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Sadhu, Veera
Publications (2 of 2) Show all publications
Wickham, A. M., Islam, M. M., Mondal, D., Phopase, J., Sadhu, V., Tamás, É., . . . Griffith, M. (2014). Polycaprolactone–thiophene-conjugated carbon nanotube meshes as scaffolds for cardiac progenitor cells. Journal of Biomedical Materials Research. Part B - Applied biomaterials, 102(7), 1553-1561
Open this publication in new window or tab >>Polycaprolactone–thiophene-conjugated carbon nanotube meshes as scaffolds for cardiac progenitor cells
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2014 (English)In: Journal of Biomedical Materials Research. Part B - Applied biomaterials, ISSN 1552-4973, E-ISSN 1552-4981, Vol. 102, no 7, p. 1553-1561Article in journal (Refereed) Published
Abstract [en]

The myocardium is unable to regenerate itself after infarct, resulting in scarring and thinning of the heart wall. Our objective was to develop a patch to buttress and bypass the scarred area, while allowing regeneration by incorporated cardiac stem/progenitor cells (CPCs). Polycaprolactone (PCL) was fabricated as both sheets by solvent casting, and fibrous meshes by electrospinning, as potential patches, to determine the role of topology in proliferation and phenotypic changes to the CPCs. Thiophene-conjugated carbon nanotubes (T-CNTs) were incorporated to enhance the mechanical strength. We showed that freshly isolated CPCs from murine hearts neither attached nor spread on the PCL sheets, both with and without T-CNT. As electrospun meshes, however, both PCL and PCL/T-CNT supported CPC adhesion, proliferation, and differentiation. The incorporation of T-CNT into PCL resulted in a significant increase in mechanical strength but no morphological changes to the meshes. In turn, proliferation, but not differentiation, of CPCs into cardiomyocytes was enhanced in T-CNT containing meshes. We have shown that changing the topology of PCL, a known hydrophobic material, dramatically altered its properties, in this case, allowing CPCs to survive and differentiate. With further development, PCL/T-CNT meshes or similar patches may become a viable strategy to aid restoration of the postmyocardial infarction myocardium.

Place, publisher, year, edition, pages
John Wiley & Sons, 2014
Keywords
topology, carbon nanotubes, polycaprolactone, cardiac progenitor cells, electrospun meshes
National Category
Clinical Medicine Basic Medicine Physical Sciences
Identifiers
urn:nbn:se:liu:diva-111488 (URN)10.1002/jbm.b.33136 (DOI)000342963000020 ()24664884 (PubMedID)
Available from: 2014-10-19 Created: 2014-10-19 Last updated: 2018-01-11Bibliographically approved
Shi, S., Sadhu, V., Moubah, R., Schmerber, G., Bao, Q. & Ravi P Silva, S. (2013). Solution-processable graphene oxide as an efficient hole injection layer for high luminance organic light-emitting diodes. JOURNAL OF MATERIALS CHEMISTRY C, 1(9), 1708-1712
Open this publication in new window or tab >>Solution-processable graphene oxide as an efficient hole injection layer for high luminance organic light-emitting diodes
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2013 (English)In: JOURNAL OF MATERIALS CHEMISTRY C, ISSN 2050-7526, Vol. 1, no 9, p. 1708-1712Article in journal (Refereed) Published
Abstract [en]

The application of solution-processable graphene oxide (GO) as a hole injection layer in organic light-emitting diodes (OLEDs) is demonstrated. High luminance of over 53 000 cd m(-2) is obtained at only 10 V. The results will unlock a route to apply GO in flexible OLEDs and other electrode applications.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2013
National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-90086 (URN)10.1039/c3tc00707c (DOI)000314809100002 ()
Note

Funding Agencies|EPSRC, UK||E.ON AG, as part of the E.ON International Research Initiative||

Available from: 2013-03-21 Created: 2013-03-19 Last updated: 2013-03-21
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