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Eriksson, Jonatan
Publications (10 of 13) Show all publications
Fredriksson, A. G., Svalbring, E., Eriksson, J., Dyverfeldt, P., Alehagen, U., Engvall, J., . . . Carlhäll, C.-J. (2016). 4D flow MRI can detect subtle right ventricular dysfunction in primary left ventricular disease.. Journal of Magnetic Resonance Imaging, 43(3), 558-565
Open this publication in new window or tab >>4D flow MRI can detect subtle right ventricular dysfunction in primary left ventricular disease.
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2016 (English)In: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 43, no 3, p. 558-565Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To investigate whether 4D flow magnetic resonance imaging (MRI) can detect subtle right ventricular (RV) dysfunction in primary left ventricular (LV) disease.

MATERIALS AND METHODS: 4D flow and morphological 3T MRI data were acquired in 22 patients with mild ischemic heart disease who were stratified into two groups based on LV end-diastolic volume index (EDVI): lower-LVEDVI and higher-LVEDVI, as well as in 11 healthy controls. The RV volume was segmented at end-diastole (ED) and end-systole (ES). Pathlines were emitted from the ED volume and traced forwards and backwards in time to ES. The blood volume was separated into flow components. The Direct Flow (DF) component was defined as RV inflow passing directly to outflow. The kinetic energy (KE) of the DF component was calculated. Echocardiographic conventional RV indices were also assessed.

RESULTS: The higher-LVEDVI group had larger LVEDVI and lower LV ejection fraction (98 ± 32 ml/m(2) ; 48 ± 13%) compared to the healthy (67 ± 12, P = 0.002; 64 ± 7, P < 0.001) and lower-LVEDI groups (62 ± 10; 68 ± 7, both P < 0.001). The RV 4D flow-specific measures "DF/EDV volume-ratio" and "DF/EDV KE-ratio at ED" were lower in the higher-LVEDVI group (38 ± 5%; 52 ± 6%) compared to the healthy (44 ± 6; 65 ± 7, P = 0.018 and P < 0.001) and lower-LVEDVI groups (44 ± 6; 64 ± 7, P = 0.011 and P < 0.001). There was no difference in any of the conventional MRI and echocardiographic RV indices between the three groups.

CONCLUSION: We found that in primary LV disease mild impairment of RV function can be detected by 4D flow-specific measures, but not by the conventional MRI and echocardiographic indices. J. Magn. Reson. Imaging 2015.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2016
Keywords
4D flow MRI; interventricular interaction; left ventricular disease; right ventricular function
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-124293 (URN)10.1002/jmri.25015 (DOI)000373000300003 ()26213253 (PubMedID)
Note

Funding agencies: Swedish Heart and Lung Foundation; Swedish Research Council; European Union [223615]; Medical Research Council of Southeast Sweden (FORSS); County Council of Ostergotland/Heart and Medicine Center

Available from: 2016-01-25 Created: 2016-01-25 Last updated: 2017-05-03
Bustamante, M., Petersson, S., Eriksson, J., Alehagen, U., Dyverfeldt, P., Carlhäll, C. & Ebbers, T. (2015). Atlas-based analysis of 4D flow CMR: Automated vessel segmentation and flow quantification. Journal of Cardiovascular Magnetic Resonance, 17(87)
Open this publication in new window or tab >>Atlas-based analysis of 4D flow CMR: Automated vessel segmentation and flow quantification
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2015 (English)In: Journal of Cardiovascular Magnetic Resonance, ISSN 1097-6647, E-ISSN 1532-429X, Vol. 17, no 87Article in journal (Refereed) Published
Abstract [en]

