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Solin, Niclas
Publications (10 of 18) Show all publications
Bäcklund, F. G., Pallbo, J. & Solin, N. (2016). Controlling Amyloid Fibril Formation by Partial Stirring. Biopolymers, 105(5), 249-259
Open this publication in new window or tab >>Controlling Amyloid Fibril Formation by Partial Stirring
2016 (English)In: Biopolymers, ISSN 0006-3525, E-ISSN 1097-0282, Vol. 105, no 5, p. 249-259Article in journal (Refereed) Published
Abstract [en]

Many proteins undergoes self-assembly into fibrillar structures known as amyloid fibrils. During the self-assembly process related structures, known as spherulites, can be formed. Herein we report a facile method where the balance between amyloid fibrils and spherulites can be controlled by stirring of the reaction mixture during the initial stages of the self-assembly process. Moreover, we report how this methodology can be used to prepare non-covalently functionalized amyloid fibrils. By stirring the reaction mixture continuously or for a limited time during the lag phase the fibril length, and hence the propensity to form liquid crystalline phases, can be influenced. This phenomena is utilized by preparing films consisting of aligned protein fibrils incorporating the laser dye Nile red. The resulting films display polarized Nile red fluorescence.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2016
National Category
Organic Chemistry Biomaterials Science
Identifiers
urn:nbn:se:liu:diva-121017 (URN)10.1002/bip.22803 (DOI)000371690100001 ()
Note

Funding agencies:  Swedish Government [2009-00971]; Knut and Alice Wallenberg foundation

Vid tiden för disputation förelåg publikationen endast som manuskript

Available from: 2015-09-02 Created: 2015-09-02 Last updated: 2017-12-04Bibliographically approved
Ajjan, F., Casado, N., Rebis, T., Elfwing, A., Solin, N., Mecerreyes, D. & Inganäs, O. (2016). High performance PEDOT/lignin biopolymer composites for electrochemical supercapacitors. Journal of Materials Chemistry A, 4(5), 1838-1847
Open this publication in new window or tab >>High performance PEDOT/lignin biopolymer composites for electrochemical supercapacitors
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2016 (English)In: Journal of Materials Chemistry A, ISSN 2050-7488, Vol. 4, no 5, p. 1838-1847Article in journal (Refereed) Published
Abstract [en]

Developing sustainable organic electrode materials for energy storage applications is an urgent task. We present a promising candidate based on the use of lignin, the second most abundant biopolymer in nature. This polymer is combined with a conducting polymer, where lignin as a polyanion can behave both as a dopant and surfactant. The synthesis of PEDOT/Lig biocomposites by both oxidative chemical and electrochemical polymerization of EDOT in the presence of lignin sulfonate is presented. The characterization of PEDOT/Lig was performed by UV-Vis-NIR spectroscopy, FTIR infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, cyclic voltammetry and galvanostatic charge-discharge. PEDOT doped with lignin doubles the specific capacitance (170.4 F g(-1)) compared to reference PEDOT electrodes (80.4 F g(-1)). The enhanced energy storage performance is a consequence of the additional pseudocapacitance generated by the quinone moieties in lignin, which give rise to faradaic reactions. Furthermore PEDOT/Lig is a highly stable biocomposite, retaining about 83% of its electroactivity after 1000 charge/discharge cycles. These results illustrate that the redox doping strategy is a facile and straightforward approach to improve the electroactive performance of PEDOT.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY, 2016
National Category
Biological Sciences
Identifiers
urn:nbn:se:liu:diva-125323 (URN)10.1039/c5ta10096h (DOI)000368839200035 ()
Note

Funding Agencies|Power Papers project from the Knut and Alice Wallenberg foundation; Wallenberg Scholar grant from the Knut and Alice Wallenberg foundation; Marie Curie network Renaissance (NA); European Research Council by Starting Grant Innovative Polymers for Energy Storage (iPes) [306250]; Basque Government

Available from: 2016-02-23 Created: 2016-02-19 Last updated: 2017-11-30
Zeglio, E., Vagin, M., Musumeci, C., Ajjan, F., Gabrielsson, R., Trinh, X. t., . . . Inganäs, O. (2015). Conjugated Polyelectrolyte Blends for Electrochromic and Electrochemical Transistor Devices. Chemistry of Materials, 27(18), 6385-6393
Open this publication in new window or tab >>Conjugated Polyelectrolyte Blends for Electrochromic and Electrochemical Transistor Devices
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2015 (English)In: Chemistry of Materials, ISSN 0897-4756, E-ISSN 1520-5002, Vol. 27, no 18, p. 6385-6393Article in journal (Refereed) Published
Abstract [en]

