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Thulesius, Olav
Publications (10 of 11) Show all publications
Thulesius, O. (2006). Phlebography and heparin for deep venous thrombosis introduced by Gunnar Bauer more than 60 years ago. Phlebology, 21(3), 107-109
Open this publication in new window or tab >>Phlebography and heparin for deep venous thrombosis introduced by Gunnar Bauer more than 60 years ago
2006 (English)In: Phlebology, ISSN 0268-3555, E-ISSN 1758-1125, Vol. 21, no 3, p. 107-109Article in journal (Refereed) Published
Abstract [en]

The story of a surgeon who in a country hospital in Sweden became a pioneer of modern phebology. He helped to set the standard of venography and heparin treatment for deep venous thrombosis and post-thrombotic valvular insufficiency more than 60 years ago. This happened when the surgeon Gunnar Bauer, stimulated by advancement in research and development of anticoagulants, introduced heparin treatment for deep venous thrombosis. He also started using descending phlebography for detection of venous reflux and advocated the controversial method of early ambulation after deep venous thrombosis. © 2006 Royal Society of Medicine Press.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-35208 (URN)10.1258/026835506778253319 (DOI)25648 (Local ID)25648 (Archive number)25648 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Thulesius, O. (2006). Thermal reactions of blood vessels in vascular stroke and heatstroke. Medical principles and practice, 15(4), 316-321
Open this publication in new window or tab >>Thermal reactions of blood vessels in vascular stroke and heatstroke
2006 (English)In: Medical principles and practice, ISSN 1011-7571, E-ISSN 1423-0151, Vol. 15, no 4, p. 316-321Article in journal (Refereed) Published
Abstract [en]

Research on the pathophysiology and treatment of brain damage with special focus on thermal vascular responses is the subject of this minireview. Interruption of cerebral blood supply by vascular obstruction, temporary cardiac arrest or hyperthermia causes a sudden attack of vascular stroke or heatstroke with serious consequences. It may not induce immediate cell death, but can precipitate a complex biochemical cascade leading to a delayed neuronal loss. When testing thermal vasomotor responses by stepwise cooling of isolated carotid arteries, a temperature-proportional dilatation was observed while heating induced the opposite response: a marked vasoconstriction. General hyperthermia with an increased oxygen demand combined with a reduction of blood supply therefore is a serious consequence. At the cellular level an important mechanism involving hyperthermia is the temperature-dependent regulation of K+ channel tone of vascular smooth muscle. Further, their inhibition through temperature elevation causes vasoconstriction. In heatstroke, which can induce platelet aggregation and the release of the vasoconstrictor serotonin, arterial cooling attenuates this response. General hypothermia is induced to prevent or attenuate neurological damage in stroke. The procedure is not without serious side effects. Therefore, rapid institution of selective brain cooling has been considered in adults and in infants with postpartum encephalopathy. Copyright © 2006 S. Karger AG.

Keywords
Heatstroke, Exertional heatstroke, Ischemic stroke, Hyperthermia, Hypothermia, Thermal vasomotor responses, Carotid artery cooling, Neuroprotection
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-35207 (URN)10.1159/000092999 (DOI)25647 (Local ID)25647 (Archive number)25647 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2017-12-13
Mustafa, S. & Thulesius, O. (2005). Hyperthermia-induced vasoconstriction of the carotid artery and the role of potassium channels. Journal of Stroke & Cerebrovascular Diseases, 14(3), 122-126
Open this publication in new window or tab >>Hyperthermia-induced vasoconstriction of the carotid artery and the role of potassium channels
2005 (English)In: Journal of Stroke & Cerebrovascular Diseases, ISSN 1052-3057, E-ISSN 1532-8511, Vol. 14, no 3, p. 122-126Article in journal (Refereed) Published
Abstract [en]

