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Helgesson, C.-F., Lee, F. & Lindén, L. (2016). Valuations of experimental designs in proteomic biomarker experiments and traditional randomised controlled trials. Journal of Cultural Economy, 9(2), 157-172
Open this publication in new window or tab >>Valuations of experimental designs in proteomic biomarker experiments and traditional randomised controlled trials
2016 (English)In: Journal of Cultural Economy, ISSN 1753-0350, E-ISSN 1753-0369, Vol. 9, no 2, p. 157-172Article in journal (Refereed) Published
Abstract [en]

This article examines the shifting conditions for biomedical knowledge production by studying trends in the design of biomedical experiments. The basic premise of the study is that the very act of establishing a research design entails a process involving a series of valuations where different values are evoked, ordered, and displaced. In focus is the articulation and ordering of what counts as central values in research design for two kinds of biomedical treatment trials, namely the traditional randomised controlled trial (RCT) and the emerging new form of biomarker trials used to assess biomarker/treatment combinations (BTTs). The empirical material consists of textbooks (RCTs) and journal articles (BTTs). We ask how these materials articulate the various scientific, medical, and economic values at play. Among the differences uncovered are a difference in relation to what counts as ethical in relation to prior knowledge, differences in the flexibility in design as well as the valuation of the risk for false positives and false negatives. More broadly, the study shows how textual accounts of different ways of producing knowledge are linked to partly different valuations of ethics, flexibility, and risk as part of establishing the research design of biomedical experiments.

Place, publisher, year, edition, pages
Taylor & Francis Group, 2016
Keywords
Valuation, knowledge production, knowledge as a public good, biomedical research, clinical trials, valuography
National Category
Social Sciences Interdisciplinary
Identifiers
urn:nbn:se:liu:diva-123446 (URN)10.1080/17530350.2015.1108215 (DOI)000378174500004 ()
Projects
Trials of Value / Prövningar av värde (Helgesson & Lee)
Funder
Riksbankens Jubileumsfond, P11-0034
Note

Funding agencies:This paper reports a sub-study within the larger project `Trials of Value' where Helgesson and Lee investigate the valuations performed in the designing of different kinds of experiments in medicine and biomedicine. The project has been made possible with a grant from Riksbankens Jubileumsfond. The authors want to thank Barbara Townley and Philip Roscoe as well as two anonymous reviewers for helpful and encouraging comments on earlier versions of this article. The article has furthermore benefited from comments on various occasions: the session `Clinical research in post-genomic medicine' at 4S/EASST Copenhagen, October 2012; the workshop `What price creativity? A workshop on the valuing of social/public goods' at University of St Andrews, December 2012; and the ValueS seminar within Technology and Social Change, Linkoping University. In particular, we want to acknowledge comments and encouragement by Alberto Cambrosio, Andrew Hoffman, Nicole Nelson, and Teun Zuiderent-Jerak.

