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Herraiz-Adillo, Á., Higueras-Fresnillo, S., Ahlqvist, V. H., Berglind, D., Syrjälä, M. B., Daka, B., . . . Henriksson, P. (2024). Life’s Essential 8 and Life’s Simple 7 in Relation to Coronary Atherosclerosis: Results From the Population-Based SCAPIS Project. Mayo Clinic proceedings, 99(1), 69-80
Open this publication in new window or tab >>Life’s Essential 8 and Life’s Simple 7 in Relation to Coronary Atherosclerosis: Results From the Population-Based SCAPIS Project
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2024 (English)In: Mayo Clinic proceedings, ISSN 0025-6196, E-ISSN 1942-5546, Vol. 99, no 1, p. 69-80Article in journal (Refereed) Published
Abstract [en]

Objective: To examine the associations between the AmericanHeart Association scores (“Life’s Essential 8” [LE8] and “Life’s Simple 7” [LS7])and 2 subclinical coronary atherosclerosis indicators: coronary computed tomographic angiography (CCTA)-stenosis and coronary artery calcium (CAC).

Patients and Methods:We includedapopulation-basedsample, aged 50 to 64 years, recruited between 2013 and 2018 from the Swedish Cardiopulmonary Bioimage Study (n¼24,819,50.3%women). CCTA-stenosis was graded as no stenosis, stenosis (1%-49%) or severe stenosis ( 50%), whereas CAC was graded as 0,1 to 99, 100 to 399, or 400 Agatston units. Multinomial logistic regression and receiver operating characteristic (ROC) curves were used to study the associations between cardiovascular health scores and subclinical coronary atherosclerosis.

Results: Odds ratios (ORs) for CCTA-stenosis and severe CCTA-stenosis between the lowest (<50 points) vs the highest ( 80points) LE8 group were 4.18 (95% CI,3.56 to 4.91) and 11.17 (95% CI, 8.36 to 14.93), respectively. For corresponding CAC results, ORs were 3.36 (95% CI, 2.84 to 3.98), 7.72 (95% CI, 6.03 to 9.89), and 14.94 (95%CI, 10.47 to 21.31) for CAC scores of 1 to 99, 100 to 399, and 400, respectively. Area under ROC curves for predicting anystenosis were 0.642 (95% CI, 0.635 to 0.649) and 0.631 (95% CI, 0.624 to 0.638, P<.001) for LE8 and LS7, respectively.

Conclusion: Our data indicate that LE8 showed a strong, graded, and inverse association with CCTA-stenosis and CAC score. The capacity to predict CCTA-stenosis was comparable between LE8 and LS7, although LE8 had slightly higher prediction capacity of any stenosis. This study provides novel evidence that the LE8 score may be a useful tool for monitoring cardiovascular health.

Place, publisher, year, edition, pages
Elsevier, 2024
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:liu:diva-200718 (URN)10.1016/j.mayocp.2023.03.023 (DOI)37843486 (PubMedID)2-s2.0-85173854770 (Scopus ID)
Note

Funding agencies: The main funding body of The Swedish CArdioPulmonary bioImage Study (SCAPIS) is the Swedish Heart-Lung Foundation. The study is also funded by the Knut and Alice Wallenberg Foundation, the Swedish Research Council and VINNOVA (Sweden‘s Innovation Agency), the University of Gothenburg and Sahlgrenska University Hospital, Karolinska Institutet and Stockholm County council, Linköping University and University Hospital, Lund University and Skåne University Hospital, Umeå University and University Hospital, and Uppsala University and University Hospital. Funding was received from the CircM strategic research network at Linköping University. Dr Higueras-Fresnillo is supported by a Margarita Salas grant from the Autonomous University of Madrid. Dr Ortega's research activity on this topic is supported by grants from the Andalusian Government (Junta de Andalucía, Plan Andaluz de Investigación, ref: P20_00124) and the Spanish Ministry of Science and Innovation (ref: PID2020-120249RB-I00).