Background: Flow volume quantification in the great thoracic vessels is used in the assessment of several cardiovascular diseases. Clinically, it is often based on semi-automatic segmentation of a vessel throughout the cardiac cycle in 2D cine phase-contrast Cardiovascular Magnetic Resonance (CMR) images. Three-dimensional (3D), time-resolved phase-contrast CMR with three-directional velocity encoding (4D flow CMR) permits assessment of net flow volumes and flow patterns retrospectively at any location in a time-resolved 3D volume. However, analysis of these datasets can be demanding. The aim of this study is to develop and evaluate a fully automatic method for segmentation and analysis of 4D flow CMR data of the great thoracic vessels. Methods: The proposed method utilizes atlas-based segmentation to segment the great thoracic vessels in systole, and registration between different time frames of the cardiac cycle in order to segment these vessels over time. Additionally, net flow volumes are calculated automatically at locations of interest. The method was applied on 4D flow CMR datasets obtained from 11 healthy volunteers and 10 patients with heart failure. Evaluation of the method was performed visually, and by comparison of net flow volumes in the ascending aorta obtained automatically (using the proposed method), and semi-automatically. Further evaluation was done by comparison of net flow volumes obtained automatically at different locations in the aorta, pulmonary artery, and caval veins. Results: Visual evaluation of the generated segmentations resulted in good outcomes for all the major vessels in all but one dataset. The comparison between automatically and semi-automatically obtained net flow volumes in the ascending aorta resulted in very high correlation (r(2) = 0.926). Moreover, comparison of the net flow volumes obtained automatically in other vessel locations also produced high correlations where expected: pulmonary trunk vs. proximal ascending aorta (r(2) = 0.955), pulmonary trunk vs. pulmonary branches (r(2) = 0.808), and pulmonary trunk vs. caval veins (r(2) = 0.906). Conclusions: The proposed method allows for automatic analysis of 4D flow CMR data, including vessel segmentation, assessment of flow volumes at locations of interest, and 4D flow visualization. This constitutes an important step towards facilitating the clinical utility of 4D flow CMR.

Place, publisher, year, edition, pages
BIOMED CENTRAL LTD, 2015
Keywords
4D flow cardiovascular magnetic resonance (4D flow CMR); Flow volume; Image segmentation; Image registration; Phase contrast
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-122197 (URN)10.1186/s12968-015-0190-5 (DOI)000362164100002 ()26438074 (PubMedID)
Note

Funding Agencies|Swedish Heart and Lung foundation; Swedish Research Council; European Research Council (HEART4FLOW) [310612]

Available from: 2015-10-26 Created: 2015-10-23 Last updated: 2018-03-22
Eriksson, J., Bolger, A. F., Carlhäll, C. & Ebbers, T. (2015). Spatial Heterogeneity of Four-Dimensional Relative Pressure Fields in the Human Left Ventricle. Magnetic Resonance in Medicine, 74(6), 1716-1725
Open this publication in new window or tab >>Spatial Heterogeneity of Four-Dimensional Relative Pressure Fields in the Human Left Ventricle
2015 (English)In: Magnetic Resonance in Medicine, ISSN 0740-3194, E-ISSN 1522-2594, Vol. 74, no 6, p. 1716-1725Article in journal (Refereed) Published
Abstract [en]

Purpose: To assess the spatial heterogeneity of the four-dimensional (4D) relative pressure fields in the healthy human left ventricle (LV) and provide reference data for normal LV relative pressure. Methods: Twelve healthy subjects underwent a cardiac MRI examination where 4D flow and morphological data were acquired. The latter data were segmented and used to define the borders of the LV for computation of relative pressure fields using the pressure Poisson equation. The LV lumen was divided into 17 pie-shaped segments. Results: In the normal left ventricle, the relative pressure in the apical segments was significantly higher relative to the basal segments (P &lt; 0.0005) along both the anteroseptal and inferolateral sides after the peaks of early (E-wave) and late (A-wave) diastolic filling. The basal anteroseptal segment showed significantly lower median pressure than the opposite basal inferolateral segment during both E-wave (P &lt; 0.0005) and A-wave (P = 0.0024). Conclusion: Relative pressure in the left ventricle is heterogeneous. During diastole, the main pressure differences in the LV occur along the basal-apical axis. However, pressure differences were also found in the short axis direction and may reflect important aspects of atrioventricular coupling. Additionally, this study provides reference data on LV pressure dynamics for a group of healthy subjects. (C) 2014 Wiley Periodicals, Inc.

