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Lantz, Linda
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Johansson, L. B. G., Bäck, M., Lantz, L., Eriksson, M., Nygren, P. & Nilsson, P. R.A variety of thiophene based ligands for detection of protein aggregates by surface plasmon resonance.
Open this publication in new window or tab >>A variety of thiophene based ligands for detection of protein aggregates by surface plasmon resonance
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Abstract [en]

By attaching an azide functional group via a tetraethylene glycol linker to the α-terminal position of a variety of oligothiophenes, thiophene-based ligands that can be utilized for detection of protein aggregates with surface plasmon resonance have been developed. All ligands displayed selectivity towards recombinant amyloid fibrils and the LCO/protein aggregate interaction could be detected by fluorescence as well as by surface plasmon resonance.

National Category
Chemical Sciences
Identifiers
urn:nbn:se:liu:diva-122274 (URN)
Available from: 2015-10-27 Created: 2015-10-27 Last updated: 2015-10-27Bibliographically approved
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