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Hamilton, Paul J.
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Publications (9 of 9) Show all publications
Strauss, T., Rottstaedt, F., Sailer, U., Schellong, J., Hamilton, P. J., Raue, C., . . . Croy, I. (2019). Touch aversion in patients with interpersonal traumatization. Depression and anxiety (Print), 36(7), 635-646
Open this publication in new window or tab >>Touch aversion in patients with interpersonal traumatization
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2019 (English)In: Depression and anxiety (Print), ISSN 1091-4269, E-ISSN 1520-6394, Vol. 36, no 7, p. 635-646Article in journal (Refereed) Published
Abstract [en]

Background Interpersonal touch is a key aspect of human interaction and a usually very comforting experience. For patients suffering from posttraumatic stress disorders (PTSD) caused by interpersonal traumatization, such touch is affectively ambiguous. Methods In two studies, we investigated the experience and neural processing of various types of interpersonal and impersonal touch in patients as compared with healthy controls. Results Patients strongly disliked show, interpersonal skin-to-skin stroking, while controls appreciated this kind of touch. No group differences were observed for ratings of impersonal touch. Similarly, the neural activation differed between groups for interpersonal, but not for impersonal touch. The interpersonal touch aversion in patients was accompanied by enhanced blood-oxygen-level-dependent response in the superior temporal gyrus and by a pronounced reduction of response in the hippocampus. This reduction was significantly correlated to symptoms of negative alterations and arousal within the patients. Conclusion We interpret the hippocampal suppression as an attempt to control traumatic memories, evoked by interpersonal touch. This mechanism may maintain the aversion of interpersonal touch in patients with interpersonal trauma-related PTSD.

Place, publisher, year, edition, pages
WILEY, 2019
Keywords
fMRI; hippocampus; PTSD; superior temporal; touch
National Category
Psychiatry
Identifiers
urn:nbn:se:liu:diva-159065 (URN)10.1002/da.22914 (DOI)000474304700007 ()31209965 (PubMedID)
Note

Funding Agencies|Graduate Academy of TU Dresden - German Academic Exchange Service

Available from: 2019-07-22 Created: 2019-07-22 Last updated: 2019-07-22
Sacchet, M. D., Levy, B. J., Hamilton, P. J., Maksimovskiy, A., Hertel, P. T., Joormann, J., . . . Gotlib, I. H. (2017). Cognitive and neural consequences of memory suppression in major depressive disorder. Cognitive, Affective, & Behavioral Neuroscience, 17(1), 77-93
Open this publication in new window or tab >>Cognitive and neural consequences of memory suppression in major depressive disorder
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2017 (English)In: Cognitive, Affective, & Behavioral Neuroscience, ISSN 1530-7026, E-ISSN 1531-135X, Vol. 17, no 1, p. 77-93Article in journal (Refereed) Published
Abstract [en]

Negative biases in cognition have been documented consistently in major depressive disorder (MDD), including difficulties in the ability to control the processing of negative material. Although negative information-processing biases have been studied using both behavioral and neuroimaging paradigms, relatively little research has been conducted examining the difficulties of depressed persons with inhibiting the retrieval of negative information from long-term memory. In this study, we used the think/no-think paradigm and functional magnetic resonance imaging to assess the cognitive and neural consequences of memory suppression in individuals diagnosed with depression and in healthy controls. The participants showed typical behavioral forgetting effects, but contrary to our hypotheses, there were no differences between the depressed and nondepressed participants or between neutral and negative memories. Relative to controls, depressed individuals exhibited greater activity in right middle frontal gyrus during memory suppression, regardless of the valence of the suppressed stimuli, and differential activity in the amygdala and hippocampus during memory suppression involving negatively valenced stimuli. These findings indicate that depressed individuals are characterized by neural anomalies during the suppression of long-term memories, increasing our understanding of the brain bases of negative cognitive biases in MDD.