Available from: 2024-02-05 Created: 2024-02-05 Last updated: 2024-02-06
Herraiz-Adillo, Á., Ahlqvist, V. H., Daka, B., Wångdahl, J., Wennberg, P., Carlsson, J., . . . Henriksson, P. (2024). Life’s Essential 8 in relation to self-rated health and health-related quality of life in a large population-based sample: the SCAPIS project. Quality of Life Research
Open this publication in new window or tab >>Life’s Essential 8 in relation to self-rated health and health-related quality of life in a large population-based sample: the SCAPIS project
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2024 (English)In: Quality of Life Research, ISSN 0962-9343, E-ISSN 1573-2649Article in journal (Refereed) Epub ahead of print
Abstract [en]

Purpose To monitor cardiovascular health, in 2022, the American Heart Association (AHA) updated the construct “Life’s Simple 7” (LS7) to “Life’s Essential 8” (LE8). This study aims to analyze the associations and capacity of discrimination of LE8 and LS7 in relation to self-rated health (SRH) and health-related quality of life (HRQoL). 

Methods This study from the Swedish CArdioPulmonary bioImage Study (SCAPIS) included 28 731 Swedish participants, aged 50–64 years. Three diferent scores were derived from the SF-12 questionnaire: 1-item question SRH (“In general, would you say your health is …?”), mental-HRQoL and physical-HRQoL. Logistic regression, restricted cubic splines, and ROC analysis were used to study the associations between the AHA scores in relation to SRH and HRQoL. 

Results Compared to those with a LE8 score of 80, participants with a LE8 score of 40 were 14.8 times more likely to report poor SRH (OR: 14.8, 95% CI: 13.0–17.0), after adjustments. Moreover, they were more likely to report a poor mental-HRQoL (OR: 4.9, 95% CI: 4.2–5.6) and a poor physical-HRQoL (OR: 8.0, 95% CI: 7.0–9.3). Area under curves for discriminating poor SRH were 0.696 (95% CI: 0.687–0.704), 0.666 (95% CI: 0.657–0.674), and 0.643 (95% CI: 0.634–0.651) for LE8, LS7 (0–14), and LS7 (0–7), respectively, all p values <0.001 in the DeLong’s tests.

Conclusion LE8 and LS7 had strong and inverse associations with SRH, mental-HRQoL, and physical-HRQoL, though LE8 had a somewhat higher capacity of discrimination than LS7. The novel LE8, a construct initially conceived to monitor cardiovascular health, also conveys SRH and HRQoL.

Place, publisher, year, edition, pages
Springer, 2024
Keywords
Health-related quality of life; Ideal cardiovascular health; Life's Essential 8; Quality of life; Self-rated health
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:liu:diva-200716 (URN)10.1007/s11136-023-03580-1 (DOI)001149863400001 ()38270740 (PubMedID)2-s2.0-85183002617 (Scopus ID)
Note

Funding agencies: Open access funding provided by Linköping University. The main funding body of The Swedish CArdioPulmonary bioImage Study(SCAPIS) is the Swedish Heart–Lung Foundation. The study is also funded by the Knut and Alice Wallenberg Foundation, the Swedish Research Council and VINNOVA (Sweden’s Innovation Agency), the University of Gothenburg and Sahlgrenska University Hospital, Karolinska Institutet and Stockholm County council, Linköping University and University Hospital, Lund University and Skåne University Hospital, Umeå University and University Hospital, Uppsala University and University Hospital. SHF is supported by a Margarita Salas grantfrom the Autonomous University of Madrid.

Available from: 2024-02-05 Created: 2024-02-05 Last updated: 2024-03-15
De-la-O, A., Jurado-Fasoli, L., Gracia-Marco, L., Henriksson, P., Castillo, M. J. & Amaro-Gahete, F. J. (2022). Association of Energy and Macronutrients Intake with S-Klotho Plasma Levels in Middle-Aged Sedentary Adults: A Cross-Sectional Study. The Journal of Nutrition, Health & Aging, 26, 360-367
Open this publication in new window or tab >>Association of Energy and Macronutrients Intake with S-Klotho Plasma Levels in Middle-Aged Sedentary Adults: A Cross-Sectional Study
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2022 (English)In: The Journal of Nutrition, Health & Aging, ISSN 1279-7707, E-ISSN 1760-4788, Vol. 26, p. 360-367Article in journal (Refereed) Published
Abstract [en]

