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Hagenblad, Jenny, Associate ProfessorORCID iD iconorcid.org/0000-0002-9850-5546
Publications (10 of 30) Show all publications
Hagenblad, J., Leino, M. W., Hernàndez Afonso, G. & Afonso Morales, D. (2019). Morphological and genetic characterization of barley (Hordeum vulgare L.) landraces in the Canary Islands. Genetic Resources and Crop Evolution, 66(2), 465-480
Open this publication in new window or tab >>Morphological and genetic characterization of barley (Hordeum vulgare L.) landraces in the Canary Islands
2019 (English)In: Genetic Resources and Crop Evolution, ISSN 0925-9864, E-ISSN 1573-5109, Vol. 66, no 2, p. 465-480Article in journal (Refereed) Published
Abstract [en]

Barley has been continuously cultivated in the Canary archipelago for millennia, and to this day landrace barley is the preferred choice for cultivation. We have morphologically and genetically characterized 57 landraces collected during the twenty-first century and conserved in genebanks. The majority of accessions were of the six-row type. Although landraces from the same island tended to be similar, the results showed morphological and genetic diversity both within and in the case of genetic data among islands. Accessions from the easternmost islands were genetically distinct from those from the central and western islands. Accessions from the western islands often had a mixed genetical composition, suggesting more recent exchange of plant material with the central islands. The geographic distribution of diversity suggests that conservation of barley genetic resources needs to consider all islands in the archipelago. Landrace barley from the Canary archipelago was found to be morphologically distinct from continental landrace barley. We suggest the uniqueness of Canarian barley, in terms of morphology and genetic diversity, can be used for marketing purposes providing added market value to the crop.

Place, publisher, year, edition, pages
Springer Netherlands, 2019
Keywords
Landrace barley, Genebank conservation, Morphological characterization, Genetic diversity, Hordeum vulgare
National Category
Natural Sciences Ecology
Identifiers
urn:nbn:se:liu:diva-153233 (URN)10.1007/s10722-018-0726-2 (DOI)000457581200013 ()
Funder
The Royal Swedish Academy of Letters, History and Antiquities (KVHAA)
Note

Funding agencies: Olle Engkvist Byggmastare foundation; Royal Swedish Academy of Letters, History and Antiquities

Available from: 2018-12-04 Created: 2018-12-04 Last updated: 2019-02-20Bibliographically approved
Helsen, K., Hagenblad, J., Acharya, K. P., Brunet, J., Cousins, S. A., Decocq, G., . . . Graae, B. J. (2019). No genetic erosion after five generations for Impatiens glandulifera populationsacross the invaded range in Europe. BMC Genetics, 20, Article ID 20.
Open this publication in new window or tab >>No genetic erosion after five generations for Impatiens glandulifera populationsacross the invaded range in Europe
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2019 (English)In: BMC Genetics, ISSN 1471-2156, E-ISSN 1471-2156, Vol. 20, article id 20Article in journal (Refereed) Published
Abstract [en]

Background: The observation that many alien species become invasive despite low genetic diversity has long been considered the ‘genetic paradox’ in invasion biology. This paradox is often resolved through the temporal buildup genetic diversity through multiple introduction events. These temporal dynamics in genetic diversity are especially important for annual invasive plants that lack a persistent seed bank, for which population persistence is strongly dependent on consecutive seed ‘re-establishment’ in each growing season. Theory predicts that the number of seeds during re-establishment, and the levels of among-population gene flow can strongly affect recolonization dynamics, resulting in either an erosion or build-up of population genetic diversity through time. This study focuses on temporal changes in the population genetic structure of the annual invasive plant Impatiens glandulifera across Europe. We resampled 13 populations in 6 regions along a 1600 km long latitudinal gradient from northern France to central Norway after 5 years, and assessed population genetic diversity with 9 microsatellite markers.

Results: Our study suggests sufficiently high numbers of genetically diverse founders during population re- establishment, which prevent the erosion of local genetic diversity. We furthermore observe that I. glanduliferaexperiences significant among-population gene flow, gradually resulting in higher genetic diversity and lower overall genetic differentiation through time. Nonetheless, moderate founder effects concerning population genetic composition (allele frequencies) were evident, especially for smaller populations.