Place, publisher, year, edition, pages
SPRINGER, 2017
Keywords
Major depressive disorder (MDD); Functional magnetic resonance imaging (fMRI); Memory suppression; Think/No-Think (TNT); Cognitive neuroscience; Negative valence
National Category
Psychology (excluding Applied Psychology)
Identifiers
urn:nbn:se:liu:diva-135721 (URN)10.3758/s13415-016-0464-x (DOI)000393772800004 ()27649971 (PubMedID)
Note

Funding Agencies|NSF [0801700, DGE-1147470]; NIMH [T32 MH020016, R01-MH59259]; UK Medical Research Council [MC-A060-5PR00]

Available from: 2017-03-17 Created: 2017-03-17 Last updated: 2018-04-19
Chau, D. T., Fogelman, P., Nordanskog, P., Drevets, W. C. & Hamilton, P. J. (2017). Distinct Neural-Functional Effects of Treatments With Selective Serotonin Reuptake Inhibitors, Electroconvulsive Therapy, and Transcranial Magnetic Stimulation and Their Relations to Regional Brain Function in Major Depression: A Meta-analysis. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2(4), 318-326
Open this publication in new window or tab >>Distinct Neural-Functional Effects of Treatments With Selective Serotonin Reuptake Inhibitors, Electroconvulsive Therapy, and Transcranial Magnetic Stimulation and Their Relations to Regional Brain Function in Major Depression: A Meta-analysis
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2017 (English)In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, ISSN 2451-9030, Vol. 2, no 4, p. 318-326Article in journal (Refereed) Published
Abstract [en]

Functional neuroimaging studies have examined the neural substrates of treatments for major depressive disorder (MDD). Low sample size and methodological heterogeneity, however, undermine the generalizability of findings from individual studies. We conducted a meta-analysis to identify reliable neural changes resulting from different modes of treatment for MDD and compared them with each other and with reliable neural functional abnormalities observed in depressed versus control samples.

Place, publisher, year, edition, pages
Elsevier, 2017
Keywords
Electroconvulsive therapy; Major depressive disorder; Meta-analysis; Positron emission tomography; Selective serotonin reuptake inhibitors; Transcranial magnetic stimulation
National Category
Psychiatry
Identifiers
urn:nbn:se:liu:diva-146140 (URN)10.1016/j.bpsc.2017.01.003 (DOI)29560920 (PubMedID)
Available from: 2018-03-29 Created: 2018-03-29 Last updated: 2018-04-17
Bergamino, M., Farmer, M., Yeh, H.-W., Paul, E. & Hamilton, P. J. (2017). Statistical differences in the white matter tracts in subjects with depression by using different skeletonized voxel-wise analysis approaches and DTI fitting procedures. Brain Research, 1669, 131-140
Open this publication in new window or tab >>Statistical differences in the white matter tracts in subjects with depression by using different skeletonized voxel-wise analysis approaches and DTI fitting procedures
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2017 (English)In: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 1669, p. 131-140Article in journal (Refereed) Published
Abstract [en]

Major depressive disorder (MDD) is one of the most significant contributors to the global burden of illness. Diffusion tensor imaging (DTI) is a procedure that has been used in several studies to characterize abnormalities in white matter (WM) microstructural integrity in MDD. These studies, however, have provided divergent findings, potentially due to the large variety of methodological alternatives available in conducting DTI research. In order to determine the importance of different approaches to coregistration of DTI-derived metrics to a standard space, we compared results from two different skeletonized voxel-wise analysis approaches: the standard TBBS pipeline and the Advanced Normalization Tools (ANTs) approach incorporating a symmetric image normalization (SyN) algorithm and a group-wise template (ANTs TBSS). We also assessed effects of applying twelve different fitting procedures for the diffusion tensor. For our dataset, lower fractional anisotropy (FA) and axial diffusivity (AD) in depressed subjects compared with healthy controls were found for both methods and for all fitting procedures. No group differences were found for radial and mean diffusivity indices. Importantly, for the AD metric, the normalization methods and fitting procedures showed reliable differences, both in the volume and in the number of significant between-groups difference clusters detected. Additionally, a significant voxel-based correlation, in the left inferior fronto-occipital fasciculus, between AD and self-reported stress was found only for one of the normalization procedure (ANTs TBSS). In conclusion, the sensitivity to detect group-level effects on DTI metrics might depend on the DTI normalization and/or tensor fitting procedures used.

