liu.seSearch for publications in DiVA
Change search
Link to record
Permanent link

Direct link
BETA
Messner, Karola
Publications (10 of 18) Show all publications
Fahlgren, A., Chubinskaya, S., Messner, K. & Aspenberg, P. (2006). A capsular incision leads to a fast osteoarthritic response, but also elevated levels of activated osteogenic protein-1 in rabbit knee joint cartilage. Scandinavian Journal of Medicine and Science in Sports, 16(6), 456-462
Open this publication in new window or tab >>A capsular incision leads to a fast osteoarthritic response, but also elevated levels of activated osteogenic protein-1 in rabbit knee joint cartilage
2006 (English)In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 16, no 6, p. 456-462Article in journal (Refereed) Published
Abstract [en]

We studied whether a small capsular incision alone, or combined with meniscectomy could induce early osteoarthritic changes in the rabbit knee. Thirty-one rabbits were operated on with a capsular incision in the left knee and meniscectomy in the right knee. Another 12 rabbits were used as controls. The rabbits were killed 3, 6 and 12 weeks after surgery. Osteoarthritic changes in the articular cartilage were evaluated by the modified Mankin score. The subchondral bone was evaluated by scintimetry (99mTc-HDP) and semiquantitative grading of histological changes. Osteogenic protein (OP-1) in its mature and pro-form was examined by immunohistochemistry. Both a capsular incision and meniscectomy induced articular cartilage fibrillation and increased bone metabolic activity during the initial weeks after surgery. Capsular incision led to lesser changes than meniscectomy. Mature OP-1 was elevated, and its pro-form reduced, in meniscectomized knees. A similar pattern was observed in knees with capsular incision. Already 3 weeks after surgery, the articular cartilage and subchondral bone showed typical signs of early osteoarthritis (OA), and a reparative response was suggested by increased intensity of OP-1 staining. As these signs were also found in knees with capsular incision only, it appears that trauma-related factors such as increased bleeding and inflammation are critical for the development of OA. Copyright © Blackwell Munksgaard 2006.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-36593 (URN)10.1111/j.1600-0838.2005.00513.x (DOI)31706 (Local ID)31706 (Archive number)31706 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Fahlgren, A., Messner, K. & Aspenberg, P. (2003). Meniscectomy leads to an early increase in subchondral bone plate thickness in the rabbit knee. Acta Orthopaedica Scandinavica, 74(4), 437-441
Open this publication in new window or tab >>Meniscectomy leads to an early increase in subchondral bone plate thickness in the rabbit knee
2003 (English)In: Acta Orthopaedica Scandinavica, ISSN 0001-6470, Vol. 74, no 4, p. 437-441Article in journal (Refereed) Published
Abstract [en]

We evaluated morphological changes in the tibial bone after meniscectomy in a rabbit model. 15 rabbits subjected to a medial meniscectomy in the right knee and a sham-operation in the left. Histomorphometric parameters were evaluated in the subchondral bone plate and the underlying trabecular bone, 13, 25 and 40 weeks after surgery. 5 rabbits were used as unoperated controls.Meniscectomized knees had a thicker subchondral bone plate than sham-operated contralateral ones in 13 of the 15 rabbits (p= 0.01), but the trabecular bone showed no morphological differences. The meniscectomized knees of these rabbits developed mild osteoarthrosis, described elsewhere, which may have been partly due to a change in the mechanical properties of the thickened subchondral bone plate. Our findings suggest that the first bony response after meniscectomy occurs in the subchondral bone plate rather than in the trabecular bone.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27640 (URN)10.1080/00016470310017758 (DOI)12376 (Local ID)12376 (Archive number)12376 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved
Messner, K., Fahlgren, A., Persliden, J. & Andersson, B.-M. (2001). Radiographic joint space narrowing and histologic changes in a rabbit meniscectomy model of early knee osteoarthrosis. American Journal of Sports Medicine, 29(2), 151-160
Open this publication in new window or tab >>Radiographic joint space narrowing and histologic changes in a rabbit meniscectomy model of early knee osteoarthrosis
2001 (English)In: American Journal of Sports Medicine, ISSN 0363-5465, E-ISSN 1552-3365, Vol. 29, no 2, p. 151-160Article in journal (Refereed) Published
Abstract [en]

