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Post, Claes
Publications (3 of 3) Show all publications
Alehagen, U., Johansson, P., Björnstedt, M., Rosén, A., Post, C. & Aaseth, J. (2016). Relatively high mortality risk in elderly Swedish subjects with low selenium status. European Journal of Clinical Nutrition, 70(1), 91-96
Open this publication in new window or tab >>Relatively high mortality risk in elderly Swedish subjects with low selenium status
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2016 (English)In: European Journal of Clinical Nutrition, ISSN 0954-3007, E-ISSN 1476-5640, Vol. 70, no 1, p. 91-96Article in journal (Refereed) Published
Abstract [en]

Background/Objectives: 

The daily dietary intake of selenium (Se), an essential trace element, is still low in Sweden in spite of decades of nutritional information campaigns and the effect of this on the public health is presently not well known. The objective of this study was to determine the serum Se levels in an elderly Swedish population and to analyze whether a low Se status had any influence on mortality.

Subjects/Methods: 

Six-hundred sixty-eight (n=668) elderly participants were invited from a municipality and evaluated in an observational study. Individuals were followed for 6.8 years and Se levels were re-evaluated in 98 individuals after 48 months. Clinical examination of all individuals included functional classification, echocardiography, electrocardiogram and serum Se measurement. All mortality was registered and endpoints of mortality were assessed by Kaplan–Meier plots, and Cox proportional hazard ratios adjusted for potential confounding factors were calculated.

Results: 

The mean serum Se level of the study population (n=668) was 67.1 μg/l, corresponding to relatively low Se intake. After adjustment for male gender, smoking, ischemic heart disease, diabetes, chronic obstructive pulmonary disease and impaired heart function, persons with serum Se in the lowest quartile had 43% (95% confidence interval (CI): 1.02–2.00) and 56% (95% CI: 1.03–2.36) increased risk for all-cause and cardiovascular mortality, respectively. The result was not driven by inflammatory effects on Se concentration in serum.

Conclusion: 

The mean serum Se concentration in an elderly Swedish population was 67.1 μg/l, which is below the physiological saturation level for several selenoprotein enzymes. This result may suggest the value of modest Se supplementation in order to improve the health of the Swedish population.

Place, publisher, year, edition, pages
Nature Publishing Group, 2016
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:liu:diva-120772 (URN)10.1038/ejcn.2015.92 (DOI)000369434800015 ()26105108 (PubMedID)
Note

Funding agencies: County Council of Ostergotland; University of Linkoping; Cancer-och Allergifonden

Available from: 2015-08-24 Created: 2015-08-24 Last updated: 2017-09-22Bibliographically approved
Milovanovic, M., Eriksson, K., Winblad, B., Nilsson, S., Lindahl, T., Post, C. & Järemo, P. (2014). Alzheimer and platelets: Low-density platelet populations reveal increased serotonin content in Alzheimer type dementia. Clinical Biochemistry, 47(15), 51-53
Open this publication in new window or tab >>Alzheimer and platelets: Low-density platelet populations reveal increased serotonin content in Alzheimer type dementia
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2014 (English)In: Clinical Biochemistry, ISSN 0009-9120, E-ISSN 1873-2933, Vol. 47, no 15, p. 51-53Article in journal (Refereed) Published
Abstract [en]

Introduction: Alzheimers disease (AD) is a progressive form of dementia characterized by an increase in the toxic substance beta-amyloid in the brain. Platelets display a substantial heterogeneity with respect to density. They further contain a substantial amount of beta-amyloid precursor protein. Platelets take up and store serotonin (5-HT) that plays an important role in the pathogenesis of severe depression. The current study aims to investigate platelet serotonin content in different platelet density populations. Material and methods: The study involved 8 patients (age 70 +/- 8 (SD) years) (3 females/5 males) with moderate AD. 6 healthy elderly subjects (age 66 +/- 9 (SD) years) (3 females/3 males) served as controls. The platelet population was divided into 17 subpopulations according to density, using a linear Percoll (TM) gradient. Platelets were counted in all fractions. After cell lysis an ELISA technique was employed to determine the 5-HT content in each platelet subfraction. Results: The two study groups did not differ significantly regarding platelet distribution in the gradients, but AD sufferers have a significantly higher 5-HT content (p less than 0.05) in the lighter platelet populations. Discussion: AD-type dementia proved to be associated with lighter platelets containing more 5-HT. It is possible that platelets from AD patients release less 5-HT. It is speculated that AD synapses are affected in a manner comparable to platelets, which could explain why 5-HT reuptake inhibitors are less effective in AD dementia.

Place, publisher, year, edition, pages
Elsevier, 2014
Keywords
Alzheimers disease; Fibrinogen; Platelets; Platelet activity; Platelet density; Platelet heterogeneity; Serotonin
National Category
Basic Medicine Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-111746 (URN)10.1016/j.clinbiochem.2014.07.007 (DOI)000342822100008 ()25041722 (PubMedID)
Note

Funding Agencies|Ahlens Foundation; Gun and Bertil Stohnes Foundation; Magnus Bergvalls Foundation; "Stiftelsen for Gamla Tjanarinnor"; Swedish Alzheimer Foundation; Swedish Board for Health and Welfare; Pfizer AB, Sweden

Available from: 2014-10-31 Created: 2014-10-31 Last updated: 2018-01-11Bibliographically approved
Järemo, P., Milovanovic, M., Nilsson, S., Buller, C., Post, C. & Winblad, B. (2011). Alzheimer's disease is characterized by more low-density erythrocytes with increased volume and enhanced β-amyloid x-40 content [Letter to the editor]. Journal of Internal Medicine, 270(5), 489-492
Open this publication in new window or tab >>Alzheimer's disease is characterized by more low-density erythrocytes with increased volume and enhanced β-amyloid x-40 content
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2011 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 270, no 5, p. 489-492Article in journal, Letter (Other academic) Published
Place, publisher, year, edition, pages
Wiley-Blackwell, 2011
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-74252 (URN)10.1111/j.1365-2796.2011.02388.x (DOI)000297021600013 ()
Available from: 2012-01-22 Created: 2012-01-22 Last updated: 2017-12-08Bibliographically approved
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