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Håkansson, Irene
Publications (2 of 2) Show all publications
Blystad, I., Håkansson, I., Tisell, A., Ernerudh, J., Smedby, Ö., Lundberg, P. & Larsson, E.-M. (2016). Quantitative MRI for Analysis of Active Multiple Sclerosis Lesions without Gadolinium-Based Contrast Agent. American Journal of Neuroradiology, 37(1), 94-100
Open this publication in new window or tab >>Quantitative MRI for Analysis of Active Multiple Sclerosis Lesions without Gadolinium-Based Contrast Agent
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2016 (English)In: American Journal of Neuroradiology, ISSN 0195-6108, E-ISSN 1936-959X, Vol. 37, no 1, p. 94-100Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND PURPOSE: Contrast-enhancing MS lesions are important markers of active inflammation in the diagnostic work-up of MS and in disease monitoring with MR imaging. Because intravenous contrast agents involve an expense and a potential risk of adverse events, it would be desirable to identify active lesions without using a contrast agent. The purpose of this study was to evaluate whether pre-contrast injection tissue-relaxation rates and proton density of MS lesions, by using a new quantitative MR imaging sequence, can identify active lesions. MATERIALS AND METHODS: Forty-four patients with a clinical suspicion of MS were studied. MR imaging with a standard clinical MS protocol and a quantitative MR imaging sequence was performed at inclusion (baseline) and after 1 year. ROIs were placed in MS lesions, classified as nonenhancing or enhancing. Longitudinal and transverse relaxation rates, as well as proton density were obtained from the quantitative MR imaging sequence. Statistical analyses of ROI values were performed by using a mixed linear model, logistic regression, and receiver operating characteristic analysis. RESULTS: Enhancing lesions had a significantly (P < .001) higher mean longitudinal relaxation rate (1.22 0.36 versus 0.89 +/- 0.24), a higher mean transverse relaxation rate (9.8 +/- 2.6 versus 7.4 +/- 1.9), and a lower mean proton density (77 +/- 11.2 versus 90 +/- 8.4) than nonenhancing lesions. An area under the receiver operating characteristic curve value of 0.832 was obtained. CONCLUSIONS: Contrast-enhancing MS lesions often have proton density and relaxation times that differ from those in nonenhancing lesions, with lower proton density and shorter relaxation times in enhancing lesions compared with nonenhancing lesions.

Place, publisher, year, edition, pages
National Category
Clinical Medicine
urn:nbn:se:liu:diva-124482 (URN)10.3174/ajnr.A4501 (DOI)000367466500019 ()26471751 (PubMedID)

Funding Agencies|National Science and Engineering Research Council; University of Linkoping; University Hospital Research Funds

Available from: 2016-02-02 Created: 2016-02-01 Last updated: 2017-11-16
Söderfeldt, B., Ragnehed, M., Håkansson, I., Lundberg, P., Nilsson, M., Ahlner, J. & Engström, M. (2006). Influence of Diazepam on Clinically Designed fMRI. Paper presented at Am Neuropsychiatric Association (ANPA) 2006, San Diego, USA.
Open this publication in new window or tab >>Influence of Diazepam on Clinically Designed fMRI
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2006 (English)Conference paper, Published paper (Other academic)
National Category
Medical and Health Sciences
urn:nbn:se:liu:diva-64247 (URN)
Am Neuropsychiatric Association (ANPA) 2006, San Diego, USA
Available from: 2011-01-17 Created: 2011-01-17 Last updated: 2014-10-02

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