Place, publisher, year, edition, pages
WILEY-BLACKWELL, 2015
Keywords
relative pressure; magnetic resonance; 4D flow; physiology; cardiac function; ventricular pressure
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-124503 (URN)10.1002/mrm.25539 (DOI)000367737300023 ()25427056 (PubMedID)
Note

Funding Agencies|Swedish Research Council [621-2011-5204]; Swedish Heart and Lung foundation [hlf 2010/273-31]; Emil and Vera Cornell Foundation; European Research Council [HEART4FLOW, 310612]

Available from: 2016-02-02 Created: 2016-02-01 Last updated: 2017-11-30
Zajac, J., Eriksson, J., Dyverfeldt, P., Bolger, A. F., Ebbers, T. & Carlhäll, C.-J. (2015). Turbulent Kinetic Energy in Normal and Myopathic Left Ventricles. Journal of Magnetic Resonance Imaging, 41(4), 1021-1029
Open this publication in new window or tab >>Turbulent Kinetic Energy in Normal and Myopathic Left Ventricles
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2015 (English)In: Journal of Magnetic Resonance Imaging, ISSN 1053-1807, E-ISSN 1522-2586, Vol. 41, no 4, p. 1021-1029Article in journal (Refereed) Published
Abstract [en]

Purpose: To assess turbulent kinetic energy (TKE) within the left ventricle (LV) of healthy subjects using novel 4D flow MRI methods and to compare TKE values to those from a spectrum of patients with dilated cardiomyopathy (DCM).

Methods: 4D flow and morphological MRI-data were acquired in 11 healthy subjects and 9 patients with different degrees of diastolic dysfunction. TKELV was calculated within the LV at each diastolic time frame. At peak early (E) and late (A) diastolic filling, the TKELV was compared to transmitral peak velocity, LV diameter and mitral annular diameter.

Results: In the majority of all subjects, peaks in TKELV could be observed at E and A. Peak TKELV at E was not different between the groups, and correlated with mitral annular dimensions. Peak TKELV at A was higher in DCM patients compared to healthy subjects, and was related to LV diameter and transmitral velocity.

Conclusions: In normal LVs, TKE values are low. Values are highest during early diastole, and diminish with increasing LV size. In a heterogeneous group of DCM patients, late diastolic TKE values are higher than in healthy subjects. Kinetic energy loss due to elevated late diastolic TKE may reflect inefficient flow in dilated LVs.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2015
Keywords
Magnetic resonance imaging, blood flow, turbulent flow, cardiac function, diastolic dysfunction, heart failure
National Category
Medical Engineering Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:liu:diva-99957 (URN)10.1002/jmri.24633 (DOI)000351521700019 ()
Note

Contract grant sponsor: Swedish Heart-Lung Foundation; Contract grant sponsor: Swedish Research Council; Contract grant sponsor: European Research Council.

Available from: 2013-10-24 Created: 2013-10-24 Last updated: 2017-12-06Bibliographically approved
Eriksson, J., Bolger, A. F., Ebbers, T. & Carlhäll, C.-J. (2013). Four-dimensional blood flow-specific markers of LV dysfunction in dilated cardiomyopathy. European Heart Journal Cardiovascular Imaging, 14(5), 417-424
Open this publication in new window or tab >>Four-dimensional blood flow-specific markers of LV dysfunction in dilated cardiomyopathy
2013 (English)In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 14, no 5, p. 417-424Article in journal (Refereed) Published
Abstract [en]

Aims : Patients with mild heart failure (HF) who are clinically compensated may have normal left ventricular (LV) stroke volume (SV). Despite this, altered intra-ventricular flow patterns have been recognized in these subjects. We hypothesized that, compared with normal LVs, flow in myopathic LVs would demonstrate a smaller proportion of inflow volume passing directly to ejection and diminished the end-diastolic preservation of the inflow kinetic energy (KE).

Methods and results : In 10 patients with dilated cardiomyopathy (DCM) (49 ± 14 years, six females) and 10 healthy subjects (44 ± 17 years, four females), four-dimensional MRI velocity and morphological data were acquired. A previously validated method was used to separate the LV end-diastolic volume (EDV) into four flow components based on the blood's locations at the beginning and end of the cardiac cycle. KE was calculated over the cardiac cycle for each component. The EDV was larger (P = 0.021) and the ejection fraction smaller (P < 0.001) in DCM compared with healthy subjects; the SV was equivalent (DCM: 77 ± 19, healthy: 79 ± 16 mL). The proportion of the total LV inflow that passed directly to ejection was smaller in DCM (P = 0.000), but the end-diastolic KE/mL of the direct flow was not different in the two groups (NS).

