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Wretman, Anna
Publications (2 of 2) Show all publications
Witt, S. T., Drissi, N. M., Tapper, S., Wretman, A., Szakács, A., Hallböök, T., . . . Engström, M. (2018). Evidence for cognitive resource imbalance in adolescents with narcolepsy. Brain Imaging and Behavior, 12(2), 411-424
Open this publication in new window or tab >>Evidence for cognitive resource imbalance in adolescents with narcolepsy
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2018 (English)In: Brain Imaging and Behavior, ISSN 1931-7557, E-ISSN 1931-7565, Vol. 12, no 2, p. 411-424Article in journal (Refereed) Published
Abstract [en]

The study investigated brain activity changes during performance of a verbal working memory task in a population of adolescents with narcolepsy. Seventeen narcolepsy patients and twenty healthy controls performed a verbal working memory task during simultaneous fMRI and EEG acquisition. All subjects also underwent MRS to measure GABA and Glutamate concentrations in the medial prefrontal cortex. Activation levels in the default mode network and left middle frontal gyrus were examined to investigate whether narcolepsy is characterized by an imbalance in cognitive resources. Significantly increased deactivation within the default mode network during task performance was observed for the narcolepsy patients for both the encoding and recognition phases of the task. No evidence for task performance deficits or reduced activation within the left middle frontal gyrus was noted for the narcolepsy patients. Correlation analyses between the spectroscopy and fMRI data indicated that deactivation of the anterior aspect of the default mode in narcolepsy patients correlated more with increased concentrations of Glutamate and decreased concentrations of GABA. In contrast, deactivation in the default mode was correlated with increased concentrations of GABA and decreased concentrations of Glutamate in controls. The results suggested that narcolepsy is not characterized by a deficit in working memory but rather an imbalance of cognitive resources in favor of monitoring and maintaining attention over actual task performance. This points towards dysregulation within the sustained attention system being the origin behind self-reported cognitive difficulties in narcolepsy.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2018
EEG, GABA, MRS, Narcolepsy, Working memory, fMRI
National Category
Radiology, Nuclear Medicine and Medical Imaging
urn:nbn:se:liu:diva-145535 (URN)10.1007/s11682-017-9706-y (DOI)000429029000011 ()28321606 (PubMedID)2-s2.0-85015625386 (Scopus ID)
Available from: 2018-03-05 Created: 2018-03-05 Last updated: 2019-05-01Bibliographically approved
Nieminen, K., Berg, I., Frankenstein, K., Viita, L., Larsson, K., Persson, U., . . . Wijma, K. (2016). Internet-provided cognitive behaviour therapy of posttraumatic stress symptoms following childbirth—a randomized controlled trial. Cognitive Behaviour Therapy, 45(4), 287-306
Open this publication in new window or tab >>Internet-provided cognitive behaviour therapy of posttraumatic stress symptoms following childbirth—a randomized controlled trial
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2016 (English)In: Cognitive Behaviour Therapy, ISSN 1650-6073, E-ISSN 1651-2316, Vol. 45, no 4, p. 287-306Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to analyse the effects of trauma-focused guided Internet-based cognitive behaviour therapy for relieving posttraumatic stress disorder (PTSD) symptoms following childbirth, a problem that about 3% women encounter postpartum. Following inclusion, 56 traumatized women were randomized to either treatment or to a waiting list control group. Primary outcome measures were the Traumatic Event Scale (TES) and Impact of Event Scale—Reversed (IES-R). Secondary measures were Beck depression inventory II, Patient Health Questionnaire (PHQ-9), Beck Anxiety Inventory, Quality Of Life Inventory and the EuroQol 5 Dimensions. The treatment was guided by a clinician and lasted eight weeks and comprised eight modules of written text. The between-group effect size (ES) was d = .82 (p < .0001) for the IES-R. The ES for the TES was small (d = .36) and not statistically significant (p = .09). A small between-group ES (d = .20; p = .02) was found for the PHQ-9. The results from pre- to post-treatment showed large within-group ESs for PTSD symptoms in the treatment group both on the TES (d = 1.42) and the IES-R (d = 1.30), but smaller ESs in the control group from inclusion to after deferred treatment (TES, d = .80; IES-R d = .45). In both groups, the treatment had positive effects on comorbid depression and anxiety, and in the treatment group also on quality of life. The results need to be verified in larger trials. Further studies are also needed to examine long-term effects.

Place, publisher, year, edition, pages
Routledge, 2016
Childbirth; Internet-based cognitive behaviour therapy (ICBT); posttraumatic stress disorder (PTSD); trauma-focused psychotherapy
National Category
Applied Psychology
urn:nbn:se:liu:diva-127695 (URN)10.1080/16506073.2016.1169626 (DOI)000379764500003 ()27152849 (PubMedID)

Funding agencies: Linkoping University (LiU) Department of Behavioral Sciences and Learning; Region Council in Ostergotland (RO)

Available from: 2016-05-09 Created: 2016-05-09 Last updated: 2018-03-20Bibliographically approved

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