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Möller, Peter
Publications (8 of 8) Show all publications
Kilpijärvi, J., Sobocinski, M., Halonen, N., Hassinen, A., Prakash, S. B., Möller, P., . . . Lloyd Spetz, A. (2016). LTCC packaging for lab-on-CMOS applied in cell viability monitoring. In: Proceedings EMRS 2016: . Paper presented at EMRS 2016.
Open this publication in new window or tab >>LTCC packaging for lab-on-CMOS applied in cell viability monitoring
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2016 (English)In: Proceedings EMRS 2016, 2016Conference paper, Poster (with or without abstract) (Refereed)
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-129119 (URN)
Conference
EMRS 2016
Available from: 2016-06-12 Created: 2016-06-12 Last updated: 2016-06-28
Halonen, N., Kilpijärvi, J., Sobocinski, M., Datta-Chaudhuri, T., Hassinen, A., Prakash, S. B., . . . Lloyd Spetz, A. (2015). Low temperature co-fired ceramic package for lab-on-a­chip applied in cell viability monitoring. In: Proceedings Eurosensors 2015: . Paper presented at Eurosensors 2015 (pp. 1187-1190).
Open this publication in new window or tab >>Low temperature co-fired ceramic package for lab-on-a­chip applied in cell viability monitoring
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2015 (English)In: Proceedings Eurosensors 2015, 2015, p. 1187-1190Conference paper, Poster (with or without abstract) (Refereed)
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-129112 (URN)
Conference
Eurosensors 2015
Available from: 2016-06-12 Created: 2016-06-12 Last updated: 2016-06-28
Halonen, N., Kilpijärvi, J., Sobocinski, M., Datta-Chaudhuri, T., Hassinen, A., Prakash, S. B., . . . Lloyd Spetz, A. (2015). Low temperature co-fired ceramic package for lab-on-CMOS applied in cell viability monitoring. Paper presented at Conference on EUROSENSORS. Procedia Engineering, 120, 1079-1082
Open this publication in new window or tab >>Low temperature co-fired ceramic package for lab-on-CMOS applied in cell viability monitoring
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2015 (English)In: Procedia Engineering, ISSN 1877-7058, E-ISSN 1877-7058, Vol. 120, p. 1079-1082Article in journal (Refereed) Published
Abstract [en]

Lab-on-CMOS chips (LOCMOS) are sophisticated miniaturized analysis tools based on integrated circuit (IC) microchips performing various laboratory functions. We have developed a low temperature co-fired ceramic (LTCC) package for a LOCMOS application regarding cytotoxicity assessment of nanomaterials. The LTCC packaged capacitance sensor chip is designed for long-term cell viability monitoring during nanoparticle exposure. The introduced LTCC package utilizes the flip chip bonding technique, and it is biocompatible as well as able to withstand the environmental conditions required to maintain mammalian cell culture directly on the surface of a complementary metal oxide semiconductor (CMOS) integrated circuit.

Keywords
Lab-on-CMOS;low temperature co-fired ceramics;electronics packaging;cytotoxicity assesment;capacitance sensing
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering Physical Sciences
Identifiers
urn:nbn:se:liu:diva-124051 (URN)10.1016/j.proeng.2015.08.769 (DOI)000380499300249 ()
Conference
Conference on EUROSENSORS
Available from: 2016-01-18 Created: 2016-01-18 Last updated: 2017-11-30Bibliographically approved
Möller, P., Andersson, M., Lloyd Spetz, A., Puustinen, J., Lappalainen, J. & Eriksson, J. (2015). NOx sensing with SiC field effect transistors. In: : . Paper presented at 16th International Conference on Silicon Carbide and Related Materials Giardini Naxos, Italy, October 4 - 9, 2015.
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2015 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Control Engineering
Identifiers
urn:nbn:se:liu:diva-124156 (URN)
Conference
16th International Conference on Silicon Carbide and Related Materials Giardini Naxos, Italy, October 4 - 9, 2015
Available from: 2016-01-20 Created: 2016-01-20 Last updated: 2016-02-01
Halonen, N., Datta-Chaudhuri, T., Hassinen, A., Prakash, S. B., Möller, P., Abshire, P., . . . Lloyd Spetz, A. (2014). Cell clinic; CMOS chip measuring capacitance as indication of cell adhesion applied in evaluating the cytotoxicity of nanomaterials. In: Proc. Eurosensors 2014, Brescia, Italy, September 7-10: . Paper presented at Eurosensors 2014, Brescia, Italy, September 7-10.
Open this publication in new window or tab >>Cell clinic; CMOS chip measuring capacitance as indication of cell adhesion applied in evaluating the cytotoxicity of nanomaterials
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2014 (English)In: Proc. Eurosensors 2014, Brescia, Italy, September 7-10, 2014Conference paper, Poster (with or without abstract) (Refereed)
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-113330 (URN)
Conference
Eurosensors 2014, Brescia, Italy, September 7-10
Available from: 2015-01-15 Created: 2015-01-15 Last updated: 2015-01-23
Halonen, N., Datta-Chaudhuri, T., Hassinen, A., Prakash, S. B., Möller, P., Abshire, P., . . . Lloyd Spetz, A. (2014). CMOS-Based capacitance measurements applied in evaluating cell viability and cytotoxicity of nanomaterials. In: Proc. E-MRS 2014, Lille, France May 26-30: . Paper presented at E-MRS 2014, Lille, France May 26-3.
Open this publication in new window or tab >>CMOS-Based capacitance measurements applied in evaluating cell viability and cytotoxicity of nanomaterials
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2014 (English)In: Proc. E-MRS 2014, Lille, France May 26-30, 2014Conference paper, Oral presentation with published abstract (Refereed)
National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-113323 (URN)
Conference
E-MRS 2014, Lille, France May 26-3
Available from: 2015-01-15 Created: 2015-01-15 Last updated: 2015-01-22
Datta, T., Halonen, N., Hassinen, A., Möller, P., Kellokumpu, S., Abshire, P., . . . Smela, E. (2014). Integration of CMOS Chips into LOCs for Cell-Based Sensing. In: Proceedings of Biosensors 2014, Australia: . Paper presented at Biosensors 2014, Australia.
Open this publication in new window or tab >>Integration of CMOS Chips into LOCs for Cell-Based Sensing
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2014 (English)In: Proceedings of Biosensors 2014, Australia, 2014Conference paper, Oral presentation with published abstract (Refereed)
Abstract [en]

