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Freland, Sofia
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Svensson Arvelund, J., Söderberg, D., Wendel, C., Freland, S., Geffers, R., Berg, G., . . . Ernerudh, J. (2015). Decidual macrophages contribute to the unique leukocyte composition at the fetal-maternal interface by production of IL-35, induction of Treg cells and production of homeostatic chemokines.
Open this publication in new window or tab >>Decidual macrophages contribute to the unique leukocyte composition at the fetal-maternal interface by production of IL-35, induction of Treg cells and production of homeostatic chemokines
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2015 (English)Manuscript (preprint) (Other academic)
Abstract [en]

Reproductive success depends on the ability of the maternal immune system to adapt in order to tolerate and support the growing semi-allogenic fetus. Macrophages, being a major leukocyte population in the uterine mucosa (decidua), may play a central role in promoting the unique composition and regulatory phenotype of leukocytes that is characteristic for the fetal-maternal interface. We show that decidual macrophages display a predominantly immune regulatory gene profile and produce the immunosuppressive cytokine IL-35 but no other members of the IL-12 family (IL-12, IL-23 and IL-27). Decidual macrophages also promoted the selective expansion of CD25highFoxp3+ Tregs but not of Tbet+ Th1, GATA-3+ Th2 and Rorγt+ Th17 cells. In addition, these macrophages preferentially secreted the monocyte- and Treg-associated chemokines CCL2 and CCL18, while Th1-, Th2- and Th17-related chemokines were produced at low levels. Among in vitro macrophages, distinct chemokine profiles were observed; IL-4/13 upregulated Th2-associated chemokines (CCL17, CCL22, CCL26) while LPS/IFNγ upregulated Th1-associated chemokines (CXCL9, CXCL10, CXCL11, CCL5). M(IL-10) macrophages (induced by M-CSF and IL-10) showed a chemokine profile similar to that of decidual macrophages, as shown by gene expression and protein analysis. By using M(IL-10) macrophages as a model of decidual macrophages, we show that these cells promote the recruitment of CD14+ monocytes, while migration of several lymphocyte populations was unaltered or prevented. These data implicate decidual macrophages as critical regulators of the decidual leukocyte composition and phenotype that is associated with successful reproduction.

National Category
Immunology Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-117182 (URN)
Available from: 2015-04-21 Created: 2015-04-21 Last updated: 2018-07-18Bibliographically approved
Svensson, J., Mirrasekhian, E., Freland, S., Jenmalm, M., Berg, G. & Ernerudh, J. (2012). M-CSF produced by trophoblasts induces CD163, a marker of immune regulatory decidual macrophages in JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol 94, issue 1, pp 92-92. In: JOURNAL OF REPRODUCTIVE IMMUNOLOGY (pp. 92-92). Elsevier, 94(1)
Open this publication in new window or tab >>M-CSF produced by trophoblasts induces CD163, a marker of immune regulatory decidual macrophages in JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol 94, issue 1, pp 92-92
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2012 (English)In: JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Elsevier , 2012, Vol. 94, no 1, p. 92-92Conference paper, Published paper (Refereed)
Abstract [en]

n/a

Place, publisher, year, edition, pages
Elsevier, 2012
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-78583 (URN)10.1016/j.jri.2012.03.412 (DOI)000304579400166 ()
Available from: 2012-06-15 Created: 2012-06-15 Last updated: 2012-06-15
Bhai Mehta, R., Mirrasekhian, E., Svensson, J., Freland, S., Berg, G., Sharma, S., . . . Ernerudh, J. (2011). Trophoblast cells in immune regulation: modulation of macrophage polarization and production of IL-35 in JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol 90, issue 2, pp 165-165. In: JOURNAL OF REPRODUCTIVE IMMUNOLOGY (pp. 165-165). Elsevier, 90(2)
Open this publication in new window or tab >>Trophoblast cells in immune regulation: modulation of macrophage polarization and production of IL-35 in JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol 90, issue 2, pp 165-165
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2011 (English)In: JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Elsevier , 2011, Vol. 90, no 2, p. 165-165Conference paper, Published paper (Refereed)
Abstract [en]

n/a

Place, publisher, year, edition, pages
Elsevier, 2011
Keywords
Trophoblast, Macrophage, Polarization, IL-35
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-70340 (URN)10.1016/j.jri.2011.06.061 (DOI)000293873500057 ()
Available from: 2011-09-02 Created: 2011-09-02 Last updated: 2011-09-02
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