Background The ageing process can be influenced by energy intake and different macronutrients within the diet. The soluble form of the a-Klotho gene (called S-Klotho) is widely considered as a powerful anti-ageing biomarker. Objective To analyze the association of energy, dietary energy density and macronutrient intake with S-Klotho plasma levels in middle-aged sedentary adults. Methods A total of 72 (52.8% women) middle-aged sedentary adults (53.7 +/- 5.2 years old) participated in the study. Energy and macronutrients intake (i.e. fat, carbohydrate and protein) were assessed using three non-consecutive 24-h recalls. S-Klotho plasma levels were measured in the Ethylenediaminetetraacetic acid (EDTA) plasma using a solid-phase sandwich enzyme-linked immunosorbent assay. Results No association was observed between energy, dietary energy density or macronutrient intake and S-Klotho plasma levels in men (all P &gt;= 0.1). We found an inverse association between energy, protein and carbohydrate intake with S-Klotho plasma levels in women (all P &lt;= 0.043), which disappeared after controlling for age, lean mass index and sedentary time. An inverse association was observed between dietary energy density and S-Klotho plasma levels in women after controlling for covariates (all P &lt;= 0.05). Conclusion In summary, the present study showed an inverse association of dietary energy density with S-Klotho plasma levels in middle-aged women. In addition, our data suggest that the associations between energy and macronutrient intake could be highly dependent on lean mass and sedentary time.

Place, publisher, year, edition, pages
SPRINGER FRANCE, 2022
Keywords
Protein; carbohydrate; energy; intake; longevity
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:liu:diva-184108 (URN)10.1007/s12603-022-1763-2 (DOI)000771864400001 ()35450992 (PubMedID)2-s2.0-85126881352 (Scopus ID)
Note

Funding Agencies|Spanish Ministry of EducationSpanish Government [FPU14/04172, FPU15/03960, FPU19/01609]; University of Granada UGR Research and Knowledge Transfer Fund (PPIT) 2016 (Excellence Actions Programme. Units of Scientific Excellence: Scientific Unit of Excellence on Excercise and Health [UCEES]); Plan Propio de Investigacion 2019 -Programa Contratos-Puente, by the Regional Government of Andalusia, Regional Ministry of Economy, Knowledge, Entreprises and University; European Regional Development Fund (ERDF)European Commission [SOMM17/6107/UGR]; Redes Tematicas de Investigacion Cooperativa RETIC grant [Red SAMID RD16/0022]; Junta de Andalucia, Consejeria de Conocimiento, Investigacion y Universidades (Proyectos de I+D+i en el marco del Programa Operativo FEDER Andalucia) [B-CTS-363-UGR18]

Available from: 2022-04-07 Created: 2022-04-07 Last updated: 2023-03-31Bibliographically approved
Flor-Alemany, M., Baena-Garcia, L., Hidalgo Migueles, J. H., Henriksson, P., Löf, M. & Aparicio, V. A. (2022). Associations of Mediterranean diet with psychological ill-being and well-being throughout the pregnancy course: The GESTAFIT project. Quality of Life Research, 31, 2705-2716
Open this publication in new window or tab >>Associations of Mediterranean diet with psychological ill-being and well-being throughout the pregnancy course: The GESTAFIT project
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2022 (English)In: Quality of Life Research, ISSN 0962-9343, E-ISSN 1573-2649, Vol. 31, p. 2705-2716Article in journal (Refereed) Published
Abstract [en]