Incorporating complementary metal oxide semiconductor (CMOS) chips that can perform signal processing, control, information readout, and direct sensing into microfluidic systems adds powerful capabilities to lab on a chip (LOC) devices. For example, on-chip sensors allow system miniaturization, amplifiers placed directly under the sensors provide high signal to noise ratios (SNRs), and signal processing circuitry reduces the amount of data that must be communicated off-chip. Packaging such chips to expose the sensors on the surface to a fluid environment while protecting the input/output region at the periphery has been challenging, however. We present a new packaging method based on forming an epoxy handle wafer around the chip, photolithographic patterning of metal and polymer films for interconnection and passivation, and bonding to PDMS microfluidics. Such packaged chips last for months in the incubator and can be sterilized and re-used. We will show two examples of cell-based sensing with these systems using chips produced in a commercially-available CMOS technology: monitoring the cytotoxicity of nanomaterials through capacitance changes and recording action potentials from electrogenic cells. Adherent cells normally spread out on surfaces, while stressed cells contract and apoptosis leads to detachment. A chip was produced consisting of an array of fully differential capacitance sensors and readout circuitry. Cells (kidney, Cercopithecus aethiops) were cultured on the chip surface to confluence and then exposed to cytotoxic TiO2 nanowires. Cell viability was evaluated with both the chip and a commercial cytotoxicity kit. Preliminary results indicate that viability can be monitored by capacitance measurements. In the second example, a cluster of cardiomyocytes was cultured on the surface of a different chip having an array of electrodes connected to on-chip amplifiers. Electrical recordings showed strong action potentials from the cluster, corresponding in time with the beating of the clump. The signal amplitude decreased with distance to the electrodes, as expected

National Category
Physical Sciences
Identifiers
urn:nbn:se:liu:diva-113322 (URN)
Conference
Biosensors 2014, Australia
Available from: 2015-01-15 Created: 2015-01-15 Last updated: 2015-01-22
Darmastuti, Z., Bur, C., Möller, P., Rahlin, R., Lindqvist, N., Andersson, M., . . . Lloyd Spetz, A. (2014). SiC-FET based SO2 sensor for power plant emission applications. Sensors and actuators. B, Chemical, 194, 511-520
Open this publication in new window or tab >>SiC-FET based SO2 sensor for power plant emission applications
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2014 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, E-ISSN 1873-3077, Vol. 194, p. 511-520Article in journal (Refereed) Published
Abstract [en]

Thermal power plants produce SO2 during combustion of fuel containing sulfur. One way to decrease the SO2 emission from power plants is to introduce a sensor as part of the control system of the desulphurization unit. In this study, SiC-FET sensors were studied as one alternative sensor to replace the expensive FTIR (Fourier Transform Infrared) instrument or the inconvenient wet chemical methods. The gas response for the SiC-FET sensors comes from the interaction between the test gas and the catalytic gate metal, which changes the electrical characteristics of the devices. The performance of the sensors depends on the ability of the test gas to be adsorbed, decomposed, and desorbed at the sensor surface. The feature of SO2, that it is difficult to desorb from the catalyst surface, makes it known as catalyst poison. It is difficult to quantify the SO2 with static operation, even at the optimum operation temperature of the sensor due to low response levels and saturation already at low concentration of SO2. The challenge of SO2 desorption can be reduced by introducing dynamic operation in a designed temperature cycle operation (TCO). The intermittent exposure to high temperature can help to desorb SO2. Simultaneously, additional features extracted from the sensor data can be used to reduce the influence of sensor drift. The TCO operation, together with pattern recognition, may also reduce the baseline and response variation due to changing concentration of background gases (4-10% O-2 and 0-70% RH), and thus it may improve the overall sensor performance. In addition to the laboratory experiment, testing in the desulphurization pilot unit was performed. Desulphurization pilot unit has less controlled environment compared to the laboratory conditions. Therefore, the risk of influence from the changing concentration of background gas is higher. In this study, linear discriminant analysis (LDA) and partial least square (PLS) were employed as pattern recognition methods. It was demonstrated that using LDA quantification of SO2 into several groups of concentrations up to 2000 ppm was possible. Additionally, PLS analysis indicated a good agreement between the predicted value from the model and the SO2 concentration from the reference instrument of the pilot plant.

Place, publisher, year, edition, pages
Elsevier, 2014
Keywords
SO2 sensors; SiC-FET; Pt; Temperature cycled operation (TCO); Desulphurization; Power plant
National Category
Engineering and Technology
Identifiers
urn:nbn:se:liu:diva-105569 (URN)10.1016/j.snb.2013.11.089 (DOI)000331575400067 ()
Available from: 2014-03-31 Created: 2014-03-27 Last updated: 2017-12-05Bibliographically approved
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