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Azharuddin, M., Zhu, G. H., Das, D., Ozgur, E., Uzun, L., Turner, A. P. F. & Patra, H. K. (2019). A repertoire of biomedical applications of noble metal nanoparticles. Chemical Communications, 55(49), 6964-6996
Open this publication in new window or tab >>A repertoire of biomedical applications of noble metal nanoparticles
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2019 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 55, no 49, p. 6964-6996Article, review/survey (Refereed) Published
Abstract [en]

Noble metals comprise any of several metallic chemical elements that are outstandingly resistant to corrosion and oxidation, even at elevated temperatures. This group is not strictly defined, but the tentative list includes ruthenium, rhodium, palladium, silver, osmium, iridium, platinum and gold, in order of atomic number. The emerging properties of noble metal nanoparticles are attracting huge interest from the translational scientific community and have led to an unprecedented expansion of research and exploration of applications in biotechnology and biomedicine. Noble metal nanomaterials can be synthesised both by top-down and bottom up approaches, as well as via organism-assisted routes, and subsequently modified appropriately for the field of use. Nanoscale analogues of gold, silver, platinum, and palladium in particular, have gained primary importance owing to their excellent intrinsic properties and diversity of applications; they offer unique functional attributes, which are quite unlike the bulk material. Modulation of noble metal nanoparticles in terms of size, shape and surface functionalisation has endowed them with unusual capabilities and manipulation at the chemical level, which can lead to changes in their electrical, chemical, optical, spectral and other intrinsic properties. Such flexibility in multi-functionalisation delivers Ockhams razor to applied biomedical science. In this feature article, we highlight recent advances in the adaptation of noble metal nanomaterials and their biomedical applications in therapeutics, diagnostics and sensing.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2019
National Category
Other Chemistry Topics
Identifiers
urn:nbn:se:liu:diva-158861 (URN)10.1039/c9cc01741k (DOI)000471721700001 ()31140997 (PubMedID)2-s2.0-85067297304 (Scopus ID)
Note

Funding Agencies|Swedish Research Council [VR 2015-04434 DIABETSENS]; Mucosal Infection and Inflammation Center (MIIC), Linkoping University, Sweden; Linkoping University, Sweden; EU H2020 Marie Sklodowska-Curie Individual Fellowship from European Commission [706694]; SERB, India [EMR/2016/000857]; UKIERI, UK [DST/INT/UK/P-119/2016]

Available from: 2019-07-16 Created: 2019-07-16 Last updated: 2019-08-29Bibliographically approved
Banerjee, D., Cieslar-Pobuda, A., Zhu, G. H., Wiechec, E. & Patra, H. (2019). Adding nanotechnology to the metastasis treatment arsenal. TIPS - Trends in Pharmacological Sciences, 40(6), 403-418
Open this publication in new window or tab >>Adding nanotechnology to the metastasis treatment arsenal
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2019 (English)In: TIPS - Trends in Pharmacological Sciences, ISSN 0165-6147, E-ISSN 1873-3735, Vol. 40, no 6, p. 403-418Article, review/survey (Refereed) Published
Abstract [en]

Metastasis is a major cause of cancer-related mortality, accounting for 90% of cancer deaths. The explosive growth of cancer biology research has revealed new mechanistic network information and pathways that promote metastasis. Consequently, a large number of antitumor agents have been developed and tested for their antimetastatic efficacy. Despite their exciting cytotoxic effects on tumor cells in vitro and antitumor activities in preclinical studies in vivo, only a few have shown potent antimetastatic activities in clinical trials. In this review, we provide a brief overview of current antimetastatic strategies that show clinical efficacy and review nanotechnology-based approaches that are currently being incorporated into these therapies to mitigate challenges associated with treating cancer metastasis.