Two self-doped conjugated polyelectrolytes, having semiconducting and metallic behaviors, respectively, have been blended from aqueous solutions in order to produce materials with enhanced optical and electrical properties. The intimate blend of two anionic conjugated polyelectrolytes combine the electrical and optical properties of these, and can be tuned by blend stoichiometry. In situ conductance measurements have been done during doping of the blends, while UV vis and EPR spectroelectrochemistry allowed the study of the nature of the involved redox species. We have constructed an accumulation/depletion mode organic electrochemical transistor whose characteristics can be tuned by balancing the stoichiometry of the active material.

Place, publisher, year, edition, pages
AMER CHEMICAL SOC, 2015
National Category
Materials Chemistry Condensed Matter Physics
Identifiers
urn:nbn:se:liu:diva-122212 (URN)10.1021/acs.chemmater.5b02501 (DOI)000361935000028 ()
Note

Funding Agencies|Marie Curie network "Renaissance"; Knut and Alice Wallenberg foundation through Wallenberg Scholar grant; Swedish Research Council [VR-2014-3079, D0556101]; Carl Trygger Foundation [CTS 12:206]

Available from: 2015-10-26 Created: 2015-10-23 Last updated: 2017-12-01
Johansson, P., Jullesson, D., Elfwing, A., Liin, S., Musumeci, C., Zeglio, E., . . . Inganäs, O. (2015). Electronic polymers in lipid membranes. Scientific Reports, 5(11242)
Open this publication in new window or tab >>Electronic polymers in lipid membranes
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2015 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, no 11242Article in journal (Refereed) Published
Abstract [en]

Electrical interfaces between biological cells and man-made electrical devices exist in many forms, but it remains a challenge to bridge the different mechanical and chemical environments of electronic conductors (metals, semiconductors) and biosystems. Here we demonstrate soft electrical interfaces, by integrating the metallic polymer PEDOT-S into lipid membranes. By preparing complexes between alkyl-ammonium salts and PEDOT-S we were able to integrate PEDOT-S into both liposomes and in lipid bilayers on solid surfaces. This is a step towards efficient electronic conduction within lipid membranes. We also demonstrate that the PEDOT-S@alkyl-ammonium: lipid hybrid structures created in this work affect ion channels in the membrane of Xenopus oocytes, which shows the possibility to access and control cell membrane structures with conductive polyelectrolytes.

Place, publisher, year, edition, pages
Nature Publishing Group, 2015
National Category
Biophysics
Identifiers
urn:nbn:se:liu:diva-120045 (URN)10.1038/srep11242 (DOI)000356090400002 ()26059023 (PubMedID)
Note

Funding Agencies|Knut and Alice Wallenberg Foundation; Swedish Research Council

Available from: 2015-07-06 Created: 2015-07-06 Last updated: 2018-01-25
Elfwing, A., Bäcklund, F., Musumeci, C., Inganäs, O. & Solin, N. (2015). Protein nanowires with conductive properties. Journal of Materials Chemistry C, 3(25), 6499-6504
Open this publication in new window or tab >>Protein nanowires with conductive properties
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2015 (English)In: Journal of Materials Chemistry C, ISSN 2050-7526, E-ISSN 2050-7534, Vol. 3, no 25, p. 6499-6504Article in journal (Refereed) Published
Abstract [en]

Herein we report on the investigation of self-assembled protein nanofibrils functionalized with metallic organic compounds. We have characterized the electronic behaviour of individual nanowires using conductive atomic force microscopy. In order to follow the self assembly process we have incorporated fluorescent molecules into the protein and used the energy transfer between the internalized dye and the metallic coating to probe the binding of the polyelectrolyte to the fibril.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2015
National Category
Biological Sciences
Identifiers
urn:nbn:se:liu:diva-120179 (URN)10.1039/c5tc00896d (DOI)000356529100010 ()
Note

Funding Agencies|Knut and Alice Wallenberg Foundation through a Wallenberg Scholar grant

Available from: 2015-07-13 Created: 2015-07-13 Last updated: 2017-12-04
Bäcklund, F. G. & Solin, N. (2015). Tuning the aqueous self-assembly process of insulin by a hydrophobic additive. RSC ADVANCES, 5(112), 92254-92262
Open this publication in new window or tab >>Tuning the aqueous self-assembly process of insulin by a hydrophobic additive
2015 (English)In: RSC ADVANCES, ISSN 2046-2069, Vol. 5, no 112, p. 92254-92262Article in journal (Refereed) Published
Abstract [en]

