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Grönqvist, Anders
Publications (5 of 5) Show all publications
Mellergård, J., Tisell, A., Blystad, I., Grönqvist, A., Blennow,, K., Olsson,, B., . . . Ernerudh, J. (2017). Cerebrospinal fluid levels of neurofilament and tau correlate with brain atrophy in natalizumab-treated multiple sclerosis. European Journal of Neurology, 24(1), 112-121
Open this publication in new window or tab >>Cerebrospinal fluid levels of neurofilament and tau correlate with brain atrophy in natalizumab-treated multiple sclerosis
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2017 (English)In: European Journal of Neurology, ISSN 1351-5101, E-ISSN 1468-1331, Vol. 24, no 1, p. 112-121Article in journal (Refereed) Published
Abstract [en]

Background and purpose

Brain atrophy is related to clinical deterioration in multiple sclerosis (MS) but its association with intrathecal markers of inflammation or neurodegeneration is unclear. Our aim was to investigate whether cerebrospinal fluid (CSF) markers of inflammation or neurodegeneration are associated with brain volume change in natalizumab-treated MS and whether this change is reflected in non-lesional white matter metabolites.

Methods

About 25 patients with natalizumab-treated MS were followed for 3 years with assessment of percentage brain volume change (PBVC) and absolute quantification of metabolites with proton magnetic resonance spectroscopy (1H MRS). Analyses of inflammatory [interleukin 1β (IL-1β), IL-6, C-X-C motif chemokine 8 (CXCL8), CXCL10, CXCL11, C-C motif chemokine 22] and neurodegenerative [neurofilament light protein (NFL), glial fibrillary acidic protein, myelin basic protein, tau proteins] markers were done at baseline and 1-year follow-up.

Results

The mean decline in PBVC was 3% at the 3-year follow-up, although mean 1H MRS metabolite levels in non-lesional white matter were unchanged. CSF levels of NFL and tau at baseline correlated negatively with PBVC over 3 years (r = −0.564, P = 0.012, and r = −0.592, P = 0.010, respectively).

Conclusions

A significant 3-year whole-brain atrophy was not reflected in mean metabolite change of non-lesional white matter. In addition, our results suggest that CSF levels of NFL and tau correlate with brain atrophy development and may be used for evaluating treatment response in inflammatory active MS.

Place, publisher, year, edition, pages
Blackwell Publishing, 2017
Keywords
brain atrophy, magnetic resonance spectroscopy, multiple sclerosis, natalizumab, neurofilament, quantitative magnetic resonance imaging, tau
National Category
Neurology Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:liu:diva-134153 (URN)10.1111/ene.13162 (DOI)000392806700007 ()
Note

Funding agencies: Medical Research Council [K2013-61X-22310-01-4]; Swedish Society of Neurologically Disabled; Swedish Society of Medicine; National Research Council (VR/NT); Linkoping University; Linkoping University Hospital; County Council of Ostergotland

Available from: 2017-01-26 Created: 2017-01-26 Last updated: 2018-04-17
Karlsson, A., Rosander, J., Tallberg, J., Grönqvist, A., Borga, M. & Dahlqvist Leinhard, O. (2015). Automatic and Quantitative Assessment of Total and Regional Muscle Tissue Volume using Multi-Atlas Segmentation. In: International Society for Magnetic Resonance in Medicince Annual Meeting: Proceedings. Paper presented at 23rd International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition, Toronto, Ontario, Canada, May 30 - June 5, 2015.
Open this publication in new window or tab >>Automatic and Quantitative Assessment of Total and Regional Muscle Tissue Volume using Multi-Atlas Segmentation
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2015 (English)In: International Society for Magnetic Resonance in Medicince Annual Meeting: Proceedings, 2015Conference paper, Oral presentation with published abstract (Other academic)
Abstract [en]

The purpose is to develop and demonstrate a rapid whole-body MRI method for automatic quantification of total and regional lean skeletal muscle volume. Quantitative water and fat separated image volumes of the whole body are manually segmented and used as atlases. The atlases are non-rigidly registered onto to a new image volume and the muscle groups are classified using a voting scheme. A leave-one-out approach with subjects scanned in a 1.5 T and a 3.0 T scanner is used for validation. The method quantifies the whole-body skeletal muscle volumes and the volumes of separate muscle groups independently of image resolution.