Clinical experience and experimental studies have shown that hyperthermia can cause cerebral ischaemia and brain damage. By in vitro experiments with heating, we previously were able to induce carotid artery constriction. The objective of the present study was to clarify the mechanism of this thermal response. Isometric tension was recorded in rabbit carotid artery specimens using organ baths during stepwise temperature elevation. The heating responses were investigated at basal tone, in precontracted vessels, after blocking of adrenergic responses and administration of potassium (K)-channel activators and inhibitors. Stepwise heating of carotid artery strips from 37°C to 47°C induced reproducible graded contraction. The hyperthermic responses were not due to adrenergic stimulation, which were reduced and resistant to neurogenic blockade by tetrodotoxin. Heating-induced contractions were potentiated by the K-channel inhibitors tetraethylammonium, BaCl2, charybdotoxin, and the Na+/K+ ATPase inhibitor ouabain. Levcromakalim (BRL), a K+-channel activator, reduced heating induced contractions. Heating of carotid artery preparations induced reversible graded vasoconstriction proportional to temperature. The heating-induced contractions were not mediated by an adrenergenic process, but rather were due to inhibition of K+ channels, which increases Ca2+ entry. In vivo, this reaction may lead to a disturbance of autoregulation of cerebral blood flow and ischemia with brain damage. © 2005 by National Stroke Association.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-31935 (URN)10.1016/j.jstrokecerebrovasdis.2004.12.006 (DOI)17769 (Local ID)17769 (Archive number)17769 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13
Thulesius, O. & Waddell, W. J. (2004). Human exposures to acrylamide are below the threshold for carcinogenesis. Human and Experimental Toxicology, 23(7), 357-358
Open this publication in new window or tab >>Human exposures to acrylamide are below the threshold for carcinogenesis
2004 (English)In: Human and Experimental Toxicology, ISSN 0960-3271, E-ISSN 1477-0903, Vol. 23, no 7, p. 357-358Article in journal (Refereed) Published
Abstract [en]

Dose-response calculations for a threshold of carcinogenesis in animal studies do not support the notion that acrylamide (ACR) with the present status of consumption in food is carcinogenic for humans. This is in agreement with the recent reassuring epidemiological studies which have shown a lack of correlation between exposure to ACR in food and the incidence of cancer. © Arnold 2004.

Place, publisher, year, edition, pages
Sage Publications, 2004
Keywords
acrylamide, carcinogenesis, threshold
National Category
Occupational Health and Environmental Health
Identifiers
urn:nbn:se:liu:diva-28454 (URN)10.1191/0960327104ht461sc (DOI)000223054100007 ()15311854 (PubMedID)2-s2.0-4344637631 (Scopus ID)13601 (Local ID)13601 (Archive number)13601 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2018-01-13
Tanaka, H., Borres, M., Thulesius, O., Tamai, H., Ericson, M. & Lindblad, L.-E. (2002). Evidence of decreased sympathetic function in children with psychosomatic symptoms. Clinical Autonomic Research, 12(6), 477-482
Open this publication in new window or tab >>Evidence of decreased sympathetic function in children with psychosomatic symptoms
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2002 (English)In: Clinical Autonomic Research, ISSN 0959-9851, E-ISSN 1619-1560, Vol. 12, no 6, p. 477-482Article in journal (Refereed) Published
Abstract [en]

We investigated cardiovascular autonomic function using power spectral analysis of heart rate variation and beat-to-beat finger arterial pressure at rest and while standing and correlated these findings with self-reported psychosomatic and psychosocial symptoms in 122 schoolchildren. Children with three or more psychosomatic and psychosocial symptoms (somatizers) were found to have significantly lower blood pressure than children without symptoms. Somatizers had the more decreased spectral power of the low frequency (LF) band of arterial pressure and RR intervals in the supine position. The high frequency (HF) power did not differ between the two groups. Somatizers showed a more marked reduction in systolic arterial pressure at the onset of standing than did subjects without symptoms but somatizers showed an identical response in systolic arterial pressure when compared to subjects without symptoms during the later stage of standing. The increases in the LF band of arterial pressure and LF/HF of RR intervals during standing were higher in somatizers. These results suggest that somatizers have decreased sympathetic modulation. We conclude that psychosomatic and psychosocial symptoms in children might be associated with low blood pressure and decreased sympathetic modulation.

