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Boivie, Jörgen
Alternative names
Publications (10 of 16) Show all publications
Österberg, A. & Boivie, J. (2010). Central pain in multiple sclerosis: sensory abnormalities. European Journal of Pain, 14(1), 104-110
Open this publication in new window or tab >>Central pain in multiple sclerosis: sensory abnormalities
2010 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 14, no 1, p. 104-110Article in journal (Refereed) Published
Abstract [en]

Many patients with multiple sclerosis (MS) develop central neuropathic pain (CP). In the present study somatosensory abnormalities have been analysed in detail in 62 patients with MS and CP (42 women, 20 men; mean age 52 years) and in a control group of 10 women and 6 men (mean age 47 years) with MS and sensory symptoms, but without pain.

Assessment included clinical testing and quantitative methods (QST) for the measurement of perception thresholds for touch, vibration, and temperatures.

All CP patients except two (97%) had abnormal thresholds for innoxious and/or noxious temperatures, compared to 81% in the control group (p < 0.05). There was a tendency towards the opposite regarding sensibility to touch, which was decreased in 66% vs. 87% (n.s.), vibration (55% vs. 81%; n.s.) and to joint movement (32% vs. 62%; p < 0.04).

Comparisons between painful and non-painful regions showed both the absolute threshold values and the index values to be significantly more abnormal, in the CP regions, for warmth (p < 0.001), cold (p < 0.05), difference limen (innoxious warmth and cold, p < 0.01), cold pain (p < 0.01) and heat pain/cold pain combined (p < 0.001).

Also the comparisons between regions with central pain and regions with sensory symptoms in the controls showed significantly more abnormal thresholds in the CP patients for warmth (p < 0.05), cold (p < 0.01), difference limen (innoxious warmth and cold, p < 0.01) and heat pain/cold pain combined (p < 0.001).

The results support the general hypothesis that only patients who have lesions affecting the spinothalamo-cortical pathways run the risk of developing central pain.

Keywords
Multiple sclerosis, Central neuropathic pain, Sensibility, Quantitative sensory test (QST)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-54155 (URN)10.1016/j.ejpain.2009.03.003 (DOI)000274481800017 ()
Available from: 2010-02-26 Created: 2010-02-26 Last updated: 2017-12-12Bibliographically approved
Gordh, T., Stubhaug, A., Jensen, T., Arner, S., Biber, B., Boivie, J., . . . Kalso, E. (2008). Gabapentin in traumatic nerve injury pain: A randomized, double-blind, placebo-controlled, cross-over, multi-center study. Pain, 138(2), 255-266
Open this publication in new window or tab >>Gabapentin in traumatic nerve injury pain: A randomized, double-blind, placebo-controlled, cross-over, multi-center study
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2008 (English)In: Pain, ISSN 0304-3959, E-ISSN 1872-6623, Vol. 138, no 2, p. 255-266Article in journal (Refereed) Published
Abstract [en]

A double-blind, randomized, placebo-controlled cross-over multi-center study was conducted to evaluate the efficacy and safety of gabapentin in the treatment of neuropathic pain caused by traumatic or postsurgical peripheral nerve injury, using doses up to 2400 mg/day. The study comprised a run-in period of two weeks, two treatment periods of five weeks separated by a three weeks' washout period. The primary efficacy variable was the change in the mean pain intensity score from baseline to the last week of treatment. Other variables included pain relief, health related quality of life (SF-36), interference of sleep by pain, Clinician and Patient Global Impression of Change, and adverse effects. Nine centers randomized a total of 120 patients, 22 of whom withdrew. There was no statistically significant difference between the treatments for the primary outcome efficacy variable. However, gabapentin provided significantly better pain relief (p = 0.015) compared with placebo. More patients had at least a 30% pain reduction with gabapentin compared with placebo (p = 0.040) and pain interfered significantly less with sleep during gabapentin treatment compared with placebo (p = 0.0016). Both the Patient (p = 0.023) and Clinician (p = 0.037) Global Impression of Change indicated a better response with gabapentin compared with placebo. Gabapentin was well tolerated. The most common adverse effects were dizziness and tiredness. © 2007 International Association for the Study of Pain.