Place, publisher, year, edition, pages
Cambridge, Massachusets: Elsevier, 2019
Keywords
metastasis; nanotechnology; chemotherapy; combination therapy
National Category
Other Clinical Medicine Cancer and Oncology Pharmaceutical Sciences
Identifiers
urn:nbn:se:liu:diva-156845 (URN)10.1016/j.tips.2019.04.002 (DOI)000469437500007 ()31076247 (PubMedID)
Note

Funding agencies: EU H2020 Marie Sklodowska-Curie Individual Fellowship [706694]; Wolfson College (University of Cambridge, UK); MIIC Seed Grant from Linkoping University (LiU), Sweden

Available from: 2019-05-14 Created: 2019-05-14 Last updated: 2019-09-24
Patra, H. K., Azharuddin, M., Islam, M. M., Papapavlou, G., Deb, S., Osterrieth, J., . . . Slater, N. K. H. (2019). Rational Nanotoolbox with Theranostic Potential for Medicated Pro-Regenerative Corneal Implants. Advanced Functional Materials, Article ID 1903760.
Open this publication in new window or tab >>Rational Nanotoolbox with Theranostic Potential for Medicated Pro-Regenerative Corneal Implants
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2019 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, article id 1903760Article in journal (Refereed) Epub ahead of print
Abstract [en]

Cornea diseases are a leading cause of blindness and the disease burden is exacerbated by the increasing shortage around the world for cadaveric donor corneas. Despite the advances in the field of regenerative medicine, successful transplantation of laboratory‐made artificial corneas is not fully realized in clinical practice. The causes of failure of such artificial corneal implants are multifactorial and include latent infections from viruses and other microbes, enzyme overexpression, implant degradation, extrusion or delayed epithelial regeneration. Therefore, there is an urgent unmet need for developing customized corneal implants to suit the host environment and counter the effects of inflammation or infection, which are able to track early signs of implant failure in situ. This work reports a nanotoolbox comprising tools for protection from infection, promotion of regeneration, and noninvasive monitoring of the in situ corneal environment. These nanosystems can be incorporated within pro‐regenerative biosynthetic implants, transforming them into theranostic devices, which are able to respond to biological changes following implantation.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
herpes simplex virus type 1 (HSV-1), magnetic resonance imaging (MRI), premedicated cornea implants, pro-regeneration, theranostics
National Category
Microbiology in the medical area
Identifiers
urn:nbn:se:liu:diva-159097 (URN)10.1002/adfm.201903760 (DOI)000476281800001 ()2-s2.0-85069940064 (Scopus ID)
Note

Funding agencies: EU H2020 Marie Sklodowska-Curie Individual Fellowship [706694]; MIIC Strategic Postdoc Grant; MIIC Seed Grant at Linkoping University (LiU), Sweden

Available from: 2019-07-24 Created: 2019-07-24 Last updated: 2019-08-23Bibliographically approved
Azzouzi, S., Patra, H. K., Ben Ali, M., Nooredeen Abbas, M., Dridi, C., Errachid, A. & Turner, A. (2016). Citrate-selective electrochemical mu-sensor for early stage detection of prostate cancer. Sensors and actuators. B, Chemical, 228, 335-346
Open this publication in new window or tab >>Citrate-selective electrochemical mu-sensor for early stage detection of prostate cancer
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2016 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 228, p. 335-346Article in journal (Refereed) Published
Abstract [en]

The extremely specialised anatomical function of citrate inside the prostate, make it one of the preferred biomarkers for early stage detection of prostate cancer. However, current detection methods are seriously limited due to the very low citrate concentrations that need to be measured in order to follow disease progression. In the present work, we report a novel citrate-selective-sensor based on iron (III) phthalocyanine chloride-C-monoamido-Poly-n-Butyl Acrylate (Fe(III)MAPcC1 P n BA) modified gold -electrodes for the electrochemical determination and estimation of the pathophysiological range of citrate. The newly synthesised ionophore has been structurally characterised using Fourier transform infrared (FTIR) and UV-vis spectroscopy. Contact angle measurements and atomic force microscopy (AFM) have been used to investigate the adhesion and morphological properties of the membrane. The developed citrate-selective-electrodes had a Nernstian sensitivity of-19.34 +/- 0.83 mV/decade with a detection limit of about 9 x 10-6M and a linear range from 4 x 10(-5)M to 10(-1) M, which covered the pathologically important clinical range. Electrochemical impedance spectroscopy (EIS) showed very high sensitivity with a lower Limit of detection 1.7 x 10(-9) M and linear detection range (10(-8)-10(-1) M), which is very important not only for the early-stage diagnosis and screening procedures, but also in mapping the stage of the cancer too. (C) 2016 Elsevier B.V. All rights reserved.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE SA, 2016
Keywords
Citrate selective ionophore; Potentiometry; Impedance spectroscopy; Prostate cancer; Early-stage detection
National Category
Medical Laboratory and Measurements Technologies Analytical Chemistry
Identifiers
urn:nbn:se:liu:diva-126791 (URN)10.1016/j.snb.2016.01.056 (DOI)000371027900045 ()
Note