Despite the initially low genetic diversity, this species seems to be successful at persisting across its invaded range, and will likely continue to build up higher genetic diversity at the local scale.

Place, publisher, year, edition, pages
BioMed Central, 2019
Keywords
Colonization event, Founder effect, Genetic bottleneck, Himalayan balsam, Latitudinal gradient, Population re-establishment, SSRs
National Category
Biological Sciences
Identifiers
urn:nbn:se:liu:diva-154518 (URN)10.1186/s12863-019-0721-4 (DOI)000459422100001 ()30782117 (PubMedID)
Note

Funding agencies:  Norwegian University of Science and Technology (NTNU) [81617824]; Det Kongelige Norske Videnskabers Selskab (DKNVS) through the I.K. Lykke research grant

Available from: 2019-02-20 Created: 2019-02-20 Last updated: 2019-03-08Bibliographically approved
Lempiäinen-Avci, M., Lundström, M., Huttunen, S., Leino, M. W. & Hagenblad, J. (2018). Archaeological and Historical Materials as a Means to Explore Finnish Crop History. Environmental Archaeology
Open this publication in new window or tab >>Archaeological and Historical Materials as a Means to Explore Finnish Crop History
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2018 (English)In: Environmental Archaeology, ISSN 1461-4103, E-ISSN 1749-6314Article in journal (Refereed) Epub ahead of print
Abstract [en]

In Northern Europe, barley (Hordeum vulgare L.) has been cultivated for almost 6000 years. Thus far, 150-year-old grains from historical collections have been used to investigate the distribution of barley diversity and how the species has spread across the region. Genetic studies of archaeobotanical material from agrarian sites could potentially clarify earlier migration patterns and cast further light on the origin of barley landraces. In this study, we aimed to evaluate different archaeological and historical materials with respect to DNA content, and to explore connections between Late Iron Age and medieval barley populations and historical samples of barley landraces in north-west Europe. The material analysed consisted of archaeological samples of charred barley grains from four sites in southern Finland, and historical material, with 33 samples obtained from two herbaria and the seed collections of the Swedish museum of cultural history.

The DNA concentrations obtained from charred archaeological barley remains were too low for successful KASP genotyping confirming previously reported difficulties in obtaining aDNA from charred remains. Historical samples from herbaria and seed collection confirmed previously shown strong genetic differentiation between two-row and six-row barley. Six-row barley accessions from northern and southern Finland tended to cluster apart, while no geographical structuring was observed among two-row barley. Genotyping of functional markers revealed that the majority of barley cultivated in Finland in the late nineteenth and early twentieth century was late-flowering under increasing day-length, supporting previous findings from northern European barley.

Place, publisher, year, edition, pages
Routledge, 2018
Keywords
aDNA, archaeobotany, barley, genetic diversity, Hordeum vulgare, KASP, landraces
National Category
Genetics
Identifiers
urn:nbn:se:liu:diva-151277 (URN)10.1080/14614103.2018.1482598 (DOI)2-s2.0-85048366875 (Scopus ID)
Available from: 2018-09-14 Created: 2018-09-14 Last updated: 2018-12-11Bibliographically approved
Lundström, M., Forsberg, N., Heimdahl, J., Hagenblad, J. & Leino, M. W. (2018). Genetic analyses of Scandinavian desiccated, charred and waterlogged remains of barley (Hordeum vulgare L.). Journal of Archaeological Science: Reports, 22, 11-20
Open this publication in new window or tab >>Genetic analyses of Scandinavian desiccated, charred and waterlogged remains of barley (Hordeum vulgare L.)
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2018 (English)In: Journal of Archaeological Science: Reports, ISSN 2352-409X, Vol. 22, p. 11-20Article in journal (Refereed) Published
Abstract [en]

