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Mondal, Debasish
Publications (4 of 4) Show all publications
Wickham, A. M., Islam, M. M., Mondal, D., Phopase, J., Sadhu, V., Tamás, É., . . . Griffith, M. (2014). Polycaprolactone–thiophene-conjugated carbon nanotube meshes as scaffolds for cardiac progenitor cells. Journal of Biomedical Materials Research. Part B - Applied biomaterials, 102(7), 1553-1561
Open this publication in new window or tab >>Polycaprolactone–thiophene-conjugated carbon nanotube meshes as scaffolds for cardiac progenitor cells
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2014 (English)In: Journal of Biomedical Materials Research. Part B - Applied biomaterials, ISSN 1552-4973, E-ISSN 1552-4981, Vol. 102, no 7, p. 1553-1561Article in journal (Refereed) Published
Abstract [en]

The myocardium is unable to regenerate itself after infarct, resulting in scarring and thinning of the heart wall. Our objective was to develop a patch to buttress and bypass the scarred area, while allowing regeneration by incorporated cardiac stem/progenitor cells (CPCs). Polycaprolactone (PCL) was fabricated as both sheets by solvent casting, and fibrous meshes by electrospinning, as potential patches, to determine the role of topology in proliferation and phenotypic changes to the CPCs. Thiophene-conjugated carbon nanotubes (T-CNTs) were incorporated to enhance the mechanical strength. We showed that freshly isolated CPCs from murine hearts neither attached nor spread on the PCL sheets, both with and without T-CNT. As electrospun meshes, however, both PCL and PCL/T-CNT supported CPC adhesion, proliferation, and differentiation. The incorporation of T-CNT into PCL resulted in a significant increase in mechanical strength but no morphological changes to the meshes. In turn, proliferation, but not differentiation, of CPCs into cardiomyocytes was enhanced in T-CNT containing meshes. We have shown that changing the topology of PCL, a known hydrophobic material, dramatically altered its properties, in this case, allowing CPCs to survive and differentiate. With further development, PCL/T-CNT meshes or similar patches may become a viable strategy to aid restoration of the postmyocardial infarction myocardium.

Place, publisher, year, edition, pages
John Wiley & Sons, 2014
Keywords
topology, carbon nanotubes, polycaprolactone, cardiac progenitor cells, electrospun meshes
National Category
Clinical Medicine Basic Medicine Physical Sciences
Identifiers
urn:nbn:se:liu:diva-111488 (URN)10.1002/jbm.b.33136 (DOI)000342963000020 ()24664884 (PubMedID)
Available from: 2014-10-19 Created: 2014-10-19 Last updated: 2018-01-11Bibliographically approved
Merrett, K., Kozak Ljunggren, M., Mondal, D., Griffith, M. & Rafat, M. (2012). Collagen Type I: A Promising Scaffold Material for Tissue Engineering and Regenerative Medicine. In: Maria Eduarda Henriques and Marcio Pinto (Ed.), Type I collagen: biological functions, synthesis & medicinal applications (pp. 1-43). Nova Science Publishers, Inc.
Open this publication in new window or tab >>Collagen Type I: A Promising Scaffold Material for Tissue Engineering and Regenerative Medicine
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2012 (English)In: Type I collagen: biological functions, synthesis & medicinal applications / [ed] Maria Eduarda Henriques and Marcio Pinto, Nova Science Publishers, Inc., 2012, p. 1-43Chapter in book (Other academic)
Abstract [en]

It is now recognized that biological macromolecules such as components of the extracellular matrix (ECM) are important as instructive templates in Regenerative Medicine applications. They are now increasingly used in the development of a new generation of bio-mimetic materials that allow for restoration of function when the self-renewal capacity of a tissue or organ cannot overcome degeneration caused by disease, injury or age-related wear. For example, macromolecules derived from connective tissue have been isolated, chemically modified, and used in medical applications ranging from tissue repair and reconstruction to drug and cell delivery systems. Common ECM macromolecules of vertebrates include collagen, proteoglycans, elastin, and other cell-interactive proteins such as fibronectin and laminin. Of these, type I collagen is the most abundant ECM macromolecule and is the primary scaffolding material that maintains the 3-dimensional structure of tissues and organs within the body. It also provides the micro-environmental milieu for cellular attachment, migration, and proliferation.