The purpose of this study was to compare weightbearing radiographs with histologic cartilage evaluation in a rabbit meniscectomy model of the early stage of osteoarthrosis. Fifteen rabbits had a medial meniscectomy performed in one knee and a sham operation in the other knee. Five rabbits each were sacrificed at 13, 25, and 40 weeks after surgery. Radiographic joint space width and histologic cartilage changes of the medial knee compartment were quantified. Five nonoperated knees and five knees in which the meniscus had been removed immediately before the evaluations served as control specimens. Overall, the joint space of the peripheral part of the medial knee compartment was narrower in knees operated on for meniscus removal than in sham-operated knees (P < 0.003). In the knees with the meniscus removed, more cartilage changes were seen at the joint surface area of contact on radiographs than in the sham-operated knees (P < 0.0015). Indeed, the area of contact had cartilage changes similar to those in the whole medial compartment. However, there was no correlation between the degree of histologic cartilage change and the corresponding joint space measurements. Joint space width as measured on weightbearing radiographs is reduced after meniscectomy in the rabbit, but it does not reflect the degree of cartilage damage of the loaded joint surfaces in early stages of osteoarthrosis.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-25901 (URN)10342 (Local ID)10342 (Archive number)10342 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved
Fahlgren, A., Andersson, B.-M. & Messner, K. (2001). TGF-β1 as a prognostic factor in the process of early osteoarthrosis in the rabbit knee. Osteoarthritis and Cartilage, 9(3), 195-202
Open this publication in new window or tab >>TGF-β1 as a prognostic factor in the process of early osteoarthrosis in the rabbit knee
2001 (English)In: Osteoarthritis and Cartilage, ISSN 1063-4584, E-ISSN 1522-9653, Vol. 9, no 3, p. 195-202Article in journal (Refereed) Published
Abstract [en]

Objective To assess changes in knee joint fluid concentrations of transforming growth factor-β1 (TGF-β1) and proteoglycan (PG) fragments during the early course of post-traumatic osteoarthrosis (OA) after meniscectomy in the rabbit knee, and to ascertain whether the concentrations of these substances shortly after operation could be used as prognostic markers for the OA process.

Design In 15 rabbits with medial meniscectomy in one knee and a sham operation in the other knee, synovial lavage fluid samples were taken repeatedly, before operation, every third week post-operatively until 12 weeks, thereafter every sixth week, and at death. Five rabbits each were killed at 13, 25 and 40 weeks. Synovial lavage fluid samples from five non-operated rabbits served as controls. At death, two histological scores were formed that characterized the highest (MAX) and the overall (ALL) degree of OA changes in each joint.

Results TGF-β1 and PG fragment concentrations in synovial lavage fluid correlated highly (R=0.81, P< 0.001). Both OA scores were higher in meniscectomized than controls (P< 0.05). The synovial lavage fluid concentration of TGF-β1 at 3 weeks, but no other time point, correlated to the histological scores (ALL, R=0.58; MAX, R=0.52;P< 0.001).

Conclusion Higher concentrations of TGF-β1 in synovial lavage fluid early after surgery seemed indicative for the later development of more severe OA changes in contrast to lower concentrations. The association between TGF-β1 and the changes found later in the cartilage was underlined by the high correlations between this substance and PG fragment concentrations in synovial lavage fluid at all time points.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27601 (URN)10.1053/joca.2000.0376 (DOI)12331 (Local ID)12331 (Archive number)12331 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved
Messner, K. & Roos, H. (2000). Editorial. Scandinavian Journal of Medicine and Science in Sports, 10(4), 183-185
Open this publication in new window or tab >>Editorial
2000 (English)In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 10, no 4, p. 183-185p. 183-185Article in journal, Editorial material (Other academic) Published
Place, publisher, year, edition, pages
John Wiley & Sons, 2000. p. 183-185
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-49682 (URN)10.1034/j.1600-0838.2000.010004183.x (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2019-10-18Bibliographically approved
Räsänen, T. & Messner, K. (2000). Estrogen-dependent tensile properties of the rabbit knee medial collateral ligament. Scandinavian Journal of Medicine and Science in Sports, 10(1), 20-27
Open this publication in new window or tab >>Estrogen-dependent tensile properties of the rabbit knee medial collateral ligament
2000 (English)In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 10, no 1, p. 20-27Article in journal (Refereed) Published
Abstract [en]

The influence of oophorectomy or continuous administration of estradiol on the tensile properties of the rabbit knee medial collateral ligament was investigated. Young postpubertal female New Zealand white rabbits were either oophorectomized or underwent a sham operation. The sham-operated animals received in addition a daily dosage of 4 mg 17▀-estradiol. After 5 months the animals were killed, and the material properties of the bone-ligament- bone complex in one knee were determined using a material testing machine and video system, and compared to non-treated control animals. There was no difference in elastic modulus between the groups. However, the ligaments from low-dose estrogen-treated animals had a smaller cross-sectional area and a higher ultimate tensile strength than those from controls or oophorectomized rabbits (P<0.04-0.0003).