Purpose The relation between diet and maternal mental health during pregnancy might be relevant to prevent adverse materno-foetal outcomes. This study examined the association of Mediterranean diet (MD) adherence and MD components with mental health during pregnancy. Methods This secondary analysis of the GESTAFIT trial included longitudinal data from 152 pregnant women. Dietary habits were assessed with a food frequency questionnaire, and MD adherence was derived from it using the Mediterranean Food pattern. Psychological ill-being (i.e., negative affect, anxiety, and depression) and well-being (i.e., emotional intelligence, resilience, positive affect) were assessed with the Spanish version of well-established self-reported questionnaires. Cross-sectional (16th gestational week [g.w.]) and longitudinal associations (34th g.w.) between MD and mental health were studied using linear regression models. Results A greater MD adherence was inversely associated with negative affect and anxiety; and positively associated with emotional regulation, resilience and positive affect at the 16th and 34th g.w. (|beta| ranging from 0.179 to 0.325, all p &lt; 0.05). Additionally, a higher intake of whole grain cereals, fruits, vegetables, fish, olive oil and nuts, and a lower intake of red meat and subproducts and sweets were associated with lower negative affect, anxiety, depression and higher emotional regulation, resilience and positive affect throughout gestation (|beta| ranging from 0.168 to 0.415, all p &lt; 0.05). Conclusion A higher intake of whole grain cereals, fruits, vegetables, fish, olive oil and nuts, together with a lower intake of red meat and sweets, resulted in a higher MD adherence, which was associated with a better mental health during pregnancy.

Place, publisher, year, edition, pages
Springer, 2022
Keywords
Anxiety; Depression; Diet; Mediterranean; Mental Health; Pregnancy; Pregnant women
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:liu:diva-184130 (URN)10.1007/s11136-022-03121-2 (DOI)000769853900001 ()35297499 (PubMedID)2-s2.0-85126343812 (Scopus ID)
Note

Funding Agencies|Regional Ministry of Health of the Junta de Andalucia [PI-0395-2016]; Research and Knowledge Transfer Fund [(PPIT) 2016]; Excellence Actions Programme: Scientific Units of Excellence (UCEES); Regional Ministry of Economy, Knowledge, Enterprises and University, European Regional Development Funds of the University of Granada [SOMM17/6107/UGR]; Spanish Ministry of Education, Culture and SportsSpanish Government [FPU17/03715]; Swedish Council for Health, Working Life and Welfare [2021-00036]

Available from: 2022-04-07 Created: 2022-04-07 Last updated: 2023-03-31Bibliographically approved
Bendtsen, M., Seiterö, A., Bendtsen, P., Olsson, H., Henriksson, P., Thomas, K., . . . Müssener, U. (2021). mHealth intervention for multiple lifestyle behaviour change among high school students in Sweden (LIFE4YOUth): Protocol for a randomised controlled trial. Public Health Nursing, 21(1)
Open this publication in new window or tab >>mHealth intervention for multiple lifestyle behaviour change among high school students in Sweden (LIFE4YOUth): Protocol for a randomised controlled trial
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2021 (English)In: Public Health Nursing, ISSN 0737-1209, E-ISSN 1525-1446, Vol. 21, no 1Article in journal (Refereed) Published
Abstract [en]

BackgroundNational surveys in Sweden demonstrate that the majority of young people do not engage in health promoting behaviours at levels recommended by the Public Health Agency of Sweden. The objective of this study is to estimate the effectiveness of a novel mHealth intervention named LIFE4YOUth, which targets multiple lifestyle behaviours (alcohol, diet, physical activity, and smoking) among high school students in Sweden.MethodsA 2-arm parallel groups single blind randomised controlled trial (1:1) will be employed to estimate the effectiveness of the novel mHealth intervention. Students will be recruited at high schools throughout Sweden, and will be included if they fulfil one of six criteria relating to unhealthy behaviours with respect to alcohol, diet, physical activity and smoking. Eligible participants will be randomised to either receive the novel intervention immediately, or to be placed on a waiting list for 4 months. The intervention consists of a combination of recurring screening, text messages, and an interactive platform which is adaptable to individual preferences. Outcome measures with respect to alcohol, diet, physical activity and smoking will be assessed through questionnaires at 2 and 4 months post randomisation.DiscussionThe findings of this trial could be generalised to a diverse high-school student population as our recruitment encompass a large proportion of schools throughout Sweden with various educational profiles. Furthermore, if effective, the mHealth intervention has good potential to be able to be scaled up and disseminated at high schools nationally.Trial registrationRegistered prospectively on 2020-05-20 in ISRCTN (ISRCTN34468623).

