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Publications (9 of 9) Show all publications
Senti, G., Freiburghaus, A. U., Larenas-Linnemann, D., Hoffmann, H. J., Patterson, A. M., Klimek, L., . . . Kündig, T. M. (2019). Intralymphatic Immunotherapy: Update and Unmet Needs.. International Archives of Allergy and Immunology, 178(2), 141-149
Open this publication in new window or tab >>Intralymphatic Immunotherapy: Update and Unmet Needs.
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2019 (English)In: International Archives of Allergy and Immunology, ISSN 1018-2438, E-ISSN 1423-0097, Vol. 178, no 2, p. 141-149Article, review/survey (Refereed) Published
Abstract [en]

Allergen-specific immunotherapy (AIT) is the only allergy treatment that confers long-term symptom amelioration for patients suffering from allergy. The most frequently used allergen application route is subcutaneous injection (SCIT), commonly taken as the gold standard, followed by sublingual (SLIT) or oral (OIT) application of allergen preparations. This is an up-to-date review of the clinical evidence for a novel route of allergen application, i.e., directly into lymph nodes - intralymphatic immunotherapy (ILIT). The major advantages of ILIT over the current AIT approaches are its short duration and the low allergen doses administered. The whole treatment consists of merely 3 ultrasound-guided injections into inguinal lymph nodes 1 month apart. While the number of patients included in randomised controlled trials is still limited, the clinical results for ILIT are encouraging, but more clinical trials are needed, as well as more preclinical work for optimising formulations.

Place, publisher, year, edition, pages
S. Karger, 2019
Keywords
Allergen-specific immunotherapy, Allergy, Clinical trials, Intralymphatic immunotherapy
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:liu:diva-154633 (URN)10.1159/000493647 (DOI)000459512200005 ()30391954 (PubMedID)
Note

Funding agencies: EAACI Task Force

Available from: 2019-02-24 Created: 2019-02-24 Last updated: 2019-03-08
Nyström, U. & Ahlbeck, L. (2018). Allergi och annan överkänslighet (6ed.). In: Ulf Dahlström, Stergios Kechagias, Leif Stenke (Ed.), Internmedicin: (pp. 31-58). Liber
Open this publication in new window or tab >>Allergi och annan överkänslighet
2018 (English)In: Internmedicin / [ed] Ulf Dahlström, Stergios Kechagias, Leif Stenke, Liber, 2018, 6, p. 31-58Chapter in book (Other academic)
Place, publisher, year, edition, pages
Liber, 2018 Edition: 6
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:liu:diva-154642 (URN)9789147113262 (ISBN)
Available from: 2019-02-24 Created: 2019-02-24 Last updated: 2019-02-25Bibliographically approved
Ahlbeck, L. (2018). Astma lathund: Astma hos vuxna. AstraZeneca Nordic-Baltic
Open this publication in new window or tab >>Astma lathund: Astma hos vuxna
2018 (Swedish)Other (Other academic)
Abstract [sv]

Åtta till tio procent av den vuxna befolkningen har astma. Av dessa har65 procent lindrig, 25 procent medelsvår och 10 procent svår astma.Astma är en heterogen sjukdom, där en kronisk luftvägsinflammationoftast föreligger.

Sjukdomen kännetecknas av återkommande luftvägssymtom såsom pipi bröstet, andnöd, trånghetskänsla i bröstet och hosta som varierar övertiden tillsammans med en variabel luftvägsobstruktion.

Place, publisher, year, pages
AstraZeneca Nordic-Baltic, 2018. p. 20
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:liu:diva-154862 (URN)
Available from: 2019-03-01 Created: 2019-03-01 Last updated: 2019-03-05Bibliographically approved
Nyström Kronander, U. & Ahlbeck, L. (2018). Atopi, allergi och överkänslighet. In: Läkemedelsboken: . Läkemedelsverket
Open this publication in new window or tab >>Atopi, allergi och överkänslighet
2018 (Swedish)In: Läkemedelsboken, Läkemedelsverket , 2018Chapter in book (Other academic)
Place, publisher, year, edition, pages
Läkemedelsverket, 2018
Series
Läkemedelsboken, ISSN 0347-8343
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:liu:diva-154641 (URN)
Available from: 2019-02-24 Created: 2019-02-24 Last updated: 2019-03-08
Ahlbeck, L., Ahlberg, E., Nyström Kronander, U., Björkander, J. & Jenmalm, M. (2018). Intralymphatic allergen immunotherapy against pollen allergy. A 3-year open follow-up study of 10 patients. Annals of Allergy, Asthma & Immunology, 121(5), 626-627
Open this publication in new window or tab >>Intralymphatic allergen immunotherapy against pollen allergy. A 3-year open follow-up study of 10 patients
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2018 (English)In: Annals of Allergy, Asthma & Immunology, ISSN 1081-1206, E-ISSN 1534-4436, Vol. 121, no 5, p. 626-627Article in journal (Refereed) Published
Abstract [en]

To date, allergen immunotherapy (AIT) is the only treatment that affects the long-term development of allergic rhinoconjunctivitis and induces clinical tolerance primarily by stimulating regulatory T (Treg) cells, attenuating T helper 2 (Th2) responses and synthesis of blocking antibodies1. Conventional AIT with subcutaneous injections, sublingual tablets or drops is effective, but consumes time and resources 2.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Immunotherapy, Intralymphatic, Allergy, Rhinoconjunctivitis, T-cells
National Category
Clinical Medicine
Identifiers
urn:nbn:se:liu:diva-150594 (URN)10.1016/j.anai.2018.07.010 (DOI)000448665400022 ()30021119 (PubMedID)
Note

