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Nordin, Teresa
Alternative names
Publications (6 of 6) Show all publications
Nordin, T., Stenmark Persson, R., Blomstedt, P. & Wårdell, K. (2019). Improvement Maps for Deep Brain Stimulation in Parkinson’s Disease. In: : . Paper presented at 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society Berlin.
Open this publication in new window or tab >>Improvement Maps for Deep Brain Stimulation in Parkinson’s Disease
2019 (English)Conference paper, Poster (with or without abstract) (Other academic)
National Category
Medical Engineering
Identifiers
urn:nbn:se:liu:diva-160833 (URN)
Conference
41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society Berlin
Available from: 2019-10-10 Created: 2019-10-10 Last updated: 2019-10-10
Nordin, T., Zsigmond, P., Pujol, S., Westin, C.-F. & Wårdell, K. (2019). White matter tracing combined with electric field simulation –€“ A patient-specific approach for deep brain stimulation. NeuroImage: Clinical, 24, 1-11, Article ID 102026.
Open this publication in new window or tab >>White matter tracing combined with electric field simulation –€“ A patient-specific approach for deep brain stimulation
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2019 (English)In: NeuroImage: Clinical, ISSN 0353-8842, E-ISSN 2213-1582, Vol. 24, p. 1-11, article id 102026Article in journal (Refereed) Published
Abstract [en]

Objective

Deep brain stimulation (DBS) in zona incerta (Zi) is used for symptom alleviation in essential tremor (ET). Zi is positioned along the dentato-rubro-thalamic tract (DRT). Electric field simulations with the finite element method (FEM) can be used for estimation of a volume where the stimulation affects the tissue by applying a fixed isolevel (VDBS). This work aims to develop a workflow for combined patient-specific electric field simulation and white matter tracing of the DRT, and to investigate the influence on the VDBS from different brain tissue models, lead design and stimulation modes. The novelty of this work lies in the combination of all these components.

Method

Patients with ET were implanted in Zi (lead 3389, n = 3, voltage mode; directional lead 6172, n = 1, current mode). Probabilistic reconstruction from diffusion MRI (dMRI) of the DRT (n = 8) was computed with FSL Toolbox. Brain tissue models were created for each patient (two homogenous, one heterogenous isotropic, one heterogenous anisotropic) and the respective VDBS (n = 48) calculated from the Comsol Multiphysics FEM simulations. The DRT and VDBS were visualized with 3DSlicer and superimposed on the preoperative T2 MRI, and the common volumes calculated. Dice Coefficient (DC) and level of anisotropy were used to evaluate and compare the brain models.

Result

Combined patient-specific tractography and electric field simulation was designed and evaluated, and all patients showed benefit from DBS. All VDBS overlapped the reconstructed DRT. Current stimulation showed prominent difference between the tissue models, where the homogenous grey matter deviated most (67 < DC < 69). Result from heterogenous isotropic and anisotropic models were similar (DC > 0.95), however the anisotropic model consistently generated larger volumes related to a greater extension of the electric field along the DBS lead. Independent of tissue model, the steering effect of the directional lead was evident and consistent.

Conclusion

A workflow for patient-specific electric field simulations in combination with reconstruction of DRT was successfully implemented. Accurate tissue classification is essential for electric field simulations, especially when using the current control stimulation. With an accurate targeting and tractography reconstruction, directional leads have the potential to tailor the electric field into the desired region.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Deep brain stimulation (DBS), Essential tremor (ET), Diffusion MRI (dMRI), Tractography, Dentato-rubro-thalamic tract (DRT), Zona Incerta (Zi), Electrical conductivity tensor
National Category
Medical Laboratory and Measurements Technologies Medical Engineering
Identifiers
urn:nbn:se:liu:diva-162461 (URN)10.1016/j.nicl.2019.102026 (DOI)
Available from: 2019-12-05 Created: 2019-12-05 Last updated: 2019-12-05Bibliographically approved
Stenmark Persson, R., Nordin, T., Hariz, G.-M., Hariz, M. & Blomstedt, P. (2018). Bilateral deep brain stimulation in the caudal zona incerta for Parkinson’s disease – 1-year follow-up. In: : . Paper presented at XXIIIrd congress of the European Society for Stereotactic and Functional Neurosurgery, 26-29 september 2018, Edinburgh, Scotland (ESSFN).
Open this publication in new window or tab >>Bilateral deep brain stimulation in the caudal zona incerta for Parkinson’s disease – 1-year follow-up
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2018 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Medical Engineering
Identifiers
urn:nbn:se:liu:diva-152030 (URN)
Conference
XXIIIrd congress of the European Society for Stereotactic and Functional Neurosurgery, 26-29 september 2018, Edinburgh, Scotland (ESSFN)
Available from: 2018-10-17 Created: 2018-10-17 Last updated: 2018-10-17
Nordin, T., Zsigmond, P., Pujol, S., Westin, C.-F. & Wårdell, K. (2018). Computer models in deep brain stimulation based on diffusion MRI. In: : . Paper presented at Medicinteknikdagarna, 9-10 oktober 2018, Umeå, Sverige.
Open this publication in new window or tab >>Computer models in deep brain stimulation based on diffusion MRI
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2018 (English)Conference paper, Oral presentation only (Refereed)
National Category
Medical Engineering
Identifiers
urn:nbn:se:liu:diva-152025 (URN)
Conference
Medicinteknikdagarna, 9-10 oktober 2018, Umeå, Sverige
Available from: 2018-10-17 Created: 2018-10-17 Last updated: 2018-10-17
Nordin, T., Zsigmond, P., Pujol, S., Westin, C.-F. & Wårdell, K. (2018). Deep brain stimulation: Patient-specific electrical field simulation. In: : . Paper presented at XXIIIrd congress of the European Society for Stereotactic and Functional Neurosurgery, 26-29 september 2018, Edinburgh, Scotland (ESSFN).
Open this publication in new window or tab >>Deep brain stimulation: Patient-specific electrical field simulation
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2018 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Medical Engineering
Identifiers
urn:nbn:se:liu:diva-152027 (URN)
Conference
XXIIIrd congress of the European Society for Stereotactic and Functional Neurosurgery, 26-29 september 2018, Edinburgh, Scotland (ESSFN)
Available from: 2018-10-17 Created: 2018-10-17 Last updated: 2018-10-17
Blystad, I., Warntjes, M., Helmersson, T. & Lundberg, P. (2011). Contrast assessment of Synthetic Magnetic Resonance Imaging in clinical practice. In: : . Paper presented at ISMRM, Montreal 2011.
Open this publication in new window or tab >>Contrast assessment of Synthetic Magnetic Resonance Imaging in clinical practice
2011 (English)Conference paper, Published paper (Refereed)
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-73689 (URN)
Conference
ISMRM, Montreal 2011
Available from: 2012-01-11 Created: 2012-01-11 Last updated: 2016-02-23
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