Keywords
Gabapentin, Neuropathic pain, Randomized controlled cross-over trial, Traumatic nerve injury
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-50453 (URN)10.1016/j.pain.2007.12.011 (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-12
Gerdle, B., Boivie, J. & Johansson, E. (2006). Inledning (2ed.). In: Statens beredning för medicinsk utvärdering (Ed.), Metoder för behandling av långvarig smärta - en systematisk litteraturöversikt: (pp. 47-107). Stockholm: Statens beredning för medicinsk utvärdering (SBU)
Open this publication in new window or tab >>Inledning
2006 (Swedish)In: Metoder för behandling av långvarig smärta - en systematisk litteraturöversikt / [ed] Statens beredning för medicinsk utvärdering, Stockholm: Statens beredning för medicinsk utvärdering (SBU) , 2006, 2, p. 47-107Chapter in book (Other academic)
Abstract [sv]

  

Syftet med rapporten är att sammanfatta det vetenskapliga underlaget rörande effekter, biverkningar samt kostnadseffektivitet för metoder som används för att behandla långvarig, icke-cancerrelaterad smärta. Behandling som innebär öppen kirurgi har exkluderats från genomgången.

Place, publisher, year, edition, pages
Stockholm: Statens beredning för medicinsk utvärdering (SBU), 2006 Edition: 2
Series
SBU-rapport, ISSN 1400-1403 ; 177:1
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-36777 (URN)32529 (Local ID)91-85413-08-9 (ISBN)91-85413-09-7 (ISBN)32529 (Archive number)32529 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2013-09-06
Landtblom, A.-M., Boivie, J., Fridriksson, S., Hillman, J., Johansson, G. & Johansson, I. (2006). Åskknallshuvudvärk: oftast ett godartat tillstånd. Läkartidningen, 103(37), 2632-2637
Open this publication in new window or tab >>Åskknallshuvudvärk: oftast ett godartat tillstånd
Show others...
2006 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 103, no 37, p. 2632-2637Article in journal (Refereed) Published
Abstract [en]

We have performed a study of 137 consecutive patients with thunderclap headache (TCH), showing that a large majority of the patients do not have a subarachnoidal haemorrhage (SAH). It is concluded that 11% of all TCH is caused by SAH and that history and findings in the clinical neurological examination cannot discriminate safely between an SAH and a more benign cause. All patients should be investigated with a CT scan and an analyses of the cerebrospinal fluid to exclude a SAH if the CT scan did not show an SAH. The 10-year follow-up showed that none of the patients with TH without SAH had a cerebral haemorrhage of any kind. Pathological results on CT and CSF examinations were found in 14 of the patients with non-SAH TCH, including five with cerebral infarction, three with intracerebral haemorrhage, four with aseptic meningitis and one with venous sinus thrombosis.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-37171 (URN)33856 (Local ID)33856 (Archive number)33856 (OAI)
Available from: 2009-10-10 Created: 2009-10-10 Last updated: 2018-03-20
Boivie, J. (2005). Central Pain. In: Harold Merskey, John D. Loeser, Ronald Dubner (Ed.), The paths of pain 1975-2005: (pp. 45-45). Seattle: IASP
Open this publication in new window or tab >>Central Pain
2005 (English)In: The paths of pain 1975-2005 / [ed] Harold Merskey, John D. Loeser, Ronald Dubner, Seattle: IASP , 2005, p. 45-45Chapter in book (Other academic)
Abstract [en]

The Paths of Pain celebrates 30 years of pain research and management by the world's leading basic scientists and clinicians in the field. Combining history and science, it provides an unrivalled, authoritative selection of chapters that examine the problems and achievements in the topic. It looks at the way pain has been understood, investigated, and treated from before the foundation of the IASP up to the present time.The achievements of this period include the development and refinement of the gate control theory of pain in physiology, as well as enormous strides in the identification of cellular and molecular mechanisms of pain, a better appreciation of the psychological aspects of pain, the evolution of more effective analgesics, coordinated comprehensive pain clinics, acute pain services, and the improved definition of painful illnesses. The reader has the opportunity to explore a book by many hands in which the description of the advances is often provided by those who achieved them.