Conclusion : Despite equivalent LVSVs, HF patients with mild LV remodelling demonstrate altered diastolic flow routes through the LV and impaired preservation of inflow KE at pre-systole compared with healthy subjects. These unique flow-specific changes in the flow route and energetics are detectable despite clinical compensation, and may prove useful as subclinical markers of LV dysfunction.

Place, publisher, year, edition, pages
Oxford University Press, 2013
Keywords
4D flow, Heart failure, Magnetic resonance imaging, Stroke volume
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-87616 (URN)10.1093/ehjci/jes159 (DOI)000318088300003 ()22879457 (PubMedID)
Available from: 2013-01-19 Created: 2013-01-19 Last updated: 2017-12-06
Eriksson, J. (2013). Quantification of 4D Left Ventricular Blood Flow in Health and Disease. (Doctoral dissertation). Linköping: Linköping University Electronic Press
Open this publication in new window or tab >>Quantification of 4D Left Ventricular Blood Flow in Health and Disease
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The main function of the heart is to pump blood throughout the cardiovascular system by generating pressure differences created through volume changes. Although the main purpose of the heart and vessels is to lead the flowing blood throughout the body, clinical assessments of cardiac function are usually based on morphology, approximating the flow features by viewing the motion of the myocardium and vessels. Measurement of three-directional, three-dimensional and time-resolved velocity (4D Flow) data is feasible using magnetic resonance (MR). The focus of this thesis is the development and application of methods that facilitate the analysis of larger groups of data in order to increase our understanding of intracardiac flow patterns and take the 4D flow technique closer to the clinical setting.

In the first studies underlying this thesis, a pathline based method for analysis of intra ventricular blood flow patterns has been implemented and applied. A pathline is integrated from the velocity data and shows the path an imaginary massless particle would take through the data volume. This method separates the end-diastolic volume (EDV) into four functional components, based on the position for each individual pathline at end-diastole (ED) and end-systole (ES). This approach enables tracking of the full EDV over one cardiac cycle and facilitates calculation of parameters such as e.g. volumes and kinetic energy (KE). Besides blood flow, pressure plays an important role in the cardiac dynamics. In order to study this parameter in the left ventricle, the relative pressure field was computed using the pressure Poisson equation. A comprehensive presentation of the pressure data was obtained dividing the LV blood pool into 17 pie-shaped segments based on a modification of the standard seventeen segment model. Further insight into intracardiac blood flow dynamics was obtained by studying the turbulent kinetic energy (TKE) in the LV. The methods were applied to data from a group of healthy subjects and patients with dilated cardiomyopathy (DCM). DCM is a pathological state where the cardiac function is impaired and the left ventricle or both ventricles are dilated.

The validation study of the flow analysis method showed that a reliable user friendly tool for intra ventricular blood flow analysis was obtained. The application of this tool also showed that roughly one third of the blood that enters the LV, directly leaves the LV again in the same heart beat. The distribution of the four LV EDV components was altered in the DCM group as compared to the healthy group; the component that enters and leaves the LV during one cardiac cycle (Direct Flow) was significantly larger in the healthy subjects. Furthermore, when the kinetic energy was normalized by the volume for each component, at time of ED, the Direct Flow had the highest values in the healthy subjects. In the DCM group, however, the Retained Inflow and Delayed Ejection Flow had higher values. The relative pressure field showed to be highly heterogeneous, in the healthy heart. During diastole the predominate pressure differences in the LV occur along the long axis from base to apex. The distribution and variability of 3D pressure fields differ between early and late diastolic filling phases, but common to both phases is a relatively lower pressure in the outflow segment. In the normal LV, TKE values are low. The highest TKE values can be seen during early diastole and are regionally distributed near the basal LV regions. In contrast, in a heterogeneous group of DCM patients, total diastolic and late diastolic TKE values are higher than in normals, and increase with the LV volume.