Keywords
Finger arterial pressure, Health questionnaire, Heart rate variation, Power spectral analysis, Somatization
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-46827 (URN)10.1007/s10286-002-0071-5 (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13
Thulesius, O. (2002). Vensystemets fysiologi och patofysiologi. In: Tomas Jogestrand, Stefan Rosfors (Ed.), Klinisk fysiologisk kärldiagnostik: (pp. 245-254). Lund: Studentlitteratur AB
Open this publication in new window or tab >>Vensystemets fysiologi och patofysiologi
2002 (Swedish)In: Klinisk fysiologisk kärldiagnostik / [ed] Tomas Jogestrand, Stefan Rosfors, Lund: Studentlitteratur AB, 2002, p. 245-254Chapter in book (Other academic)
Place, publisher, year, edition, pages
Lund: Studentlitteratur AB, 2002
Keywords
Veins, Vener
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-114532 (URN)978-91-440-2189-8 (ISBN)91-44-02189-5 (ISBN)
Available from: 2015-02-26 Created: 2015-02-26 Last updated: 2015-03-11Bibliographically approved
Jönsson, B., Lindberg, L.-G., Skau, T. & Thulesius, O. (2001). Is oscillometric ankle pressure reliable in leg vascular disease?. Clinical Physiology and Functional Imaging, 21(2), 155-163
Open this publication in new window or tab >>Is oscillometric ankle pressure reliable in leg vascular disease?
2001 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 21, no 2, p. 155-163Article in journal (Refereed) Published
Abstract [en]

The objective of the study was to evaluate the validity of oscillometric systolic ankle pressure in symptomatic leg arterial occlusive disease. Ankle pressure measurements using oscillometric curves obtained using a standard 12-cm cuff with a specially designed device for signal processing were validated against the continuous wave (CW) Doppler technique. Thirty-four subjects without signs or symptoms of peripheral vascular disease (68 legs) and 47 patients with leg ischaemia (85 legs) varying from moderate claudication to critical ischaemia were examined. The oscillometric curves were analysed using several algorithms reported in the literature, based on the assumption that maximum oscillations are recorded near mean arterial pressure. In normals, reasonable agreement between CW Doppler and oscillometric methods was seen. When an algorithm that determined the lowest cuff pressure at which maximum oscillations occurred, and a characteristic ratio for systolic pressure of 0·52 was used, the mean difference between CW Doppler and oscillometry was 1·7 mmHg [range −19 to +27, limits of agreement (2 SD) 21·1 mmHg]. In ischaemic legs, oscillometry overestimated systolic ankle pressure by a mean of 28·8 mmHg [range –126 to +65, limits of agreement 82·8 mmHg]. The difference was more pronounced among patients with critical ischaemia compared with claudicants, and also more evident among diabetics. The error of oscillometric pressure determination in subjects with leg arterial disease inversely increased with CW Doppler ankle pressure. In 39% of the recordings in legs with a CW Doppler systolic pressure below 100 mmHg, the oscillometric mean arterial pressure was higher than the recorded CW Doppler systolic pressure. In conclusion, the oscillometric method to determine systolic ankle pressure, based on the concept of maximum cuff oscillations occurring near mean arterial pressure, is not reliable in leg arterial disease, usually overestimating ankle pressure.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-26714 (URN)10.1046/j.1365-2281.2001.00314.x (DOI)11308 (Local ID)11308 (Archive number)11308 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2017-12-13Bibliographically approved
Yousif, M. & Thulesius, O. (2000). A pharmacological study of bronchodilator properties of NKH477, forskolin, and beta-agonists on guinea pig and ovine isolated bronchioles. Drug development research (Print), 51(3), 169-176
Open this publication in new window or tab >>A pharmacological study of bronchodilator properties of NKH477, forskolin, and beta-agonists on guinea pig and ovine isolated bronchioles
2000 (English)In: Drug development research (Print), ISSN 0272-4391, E-ISSN 1098-2299, Vol. 51, no 3, p. 169-176Article in journal (Refereed) Published
Abstract [en]