Biomolecular self-assembly is an efficient way of preparing soft-matter based materials. Herein we report a novel method, based on the use of insoluble additives in aqueous media, for influencing the self-assembly process. Due to their low solubility, the use of hydrophobic additives in aqueous media is problematic; however, by mixing the additive with the biomolecule in the solid state, prior to solvation, this problem can be circumvented. In the investigated self-assembly system, where bovine insulin self-assembles into spherical structures, the inclusion of the hydrophobic material α-sexithiophene (6T) results in significant changes in the self-assembly process. Under our reaction conditions, in the case of materials prepared from insulin-only the growth of spherulites typically stops at a diameter of 150μm. However, by adding 2 weight % of hydrophobic material, spherulite growth continues up to diameters in the mm-range. The spherulites incorporate 6T and are thus fluorescent. The method reported herein should be of interest to all scientists working in the field of self-assembly as the flexible materials preparation, based simply on co-grinding of commercially available materials, adds another option to influence the structure and properties of products formed by  self-assembly reactions.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2015
National Category
Organic Chemistry Biomaterials Science
Identifiers
urn:nbn:se:liu:diva-121018 (URN)10.1039/c5ra16144d (DOI)000364032500040 ()
Note

Funding agencies: Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University (Faculty Grant SFO-Mat-LiU) [2009-00971]; Knut and Alice Wallenberg foundation

Available from: 2015-09-02 Created: 2015-09-02 Last updated: 2015-12-03
Bäcklund, F., Wigenius, J., Westerlund, F., Inganäs, O. & Solin, N. (2014). Amyloid fibrils as dispersing agents for oligothiophenes: control of photophysical properties through nanoscale templating and flow induced fibril alignment. Journal of Materials Chemistry C, 2(37), 7811-7822
Open this publication in new window or tab >>Amyloid fibrils as dispersing agents for oligothiophenes: control of photophysical properties through nanoscale templating and flow induced fibril alignment
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2014 (English)In: Journal of Materials Chemistry C, ISSN 2050-7526, E-ISSN 2050-7534, Vol. 2, no 37, p. 7811-7822Article in journal (Refereed) Published
Abstract [en]

Herein we report that protein fibrils formed from aggregated proteins, so called amyloid fibrils, serve as an excellent dispersing agent for hydrophobic oligothiophenes such as alpha-sexithiophene (6T). Furthermore, the protein fibrils are capable of orienting 6T along the fibril long axis, as demonstrated by flow-aligned linear dichroism spectroscopy and polarized fluorescence microscopy. The materials are prepared by solid state mixing of 6T with a protein capable of self-assembly. This results in a water soluble composite material that upon heating in aqueous acid undergoes self-assembly into protein fibrils non-covalently functionalized with 6T, with a typical diameter of 5-10 nm and lengths in the micrometre range. The resulting aqueous fibril dispersions are a readily available source of oligothiophenes that can be processed from aqueous solvent, and we demonstrate the fabrication of macroscopic structures consisting of aligned 6T functionalized protein fibrils. Due to the fibril induced ordering of 6T these structures exhibit polarized light emission.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2014
National Category
Biological Sciences
Identifiers
urn:nbn:se:liu:diva-111311 (URN)10.1039/c4tc00692e (DOI)000341458000013 ()
Note

Funding Agencies|Swedish Research Council [20114324]; Swedish Strategic Research Foundation (SSF); Knut and Alice Wallenberg foundation through a Wallenberg Scholar grant; Chalmers Area of Advance in Nanoscience and Nanotechnology; Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University (Faculty Grant SFO-Mat-LiU) [2009-00971]

Available from: 2014-10-14 Created: 2014-10-14 Last updated: 2017-12-05
Bäcklund, F. & Solin, N. (2014). Development and Application of Methodology for Rapid Screening of Potential Amyloid Probes. ACS COMBINATORIAL SCIENCE, 16(12), 721-729
Open this publication in new window or tab >>Development and Application of Methodology for Rapid Screening of Potential Amyloid Probes
2014 (English)In: ACS COMBINATORIAL SCIENCE, ISSN 2156-8952, Vol. 16, no 12, p. 721-729Article in journal (Refereed) Published
Abstract [en]