Place, publisher, year, edition, pages
BMC, 2021
Keywords
Telemedicine; Multiple behaviour; mHealth; High school students; Randomised controlled trial
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:liu:diva-178080 (URN)10.1186/s12889-021-11446-9 (DOI)000675238000003 ()34271882 (PubMedID)
Note

Funding: Swedish Research Council for Health, Working Life and WelfareSwedish Research CouncilSwedish Research Council for Health Working Life & Welfare (Forte) [2018-01410]; Linkoping University

Available from: 2021-07-27 Created: 2021-07-27 Last updated: 2021-08-27
Leppanen, M. H., Migueles, J. H., Cadenas-Sanchez, C., Henriksson, P., Mora-Gonzalez, J., Henriksson, H., . . . Ortega, F. B. (2020). Hip and wrist accelerometers showed consistent associations with fitness and fatness in children aged 8-12 years. Acta Paediatrica, 109(5), 995-1003
Open this publication in new window or tab >>Hip and wrist accelerometers showed consistent associations with fitness and fatness in children aged 8-12 years
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2020 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 109, no 5, p. 995-1003Article in journal (Refereed) Published
Abstract [en]

Aim Physical activity (PA) has traditionally been measured wearing accelerometers on the hip, but they are increasingly being worn on the wrist. We compared hip and wrist accelerometers with regard to their acceptability and any associations between PA and fatness and fitness. Methods This cross-sectional study comprised 103 children aged 8-12 years (62% boys) who participated in the ActiveBrains trial by the University of Granada, Spain, in 2014-2016. The children wore both ActiGraph GT3X+ hip and wrist accelerometers round the clock for 7 days. The acceptability of both placements was evaluated by a questionnaire, while the childrens fat mass index, waist circumference and cardiorespiratory fitness (CRF) were assessed. Results Wearing wrist accelerometers caused less disturbance, mainly because hip accelerometers caused more issues during the night. The measurements from both placements showed that lower PA levels were associated with fatness and that higher PA levels were associated with better CRF. Conclusion Both placements showed consistent results with regard to measuring associations between PA levels and fatness and fitness. However, wearing them on the wrist caused less discomfort at night. Future studies are needed to confirm the best placement for accelerometers during PA studies.

Place, publisher, year, edition, pages
WILEY, 2020
Keywords
adiposity; exercise; hip accelerometers; physical fitness; waist accelerometers
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:liu:diva-161610 (URN)10.1111/apa.15043 (DOI)000491011900001 ()31583747 (PubMedID)
Note

Funding Agencies|MINECO/FEDER [DEP2013-47540, DEP2016-79512-R, RYC-2011-09011]; University of Granada, Research and Knowledge Transfer Fund; Unit of Excellence on Exercise and Health; Andalusian Regional Government, Consejeria de Conocimiento, Investigacion y Universidades; European Regional Development FundEuropean Union (EU) [SOMM17/6107/UGR]; SAMID III network (RETICS); ISCIII- Sub-Directorate General for Research Assessment and Promotion; EXERNET Research Network on Exercise and Health in Special Populations [DEP2005-00046/ACTI]; European UnionEuropean Union (EU) [667302]; Spanish Ministry of Education, Culture and Sport [FPU15/02645]; Spanish Ministry of Economy and Competitiveness [BES-2014-068829]; Strategic Research Area Health Care Science, Karolinska Institutet and Umea University; Alicia Koplowitz Foundation; Excellence actions: Scientific Units of Excellence