Barley, Hordeum vulgare L., has been cultivated in Fennoscandia (Denmark, Norway, Sweden, Finland) since the start of the Neolithic around 4000 years BCE. Genetic studies of extant and 19th century barley landraces from the area have previously shown that distinct genetic groups exist with geographic structure according to latitude, suggesting strong local adaptation of cultivated crops. It is, however, not known what time depth these patterns reflect. Here we evaluate different archaeobotanical specimens of barley, extending several centuries in time, for their potential to answer this question by analysis of aDNA. Forty-six charred grains, nineteen waterlogged specimens and nine desiccated grains were evaluated by PCR and KASP genotyping. The charred samples did not contain any detectable endogenous DNA. Some waterlogged samples permitted amplification of endogenous DNA, however not sufficient for subsequent analysis. Desiccated plant materials provided the highest genotyping success rates of the materials analysed here in agreement with previous studies. Five desiccated grains from a grave from 1679 in southern Sweden were genotyped with 100 SNP markers and data compared to genotypes of 19th century landraces from Fennoscandia. The results showed that the genetic composition of barley grown in southern Sweden changed very little from late 17th to late 19th century and farmers stayed true to locally adapted crops in spite of societal and agricultural development.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Ancient DNA, Barley, Population structure, 17th century, Landraces
National Category
Genetics
Identifiers
urn:nbn:se:liu:diva-151282 (URN)10.1016/j.jasrep.2018.09.006 (DOI)
Available from: 2018-09-14 Created: 2018-09-14 Last updated: 2018-12-11Bibliographically approved
Lundström, M., Leino, M. W. & Hagenblad, J. (2017). Evolutionary history of the NAM-B1 gene in wild and domesticated tetraploid wheat. BMC Genetics, 18, Article ID 118.
Open this publication in new window or tab >>Evolutionary history of the NAM-B1 gene in wild and domesticated tetraploid wheat
2017 (English)In: BMC Genetics, ISSN 1471-2156, E-ISSN 1471-2156, Vol. 18, article id 118Article in journal (Refereed) Published
Abstract [en]

Background

The NAM-B1 gene in wheat has for almost three decades been extensively studied and utilized in breeding programs because of its significant impact on grain protein and mineral content and pleiotropic effects on senescence rate and grain size. First detected in wild emmer wheat, the wild-type allele of the gene has been introgressed into durum and bread wheat. Later studies have, however, also found the presence of the wild-type allele in some domesticated subspecies. In this study we trace the evolutionary history of the NAM-B1 in tetraploid wheat species and evaluate it as a putative domestication gene.

Results

Genotyping of wild and landrace tetraploid accessions showed presence of only null alleles in durum. Domesticated emmer wheats contained both null alleles and the wild-type allele while wild emmers, with one exception, only carried the wild-type allele. One of the null alleles consists of a deletion that covers several 100 kb. The other null-allele, a one-basepair frame-shift insertion, likely arose among wild emmer. This allele was the target of a selective sweep, extending over several 100 kb.

Conclusions

The NAM-B1 gene fulfils some criteria for being a domestication gene by encoding a trait of domestication relevance (seed size) and is here shown to have been under positive selection. The presence of both wild-type and null alleles in domesticated emmer does, however, suggest the gene to be a diversification gene in this species. Further studies of genotype-environment interactions are needed to find out under what conditions selection on different NAM-B1 alleles have been beneficial.

Place, publisher, year, edition, pages
BioMed Central, 2017
Keywords
Selective sweep, Grain protein content (GPC), Emmer, Durum, Domestication gene
National Category
Genetics Evolutionary Biology
Identifiers
urn:nbn:se:liu:diva-144103 (URN)10.1186/s12863-017-0566-7 (DOI)000418687000001 ()
Available from: 2018-01-05 Created: 2018-01-05 Last updated: 2018-12-11Bibliographically approved
Karlsson, A.-C., Fallahsharoudi, A., Johnsen, H., Hagenblad, J., Wright, D., Andersson, L. & Jensen, P. (2016). A domestication related mutation in the thyroid stimulating hormonereceptor gene (TSHR) modulates photoperiodic response andreproduction in chickens. General and Comparative Endocrinology, 228, 69-78
Open this publication in new window or tab >>A domestication related mutation in the thyroid stimulating hormonereceptor gene (TSHR) modulates photoperiodic response andreproduction in chickens
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2016 (English)In: General and Comparative Endocrinology, ISSN 0016-6480, E-ISSN 1095-6840, Vol. 228, p. 69-78Article in journal (Refereed) Published
Abstract [en]