In conclusion, in this thesis, methods for analysis of multidirectional intra cardiac velocity data have been obtained. These methods allow assessment of data quality, intra cardiac blood flow patterns, relative pressure fields, and TKE. Using these methods, new insights have been obtained in intra cardiac blood flow dynamics in health and disease. The work underlying this thesis facilitates assessment of data from a larger population of healthy subjects and patients, thus bringing the 4D Flow MRI technique closer to the clinical setting.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2013. p. 63
Series
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1374
Keywords
MRI, relative pressure, 4D flow, quantification, turbulent kinetic energy, dilated cardiomyopathy, magnetic resonance imaging, physiology, cardiac function, diastolic dysfunction
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-98786 (URN)10.3384/diss.diva-99958 (DOI)978-91-7519-542-1 (ISBN)
Public defence
2013-11-22, Berzeliussalen, Campus US, Linköpings universitet, Linköping, 09:00 (English)
Opponent
Supervisors
Available from: 2013-10-14 Created: 2013-10-14 Last updated: 2019-12-08Bibliographically approved
Eriksson, J., Bolger, A. F., Carlhäll, C.-J. & Ebbers, T. (2013). Spatial heterogeneity of 4D relative pressure fields in the human left ventricle. , 14
Open this publication in new window or tab >>Spatial heterogeneity of 4D relative pressure fields in the human left ventricle
2013 (English)Manuscript (preprint) (Other academic)
Abstract [en]

Blood flow throughout the cardiovascular system is driven by pressure differences generated by the contraction and relaxation of the heart, where blood accelerates from high to low pressure areas. Absolute intracardiac pressure cannot be measured noninvasively, but relative pressure can be calculated. The aim of this study was to assess the spatial heterogeneity of the 4D relative pressure fields in the human left ventricle (LV).

Twelve healthy subjects underwent MRI examination where 4D flow as well as morphological data were acquired. The morphological data were segmented, and the segmentation used as boundary condition when computing relative pressure fields from the pressure Poisson equation using a multi grid solver. The LV lumen was divided according to a seventeen segment model in order to assess spatial heterogeneity and present the extensive amount of data in a comprehensive manner.

The basal anteroseptal segment shows a significantly lower median pressure than the opposite basal inferolateral segment during both early and late diastolic filling (p<0.0005 and p=0.0024, respectively). Along the long axis, the relative pressure in the apical segments are significantly higher relative to the basal segments (p<0.0005) along both the anteroseptal and inferolateral sides at and after the peaks of E-wave and A-wave.

During diastole the main pressure differences in the LV occur along the basal-apical axis. However, pressure differences can also be found in the short-axis direction, and may also reflect important aspects of atrioventricular coupling.

Keywords
Relative pressure, Magnetic resonance, 4D flow, physiology, cardiac function
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-99956 (URN)
Available from: 2013-10-24 Created: 2013-10-24 Last updated: 2014-04-23Bibliographically approved
Fredriksson, A. G., Zajac, J., Eriksson, J., Dyverfeldt, P., Bolger, A. F., Ebbers, T. & Carlhäll, C. (2011). 4-D blood flow in the human right ventricle. American Journal of Physiology. Heart and Circulatory Physiology, 301(6), H2344-H2350
Open this publication in new window or tab >>4-D blood flow in the human right ventricle
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2011 (English)In: American Journal of Physiology. Heart and Circulatory Physiology, ISSN 0363-6135, E-ISSN 1522-1539, Vol. 301, no 6, p. H2344-H2350Article in journal (Refereed) Published
Abstract [en]

Right ventricular (RV) function is a powerful prognostic indicator in many forms of heart disease, but its assessment remains challenging and inexact. RV dysfunction may alter the normal patterns of RV blood flow, but those patterns have been incompletely characterized. We hypothesized that, based on anatomic differences, the proportions and energetics of RV flow components would differ from those identified in the left ventricle (LV) and that the portion of the RV inflow passing directly to outflow (Direct Flow) would be prepared for effective systolic ejection as a result of preserved kinetic energy (KE) compared with other RV flow components. Three-dimensional, time-resolved phase-contrast velocity, and balanced steady-state free-precession morphological data were acquired in 10 healthy subjects using MRI. A previously validated method was used to separate the RV and LV end-diastolic volumes into four flow components and measure their volume and KE over the cardiac cycle. The RV Direct Flow: 1) followed a smoothly curving route that did not extend into the apical region of the ventricle; 2) had a larger volume and possessed a larger presystolic KE (0.4 +/- 0.3 mJ) than the other flow components (P andlt; 0.001 and P andlt; 0.01, respectively); and 3) represented a larger part of the end-diastolic blood volume compared with the LV Direct Flow (P andlt; 0.01). These findings suggest that diastolic flow patterns distinct to the normal RV create favorable conditions for ensuing systolic ejection of the Direct Flow component. These flow-specific aspects of RV diastolic-systolic coupling provide novel perspectives on RV physiology and may add to the understanding of RV pathophysiology.

