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Gunnarsson, Tove
Publications (10 of 16) Show all publications
Gunnarsson, T., Mahoney, C., Shlik, J., Bradwejn, J. & Knott, V. (2003). Acute Effects of Cholecystokinin Tetrapeptide on Brain Stem Auditory Evoked Potentials in Healthy Volunteers. Pharmacopsychiatry, 36(5), 181-186
Open this publication in new window or tab >>Acute Effects of Cholecystokinin Tetrapeptide on Brain Stem Auditory Evoked Potentials in Healthy Volunteers
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2003 (English)In: Pharmacopsychiatry, ISSN 0176-3679, E-ISSN 1439-0795, Vol. 36, no 5, p. 181-186Article in journal (Refereed) Published
Abstract [en]

This study investigated the effects of continuous slow intravenous infusion of cholecystokinin tetrapeptide (CCK-4) on brain stem auditory evoked potentials (BSAEP) in healthy subjects. Twenty-four subjects, 15 females and 9males, were assigned to infusion with either placebo or CCK-4 in a randomized, double-blind, parallel group design. BSAEPs, mood, physical symptoms, and vital signs were assessed once before infusion and at 10 min and 40 min after the onset of infusion. In the 16 subjects (N = 8, CCK-4; N = 8, placebo) CCK-4, compared to placebo, delayed peak I latency during early infusion, slowed the latencies of peaks III and V, and decreased the amplitude of peak III throughout the infusion. No significant treatment differences were observed with respect to symptoms, mood, or cardiovascular measures. These preliminary findings suggest that CCK-4 may interfere with information processing in the brain stem auditory pathways and that prolonged intravenous CCK-4 administration may be a useful challenge paradigm for investigating CCK's modulatory role on brain stem mechanisms mediating anxiety and panic in humans.

Keywords
Cholecystokinin, CCK-4, brain stem auditory evoked potentials, anxiety, panic
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27796 (URN)10.1055/s-2003-43047 (DOI)12543 (Local ID)12543 (Archive number)12543 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved
Knott, V., Mahoney, C., Bradwejn, J., Shlik, J. & Gunnarsson, T. (2003). Effects of acute cholecystokinin infusion on hemispheric EEG asymmetry and coherence in healthy volunteers. Progress in Neuro-psychopharmacology and Biological Psychiatry, 27(1), 179-184
Open this publication in new window or tab >>Effects of acute cholecystokinin infusion on hemispheric EEG asymmetry and coherence in healthy volunteers
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2003 (English)In: Progress in Neuro-psychopharmacology and Biological Psychiatry, ISSN 0278-5846, E-ISSN 1878-4216, Vol. 27, no 1, p. 179-184Article in journal (Refereed) Published
Abstract [en]

This study investigated the effects of continuous slow infusion of cholecystokinin tetrapeptide (CCK-4), a neuropeptide with panicogenic properties, on functional hemispheric differences, as indexed by quantitative electroencephalographic (EEG) asymmetry and coherence measures. Twenty-four adult volunteers (15 females and 9 males) were assigned to infusion with either placebo or CCK-4 in a randomized, double-blind, parallel-group design, with EEG being recorded before and during (10 and 40 min) a 60-min infusion period. No significant treatment differences were observed for absolute EEG power but, compared to placebo, CCK-4 infusion increased asymmetry and reduced coherence of slow-wave activity at midtemporal recording sites. These findings support the contention that functional imbalance of the temporal cortex, perhaps mediated by CCK-4, is involved in panic disorder (PD).

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27795 (URN)10.1016/S0278-5846(02)00350-0 (DOI)12542 (Local ID)12542 (Archive number)12542 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
Wikström, S., Gunnarsson, T. & Nordin, C. (2003). Tactile stimulus and neurohormonal response: A pilot study. International Journal of Neuroscience, 113(6), 787-793
Open this publication in new window or tab >>Tactile stimulus and neurohormonal response: A pilot study
2003 (English)In: International Journal of Neuroscience, ISSN 0020-7454, E-ISSN 1563-5279, Vol. 113, no 6, p. 787-793Article in journal (Refereed) Published
Abstract [en]

The effects of tactile stimuli on plasma oxytocin and neuropeptide Y (NPY) were investigated in 21 volunteers exposed to massage. Blood samples for basal values were drawn immediately before and immediately after finishing the massage. A third sample was drawn after 60 min of restricted rest. On focusing on the difference between oxytocin concentrations before and immediately after massage, we found a sex difference. An opposite sex difference was found for NPY. The results imply that there might be sex-related difference in neurohormonal response to tactile stimuli such as in massage, and the results contradict those of previously reported animal experiments.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27794 (URN)10.1080/00207450390200954 (DOI)12541 (Local ID)12541 (Archive number)12541 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
Lundmark, J., Gunnarsson, T. & Bengtsson, F. (2002). A possible interaction between lithium and rofecoxib [1]. British Journal of Clinical Pharmacology, 53(4), 403-404
Open this publication in new window or tab >>A possible interaction between lithium and rofecoxib [1]
2002 (English)In: British Journal of Clinical Pharmacology, ISSN 0306-5251, E-ISSN 1365-2125, Vol. 53, no 4, p. 403-404Article in journal (Refereed) Published
Abstract [en]

[No abstract available]