Funding Agencies|NATO Science for Peace (SFP) Project [CBP.NUKR.SFP 984173]; FP7-PEOPLE-IRSES [318053]; SEA-on-a-Chip project [614168]

Available from: 2016-04-07 Created: 2016-04-05 Last updated: 2017-11-30
Tiwari, A., Patra, H. & Turner, A. (Eds.). (2015). Advanced Bioelectronic Materials. Beverly, MA, USA: Wiley-Scrivener
Open this publication in new window or tab >>Advanced Bioelectronic Materials
2015 (English)Collection (editor) (Other academic)
Abstract [en]

This book covers the recent advances in the development of bioelectronics systems and their potential application in future biomedical applications starting from system design to signal processing for physiological monitoring, to in situ biosensing.

Advanced Bioelectronics Materialshas contributions from distinguished international scholars whose backgrounds mirror the multidisciplinary readership ranging from the biomedical sciences, biosensors and engineering communities with diverse backgrounds, interests and proficiency in academia and industry. The readers will benefit from the widespread coverage of the current literature, state-of-the-art overview of all facets of advanced bioelectronics materials ranging from real time monitoring, in situ diagnostics, in vivo imaging, image-guided therapeutics, biosensors, and translational biomedical devices and personalized monitoring.

Place, publisher, year, edition, pages
Beverly, MA, USA: Wiley-Scrivener, 2015. p. 500
Keywords
Advanced materials; functional materials; biosensors; bioelectronics
National Category
Other Natural Sciences
Identifiers
urn:nbn:se:liu:diva-123684 (URN)10.1002/9781118998861 (DOI)9781118998304 (ISBN)9781118998861 (ISBN)
Available from: 2016-01-08 Created: 2016-01-08 Last updated: 2016-01-14Bibliographically approved
Patra, H. K., Imani, R., Jangamreddy, J., Pazoki, M., Iglic, A., Turner, A. & Tiwari, A. (2015). On/off-switchable anti-neoplastic nanoarchitecture. Scientific Reports, 5(14571), 1-9
Open this publication in new window or tab >>On/off-switchable anti-neoplastic nanoarchitecture
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2015 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 5, no 14571, p. 1-9Article in journal (Refereed) Published
Abstract [en]

Throughout the world, there are increasing demands for alternate approaches to advanced cancer therapeutics. Numerous potentially chemotherapeutic compounds are developed every year for clinical trial and some of them are considered as potential drug candidates. Nanotechnology-based approaches have accelerated the discovery process, but the key challenge still remains to develop therapeutically viable and physiologically safe materials suitable for cancer therapy. Here, we report a high turnover, on/off-switchable functionally popping reactive oxygen species (ROS) generator using a smart mesoporous titanium dioxide popcorn (TiO2 Pops) nanoarchitecture. The resulting TiO2 Pops, unlike TiO2 nanoparticles (TiO2 NPs), are exceptionally biocompatible with normal cells. Under identical conditions, TiO2 Pops show very high photocatalytic activity compared to TiO2 NPs. Upon on/off-switchable photo activation, the TiO2 Pops can trigger the generation of high-turnover flash ROS and can deliver their potential anticancer effect by enhancing the intracellular ROS level until it crosses the threshold to open the death gate, thus reducing the survival of cancer cells by at least six times in comparison with TiO2 NPs without affecting the normal cells.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP, 2015
National Category
Cancer and Oncology Other Basic Medicine
Identifiers
urn:nbn:se:liu:diva-122109 (URN)10.1038/srep14571 (DOI)000361873500001 ()26415561 (PubMedID)
Note