Place, publisher, year, edition, pages
American Physiological Society, 2011
Keywords
cardiac disease, interventricular function, kinetic energy, phase-contrast magnetic resonance imaging, pump physiology
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-74161 (URN)10.1152/ajpheart.00622.2011 (DOI)000298325200020 ()
Note
Funding Agencies|Swedish Research Council||Swedish Heart-Lung Foundation||Emil and Wera Cornell Foundation||Available from: 2012-01-20 Created: 2012-01-20 Last updated: 2017-12-08
Eriksson, J., Dyverfeldt, P., Engvall, J., Bolger, A. F., Ebbers, T. & Carlhäll, C. (2011). Quantification of presystolic blood flow organization and energetics in the human left ventricle. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 300(6), H2135-H2141
Open this publication in new window or tab >>Quantification of presystolic blood flow organization and energetics in the human left ventricle
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2011 (English)In: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, ISSN 0363-6135, Vol. 300, no 6, p. H2135-H2141Article in journal (Refereed) Published
Abstract [en]

Intracardiac blood flow patterns are potentially important to cardiac pumping efficiency. However, these complex flow patterns remain incompletely characterized both in health and disease. We hypothesized that normal left ventricular (LV) blood flow patterns would preferentially optimize a portion of the end-diastolic volume (LVEDV) for effective and rapid systolic ejection by virtue of location near and motion towards the LV outflow tract (LVOT). Three-dimensional cine velocity and morphological data were acquired in 12 healthy persons and 1 patient with dilated cardiomyopathy using MRI. A previously validated method was used for analysis in which the LVEDV was separated into four functional flow components based on the bloods locations at the beginning and end of the cardiac cycle. Each components volume, kinetic energy (KE), site, direction, and linear momentum relative to the LVOT were calculated. Of the four components, the LV inflow that passes directly to outflow in a single cardiac cycle (Direct Flow) had the largest volume. At the time of isovolumic contraction, Direct Flow had the greatest amount of KE and the most favorable combination of distance, angle, and linear momentum relative to the LVOT. Atrial contraction boosted the late diastolic KE of the ejected components. We conclude that normal diastolic LV flow creates favorable conditions for ensuing ejection, defined by proximity and energetics, for the Direct Flow, and that atrial contraction augments the end-diastolic KE of the ejection volume. The correlation of Direct Flow characteristics with ejection efficiency might be a relevant investigative target in cardiac failure.

Place, publisher, year, edition, pages
AMER PHYSIOLOGICAL SOC, 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA, 2011
Keywords
phase-contrast magnetic resonance imaging, kinetic energy, heart, cardiac physiology
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-69186 (URN)10.1152/ajpheart.00993.2010 (DOI)000291209300019 ()
Available from: 2011-06-17 Created: 2011-06-17 Last updated: 2013-12-17
Carhall, C., Eriksson, J., Dyverfeldt, P., Engvall, J., Ebbers, T. & Bolger, A. (2010). Pre-systolic preparation for left ventricular ejection is impaired in heart failure in EUROPEAN HEART JOURNAL, vol 31, issue , pp 726-727. In: EUROPEAN HEART JOURNAL (pp. 726-727). Oxford University Press, 31
Open this publication in new window or tab >>Pre-systolic preparation for left ventricular ejection is impaired in heart failure in EUROPEAN HEART JOURNAL, vol 31, issue , pp 726-727
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2010 (English)In: EUROPEAN HEART JOURNAL, Oxford University Press , 2010, Vol. 31, p. 726-727Conference paper, Published paper (Refereed)
Abstract [en]

n/a

Place, publisher, year, edition, pages
Oxford University Press, 2010
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-67385 (URN)000281531904528 ()
Available from: 2011-04-11 Created: 2011-04-11 Last updated: 2013-09-03
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