Available from: 2019-11-05 Created: 2019-11-05 Last updated: 2021-05-05
Bendtsen, M., Bendtsen, P., Henriksson, H., Henriksson, P., Müssener, U., Thomas, K. & Löf, M. (2020). The Mobile Health Multiple Lifestyle Behavior Interventions Across the Lifespan (MoBILE) Research Program: Protocol for Development, Evaluation, and Implementation. JMIR Research Protocols, 9(4), Article ID e14894.
Open this publication in new window or tab >>The Mobile Health Multiple Lifestyle Behavior Interventions Across the Lifespan (MoBILE) Research Program: Protocol for Development, Evaluation, and Implementation
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2020 (English)In: JMIR Research Protocols, E-ISSN 1929-0748, Vol. 9, no 4, article id e14894Article in journal (Refereed) Published
Abstract [en]

Background: Clustering of multiple lifestyle risk behaviors has been associated with a greater risk of noncommunicable diseases and mortality than one lifestyle risk behavior or no lifestyle risk behaviors. The National Board of Health and Welfare in Sweden reported in 2018 that it is important to provide additional support to individuals with multiple lifestyle risk behaviors, as risks from these behaviors are multiplicative rather than additive. However, the same report emphasized that there is a lack of knowledge regarding interventions that support changes to unhealthy lifestyle behaviors.

Objective: The MoBILE (Mobile health Multiple lifestyle Behavior Interventions across the LifEspan) research program has brought together two Swedish research groups supported by international collaborators. Through this collaboration, we aim to design and evaluate a number of novel and tailored mobile health (mHealth) multiple lifestyle behavior interventions across the life span of different health care populations. In addition, the MoBILE research program will extend ongoing research to include mHealth interventions for migrant pregnant women and children.

Methods: Each project within the MoBILE program will focus on a specific group: pregnant women, preschool children, high school and university students, and adults in primary and clinical care. All the projects will follow the same 4 phases: requirements, development, evaluation, and implementation. During the requirements phase, implementers and end users will aid the design of content and functionality of the interventions. In the development phase, findings from the first phase will be synthesized with expert domain knowledge and theoretical constructs to create interventions tailored to the target groups. The third phase, evaluation, will comprise randomized controlled trials conducted to estimate the effects of the interventions on multiple lifestyle risk behaviors (eg, alcohol, nutrition, physical activity, and smoking). The final phase will investigate how the interventions, if found effective, can be disseminated into different health care contexts.

Results: The research program commenced in 2019, and the first results will be available in 2020. Projects involving pregnant women, preschool children, and high school and university students will be completed in the first 3 years, with the remaining projects being planned for the program’s final 3 years.

Conclusions:The development of evidence-based digital tools is complex, as they should be guided by theoretical frameworks, and requires large interdisciplinary teams with competence in technology, behavioral science, and lifestyle-specific areas. Individual researchers or smaller research groups developing their own tools is not the way forward, as it means reinventing the wheel over and over again. The MoBILE research program therefore aims to join forces and learn from the past 10 years of mHealth research to maximize scientific outcomes, as well as the use of financial resources to expand the growing body of evidence for mHealth lifestyle behavior interventions.

 

Place, publisher, year, edition, pages
Toronto, Canada: JMIR Publications Inc, 2020
Keywords
telemedicine; mHealth; eHealth; life style; randomized controlled trial; focus groups
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:liu:diva-173996 (URN)10.2196/14894 (DOI)000537951700002 ()32310147 (PubMedID)2-s2.0-85084394616 (Scopus ID)
Note

Funding Agencies|Swedish Research Council for Health, Working Life, and Welfare (FORTE) [2018-01410]

Available from: 2021-03-16 Created: 2021-03-16 Last updated: 2024-01-17Bibliographically approved
Henriksson, H., Henriksson, P., Tynelius, P. & Ortega, F. B. (2019). Muscular weakness in adolescence is associated with disability 30 years later: a population-based cohort study of 1.2 million men. British Journal of Sports Medicine, 53(19), 1221
Open this publication in new window or tab >>Muscular weakness in adolescence is associated with disability 30 years later: a population-based cohort study of 1.2 million men
2019 (English)In: British Journal of Sports Medicine, ISSN 0306-3674, E-ISSN 1473-0480, Vol. 53, no 19, p. 1221-Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate the associations of muscular strength in adolescence with later disability pension (DP), across different body mass index (BMI) categories and in combination with aerobic fitness.