Funding Agencies|Swedish Research Council [VR-2011-6058357]; IGEN (Post-Doctoral Fellowship); Slovenian Research Agency (ARRS) [J1-6728, P2-0232]

Available from: 2015-10-19 Created: 2015-10-19 Last updated: 2018-01-11
Tiwari, A., Patra, H. & Turner, A. (2015). Preface. In: Ashutosh Tiwari, Hirak Patra and Anthony Turner (Ed.), Advanced bioelectronics materials: (pp. XV). Beverly, MA, USA: Wiley-Scrivener
Open this publication in new window or tab >>Preface
2015 (English)In: Advanced bioelectronics materials / [ed] Ashutosh Tiwari, Hirak Patra and Anthony Turner, Beverly, MA, USA: Wiley-Scrivener , 2015, p. XV-Chapter in book (Other academic)
Place, publisher, year, edition, pages
Beverly, MA, USA: Wiley-Scrivener, 2015
National Category
Other Natural Sciences
Identifiers
urn:nbn:se:liu:diva-123690 (URN)10.1002/9781118998861.fmatter (DOI)9781118998304 (ISBN)9781118998861 (ISBN)
Available from: 2016-01-08 Created: 2016-01-08 Last updated: 2016-01-14Bibliographically approved
Farahani, E., Patra, H. K., Jangamreddy, J. R., Rashedi, I., Kawalec, M., Rao Pariti, R. K., . . . Wiechec, E. (2014). Cell adhesion molecules and their relation to (cancer) cell stemness. Carcinogenesis, 35(4), 747-759
Open this publication in new window or tab >>Cell adhesion molecules and their relation to (cancer) cell stemness
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2014 (English)In: Carcinogenesis, ISSN 0143-3334, E-ISSN 1460-2180, Vol. 35, no 4, p. 747-759Article, review/survey (Refereed) Published
Abstract [en]

Despite decades of search for anticancer drugs targeting solid tumors, this group of diseases remains largely incurable, especially if in advanced, metastatic stage. In this review, we draw comparison between reprogramming and carcinogenesis, as well as between stem cells (SCs) and cancer stem cells (CSCs), focusing on changing garniture of adhesion molecules. Furthermore, we elaborate on the role of adhesion molecules in the regulation of (cancer) SCs division (symmetric or asymmetric), and in evolving interactions between CSCs and extracellular matrix. Among other aspects, we analyze the role and changes of expression of key adhesion molecules as cancer progresses and metastases develop. Here, the role of cadherins, integrins, as well as selected transcription factors like Twist and Snail is highlighted, not only in the regulation of epithelial-to-mesenchymal transition but also in the avoidance of anoikis. Finally, we briefly discuss recent developments and new strategies targeting CSCs, which focus on adhesion molecules or targeting tumor vasculature.

Place, publisher, year, edition, pages
Oxford University Press, 2014
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-105306 (URN)10.1093/carcin/bgu045 (DOI)000335001800002 ()
Available from: 2014-03-17 Created: 2014-03-17 Last updated: 2019-02-11Bibliographically approved
Patra, H. K., Khaliq, N. U., Romu, T., Wiechec, E., Borga, M., Turner, A. P. F. & Tiwari, A. (2014). MRI-Visual Order–Disorder Micellar Nanostructures for Smart Cancer Theranostics. Advanced Healthcare Materials, 3(4), 526-535
Open this publication in new window or tab >>MRI-Visual Order–Disorder Micellar Nanostructures for Smart Cancer Theranostics
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2014 (English)In: Advanced Healthcare Materials, ISSN 2192-2640, Vol. 3, no 4, p. 526-535Article in journal (Refereed) Published
Abstract [en]