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27886 (URN)12646 (Local ID)12646 (Archive number)12646 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
Rockborn, P. & Messner, K. (2000). Long-term results of meniscus repair and meniscectomy: A 13-year functional and radiographic follow-up study. Knee Surgery, Sports Traumatology, Arthroscopy, 8(1), 2-9
Open this publication in new window or tab >>Long-term results of meniscus repair and meniscectomy: A 13-year functional and radiographic follow-up study
2000 (English)In: Knee Surgery, Sports Traumatology, Arthroscopy, ISSN 0942-2056, E-ISSN 1433-7347, Vol. 8, no 1, p. 2-9Article in journal (Refereed) Published
Abstract [en]

This study investigated the long-term outcome of common meniscus treatment (meniscectomy, repair). A consecutive series of 30 patients with open meniscus repair were compared retrospectively to 30 patients who had an arthroscopic partial or subtotal meniscectomy. The groups were matched according to sex, age, meniscus lesion, and follow-up time. The patients were aged 13-43 years at the time of operation, all had intact cruciate ligaments, and none had had previous surgery on the knee. Patients were reexamined at a mean of 13 years after the operation. In addition, for a subgroup of 22 matched pairs, data were available from a 7-year follow-up. Four of the repaired menisci did not heal, and another three reruptured during the 13-year follow-up, these menisci were all excised (23%). Meniscal remnant surgery was needed in 6 cases (20%) after initial meniscectomy. At the 13-year follow-up there was no difference between the groups in knee function, subjective complaints, or manual findings. Almost 90% of the patients in both groups had no knee problems during daily activities. At the late follow-up radiographic signs for bone spurs, sclerosis, or flattening of the femoral condyle were found in around half of the cases in each group. Three patients (10%) with initial repair and 8 (27%) with meniscectomy had minor joint space reduction, but no patient had more severe radiographic changes. After 7 years (subgroup) joint space reduction was more common after initial meniscectomy than after repair (P < 0.05). After 13 years the incidence and severity of arthrosis did not differ significantly between the two groups, even when only the successful repairs were compared to meniscectomy (P = 0.06).

Keywords
Meniscus treatment, Long-term results, Knee function, Radiographic osteoarthrosis
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27891 (URN)10.1007/s001670050002 (DOI)12651 (Local ID)12651 (Archive number)12651 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved
Messner, K., Fahlgren, A., Ross, I. & Andersson, B.-M. (2000). Simultaneous changes in bone mineral density and articular cartilage in a rabbit meniscectomy model of knee osteoarthrosis. Osteoarthritis and Cartilage, 8(3), 197-206
Open this publication in new window or tab >>Simultaneous changes in bone mineral density and articular cartilage in a rabbit meniscectomy model of knee osteoarthrosis
2000 (English)In: Osteoarthritis and Cartilage, ISSN 1063-4584, E-ISSN 1522-9653, Vol. 8, no 3, p. 197-206Article in journal (Refereed) Published
Abstract [en]

Objective It was hypothesized that increased bone mineral density of the medial proximal tibia would precede or coincide with the development of more severe cartilage changes after meniscectomy.

Methods In a rabbit knee model, mineral density of subchondral bone and changes of articular cartilage were monitored 13 to 40 weeks after medial meniscectomy or a sham operation.

Results Both procedures resulted in a decrease of bone mineral density, especially of the medial proximal tibia, which persisted up to 40 weeks (P< 0.02–0.0007). Meniscectomy induced cartilage changes typical for osteoarthrosis (P< 0.009), which progressed over time on the posterior aspect of the medial tibial plateau (P< 0.009), which is physiologically covered by the meniscus, but the procedure also induced iatrogenic changes which were located mainly on the anterior aspect of the concerned compartment, and which did not progress or develop to osteoarthrosis.

Conclusions The data suggest that the cartilage changes after meniscectomy in this animal model are caused by the surgical trauma, subsequent limb misuse, and altered load distribution, and initially associated by a decrease not an increase in bone mineral density of the proximal tibia. Moreover, the cartilage changes progressed without a simultaneous increase of the bone mineral density at corresponding sites.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27749 (URN)10.1053/joca.1999.0290 (DOI)12490 (Local ID)12490 (Archive number)12490 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved
Gillquist, J. & Messner, K. (1999). Anterior cruciate ligament reconstruction and the long term incidence of gonarthrosis.. Sports Medicine, 27, 143-156
Open this publication in new window or tab >>Anterior cruciate ligament reconstruction and the long term incidence of gonarthrosis.
1999 (English)In: Sports Medicine, ISSN 0112-1642, E-ISSN 1179-2035, Vol. 27, p. 143-156Article in journal (Refereed) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27778 (URN)12525 (Local ID)12525 (Archive number)12525 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
Räsänen, T. & Messner, K. (1999). Articular cartilage compressive stiffness following oophorectomy or treatment with 17-beta estradiol.. Acta Obstetricia et Gynecologica Scandinavica, 78, 357-362
Open this publication in new window or tab >>Articular cartilage compressive stiffness following oophorectomy or treatment with 17-beta estradiol.
1999 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 78, p. 357-362Article in journal (Refereed) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-27887 (URN)12647 (Local ID)12647 (Archive number)12647 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13
Organisations

Search in DiVA

Show all publications