In this study we assessed the relaxant responses of two direct adenylate cyclase activators, NKH477 and forskolin, in comparison with two beta -adrenoceptor agonists, salbutamol and isoprenaline. The possible potentiation effect of NKH477 and forskolin on beta -agonist-induced bronchodilatation was examined. The effectiveness of NKH477 and forskolin in reversing tachyphylaxis development to salbutamol or isoprenaline was also investigated. We tested the in vitro bronchodilator effect of salbutamol, NKH477, and forskolin (10(-9)-10(-4) M) On isolated guinea pig bronchiolar ring segments precontracted with carbachol (3 muM). Salbutamol, NKH477, and forskolin produced a concentration-dependent relaxation. Potency values (pD(2)) were determined from cumulative concentration-response curves. The rank order for their potencies was salbutamol > NKH477 > forskolin (7.3 +/- 0.3, 6.4 +/- 0.3, and 5.4 +/- 0.1, respectively). The bronchodilator effects of salbutamol, isoprenaline, NKH477, and forskolin (10(-9)-10(-4) M) were examined on isolated ovine bronchioles precontracted with carbachol (0.3 muM). Isoprenaline, NKH477, and forskolin produced a concentration-dependent relaxation with pot values of 6.1 +/- 0.2, 5.4 +/- 0.2, and 5.3 +/- 0.2, respectively. Tachyphylaxis to the relaxant effects of salbutamol on guinea pig isolated bronchioles was experimentally induced and the potency of salbutamol was reduced to 5.9 +/- 0.2 after 24 h incubation with salbutamol (10(-5) M). NKH477 and forskolin (10(-6) M) produced a partial reversal of tachyphylaxis to salbutamol-induced relaxation using salbutamol pretreated tissues. The potency of salbutamol was increased to 6.6 +/- 0.2 and 5.9 +/- 0.2 after incubation with NKH477 or forskolin (10(-6) M), respectively Tachyphylaxis to the relaxant effects of isoprenaline resulted in a reduced potency of 5.7 +/- 0.2. Forskolin (10-6 M) Produced a partial reversal of tachyphylaxis, while NKH477 (10(-6) M) produced a complete reversal of tachyphylaxis to isoprenaline-induced relaxation with an pot value of 6.3 +/- 0.1. In conclusion, the guinea pig and sheep isolated bronchioles serve as good models to study the relaxant effects of the bronchodilator agents salbutamol, isoprenaline, NKH477, and forskolin. The beta -agonists examined had higher potencies than NKH477 or forskolin. However, the two adenylate cyclase activators, with greater effectiveness of NKH477, when used in combination with the beta -agonists, could produce an increase in the potency of the beta -agonists. Furthermore, the effectiveness of NKH477 and forskolin in reversing tachyphylaxis to the bronchodilator effects of the beta -agonists, particularly salbutamol, may provide an advantage in long-term use of beta -agonists in bronchial asthma therapy. Drug Dev. Res. 51:169-176, 2000. (C) 2001 Wiley-Liss, Inc.

Keywords
NKH477, forskolin, cyclic AMP, tachyphylaxis, salbutamol, bronchioles
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-49396 (URN)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12
Tanaka, H., Borres, M., Thulesius, O., Tamai, H., Ericson, M. & Lindblad, L. (2000). Blood pressure and cardiovascular autonomic function in healthy children and adolescents. Journal of Pediatrics, 137(1), 63-67
Open this publication in new window or tab >>Blood pressure and cardiovascular autonomic function in healthy children and adolescents
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2000 (English)In: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 137, no 1, p. 63-67Article in journal (Refereed) Published
Abstract [en]