Funding agencies: Region Ostergotland; Allergy Center in Linkoping; Medical Research Council of Southeast Sweden (FORSS); Bergh Foundation; Asthma and Allergy Association of Sweden

Available from: 2018-08-28 Created: 2018-08-28 Last updated: 2019-04-09Bibliographically approved
Stridh, B., Romberg, K., Ställberg, B., Ahlbeck, L., Kiotseridis, H. & Janson, C. (2018). Många överbehandlas med astmamedicin [When and how to step down asthma treatment]. Läkartidningen, 115
Open this publication in new window or tab >>Många överbehandlas med astmamedicin [When and how to step down asthma treatment]
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2018 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 115Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Stockholm, Sweden: Läkartidningen Förlag AB, 2018
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:liu:diva-152144 (URN)
Available from: 2018-10-19 Created: 2018-10-19 Last updated: 2019-05-03Bibliographically approved
Løkke, A., Ahlbeck, L., Bjermer, L., Mortensen, J., Østrem, A., Pasternack, I., . . . Torvinen, S. (2015). Expert Nordic perspectives on the potential of novel inhalers to overcome unmet needs in the management of obstructive lung disease. European clinical respiratory journal, 2, 1-8, Article ID 29445.
Open this publication in new window or tab >>Expert Nordic perspectives on the potential of novel inhalers to overcome unmet needs in the management of obstructive lung disease
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2015 (English)In: European clinical respiratory journal, ISSN 2001-8525, Vol. 2, p. 1-8, article id 29445Article, review/survey (Refereed) Published
Abstract [en]

The effective self-management of obstructive lung disease is dependent upon the patient achieving good inhaler technique. However, many current inhalers are complicated to use, which may lead to handling difficulties. These difficulties can cause clinically relevant errors, whereby pharmacotherapy fails to achieve adequate lung deposition and therapeutic effect. In this report, the potential of novel inhaler devices to overcome unmet needs in the management of obstructive lung disease is considered by a panel of Nordic experts. The panel concludes that innovative inhalers can contribute to good disease management and better use of healthcare resources.

Keywords
COPD; access; asthma; choice; cost; dry powder inhaler; economic; innovation; medication errors; metered dose inhaler; obstructive lung disease; outcome; patient compliance; patient preference; price; reimbursement; substitution
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:liu:diva-126609 (URN)10.3402/ecrj.v2.29445 (DOI)26689215 (PubMedID)
Available from: 2016-03-31 Created: 2016-03-31 Last updated: 2018-03-20
Ahlbeck, L. (2014). Astmainhalator med återkopplingssystem gav bättre vård och sänkta kostnader [Asthma inhaler with feedback system provided better care and lower costs].. Läkartidningen, 111(5), 160-160
Open this publication in new window or tab >>Astmainhalator med återkopplingssystem gav bättre vård och sänkta kostnader [Asthma inhaler with feedback system provided better care and lower costs].
2014 (Swedish)In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 111, no 5, p. 160-160Article in journal, Editorial material (Other academic) Published
Place, publisher, year, edition, pages
Läkartidningen Förlag, 2014
National Category
Respiratory Medicine and Allergy
Identifiers
urn:nbn:se:liu:diva-154634 (URN)24624769 (PubMedID)
Available from: 2019-02-24 Created: 2019-02-24 Last updated: 2019-02-24
Ahlbeck, L., Faresjö, T. & Åkerlind, I. (1996). Differences in patient perception of appropriate level of care. European Journal of General Practice, 2(3), 109-112
Open this publication in new window or tab >>Differences in patient perception of appropriate level of care
1996 (English)In: European Journal of General Practice, Vol. 2, no 3, p. 109-112Article in journal (Refereed) Published
Abstract [en]

Objectives: The principle of achieving the most cost-effective level of care in relation to needs is an essential aim for all health care systems. However, it is not certain that the corresponding knowledge and attitudes with respect to the appropriate level of care for different symptoms can be found in the general population. There may be age-related differences in illness behaviour that manifest in ‘overutilisation’ of the system. We studied illness behaviour with regard to attitudes and inclination to seek care for different symptoms at various levels in the health care system.Methods: The study group consisted of a random selection of 296 persons, born in the 1940s, ′50s and ′60s, and living in a defined region in Sweden. In a questionnaire they had to choose between different levels of care for twelve symptom descriptions with varying degrees of severity. The answers were scored according to the level of care, adequacy and overutilisation.Results: The vast majority of participants chose an adequate level of care. However, overutilisation was found, particularly among women born in the 1960s and to some extent among men born in the 1940s. These two groups together constituted about 70% of all the individuals who tended to overutilise the health care in their expressed preferences.Conclusions: These individuals do not receive cost-effective care, or the most adequate care with regard to their needs. The results indicate, however, that the problem was more a question of attitude rather than a lack of knowledge and information.

Place, publisher, year, edition, pages
Taylor & Francis, 1996
National Category
General Practice
Identifiers
urn:nbn:se:liu:diva-154635 (URN)10.3109/13814789609161540 (DOI)
Available from: 2019-02-24 Created: 2019-02-24 Last updated: 2019-02-24
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-1745-6816

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