Available from: 2015-12-17 Created: 2015-12-17 Last updated: 2018-01-10
Dussauge, I., Helgesson, C.-F., Lee, F. & Woolgar, S. (2015). On the omnipresence, diversity, and elusiveness of values in the life sciences and medicine. In: Isabelle Dussauge, Claes-Fredrik Helgesson, Francis Lee (Ed.), Value practices in the life sciences and medicine: (pp. 1-28). Oxford: Oxford University Press
Open this publication in new window or tab >>On the omnipresence, diversity, and elusiveness of values in the life sciences and medicine
2015 (English)In: Value practices in the life sciences and medicine / [ed] Isabelle Dussauge, Claes-Fredrik Helgesson, Francis Lee, Oxford: Oxford University Press, 2015, p. 1-28Chapter in book (Refereed)
Place, publisher, year, edition, pages
Oxford: Oxford University Press, 2015
Keywords
Life sciences, medicine, health care, values, pragmatism, value practices, moral economy, science and technology studies, Biovetenskaper
National Category
Other Social Sciences
Identifiers
urn:nbn:se:liu:diva-114093 (URN)9780199689583 (ISBN)
Projects
Trials of Value, Helgesson and Lee
Funder
Riksbankens Jubileumsfond, P11-0034
Available from: 2015-02-08 Created: 2015-02-08 Last updated: 2015-04-07Bibliographically approved
Lee, F. (2015). Purity and interest: on relational work and epistemic value in the biomedical sciences. In: Isabelle Dussauge, Claes-Fredrik Helgesson, Francis Lee (Ed.), Value practice in the life sciences and medicine: (pp. 207-223). oxford: Oxford University Press
Open this publication in new window or tab >>Purity and interest: on relational work and epistemic value in the biomedical sciences
2015 (English)In: Value practice in the life sciences and medicine / [ed] Isabelle Dussauge, Claes-Fredrik Helgesson, Francis Lee, oxford: Oxford University Press, 2015, p. 207-223Chapter in book (Refereed)
Place, publisher, year, edition, pages
oxford: Oxford University Press, 2015
Keywords
Biovetenskaper-- etik och moral, Biovetenskaper-- teori, filosofi
National Category
Medical Bioscience
Identifiers
urn:nbn:se:liu:diva-116861 (URN)978-01-9968-958-3 (ISBN)
Available from: 2015-04-08 Created: 2015-04-08 Last updated: 2015-04-17Bibliographically approved
Dussauge, I., Helgesson, C.-F. & Lee, F. (Eds.). (2015). Value practices in the life sciences and medicine. Oxford: Oxford University Press
Open this publication in new window or tab >>Value practices in the life sciences and medicine
2015 (English)Collection (editor) (Refereed)
Abstract [en]

Many deep concerns in the life sciences and medicine have to do with the enactment, ordering and displacement of a broad range of values. This volume articulates a pragmatist stance for studying the making of values in society, which means taking seriously the work scientists, regulators, analysts, professionals, and publics regularly do to define what counts as proper conduct, what is economically valuable, and what is known and worth knowing. The volume proposes the word valuography to indicate an empirically oriented research program into the simultaneous making of seemingly separate values. Exploring various sites within life sciences and medicine, this volume features in-depth studies ranging from how zoos make animal value to how health care administrators attempts to engineer fair and efficient health care markets.

Place, publisher, year, edition, pages
Oxford: Oxford University Press, 2015. p. 331
Keywords
Life sciences, medicine, health care, values, pragmatism, value practices, moral economy, science and technology studies, Biovetenskaper
National Category
Other Social Sciences
Identifiers
urn:nbn:se:liu:diva-114092 (URN)9780199689583 (ISBN)
Available from: 2015-02-08 Created: 2015-02-08 Last updated: 2015-04-07Bibliographically approved
Dussauge, I., Helgesson, C.-F. & Lee, F. (2015). Valuography: studying the making of values. In: Isabelle Dussauge, Claes-Fredrik Helgesson, Francis Lee (Ed.), Value practices in the life sciences and medicine: (pp. 267-285). Oxford: Oxford University Press
Open this publication in new window or tab >>Valuography: studying the making of values
2015 (English)In: Value practices in the life sciences and medicine / [ed] Isabelle Dussauge, Claes-Fredrik Helgesson, Francis Lee, Oxford: Oxford University Press, 2015, p. 267-285Chapter in book (Refereed)
Place, publisher, year, edition, pages
Oxford: Oxford University Press, 2015
Keywords
Life sciences, medicine, health care, values, pragmatism, value practices, science and technology studies, Biovetenskaper
National Category
Other Social Sciences
Identifiers
urn:nbn:se:liu:diva-114095 (URN)9780199689583 (ISBN)
Projects
Trials of Value, Helgesson and Lee
Funder
Riksbankens Jubileumsfond, P11-0034
Available from: 2015-02-08 Created: 2015-02-08 Last updated: 2015-04-07Bibliographically approved
Galis, V. & Lee, F. (2014). A Sociology of Treason: The Construction of Weakness. Science, Technology and Human Values, 39(1), 154-179
Open this publication in new window or tab >>A Sociology of Treason: The Construction of Weakness
2014 (English)In: Science, Technology and Human Values, ISSN 0162-2439, E-ISSN 1552-8251, Vol. 39, no 1, p. 154-179Article in journal (Refereed) Published
Abstract [en]