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27658 (URN)10.1046/j.1365-2125.2002.01572_1.x (DOI)12396 (Local ID)12396 (Archive number)12396 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
Knott, V., Mahoney, C., Gunnarsson, T., Bradwejn, J. & Shlik, J. (2002). Acute cholecystokinin effects on event-related potentials in healthy volunteers. Human Psychopharmacology: Clinical and Experimental, 17(6), 285-291
Open this publication in new window or tab >>Acute cholecystokinin effects on event-related potentials in healthy volunteers
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2002 (English)In: Human Psychopharmacology: Clinical and Experimental, ISSN 0885-6222, E-ISSN 1099-1077, Vol. 17, no 6, p. 285-291Article in journal (Refereed) Published
Abstract [en]

This study investigated the effects of a continuous slow infusion of cholecystokinin tetrapeptide (CCK-4), a neuropeptide with panicogenic properties, on brain event-related potentials (ERPs) in healthy adults. Twenty-four volunteers, 15 females and 9 males, were assigned to infusion with either placebo or CCK-4 in a randomized, double-blind, parallel group design. ERPs, elicited within a standard auditory odd-ball paradigm requiring the counting of rare (20%) occurring 'deviant' tones interspersed among more frequent (80%) occurring 'standard' tones, were assessed once before infusion, and at 10 min and 40 min after the onset of infusion. Compared with the placebo, CCK-4 delayed the latencies of N100 and P200 components elicited by 'deviant' stimuli. No significant treatment differences were observed with respect to N200, P300b, mood or adverse symptoms. These preliminary findings suggest that CCK-4 may interfere with information processing relating to the selection of significant stimulating and as such, may be of relevance to mechanisms underlying panic disorder. Copyright © 2002 John Wiley & Sons, Ltd.

Keywords
CCK-4, Cholecystokinin, ERPs, Event-related potentials, Panic, Panic disorder
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-46926 (URN)10.1002/hup.417 (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13
Gunnarsson, T. (2002). Cholecystokinin in cerebrospinal fluid. European psychiatry, 17
Open this publication in new window or tab >>Cholecystokinin in cerebrospinal fluid
2002 (English)In: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 17, p. 51S-51SConference paper, Published paper (Other academic)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-48851 (URN)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12
Shlik, J., Nordin, C., Sjödin, I., Gunnarsson, T., Maron, E. & Toru, I. (2002). Cholecystokinin-serotonin interactions. European psychiatry, 17
Open this publication in new window or tab >>Cholecystokinin-serotonin interactions
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2002 (English)In: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 17, p. 50S-51SConference paper, Published paper (Other academic)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-48850 (URN)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12
Gunnarsson, T., Leszniewski, W., Bak, J. & Davidsson, L. (2001). An intradural cervical chordoma mimicking a neurinoma - Case illustration. Journal of Neurosurgery, 95(1)
Open this publication in new window or tab >>An intradural cervical chordoma mimicking a neurinoma - Case illustration
2001 (English)In: Journal of Neurosurgery, ISSN 0022-3085, E-ISSN 1933-0693, Vol. 95, no 1, p. 144-144Other (Other academic)
Publisher
p. 144-144
Keywords
intradural tumor, chordoma, neurinoma
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-49205 (URN)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12
Gunnarsson, T., Leszniewski, W., Bak, J. & Davidsson, L. (2001). An intradural cervical chordoma mimicking a neurinoma. Case illustration.. Journal of Neurosurgery, 95, 144-144
Open this publication in new window or tab >>An intradural cervical chordoma mimicking a neurinoma. Case illustration.
2001 (English)In: Journal of Neurosurgery, ISSN 0022-3085, E-ISSN 1933-0693, Vol. 95, p. 144-144Article in journal (Refereed) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-25781 (URN)10216 (Local ID)10216 (Archive number)10216 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
Gunnarsson, T., Sjöberg, S., Eriksson, M. & Nordin, C. (2001). Depressive Symptoms in Hypothyroid Disorder with some Observations on Biochemical Correlates. Neuropsychobiology, 43(2), 70-74
Open this publication in new window or tab >>Depressive Symptoms in Hypothyroid Disorder with some Observations on Biochemical Correlates
2001 (English)In: Neuropsychobiology, ISSN 0302-282X, E-ISSN 1423-0224, Vol. 43, no 2, p. 70-74Article in journal (Refereed) Published
Abstract [en]

Lumbar punctures and ratings of depressive symptoms were done in hypothyroid patients before and during L-thyroxine therapy. Before treatment, the most prominent symptoms were concentration difficulties, lassitude, and reduced sexual interest. All patients suffered from sleep disturbances. Suicidal thoughts did not occur at all. Inner tension was negatively correlated with the anxiogenic cholecystokinin tetrapeptide (CCK-4) in the cerebrospinal fluid (CSF), while reduced sexual interest was negatively correlated with CSF tryptophan. Furthermore, failing memory correlated negatively with T3 as well as T4 in serum. A positive correlation was found between failing memory and serum TSH. All patients improved significantly during treatment. No biochemical correlates were found. In conclusion, hypothyroidism is associated with major depressive symptoms. CSF CCK-4 and tryptophan, as well as serum thyroid hormones, may constitute biochemical correlates for some of these symptoms.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27797 (URN)10.1159/000054869 (DOI)12544 (Local ID)12544 (Archive number)12544 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved
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