Place, publisher, year, edition, pages
Elsevier, 2017
Keywords
ANTs; DTI fitting algorithms; Diffusion tensor imaging; Major depressive disorder; TBSS
National Category
Bioinformatics and Systems Biology
Identifiers
urn:nbn:se:liu:diva-146289 (URN)10.1016/j.brainres.2017.06.013 (DOI)000406729700016 ()28629742 (PubMedID)
Available from: 2018-04-07 Created: 2018-04-07 Last updated: 2019-02-11
Oltedal, L., Bartsch, H., Evjenth Sorhaug, O. J., Kessler, U., Abbott, C., Dols, A., . . . Oedegaard, K. J. (2017). The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy. NeuroImage: Clinical, 14, 422-432
Open this publication in new window or tab >>The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy
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2017 (English)In: NeuroImage: Clinical, ISSN 0353-8842, E-ISSN 2213-1582, Vol. 14, p. 422-432Article in journal (Refereed) Published
Abstract [en]

Major depression, currently the worlds primary cause of disability, leads to profound personal suffering and increased risk of suicide. Unfortunately, the success of antidepressant treatment varies amongst individuals and can take weeks to months in those who respond. Electroconvulsive therapy (ECT), generally prescribed for the most severely depressed and when standard treatments fail, produces a more rapid response and remains the most effective intervention for severe depression. Exploring the neurobiological effects of ECT is thus an ideal approach to better understand the mechanisms of successful therapeutic response. Though several recent neuroimaging studies show structural and functional changes associated with ECT, not all brain changes associate with clinical outcome. Larger studies that can address individual differences in clinical and treatment parameters may better target biological factors relating to or predictive of ECT-related therapeutic response. We have thus formed the Global ECT-MRI Research Collaboration (GEMRIC) that aims to combine longitudinal neuroimaging as well as clinical, behavioral and other physiological data across multiple independent sites. Here, we summarize the ECT sample characteristics from currently participating sites, and the common data-repository and standardized image analysis pipeline developed for this initiative. This includes data harmonization across sites and MRI platforms, and a method for obtaining unbiased estimates of structural change based on longitudinal measurements with serial MRI scans. The optimized analysis pipeline, together with the large and heterogeneous combined GEMRIC dataset, will provide new opportunities to elucidate the mechanisms of ECT response and the factors mediating and predictive of clinical outcomes, which may ultimately lead to more effective personalized treatment approaches. (C) 2017 The Author(s). Published by Elsevier Inc.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD, 2017
Keywords
Electroconvulsive therapy; MRI; Longitudinal; Mega analysis; Multi-site
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:liu:diva-139647 (URN)10.1016/j.nicl.2017.02.009 (DOI)000405984300045 ()28275543 (PubMedID)
Note

Funding Agencies|Western Norway Regional Health Authority; Haukeland University Hospital; University of Bergen, Norway; Lundbeck Foundation; German Research Foundation (DFG) [FOR2107, 1151/5-1]; Innovative Medizinische Forschung (IMF) [RE111604]; Centers of Biomedical Research Excellence [2P20GM103472-01]; Swiss National Science Foundation (NCCR Synapsy) [32003B_159780]; Foundation Parkinson Switzerland; Foundation Synapsis; Roger de Spoelberch Foundation; National Institute of Mental Health [R01MH092301, K24MH102743]; Partridge Foundation

Available from: 2017-08-16 Created: 2017-08-16 Last updated: 2019-02-05
Bergamino, M., Pasternak, O., Farmer, M., Shenton, M. E. & Hamilton, P. (2016). Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression. NeuroImage: Clinical, 10, 336-342
Open this publication in new window or tab >>Applying a free-water correction to diffusion imaging data uncovers stress-related neural pathology in depression
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2016 (English)In: NeuroImage: Clinical, ISSN 0353-8842, E-ISSN 2213-1582, Vol. 10, p. 336-342Article in journal (Refereed) Published
Abstract [en]

