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Morrison, India
Publications (2 of 2) Show all publications
Morrison, I. (2016). ALE meta-analysis reveals dissociable networks for affective and discriminative aspects of touch. Human Brain Mapping, 37(4), 1308-1320
Open this publication in new window or tab >>ALE meta-analysis reveals dissociable networks for affective and discriminative aspects of touch
2016 (English)In: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 37, no 4, p. 1308-1320Article in journal (Refereed) Published
Abstract [en]

Emotionally-laden tactile stimulationsuch as a caress on the skin or the feel of velvetmay represent a functionally distinct domain of touch, underpinned by specific cortical pathways. In order to determine whether, and to what extent, cortical functional neuroanatomy supports a distinction between affective and discriminative touch, an activation likelihood estimate (ALE) meta-analysis was performed. This meta-analysis statistically mapped reported functional magnetic resonance imaging (fMRI) activations from 17 published affective touch studies in which tactile stimulation was associated with positive subjective evaluation (n=291, 34 experimental contrasts). A separate ALE meta-analysis mapped regions most likely to be activated by tactile stimulation during detection and discrimination tasks (n=1,075, 91 experimental contrasts). These meta-analyses revealed dissociable regions for affective and discriminative touch, with posterior insula (PI) more likely to be activated for affective touch, and primary somatosensory cortices (SI) more likely to be activated for discriminative touch. Secondary somatosensory cortex had a high likelihood of engagement by both affective and discriminative touch. Further, meta-analytic connectivity (MCAM) analyses investigated network-level co-activation likelihoods independent of task or stimulus, across a range of domains and paradigms. Affective-related PI and discriminative-related SI regions co-activated with different networks, implicated in dissociable functions, but sharing somatosensory co-activations. Taken together, these meta-analytic findings suggest that affective and discriminative touch are dissociable both on the regional and network levels. However, their degree of shared activation likelihood in somatosensory cortices indicates that this dissociation reflects functional biases within tactile processing networks, rather than functionally and anatomically distinct pathways.

Place, publisher, year, edition, pages
WILEY-BLACKWELL, 2016
Keywords
affective touch; discriminative touch; posterior insula; secondary somatosensory cortex; activation likelihood estimate; meta-analytic connectivity modeling
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-127043 (URN)10.1002/hbm.23103 (DOI)000372296500003 ()26873519 (PubMedID)
Note

Funding Agencies|Templeton Positive Neuroscience award; Swedish Research Council [FYF-2013-687]

Available from: 2016-04-13 Created: 2016-04-13 Last updated: 2017-11-30
Perini, I., Morrison, I. & Olausson, H. (2015). Seeking pleasant touch: neural correlates of behavioral preferences for skin stroking. Frontiers in Behavioral Neuroscience, 9(8)
Open this publication in new window or tab >>Seeking pleasant touch: neural correlates of behavioral preferences for skin stroking
2015 (English)In: Frontiers in Behavioral Neuroscience, ISSN 1662-5153, E-ISSN 1662-5153, Vol. 9, no 8Article in journal (Refereed) Published
Abstract [en]

Affective touch is a dynamic process. In this fMRI study we investigated affective touch by exploring its effects on overt behavior. Arm and palm skin were stroked with a soft brush at five different velocities (0.3, 1, 10, 3, and 30 cm s(-1)), using a novel feedback-based paradigm. Following stimulation in each trial, participants actively chose whether the caress they would receive in the next trial would be the same speed ("repeat") or different ("change"). Since preferred stroking speeds should be sought with greater frequency than non-preferred speeds, this paradigm provided a measure of such preferences in the form of active choices. The stimulation velocities were implemented with respect to the differential subjective pleasantness ratings they elicit in healthy subjects, with intermediate velocities (1, 10, and 3 cm s(-1)) considered more pleasant than very slow or very fast ones. Such pleasantness ratings linearly correlate with changes in mean firing rates of unmyelinated low-threshold C-tactile (CT) afferent nerves in the skin. Here, gentle, dynamic stimulation optimal for activating CT-afferents not only affected behavioral choices, but engaged brain regions involved in reward-related behavior and decision-making. This was the case for both hairy skin of the arm, where CTs are abundant, and glabrous skin of the palm, where CTs are absent. These findings provide insights on central and behavioral mechanisms underlying the perception of affective touch, and indicate that seeking affective touch involves value-based neural processing that is ultimately reflected in behavioral preferences.

Place, publisher, year, edition, pages
Frontiers, 2015
Keywords
fMRI; CT afferents; affective touch; seeking behavior; interoception
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-114564 (URN)10.3389/fnbeh.2015.00008 (DOI)000348851300001 ()25698948 (PubMedID)
Note

Funding Agencies|Templeton Positive Neuroscience Award; Swedish Research Council Distinguished Young Researcher grant [FF-2013-687]

Available from: 2015-03-02 Created: 2015-02-26 Last updated: 2017-12-04
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