Series
JOURNAL OF MAGNETIC RESONANCE IMAGING, ISSN 1558–1569
National Category
Radiology, Nuclear Medicine and Medical Imaging Medical Image Processing
Identifiers
urn:nbn:se:liu:diva-128991 (URN)
Conference
23rd International Society for Magnetic Resonance in Medicine Annual Meeting & Exhibition, Toronto, Ontario, Canada, May 30 - June 5, 2015
Available from: 2016-06-07 Created: 2016-06-07 Last updated: 2019-06-14Bibliographically approved
Lundin, F., Tisell, A., Leijon, G., Dahlqvist Leinhard, O., Davidsson, L., Grönqvist, A., . . . Lundberg, P. (2013). Preoperative and postoperative H-1-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus. Journal of Neurology, Neurosurgery and Psychiatry, 84(2), 188-193
Open this publication in new window or tab >>Preoperative and postoperative H-1-MR spectroscopy changes in frontal deep white matter and the thalamus in idiopathic normal pressure hydrocephalus
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2013 (English)In: Journal of Neurology, Neurosurgery and Psychiatry, ISSN 0022-3050, E-ISSN 1468-330X, Vol. 84, no 2, p. 188-193Article in journal (Refereed) Published
Abstract [en]

Background In a previous study we found significantly decreased N-acetyl aspartate (NAA) and total N-acetyl (tNA) groups in the thalamus of patients with idiopathic normal pressure hydrocephalus (iNPH) compared with healthy individuals (HI). No significant difference between the groups could be found in the frontal deep white matter (FDWM). less thanbrgreater than less thanbrgreater thanObjective The primary aim of this study was to investigate if these metabolites in the thalamus were normalised after shunt surgery. The secondary aim was to investigate postoperative metabolic changes in FDWM. less thanbrgreater than less thanbrgreater thanSubjects and methods Fourteen patients with iNPH, mean age 74 years, and 15 HI, also mean age 74 years, were examined. Assessment of a motor score (MOSs) was performed before and after shunt surgery. Absolute quantitative H-1-MR spectroscopy (1.5 T, volumes of interest 2.5-3 ml) was performed on the patients in the FDWM and in the thalamus, before and 3 months after shunt surgery, and also once on the HI. The following metabolites were analysed: tNA, NAA, total creatine, total choline (tCho), myo-inositol (mIns), glutamate and lactate concentrations. MRI volumetric calculations of the lateral ventricles were also performed. less thanbrgreater than less thanbrgreater thanResults At 3 months postoperatively, we found no significant changes of tNA or NAA in the thalamus. In contrast, in the FDWM, there was a significant increase of tCho (p=0.01) and a borderline significant decrease of mIns (p=0.06). 12/14 patients were shunt responders (motor function). Median reduction of the lateral ventricle was 16%. A weak correlation between MOS and ventricular reduction was seen. less thanbrgreater than less thanbrgreater thanConclusions Normalisation of thalamic tNA and NAA could not be detected postoperatively. The increased tCho and decreased mIns in the FDWM postoperatively might relate to clinical improvement.

Place, publisher, year, edition, pages
BMJ Publishing Group, 2013
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-88662 (URN)10.1136/jnnp-2012-302190 (DOI)000313554700014 ()
Note

Funding Agencies|National Research Council (VR/NT)|2008-3368|University Hospital Research funds, CMIV||University of Linkoping||

Available from: 2013-02-14 Created: 2013-02-14 Last updated: 2019-06-14Bibliographically approved
Lundin, F., Tisell, A., Dahlqvist Leinhard, O., Davidsson, L., Grönkvist, A., Wikkelsö, C., . . . Leijon, G. (2011). Idiopathic Normal Pressure Hydrocephalus Pre -Postoperative 1H -MRS  changes in Frontal Deep White Matter and the Thalamus. Paper presented at Hydrocephalus, Copenhagen 2011.
Open this publication in new window or tab >>Idiopathic Normal Pressure Hydrocephalus Pre -Postoperative 1H -MRS  changes in Frontal Deep White Matter and the Thalamus
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2011 (English)Conference paper, Published paper (Refereed)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-73637 (URN)
Conference
Hydrocephalus, Copenhagen 2011
Available from: 2012-01-10 Created: 2012-01-10 Last updated: 2019-06-14
Dahlqvist Leinhard, O., Jaworski, J., Aalto, A., Grönkvist, A., Tisell, A., Smedby, Ö., . . . Lundberg, P. (2011). Is Increased normal White Matter Glutamate Concentrations a Precursor of Gliosis and Disease Progression in Multiple Sclerosis?. In: Internationell Society for Magnetic Resonance in Medicin, 2011: . Paper presented at ISMRM 19th Annual Meeting & Exhibition, 7-13 May 2011, Montreal, Canada (pp. 4089-4089).
Open this publication in new window or tab >>Is Increased normal White Matter Glutamate Concentrations a Precursor of Gliosis and Disease Progression in Multiple Sclerosis?
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2011 (English)In: Internationell Society for Magnetic Resonance in Medicin, 2011, 2011, p. 4089-4089Conference paper, Published paper (Refereed)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-73691 (URN)
Conference
ISMRM 19th Annual Meeting & Exhibition, 7-13 May 2011, Montreal, Canada
Available from: 2012-01-11 Created: 2012-01-11 Last updated: 2019-06-14Bibliographically approved
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