Diffusion tensor imaging (DTI) holds promise for developing our understanding of white-matter pathology in major depressive disorder (MDD). Variable findings in DTI-based investigations ofMDD, however, have thwarted development of this literature. Effects of extra-cellular free-water on the sensitivity of DTI metrics could account for some of this inconsistency. Here we investigated whether applying a free-water correction algorithm to DTI data could improve the sensitivity to detect clinical effects using DTI metrics. Only after applying this correction, we found: a) significantly decreased fractional anisotropy and axial diffusivity (AD) in the left inferior frontooccipital fasciculus (IFOF) in MDD; and b) increased self-reported stress that significantly correlated with decreased IFOF AD in depression. We estimated and confirmed the robustness of differences observed between free-water corrected and uncorrected approaches using bootstrapping. We conclude that applying a free-water correction to DTI data increases the sensitivity of DTI-based metrics to detect clinical effects in MDD. (C) 2015 The Authors. Published by Elsevier Inc.

Place, publisher, year, edition, pages
Elsevier, 2016
Keywords
Diffusion tensor imaging; Free-water corrected DTI; Major depressive disorder; Tract-based spatial statistics; Fractional anisotropy; Axial diffusivity
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-127461 (URN)10.1016/j.nicl.2015.11.020 (DOI)000373189000033 ()27006903 (PubMedID)
Note

Funding Agencies|Warren Foundation

Available from: 2016-04-30 Created: 2016-04-26 Last updated: 2017-11-30Bibliographically approved
Hamilton, P. J., Glover, G. H., Bagarinao, E., Chang, C., Mackey, S., Sacchet, M. D. & Gotlib, I. H. (2016). Effects of salience-network-node neurofeedback training on affective biases in major depressive disorder. Psychiatry Research: Neuroimaging, 249, 91-96
Open this publication in new window or tab >>Effects of salience-network-node neurofeedback training on affective biases in major depressive disorder
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2016 (English)In: Psychiatry Research: Neuroimaging, ISSN 0925-4927, E-ISSN 1872-7506, Vol. 249, p. 91-96Article in journal (Refereed) Published
Abstract [en]

Neural models of major depressive disorder (MDD) posit that over-response of components of the brains salience network (SN) to negative stimuli plays a crucial role in the pathophysiology of MDD. In the present proof-of-concept study, we tested this formulation directly by examining the affective consequences of training depressed persons to down-regulate response of SN nodes to negative material. Ten participants in the real neurofeedback group saw, and attempted to learn to down-regulate, activity from an empirically identified node of the SN. Ten other participants engaged in an equivalent procedure with the exception that they saw SN-node neurofeedback indices from participants in the real neurofeedback group. Before and after scanning, all participants completed tasks assessing emotional responses to negative scenes and to negative and positive self-descriptive adjectives. Compared to participants in the sham-neurofeedback group, from pre- to post-training, participants in the realneurofeedback group showed a greater decrease in SN-node response to negative stimuli, a greater decrease in self-reported emotional response to negative scenes, and a greater decrease in self-reported emotional response to negative self-descriptive adjectives. Our findings provide support for a neural formulation in which the SN plays a primary role in contributing to negative cognitive biases in MDD. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2016
Keywords
Major depressive disorder; Neurofeedback; Functional magnetic resonance imaging; Salience network; Information processing biases
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-127261 (URN)10.1016/j.pscychresns.2016.01.016 (DOI)000372526600012 ()26862057 (PubMedID)
Note

Funding Agencies|National Institutes of Health [P41 EB15891, F32 MH079651, R01 MH59259]

Available from: 2016-04-20 Created: 2016-04-19 Last updated: 2017-11-30Bibliographically approved
Croy, I., Drechsler, E., Hamilton, P., Hummel, T. & Olausson, H. (2016). Olfactory modulation of affective touch processing - A neurophysiological investigation. NeuroImage, 135, 135-141
Open this publication in new window or tab >>Olfactory modulation of affective touch processing - A neurophysiological investigation
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2016 (English)In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, Vol. 135, p. 135-141Article in journal (Refereed) Published
Abstract [en]