METHOD: This prospective cohort study consisted of males aged 16-19 years, recruited from the Swedish military conscription register between 1969 and 1994. A total of 1 212 503 adolescents met all the inclusion criteria and were therefore included in the analyses. Knee extension, handgrip and elbow flexion strength and aerobic fitness (bicycle ergometer test) were measured during conscription. Causes of DP were retrieved from the Social Insurance Office between years 1971 and 2012 (average follow-up time: 29.6 years).

RESULTS: Knee extension strength in adolescence was inversely associated with men's risk of obtaining DP due to all causes (HR 1.40, 95% CI 1.36 to 1.44 for lowest vs highest strength quintile). Thus, muscular weakness was associated with DP. The risk associated with low muscular strength differed between specific causes of DP and the strongest associations were found for psychiatric, nervous system and other causes (HRs between 1.47 and 1.90 for lowest vs highest quintile). Being strong was associated with lower DP risk across BMI categories and being unfit, weak and obese was associated with the highest DP risk (HR 3.70, 95% CI 2.99 to 4.58).

CONCLUSION: There was a strong association between muscular weakness and disability. A combination of muscular weakness and low aerobic fitness was an especially important risk factor for disability. This adds weight to call for muscular strength and fitness enhancing exercise for adolescents in all BMI categories.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2019
Keywords
aerobic fitness, bmi, disability, strength
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-155806 (URN)10.1136/bjsports-2017-098723 (DOI)000489253100010 ()29921654 (PubMedID)
Note

Funding agencies:  Swedish Society of Medicine; County Council of Ostergotland, Sweden; Henning and Johan Throne-Holst Foundation; Strategic Research Area Health Care Science, Karolinska Institutet/Umea University; European Unions Horizon 2020 research and innovation progra

Available from: 2019-03-28 Created: 2019-03-28 Last updated: 2021-04-12Bibliographically approved
Henriksson, P., Leppanen, M. H., Henriksson, H., Nystrom, C. D., Cadenas-Sanchez, C., Ek, A., . . . Löf, M. (2019). Physical fitness in relation to later body composition in pre-school children. Journal of Science and Medicine in Sport, 22(5), 574-579
Open this publication in new window or tab >>Physical fitness in relation to later body composition in pre-school children
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2019 (English)In: Journal of Science and Medicine in Sport, ISSN 1440-2440, E-ISSN 1878-1861, Vol. 22, no 5, p. 574-579Article in journal (Refereed) Published
Abstract [en]

Objectives

Although physical fitness is considered a marker of health in youth, little is known whether physical fitness in pre-school age is related to later body composition. Thus, this study investigated (i) associations of physical fitness at 4.5 years of age with body composition 12 months later and (ii) whether improvements in physical fitness during the 12-month follow-up were associated with changes in body composition.

Design

This study included 142 children, measured at 4.5 and 5.5 years, from the control group of the MINISTOP trial.

Methods

Physical fitness (cardiorespiratory fitness, lower- and upper-body muscular strength and motor fitness) was measured using the PREFIT test battery. Body composition was assessed using air-displacement plethysmography.

Results

In adjusted regression analyses, greater cardiorespiratory fitness, lower-body muscular strength and motor fitness at 4.5 years were associated with a lower fat mass index at 5.5 years (standardized β= −0.182 to −0.229, p ≤ 0.028). Conversely, greater cardiorespiratory fitness, lower- and upper-body muscular strength as well as motor fitness at 4.5 years of age were associated with a higher fat-free mass index (standardized β = 0.255–0.447, p ≤ 0.001). Furthermore, improvements in cardiorespiratory fitness, lower-body muscular strength and motor fitness during the 12-month follow-up period were associated with decreases in fat mass index and/or % fat mass.

