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Ardenfors, Oscar
Publications (2 of 2) Show all publications
Ardenfors, O., Josefsson, D. & Dasu, A. (2014). Are IMRT treatments in the head and neck region increasing the risk of secondary cancers?. Acta Oncologica, 53(8), 1041-1047
Open this publication in new window or tab >>Are IMRT treatments in the head and neck region increasing the risk of secondary cancers?
2014 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 53, no 8, p. 1041-1047Article in journal (Refereed) Published
Abstract [en]

Background: Intensity modulated radiation therapy (IMRT) has been increasingly employed for treating head and neck (H&N) tumours due to its ability to produce isodoses suitable for the complex anatomy of the region. The aim of this study was to assess possible differences between IMRT and conformal radiation therapy (CRT) with regard to risk of radiation-induced secondary malignancies for H&N tumours.

Material and Methods: IMRT and CRT plans were made for 10 H&N adult patients and the resulting treatment planning data were used to calculate the risk of radiation-induced malignancies in four different tissues. Three risk models with biologically relevant parameters were used for calculations. The influence of scatter radiation and repeated imaging sessions has also been investigated.

Results: The results showed that the total lifetime risks of developing radiation-induced secondary malignancies from the two treatment techniques, CRT and IMRT, were comparable and in the interval 0.9-2.5%. The risk contributions from the primary beam and scatter radiation were comparable, whereas the contribution from repeated diagnostic imaging was considerably smaller.

Conclusion: The results indicated that the redistribution of the dose characteristic to IMRT leads to a redistribution of the risks in individual tissues. However, the total levels of risk were similar between the two irradiation techniques considered.

Place, publisher, year, edition, pages
Informa Healthcare, 2014
National Category
Cancer and Oncology Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:liu:diva-106634 (URN)10.3109/0284186X.2014.925581 (DOI)000340892900008 ()24983652 (PubMedID)
Available from: 2014-05-16 Created: 2014-05-16 Last updated: 2017-12-05
Gudowska, I., Ardenfors, O., Toma-Dasu, I. & Dasu, A. (2014). Radiation burden from secondary doses to patients undergoing radiation therapy with photons and light ions and radiation doses from imaging modalities. Radiation Protection Dosimetry, 161(1-4), 357-362
Open this publication in new window or tab >>Radiation burden from secondary doses to patients undergoing radiation therapy with photons and light ions and radiation doses from imaging modalities
2014 (English)In: Radiation Protection Dosimetry, ISSN 0144-8420, E-ISSN 1742-3406, Vol. 161, no 1-4, p. 357-362Article in journal (Refereed) Published
Abstract [en]

Ionising radiation is increasingly used for the treatment of cancer, being the source of a considerable fraction of the medical irradiation to patients. With the increasing success rate of cancer treatments and longer life expectancy of the treated patients, the issue of secondary cancer incidence is of growing concern, especially for paediatric patients who may live long after the treatment and be more susceptible to carcinogenesis. Also, additional imaging procedures like CT, kV and MV imaging and PET, alone or in conjunction with radiation therapy, may add to the radiation burden associated with the risk of occurrence of secondary cancers. This work has been based on literature studies and is focussed on the assessment of secondary doses to healthy tissues that are delivered by the use of modern radiation therapy and diagnostic imaging modalities in the clinical environment.

National Category
Cancer and Oncology
Identifiers
urn:nbn:se:liu:diva-102458 (URN)10.1093/rpd/nct335 (DOI)000343057600077 ()24353029 (PubMedID)
Funder
Swedish Radiation Safety Authority, SSM2012-1998
Available from: 2013-12-11 Created: 2013-12-11 Last updated: 2017-12-06
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