Objectives: To investigate the relationship between blood pressure levels and cardiovascular autonomic function in adolescents and preadolescents. Study design: We measured variability of beat-to-beat arterial pressure and R-R intervals using power spectral analysis in 56 adolescents (aged 13-16 16 years, mean age, 9.0 +/- 1.4 years) and 71 preadolescents (6-12 years, mean age, 13.5 +/- 1.1 years) in the supine and standing positions. Results: Adolescents had higher levels of systolic arterial pressure and lower high-frequency power of RR intervals than preadolescents. Correlation between the basal level of arterial pressure and autonomic function rn as observed in adolescents but not in preadolescents. Tn adolescents, multivariate analysis indicated that tho basal level of arterial pressure was inversely related with the high-frequency power of RR intervals and positively with the ratio of low-frequency and high-frequency pow er. No significant relation was found in preadolescents. During standing, adolescents had a more marked increase in diastolic arterial pressure, heart rate, low frequency of R-R intervals, and low frequency of arterial pressure compared with those of preadolescents, Changes in diastolic pressure showed a significant negative correlation with changes in high frequency of R-R intervals. Conclusion: Cardiovascular autonomic function plays an important role in increasing blood pressure levels associated with increased modulation of vagal tone of the heart after puberty but does not in the preadolescent.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-47930 (URN)10.1067/mpd.2000.108098 (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13
Yousif, M. & Thulesius, O. (1999). NKH477: A novel bronchodilator produces potentiation and tachyphylaxis reversal to salbutamol in isolated guinea pig trachea. Drug development research (Print), 48(4), 154-159
Open this publication in new window or tab >>NKH477: A novel bronchodilator produces potentiation and tachyphylaxis reversal to salbutamol in isolated guinea pig trachea
1999 (English)In: Drug development research (Print), ISSN 0272-4391, E-ISSN 1098-2299, Vol. 48, no 4, p. 154-159Article in journal (Refereed) Published
Abstract [en]

The relaxant responses of the beta(2)-adrenoceptor agonist salbutamol and NKH477, an activator of adenylate cyclase, were compared and the possible potentiating effect of NKH477 on salbutamol-induced bronchodilatation was measured together with the effectiveness of NKH477 in reversing tachyphylaxis development to salbutamol. The in vitro bronchodilator effect of salbutamol and NKH477 (10(-9) - 10(-5) M) was measured on isolated guinea pig tracheal ring segments precontracted with carbachol (10(-6) M). Both salbutamol and NKH477 produced a concentration-dependent relaxation. EC50 values were determined from cumulative concentration-response curves. Salbutamol was more potent than NKH477 in relaxing the tracheal preparations (7.1 +/- 0.1 compared to 6.1 +/- 0.2, respectively). NKH477 produced a significant increase in the salbutamol-induced bronchodilator effect. The potency values recorded for salbutamol were 7.1 +/- 0.1, 7.4 +/- 0.2, 7.6 +/- 0.1, and 8.6 +/- 0.4 in the absence and presence of NKH477 (3 x 10(-8) M, 10(-7) M, and 3 x 10(-7) M, respectively). Reproducible relaxant responses could be elicited to salbutamol and NKH477 after 24 h incubation in Krebs' solution. Tachyphylaxis to the relaxant effects of salbutamol was experimentally induced by 24-h incubation of the preparations in Krebs' solution containing salbutamol (10(-6), 3 X 10(-6) or 10(-5) M). The potency of salbutamol was reduced to 6.9 +/- 0.2, 6.8 +/- 0.2, and 6.0 +/- 0.2 after 24 h incubation with salbutamol 10(-6) M, 3 X 10(-6) M or 10(-5) M, respectively. NKH477 (3 x 10(-7) M) produced a complete reversal of tachyphylaxis to salbutamol-induced relaxation in salbutamol pretreated tissues. The potency of salbutamol was increased to 7.4 +/- 0.2, 7.1 +/- 0.1, and 7.3 +/- 0.1 after the addition of NKH477 (3 x 10(-7) M) to the preparations preincubated (24 h) with salbutamol 10(-6), 3 X 10(-6), or 10(-5) M, respectively. NKH477 shares with salbutamol the ability to relax airway smooth muscle and produces an apparent increase of the bronchodilator effects of salbutamol and reverses tachyphylaxis. Drug Dev. Res. 48:154-159, 1999. (C) 1999 Wiley-Liss, Inc.

Keywords
NKH477, cyclic AMP, tachyphylaxis, beta(2)-adrenoceptor agonist, trachea
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-49855 (URN)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12
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