Animal-derived collagen is frequently used in tissue engineering applications due to its biocompatibility, but there are significant concerns about the immunogenicity of xenogeneic material as well as the possibility of pathogen transmission. Most recently, synthetic collagens and recombinant human collagens have been produced for medical application. Regardless of the source, however, macromolecules require processing and chemical treatment in order to improve their stability both in vitro and in vivo. This is most commonly achieved by cross-linking using a variety of agents. Cross-linking also allows for the development of “tailor-made” collagen-based biomaterials that possess specific properties for tissue engineering. Chemical cross-linkers such as glutaraldehyde and epoxy compounds are frequently used but their cytotoxicities have limited their clinical application. This has led to the use of zero-length cross-linkers such as carbodiimides and naturally derived agents such as genipin. Enzymatic cross-linking is becoming an attractive method to induce in situ biomaterial formation due to the mildness of the reaction. Naturally occurring enzymes such as transglutaminase are now commonly used. Photosensitizers used in combination with ultra-violet light irradiation can be used as exogenous cross-linkers. For example, riboflavin in combination with ultra-violet light is used clinically to augment the properties of collagen-based tissues such as the sclera and the cornea.

Collagen type I is a good candidate for tissue engineering and in vivo delivery systems for cells, proteins, and drugs. Important to its versatile and functional nature are its chemotactic properties, which promote cellular proliferation and differentiation, richness in cross-linking sites, and biodegradability. Collagen based delivery matrices have been reported to improve the results of cell delivery by improving cell viability.

Place, publisher, year, edition, pages
Nova Science Publishers, Inc., 2012
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-101405 (URN)978-1-62257-626-5 (ISBN)
Note

Table of Contents:

Preface

Collagen Type I: A Promising Scaffold Material for Tissue Engineering and Regenerative Medicine(Kimberly Merrett, Monika Kozak Ljunggren, Debasish Mondal, May Griffith, Mehrdad Rafat, Integrative Regenerative Medicine Centre, and Department of Clinical and Experimental Medicine, Linköping University, Linkoping, Sweden, and others)

Degradation of Type I Collagen and Pathogenesis of Infectious Diseases(Flávia Nader Motta, Clênia Azevedo, Carla Nunes de Araújo, Jaime M. Santana, Izabela M.D. Bastos, Laboratory of Pathogen-Host Interface, Department of Cell Biology, The University of Brasília, D.F., Brazil, and others)

Type I Collagen and its Utility as Specific Bone Marker(S.M. Friedman, S.N. Zeni, Oral and General Biochemistry Department, School of Dentistry, Buenos Aires University, Buenos Aires, Argentina, and others)

Development of 3-D Collagen Gel Vascularized Tissue-Engineered Constructs for Bone Replacement and Regeneration Using Embryonic and Postnatal Progenitors(Mani T. Valarmathi, John W. Fuseler, Department of Cell Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, South Carolina, USA)

Collagen I Synthesis, Biological Functions and Medical Applications during Systemic Inflammation(Ricardo Costa Petroni, Ester Correia Sarmento Rios, Francisco Garcia Soriano, Department of Emergency Medicine, University of São Paulo Medicine School, Brazil)

Collagen Scaffolds: Tissue Engineering and Repair(Eman Allam, Marco C. Bottino, Nouf Al-Shibani, L. Jack Windsor, Department of Oral Biology, Indiana University School of Dentistry, Indianapolis, Indiana, and others)