The development of MRI-visual order–disorder structures for cancer nanomedicine explores a pH-triggered mechanism for theragnosis of tumor hallmark functions. Superparamagnetic iron oxide nanoparticles (SPIONs) stabilized with amphiphilic poly(styrene)-b-poly(acrylic acid)-doxorubicin with folic acid (FA) surfacing are employed as a multi-functional approach to specifically target, diagnose, and deliver drugs via a single nanoscopic platform for cancer therapy. The functional aspects of the micellar nanocomposite is investigated in vitro using human breast SkBr3 and colon cancer HCT116 cell lines for the delivery, release, localization, and anticancer activity of the drug. For the first time, concentration-dependent T2-weighted MRI contrast for a monolayer of clustered cancer cells is shown. The pH tunable order–disorder transition of the core–shell structure induces the relative changes in MRI contrast. The outcomes elucidate the potential of this material for smart cancer theranostics by delivering non-invasive real-time diagnosis, targeted therapy, and monitoring the course and response of the action before, during, and after the treatment regimen.

Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2014
Keywords
custom-fit nanomedicine;tumor microenvironment;smart nanotheranostic;personalized therapeutics
National Category
Nano Technology Biochemistry and Molecular Biology Biomaterials Science Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:liu:diva-96875 (URN)10.1002/adhm.201300225 (DOI)000334282400008 ()
Available from: 2013-08-27 Created: 2013-08-27 Last updated: 2017-02-21Bibliographically approved
Patra, H., Imani, R., Iglic, A., Turner, A. & Tiwari, A. (2014). Novel anti-neoplastic approach for photodynamic theranostics by biocompatible TiO2 popcorn nanostructure for a high-throughput flash ROS generator. In: 24th Anniversary World Congress on Biosensors – Biosensors 2014: . Paper presented at 24th Anniversary World Congress on Biosensors – Bios ensors 2014, 27-30 May 2014, Melbourne, Australia. Elsevier
Open this publication in new window or tab >>Novel anti-neoplastic approach for photodynamic theranostics by biocompatible TiO2 popcorn nanostructure for a high-throughput flash ROS generator
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2014 (English)In: 24th Anniversary World Congress on Biosensors – Biosensors 2014, Elsevier, 2014Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Reactive oxygen species (ROS) are important secondary messengers in the intracellular signaling system for regulating redox homeostasis in normal cells. Compared to normal cells, cancer cells have increased ROS levels due to a faster metabolic rate. We have used this discriminating overproduction of ROS levels in cancer cells  as a target for a photodynamic anti-neoplastic theranostic approach using mesoporous TiO2 microbeads with a popcorn nanostructure. We have created a novel flash ROS generator  using a two-step procedure consisting of sol-gel and solvothermal processes to obtain mesoporous TiO2 microbeads with high photocatalytic efficiency. A photon-induced comparative study has been carried out for the ROS generation ability using TiO2 nanoparticles and mesoporous TiO2 microbeads.  We have shown that in under otherwise identical conditions the extent of photocatalytical ROS generated by mesoporous TiO2 microbeads is more than twice that produced by TiO2 nanoparticles. In vitro in the absence of irradiation, the mesoporous TiO2 microbeads are exceptionally biocompatible, allowing almost ~100% cellular survival rate even at a dose of 100 µg/mL. In contrast, commercial nanoparticles showed concentration dependent cytotoxicity of nearly 15% within 24h in the absence of any irradiation. Upon photo activation, the mesoporous TiO2 microbead structures delivered their potential anticancer effect by interfering with the mitochondrial activity by producing ROS in the intracellular environment and thus reducing the survival rate of cells by more than 30% in comparison with commercial nanoparticles, where only an increase of 5% in cell death was observed. Thus we have developed a smart on/off switchable photodynamic anti-neoplastic theranostic approach that can be combined with specific cell recognition elements for future cancer management.

Place, publisher, year, edition, pages
Elsevier, 2014
National Category
Natural Sciences
Identifiers
urn:nbn:se:liu:diva-108432 (URN)
Conference
24th Anniversary World Congress on Biosensors – Bios ensors 2014, 27-30 May 2014, Melbourne, Australia
Available from: 2014-06-27 Created: 2014-06-27 Last updated: 2014-08-26
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-6142-5489

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