Touch can be highly emotional, and depending on the environment, it can be perceived as pleasant and comforting or disgusting and dangerous. Here, we studied the impact of context on the processing of tactile stimuli using a functional magnetic resonance imaging (fMRI) paradigm. This was achieved by embedding tactile stimulation in a variable olfactory environment. Twenty people were scanned with BOLD fMRI while receiving the following stimulus blocks: Slow stroking Touch, Civette odor (feces like), Rose odor, Touch + Civette, and Touch + Rose. Ratings of pleasantness and intensity of tactile stimuli and ratings of disgust and intensity of olfactory stimuli were collected. The impact of the olfactory context on the processing of touch was studied using covariance analyses. Coupling between olfactory processing and somatosensory processing areas was assessed with psychophysiological interaction analysis (PPI). A subjectively disgusting olfactory environment significantly reduced the perceived pleasantness of touch. The touch fMRI activation in the secondary somatosensory cortex, operculum 1 (OP1), was positively correlated with the disgust towards the odors. Decreased pleasantness of touch was related to decreased posterior insula activity. PPI analysis revealed a significant interaction between the OP1, posterior insula, and regions processing the disgust of odors (orbitofrontal cortex and amygdala). We conclude that the disgust evaluation of the olfactory environment moderates neural reactivity in somatosensory regions by upregulation of the OP1 and downregulation of the posterior insula. This adaptive regulation of affective touch processing may facilitate adaptive reaction to a potentially harmful stimulus. (C) 2016 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE, 2016
Keywords
C tactile; Hedonic; fMRI; Somatosensory; Olfaction
National Category
Psychology (excluding Applied Psychology)
Identifiers
urn:nbn:se:liu:diva-130263 (URN)10.1016/j.neuroimage.2016.04.046 (DOI)000378047600011 ()27138206 (PubMedID)
Note

Funding Agencies|Swedish Research Council [2015-02684]; German Research Foundation (DFG) [CR 479/1-1]

Available from: 2016-08-01 Created: 2016-07-28 Last updated: 2017-11-28
Frost Bellgowan, J., Molfese, P., Marx, M., Thomason, M., Glen, D., Santiago, J., . . . Hamilton, P. J. (2015). A Neural Substrate for Behavioral Inhibition in the Risk for Major Depressive Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 54(10), 841-848
Open this publication in new window or tab >>A Neural Substrate for Behavioral Inhibition in the Risk for Major Depressive Disorder
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2015 (English)In: Journal of the American Academy of Child and Adolescent Psychiatry, ISSN 0890-8567, E-ISSN 1527-5418, Vol. 54, no 10, p. 841-848Article in journal (Refereed) Published
Abstract [en]

Objective: Behavioral inhibition (BI) is an early developing trait associated with cautiousness and development of clinical depression and anxiety. Little is known about the neural basis of BI and its predictive importance concerning risk for internalizing disorders. We looked at functional connectivity of the default-mode network (DMN) and salience network (SN), given their respective roles in self-relational and threat processing, in the risk for internalizing disorders, with an emphasis on determining the functional significance of these networks for BI. Method: We used functional magnetic resonance imaging to scan, during the resting state, children and adolescents 8 to 17 years of age who were either at high familial risk (HR; n = 16) or low familial risk (LR; n = 18) for developing clinical depression and/or anxiety. Whole-brain DMN and SN functional connectivity were estimated for each participant and compared across groups. We also compared the LR and HR groups on levels of BI and anxiety, and incorporated these data into follow-up neurobehavioral correlation analyses. Results: The HR group, relative to the LR group, showed significantly decreased DMN connectivity with the ventral striatum and bilateral sensorimotor cortices. Within the HR group, trait BI increased as DMN connectivity with the ventral striatum and sensorimotor cortex decreased. The HR and LR groups did not differ with respect to SN connectivity. Conclusion: Our findings show, in the risk for internalizing disorders, a negative functional relation between brain regions supporting self-relational processes and reward prediction. These findings represent a potential neural substrate for behavioral inhibition in the risk for clinical depression and anxiety.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV, 2015
Keywords
depression risk; default-mode; ventral striatum; behavioral inhibition; fMRI
National Category
Psychiatry
Identifiers
urn:nbn:se:liu:diva-122434 (URN)10.1016/j.jaac.2015.08.001 (DOI)000362056800012 ()26407494 (PubMedID)
Note

Funding Agencies|Warren Foundation

Available from: 2015-11-03 Created: 2015-11-02 Last updated: 2017-12-01
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