Biomedical Implications of Type I Collagen: A Marine Perspective(Ramjee Pallela, Venkateswara Rao Janapala, Yoon-Bo Shim, Se-Kwon Kim, Institute of Biophysio Sensor Technology, Department of Chemistry, Pusan National University, Busan, South Korea, and others)

Role of Extracellular Matrix in Wound Repair Process(Simona Martinotti, Bruno Burlando, Elia Ranzato, Dipartimento di Scienze e Innovazione Tecnologica, DiSIT, Universityof Piemonte Orientale “Amedeo Avogadro”, Alessandria, Italy)

Index

Available from: 2013-11-21 Created: 2013-11-21 Last updated: 2014-10-08Bibliographically approved
Mondal, D. & Tiwari, A. (2012). Electrospun Nanomatrix for Tissue Regeneration. In: Ashutosh Tiwari, Murugan Ramalingam, Hisashi Kobayashi, Anthony P. F. Turner (Ed.), Biomedical Materials and Diagnostic Devices: (pp. 577-596). USA: John Wiley & Sons
Open this publication in new window or tab >>Electrospun Nanomatrix for Tissue Regeneration
2012 (English)In: Biomedical Materials and Diagnostic Devices / [ed] Ashutosh Tiwari, Murugan Ramalingam, Hisashi Kobayashi, Anthony P. F. Turner, USA: John Wiley & Sons, 2012, p. 577-596Chapter in book (Other academic)
Abstract [en]

The functional materials with the most promising outlook have the ability to precisely adjust the biological phenomenon in a controlled mode. Engineering of advanced bio- materials has found striking applications in used for biomedical and diagnostic device applications, such as cell separation, stem-cell, drug delivery, hyperthermia, automated DNA extraction, gene targeting, resonance imaging, biosensors, tissue engineering and organ regeneration

Place, publisher, year, edition, pages
USA: John Wiley & Sons, 2012
Keywords
Biocompatible Materials, Drug Delivery Systems, Nanotechnology, Tissue Engineering, Biokompatibla material
National Category
Engineering and Technology Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-86317 (URN)978-11-180-3014-1 (ISBN)
Available from: 2012-12-12 Created: 2012-12-12 Last updated: 2014-12-01Bibliographically approved
Mondal, D. & Tiwari, A. (2012). Nanofibers Based Biomedical Devices. In: Ashutosh Tiwari, Ajay Kumar Mishra, Hisatoshi Kobayashi, Anthony P. F. Turner (Ed.), Intelligent Nanomaterials: processes, properties, and applications (pp. 679-714). USA: John Wiley & Sons
Open this publication in new window or tab >>Nanofibers Based Biomedical Devices
2012 (English)In: Intelligent Nanomaterials: processes, properties, and applications / [ed] Ashutosh Tiwari, Ajay Kumar Mishra, Hisatoshi Kobayashi, Anthony P. F. Turner, USA: John Wiley & Sons, 2012, p. 679-714Chapter in book (Other academic)
Abstract [en]

The last three decades have seen extraordinary advances in the generation of new materials based on both fundamental elements and composites, driven by advances in synthetic chemistry and often drawing inspiration from nature. The concept of an intelligent material envisions additional functionality built into the molecular structure, such that a desirable response occurs under defined conditions.

Divided into 4 parts: Inorganic Materials; Organic Materials; Composite Materials; and Biomaterials, the 22 chapters cover the latest research and developments in the processing, properties, and applications of intelligent nanomaterials. Included are molecular device materials, biomimetic materials, hybrid-type functionalized polymers-composite materials, information-and energy-transfer materials, as well as environmentally friendly materials.

Place, publisher, year, edition, pages
USA: John Wiley & Sons, 2012
Keywords
Nanostructured materials, Smart materials, Materials science, Materialteknik, Materiallära
National Category
Engineering and Technology Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-86312 (URN)978-0-470-93879-9 (ISBN)
Available from: 2012-12-12 Created: 2012-12-12 Last updated: 2014-12-01Bibliographically approved
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