The thyroid stimulating hormone receptor gene (TSHR) has been suggested to be a ‘‘domestication locus”in the chicken. A strong selective sweep over TSHR in domestic breeds together with significant effects ofa mutation in the gene on several domestication related traits, indicate that the gene has been importantfor chicken domestication. TSHR plays a key role in the signal transduction of seasonal reproduction,which is characteristically less strict in domestic animals. We used birds from an advanced intercross linebetween ancestral Red Junglefowl (RJF) and domesticated White Leghorn (WL) to investigate effects ofthe mutation on reproductive traits as well as on TSHB, TSHR, DIO2 and DIO3 gene expression duringaltered day length (photoperiod). We bred chickens homozygous for either the mutation (d/d) or wildtype allele (w/w), allowing assessment of the effect of genotype at this locus while also controlling forbackground variation in the rest of the genome. TSHR gene expression in brain was significantly lowerin both d/d females and males and d/d females showed a faster onset of egg laying at sexual maturity thanw/w. Furthermore, d/d males showed a reduced testicular size response to decreased day length, andlower levels of TSHB and DIO3 expression. Additionally, purebred White Leghorn females kept under naturalshort day length in Sweden during December had active ovaries and lower levels of TSHR and DIO3expression compared to Red Junglefowl females kept under similar conditions. Our study indicates thatthe TSHR mutation affects photoperiodic response in chicken by reducing dependence of seasonal reproduction,a typical domestication feature, and may therefore have been important for chickendomestication.

Place, publisher, year, edition, pages
Elsevier, 2016
Keywords
Domestication, DIO2, DIO3, TSHB Chicken, Gallus gallus
National Category
Zoology
Identifiers
urn:nbn:se:liu:diva-125283 (URN)10.1016/j.ygcen.2016.02.010 (DOI)000372681400010 ()26873630 (PubMedID)
Note

Funding agencies:  Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning, FORMAS (Formel Excel); Swedish Research Council, VR; European Research Council (ERC) [322206]

Available from: 2016-02-19 Created: 2016-02-19 Last updated: 2017-11-30
Vanhala, T., Normann, K. R., Lundström, M., Weller, J. L., Leino, M. & Hagenblad, J. (2016). Flowering time adaption in Swedish landrace pea (Pisum sativum L.). BMC Genetics, 17(1), 117
Open this publication in new window or tab >>Flowering time adaption in Swedish landrace pea (Pisum sativum L.)
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2016 (English)In: BMC Genetics, ISSN 1471-2156, E-ISSN 1471-2156, Vol. 17, no 1, p. 117-Article in journal (Refereed) Published
Abstract [en]

Background: Cultivated crops have repeatedly faced new climatic conditions while spreading from their site oforigin. In Sweden, at the northernmost fringe of Europe, extreme conditions with temperature-limited growthseasons and long days require specific adaptation. Pea (Pisum sativum L.) has been cultivated in Sweden formillennia, allowing for adaptation to the local environmental conditions to develop. To study such adaptation, 15Swedish pea landraces were chosen alongside nine European landraces, seven cultivars and three wild accessions.Number of days to flowering (DTF) and other traits were measured and the diversity of the flowering time genesHIGH RESPONSE TO PHOTOPERIOD (HR), LATE FLOWERING (LF) and STERILE NODES (SN) was assessed. Furthermore, theexpression profiles of LF and SN were obtained.Results: DTF was positively correlated with the length of growing season at the site of origin (GSO) of the Swedishlandraces. Alleles at the HR locus were significantly associated with DTF with an average difference of 15.43 daysbetween the two detected haplotypes. LF expression was found to have a significant effect on DTF when analysedon its own, but not when HR haplotype was added to the model. HR haplotype and GSO together explained themost of the detected variation in DTF (49.6 %).Conclusions: We show local adaptation of DTF, primarily in the northernmost accessions, and links betweengenetic diversity and diversity in DTF. The links between GSO and genetic diversity of the genes are less clear-cutand flowering time adaptation seems to have a complex genetic background.