Place, publisher, year, edition, pages
Seattle: IASP, 2005
Series
IASP Press ; 2005
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-33806 (URN)19874 (Local ID)0-931092-56-6 (ISBN)978-0-93109-256-5 (ISBN)19874 (Archive number)19874 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2013-10-10Bibliographically approved
Boivie, J. (2005). Central Pain (1ed.). In: Daniel J Wallace, Daniel J Clauw (Ed.), Fibromyalgia and Other Central Pain Syndromes: (pp. 1057-1074). Seattle: IASP Press
Open this publication in new window or tab >>Central Pain
2005 (English)In: Fibromyalgia and Other Central Pain Syndromes / [ed] Daniel J Wallace, Daniel J Clauw, Seattle: IASP Press , 2005, 1, p. 1057-1074Chapter in book (Other academic)
Abstract [en]

This volume is the first comprehensive text devoted to fibromyalgia and other centrally mediated chronic pain syndromes. Leading experts examine the latest research findings on these syndromes and present evidence-based reviews of current controversies. Chapters discuss the definition, epidemiology, and pathophysiology of chronic pain and fibromyalgia, the clinical presentations of fibromyalgia syndrome, and central sensitization syndromes associated with chronic neuromuscular pain. The contributors thoroughly examine various approaches to evaluation and management of patients with fibromyalgia and chronic pain. Other chapters focus on disability issues, prognosis, and future research directions. A critically reviewed listing of Websites and other resources is included.

Place, publisher, year, edition, pages
Seattle: IASP Press, 2005 Edition: 1
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-33809 (URN)19878 (Local ID)0-7817-5261-2 (ISBN)978-0-7817-5261-9 (ISBN)19878 (Archive number)19878 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2013-10-10Bibliographically approved
Österberg, A., Boivie, J. & Thoumas, K.-Å. (2005). Central pain in multiple sclerosis: prevalence and clinical characteristics. European Journal of Pain, 9(5), 531-542
Open this publication in new window or tab >>Central pain in multiple sclerosis: prevalence and clinical characteristics
2005 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 9, no 5, p. 531-542Article in journal (Refereed) Published
Abstract [en]

Pain is more common in multiple sclerosis (MS) than has previously been recognised. In the present study we have investigated the occurrence of central pain (CP) in MS and defined its characteristics. Questionnaires were sent to all 429 patients with definite MS in the patient register at our neurology department. All admitting to pain were interviewed and offered an extended interview and examination. Three hundred and sixty four patients responded (86%), of whom 57.5% reported pain during the course of their disease (21% nociceptive, 2% peripheral neuropathic and 1% related to spasticity). One hundred patients (27.5%) had CP, including 18 patients (4.9%) with trigeminal neuralgia.

The non-trigeminal CP was, in 87%, located in the lower and in 31% in the upper extremities. It was mostly bilateral (76%) and constant, with 88% experiencing daily pain. Only 2% had paroxysmal attacks. Aching, burning, pricking were the commonest qualities. The pain was intense with small to moderate spontaneous variation. In 5.5% of all patients (20% of the patients with CP), pain was a presenting symptom, alone or in combination with other symptoms.