Herein, we demonstrate that it is possible to rapidly screen hydrophobic fluorescent aromatic molecules with regards to their properties as amyloid probes. By grinding the hydrophobic molecule with the amyloidogenic protein insulin, we obtained a water-soluble composite material. When this material is dissolved and exposed to conditions promoting amyloid formation, the protein aggregates into amyloid fibrils incorporating the hydrophobic molecule. As a result, changes in the fluorescence spectra of the hydrophobic molecule can be correlated to the formation of amyloid fibrils, and the suitability of the hydrophobic molecular skeleton as an amyloid probe can thus be assessed. As a result, we discovered two new amyloid probes, of which one is the well-known laser dye DCM. The grinding method can also be used for rapid preparation of novel composite materials between dyes and proteins, which can be used in materials science applications such as organic electronics and photonics.

Place, publisher, year, edition, pages
ACS Publications, 2014
Keywords
amyloid probes; rapid screening; fluorescent; aromatic molecules; laser dye DCM
National Category
Biological Sciences
Identifiers
urn:nbn:se:liu:diva-113169 (URN)10.1021/co5001212 (DOI)000346114600009 ()25383488 (PubMedID)
Note

Funding Agencies|Swedish Government Strategic Research Area in Materials Science on Functional Materials at Linkoping University [2009-00971]; Knut and Alice Wallenberg Foundation

Available from: 2015-01-14 Created: 2015-01-12 Last updated: 2015-09-02
Andersson, V., Masich, S., Solin, N. & Inganäs, O. (2012). Morphology of organic electronic materials imaged via electron tomography. Journal of Microscopy, 247(3), 277-287
Open this publication in new window or tab >>Morphology of organic electronic materials imaged via electron tomography
2012 (English)In: Journal of Microscopy, ISSN 0022-2720, E-ISSN 1365-2818, Vol. 247, no 3, p. 277-287Article in journal (Refereed) Published
Abstract [en]

Several organic materials and blends have been studied with the use of electron tomography. Tomography reconstructions of active layers of organic solar cells, where various preparation techniques have been used, have been analysed and compared to device behaviour. In addition, materials with predefined structures, including contrast enhancing features, have been studied and double tilt data collection has been employed to improve reconstructions. Small changes in preparation procedures may lead to large differences in morphology and device performance, and the results also indicate a complex relation between these.

Place, publisher, year, edition, pages
Wiley, 2012
Keywords
Electron tomography, morphology, organic electronics, organic solar cell
National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-72907 (URN)10.1111/j.1365-2818.2012.03643.x (DOI)000307968600008 ()
Note

On the day of the defence date the status of this article was Manuscript.

Available from: 2011-12-09 Created: 2011-12-09 Last updated: 2017-12-08Bibliographically approved
Andersson, V., Skoglund, C., Uvdal, K. & Solin, N. (2012). Preparation of amyloidlike fibrils containing magnetic iron oxide nanoparticles: Effect of protein aggregation on proton relaxivity. Biochemical and Biophysical Research Communications - BBRC, 419(4), 682-686
Open this publication in new window or tab >>Preparation of amyloidlike fibrils containing magnetic iron oxide nanoparticles: Effect of protein aggregation on proton relaxivity
2012 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 419, no 4, p. 682-686Article in journal (Refereed) Published
Abstract [en]

A method to prepare amyloid-like fibrils functionalized with magnetic nanoparticles has been developed. The amyloid-like fibrils are prepared in a two step procedure, where insulin and magnetic nanoparticles are mixed simply by grinding in the solid state, resulting in a water soluble hybrid material. When the hybrid material is heated in aqueous acid, the insulin/nanoparticle hybrid material self assembles to form amyloid-like fibrils incorporating the magnetic nanoparticles. This results in magnetically labeled amyloid-like fibrils which has been characterized by Transmission Electron Microscopy (TEM) and electron tomography. The influence of the aggregation process on proton relaxivity is investigated. The prepared materials have potential uses in a range of bio-imaging applications.

Place, publisher, year, edition, pages
Elsevier, 2012
Keywords
Amyloid fibrils, Magnetic nanoparticles, Electron tomography, Self-assembly, Proton relaxation
National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-76954 (URN)10.1016/j.bbrc.2012.02.077 (DOI)000302335800016 ()
Note

Funding Agencies|Swedish Research Council (VR)||VINNOVA||Carl Trygger Foundation|10:388|Swedish Royal Academy of Sciences (INA)||Lars Hiertas foundation||

Available from: 2012-05-02 Created: 2012-04-27 Last updated: 2017-12-07
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