Conclusions

In conclusion, the results of this study provide evidence of the importance of physical fitness early in life. Nevertheless, further studies are needed in order to clarify the influence of physical fitness in the pre-school age with later health outcomes.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Fat-free mass; Fat mass; Cardiorespiratory fitness; Muscular strength; Motor fitness; Pre-school
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:liu:diva-158365 (URN)10.1016/j.jsams.2018.11.024 (DOI)000468256300015 ()30573178 (PubMedID)2-s2.0-85058494155 (Scopus ID)
Note

Funding Agencies|Swedish Research Council [2012-2883]; Swedish Research Council for Health, Working Life and Welfare [2012-0906]; Bo and Vera Axson John sons Foundation; Karolinska Institutet; Strategic Research Area Health Care Science, Karolinska Institutet/Umed University; Juho Vainio Foundation; Swedish Society of Medicine; County Council of Ostergotland, Sweden; Henning and Johan Throne -Hoist Foundation; Spanish Ministry of Economy and Competitiveness [RYC-2010-05957, RYC-2011-09011, BES-2014-068829]

Available from: 2019-07-02 Created: 2019-07-02 Last updated: 2021-04-12Bibliographically approved
Leppänen, M. H., Delisle Nyström, C., Henriksson, P., Pomeroy, J., Ruiz, J. R., Ortega, F. B., . . . Löf, M. (2016). Physical activity intensity, sedentary behavior, body composition and physical fitness in 4-year-old children: results from the ministop trial. International Journal of Obesity, 40(7), 1126-1133
Open this publication in new window or tab >>Physical activity intensity, sedentary behavior, body composition and physical fitness in 4-year-old children: results from the ministop trial
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2016 (English)In: International Journal of Obesity, ISSN 0307-0565, E-ISSN 1476-5497, Vol. 40, no 7, p. 1126-1133Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Existing knowledge on associations of physical activity (PA) and sedentary behavior (SB) with body composition and physical fitness in preschoolers is limited. OBJECTIVE: To examine associations of PA and SB with body composition and physical fitness in healthy Swedish 4-year-old children. METHODS: We utilized baseline data collected in 2014 for the population-based MINISTOP trial (n = 307). Light-intensity PA (LPA), moderate-intensity PA (MPA), vigorous-intensity PA (VPA), moderate-to-vigorous PA (MVPA) and SB were measured using accelerometry (ActiGraph-wGT3x-BT). Body composition was measured using air-displacement plethysmography, and physical fitness (that is, cardiorespiratory fitness, lower and upper body muscular strength and motor fitness) was measured using the PREFIT fitness test battery. Multiple linear regression models adjusted for relevant confounders, and in addition, isotemporal substitution models were applied. RESULTS: Greater MVPA was associated with lower fat mass percent (%FM, P = 0.015), and greater VPA and MVPA were associated with higher fat-free mass index (FFMI, P = 0.002 and P = 0.011). In addition, greater VPA and MVPA were associated with higher scores for all physical fitness tests (P = 0.042 to Pamp;lt;0.001). The results for MVPA were primarily due to VPA. SB was associated with weaker handgrip strength (P = 0.031) when PA was not adjusted, but after adjusting also for VPA, the significant association disappeared (P = 0.25). Substituting 5 min per day of SB, LPA or MPA with 5 min per day of VPA was associated with higher FFMI and better scores for cardiorespiratory fitness and motor fitness. Correspondingly, substituting 5 min per day of VPA with SB or LPA was associated with weaker performance for lower muscular strength. CONCLUSIONS: Time spent on VPA was associated with higher FFMI and better physical fitness. The results suggest that promoting VPA may be important to improve childhood body composition and physical fitness already at an early age.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP, 2016
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:liu:diva-130400 (URN)10.1038/ijo.2016.54 (DOI)000379498200012 ()27087109 (PubMedID)
Note

Funding Agencies|Swedish Research Council [2012-2883]; Swedish Research Council for Health, Working Life and Welfare [2012-0906]; Bo and Vera Axson Johnsons Foundation; Karolinska Institutet; Juho Vainio Foundation; Spanish Ministry of Economy and Competitiveness [RYC-2010-05957, RYC-2011-09011, BES-2014-068829]; Johan Throne-Holsts Foundation

Available from: 2016-08-15 Created: 2016-08-05 Last updated: 2019-06-28
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-2482-7048

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