The process of translation has both an excluding and including character. The analysis of actor networks, the process of mobilizing alliances, and constructing networks is a common and worthwhile focus. However, the simultaneous betrayals, dissidences, and controversies are often only implied in network construction stories. We aim to nuance the construc- tion aspect of actor–network theory (ANT) by shining the analytical searchlight elsewhere, where the theoretical tools of ANT have not yet systematically ventured. We argue that we need to understand every process of translation in relation to its simultaneous process of treason, and to add antonyms for Callon’s problematization, intressement, enrollment, and mobilization. This enables us to describe powerlessness not as a state but as a process. Our case focuses on the network building around mea- sures for disabled people in the construction of the Athens Metro, during the period 1991-1993. The discussion highlights the efforts of disability organizations to intervene in the initial construction works of the metro project and the simultaneous actions of the Greek government to exclude disability organizations from the design process and to disrupt the accessibility-metro actor network. 

Place, publisher, year, edition, pages
Sage Publications, 2014
Keywords
justice, inequality, protest, politics, power, governance, space/place/scale, dynamics
National Category
Social Sciences Interdisciplinary Sociology (excluding Social Work, Social Psychology and Social Anthropology) Other Social Sciences not elsewhere specified
Identifiers
urn:nbn:se:liu:diva-81939 (URN)10.1177/0162243913512681 (DOI)000328241400008 ()
Available from: 2012-09-25 Created: 2012-09-25 Last updated: 2018-01-12
Doganova, L., Giraudeau, M., Helgesson, C.-F., Kjellberg, H., Lee, F., Mallard, A., . . . Zuiderent-Jerak, T. (2014). Valuation Studies and the Critique of Valuation. Valuation Studies, 2(2), 87-96
Open this publication in new window or tab >>Valuation Studies and the Critique of Valuation
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2014 (English)In: Valuation Studies, ISSN 2001-5992, Vol. 2, no 2, p. 87-96Article in journal, Editorial material (Other academic) Published
Keywords
Valuation, Valuation studies, critique
National Category
Social Sciences Interdisciplinary
Identifiers
urn:nbn:se:liu:diva-114098 (URN)10.3384/vs.2001-5992.142287 (DOI)
Available from: 2015-02-08 Created: 2015-02-08 Last updated: 2018-01-11Bibliographically approved
Lee, F. (2013). On Purity and Interest: Enacting Interests and Values in Biomedical Science. In: : . Paper presented at Gothenburg Theory of Science Dept..
Open this publication in new window or tab >>On Purity and Interest: Enacting Interests and Values in Biomedical Science
2013 (English)Conference paper, Oral presentation only (Other academic)
Abstract [en]

The aim of this paper is to understand the ways in which the biosciences exist in a situation where values of pure and disinterested science meet imperatives to innovate on the basis of economic interests. I show how both these facets of the biosciences, purity and interest, are assembled in complex manners, with large consequences for how the biosciences are evaluated, socially, economically, and methodologically.

Here, I propose analyzing the dichotomous relationship between purity/interest through two modes of purification: temporal and organizational. These two modes of purification have different consequences for how the biosciences are evaluated as Good Science, and are tied to different valorizations of the "linear model" as well as "hybrid science". Thus, I attempt to complicate Boltanski & Thévenot's analysis of justification to stress the performative aspects of coordination and conflict between different orders of worth.