The most common neurological symptoms/signs besides CP were sensory abnormalities (98%, dominated by abnormal sensibility to painful stimulus and temperature). Trigeminal neuralgia in MS started later in life and after longer disease duration than non-trigeminal pain. Both types of CP existed either chronically or as a feature of relapse. Central pain is thus an important symptom in MS (around 30%) and causes much suffering.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-31877 (URN)10.1016/j.ejpain.2004.11.005 (DOI)17705 (Local ID)17705 (Archive number)17705 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2017-12-13Bibliographically approved
Boivie, J. & Casey, K. I. (2005). Central Pain in the Face and Head (1ed.). In: Daniel J. Wallace, Daniel J. Clauw (Ed.), Fibromyalgia and other central pain syndromes: . Lippincott Williams & Wilkins
Open this publication in new window or tab >>Central Pain in the Face and Head
2005 (English)In: Fibromyalgia and other central pain syndromes / [ed] Daniel J. Wallace, Daniel J. Clauw, Lippincott Williams & Wilkins , 2005, 1, p. -432Chapter in book (Other academic)
Abstract [en]

This volume is the first comprehensive text devoted to fibromyalgia and other centrally mediated chronic pain syndromes. Leading experts examine the latest research findings on these syndromes and present evidence-based reviews of current controversies.

Chapters discuss the definition, epidemiology, and pathophysiology of chronic pain and fibromyalgia, the clinical presentations of fibromyalgia syndrome, and central sensitization syndromes associated with chronic neuromuscular pain. The contributors thoroughly examine various approaches to evaluation and management of patients with fibromyalgia and chronic pain. Other chapters focus on disability issues, prognosis, and future research directions. A critically reviewed listing of Websites and other resources is included.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2005 Edition: 1
Series
Philadelphia, PA : Lippincott Williams & Wilkins, ; 2005
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-33808 (URN)19877 (Local ID)0-7817-5261-2 (ISBN)978-0-7817-5261-9 (ISBN)19877 (Archive number)19877 (OAI)
Available from: 2009-10-09 Created: 2009-10-09 Last updated: 2013-10-10Bibliographically approved
Boivie, J. (2003). Central pain (1ed.). In: Ronald Melzack OC FRSC PhD ,(Patrick D. Wall FRS DM FRCP (Ed.), Handbook of Pain Management: (pp. 305-327). Linköping: Linköpings universitet
Open this publication in new window or tab >>Central pain
2003 (English)In: Handbook of Pain Management / [ed] Ronald Melzack OC FRSC PhD ,(Patrick D. Wall FRS DM FRCP, Linköping: Linköpings universitet , 2003, 1, p. 305-327Chapter in book (Other academic)
Abstract [en]

An Essentials version of the Textbook of Pain, 4/e, this book is intended to provide the pain medicine specialist and trainee with an easy-to-access overview on the management complexities, assessment tools and multiple treatment modalities that are currently available to the physician dealing with the full spectrum of pain syndromes. The emphasis throughout is on the clinical aspects of pain medicine. It will contain the core information that the practitioner and trainee needs. Each chapter is brief and succinctly written and the text is well broken up with headings, tables and summary charts. The book is divided into 2 main sections; clinical states (acute, chronic and cancer pain) and therapeutic aspects ( pharmacological, surgical, physiotherapy, psychotherapy ) and it presents a rational, multidisciplinary approach to the management of pain.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2003 Edition: 1
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-28100 (URN)12867 (Local ID)04-43072-01-9 (ISBN)978-0-4430-7201-7 (ISBN)12867 (Archive number)12867 (OAI)
Available from: 2009-10-08 Created: 2009-10-08 Last updated: 2013-11-13Bibliographically approved
Boivie, J. (2003). Central pain and the role of quantitative sensory testing (QST) in research and diagnosis. European Journal of Pain, 7(4)
Open this publication in new window or tab >>Central pain and the role of quantitative sensory testing (QST) in research and diagnosis
2003 (English)In: European Journal of Pain, ISSN 1090-3801, E-ISSN 1532-2149, Vol. 7, no 4, p. 339-343Conference paper, Published paper (Other academic)
Abstract [en]

[No abstract available]

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-46550 (URN)10.1016/S1090-3801(03)00046-6 (DOI)
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2017-12-13
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