deletions in prostate cancer. The Prostate, 54, 103-111
Open this publication in new window or tab >>Clinical significance of chromosome 8p, 10q, and 16q deletions in prostate cancer
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2003 (English)In: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 54, p. 103-111Article in journal (Refereed) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-24929 (URN)9335 (Local ID)9335 (Archive number)9335 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
Li, C., Grönberg, H., Matsuyama, H., Weber, G., Nordenskjöld, M., Naito, K., . . . Ekman, P. (2003). Difference between Swedish and Japanese men in the association between AR CAG repeats and prostate cancer suggesting a susceptibility-modifying locus overlapping the androgen receptor gene. International Journal of Molecular Medicine, 11, 529-533
Open this publication in new window or tab >>Difference between Swedish and Japanese men in the association between AR CAG repeats and prostate cancer suggesting a susceptibility-modifying locus overlapping the androgen receptor gene
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2003 (English)In: International Journal of Molecular Medicine, ISSN 1107-3756, E-ISSN 1791-244X, Vol. 11, p. 529-533Article in journal (Refereed) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-24927 (URN)9332 (Local ID)9332 (Archive number)9332 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
Matsuyama, H., Pan, Y., Oba, K., Yoshihiro, S., Matsuda, K., Hägarth, L., . . . Ekman, P. (2003). The role of chromosome 8p22 deletion for predicting disease progression and pathological staging in prostate cancer. Aktuelle Urologie, 34, 247-249
Open this publication in new window or tab >>The role of chromosome 8p22 deletion for predicting disease progression and pathological staging in prostate cancer
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2003 (English)In: Aktuelle Urologie, ISSN 0001-7868, E-ISSN 1438-8820, Vol. 34, p. 247-249Article in journal (Refereed) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-24928 (URN)9334 (Local ID)9334 (Archive number)9334 (OAI)
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2017-12-13
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