Concretely, the paper's focus is the studied actors’ performance of science as a moral or political project and the ways in which epistemological yardsticks – such as antibody-specificity or experimental replicability – are intertwined with and contrasted against other yardsticks – like production efficiency or medical utility. The questions that the actors grapple with are “What is Good Science?” and “What should the life sciences be concerned with?”

National Category
Social Sciences Interdisciplinary
Identifiers
urn:nbn:se:liu:diva-105652 (URN)
Conference
Gothenburg Theory of Science Dept.
Available from: 2014-04-01 Created: 2014-04-01 Last updated: 2018-01-11
Lee, F. (2013). On Purity and Interest: On Interest Work and Epistemic Value. In: : . Paper presented at 4S 2013, San Diego, 9-12 October.
Open this publication in new window or tab >>On Purity and Interest: On Interest Work and Epistemic Value
2013 (English)Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

The aim of this paper is to understand the ways in which the biosciences exist in a situation where values of pure and disinterested science meet imperatives to innovate on the basis of economic interests. I show how both these facets of the biosciences, purity and interest, are assembled in complex manners, with large consequences for how the biosciences are evaluated, socially, economically, and methodologically. Here, I propose analyzing the dichotomous relationship between purity/interest through two modes of purification: temporal and organizational. These two modes of purification have different consequences for how the biosciences are evaluated as Good Science, and are tied to different valorizations of the "linear model" as well as "hybrid science". Thus, I attempt to complicate Boltanski & Thévenot's analysis of justification to stress the performative aspects of coordination and conflict between different orders of worth. Concretely, the paper's focus is the studied actors’ performance of science as a moral or political project and the ways in which epistemological yardsticks – such as antibody-specificity or experimental replicability – are intertwined with and contrasted against other yardsticks – like production efficiency or medical utility. The questions that the actors grapple with are “What is Good Science?” and “What should the life sciences be concerned with?”

National Category
Social Sciences Interdisciplinary
Identifiers
urn:nbn:se:liu:diva-105656 (URN)
Conference
4S 2013, San Diego, 9-12 October
Available from: 2014-04-01 Created: 2014-04-01 Last updated: 2018-01-11
Dussauge, I., Helgesson, C.-F. & Lee, F. (2013). On the Omnipresence, Diversity, and Elusiveness of Values in the Life Sciences. In: : . Paper presented at 4S 2013, San Diego, 9-12 October.
Open this publication in new window or tab >>On the Omnipresence, Diversity, and Elusiveness of Values in the Life Sciences
2013 (English)Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Biomedicine – health care and the life sciences – are saturated with values. Valuations of life itself are intermingled with values such as scientific reputation, profitability, fairness, competition, and accessibility of care. Reciprocally, the practices of biomedicine produce values, for instance: public health, the preservation of endangered species, profitability of tamed animals for farming, usability of clinical data, or bodily autonomy.What sets this book apart from many of the dominant theoretical approaches to values (in economics, anthropology, sociology, philosophy, history) is that we take an interest not primarily in values as given entities, but rather as how they are enacted in practices. This leads us down an analytical route where values are seen as the outcome of work, where they are the result of a wide range of activities. Fairness, to take an example that often has currency in the provision of health care services, is thus seen as a value that is inseparable from the work evoking it. In an effort to chart a “value practices” approach to the concerns raised above, we aim to focus on how values are enacted: in actions, in technical practices, and in practices of valuation. Here we will provide some first parts of an outline for such an approach to the study of values as they are enacted in biomedicine. The exercise is rooted in an ambition to consider “values” as something to be explained and explored rather than as a given entity with explanatory power. In this we will try to account both how peoples’ actions draw on values, and how agents’ actions and reactions come to enact values.

National Category
Social Sciences Interdisciplinary
Identifiers
urn:nbn:se:liu:diva-105657 (URN)
Conference
4S 2013, San Diego, 9-12 October
Available from: 2014-04-01 Created: 2014-04-01 Last updated: 2018-01-11
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-7206-2046

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