Place, publisher, year, edition, pages
BioMed Central, 2016
Keywords
Crop evolution, HIGH RESPONSE TO PHOTOPERIOD (HR), LATE FLOWERING (LF), Legumes, Local adaptation, STERILE NODES (SN
National Category
Genetics
Identifiers
urn:nbn:se:liu:diva-130546 (URN)10.1186/s12863-016-0424-z (DOI)000381569600001 ()27521156 (PubMedID)
Note

Funding agencies: Swedish Board of Agriculture; Erik Philip-Sorensen Foundation; Royal Swedish Academy of Forestry and Agriculture (CF Lundstrom foundation); Royal Swedish Academy of Forestry and Agriculture (Adolf Dahl foundation)

Available from: 2016-08-15 Created: 2016-08-15 Last updated: 2018-03-21
Hagenblad, J., Oliveira, H. R., Forsberg, N. E. G. & Leino, M. W. (2016). Geographical distribution of genetic diversity in Secale landrace and wild accessions. BMC Plant Biology, 16(23)
Open this publication in new window or tab >>Geographical distribution of genetic diversity in Secale landrace and wild accessions
2016 (English)In: BMC Plant Biology, ISSN 1471-2229, E-ISSN 1471-2229, Vol. 16, no 23Article in journal (Refereed) Published
Abstract [en]

Background: Rye, Secale cereale L., has historically been a crop of major importance and is still a key cereal in manyparts of Europe. Single populations of cultivated rye have been shown to capture a large proportion of the geneticdiversity present in the species, but the distribution of genetic diversity in subspecies and across geographical areasis largely unknown. Here we explore the structure of genetic diversity in landrace rye and relate it to that of wildand feral relatives.Results: A total of 567 SNPs were analysed in 434 individuals from 76 accessions of wild, feral and cultivated rye. Geneticdiversity was highest in cultivated rye, slightly lower in feral rye taxa and significantly lower in the wild S. strictum Presl.and S. africanum Stapf. Evaluation of effects from ascertainment bias suggests underestimation of diversity primarily inS. strictum and S. africanum. Levels of ascertainment bias, STRUCTURE and principal component analyses all supportedthe proposed classification of S. africanum and S. strictum as a separate species from S. cereale. S. afghanicum (Vav.)Roshev, S. ancestrale Zhuk., S. dighoricum(Vav.) Roshev, S. segetale (Zhuk.) Roshev and S. vavilovii Grossh. seemed, incontrast, to share the same gene pool as S. cereale and their genetic clustering was more dependent on geographicalorigin than taxonomic classification. S. vavilovii was found to be the most likely wild ancestor of cultivated rye. Amongcultivated rye landraces from Europe, Asia and North Africa five geographically discrete genetic clusters were identified.These had only limited overlap with major agro-climatic zones. Slash-and-burn rye from the Finnmark area in Scandinaviaformed a distinct cluster with little similarity to other landrace ryes. Regional studies of Northern and South-West Europedemonstrate different genetic distribution patterns as a result of varying cultivation intensity.Conclusions: With the exception of S. strictum and S. africanum different rye taxa share the majority of the geneticvariation. Due to the vast sharing of genetic diversity within the S. cereale clade, ascertainment bias seems to be a lesserproblem in rye than in predominantly selfing species. By exploiting within accession diversity geographic structure can beshown on a much finer scale than previously reported.

Place, publisher, year, edition, pages
BioMed Central, 2016
Keywords
Rye, Population structure, SNP, Ascertainment bias, Genetic variation, Phylogeography
National Category
Genetics
Identifiers
urn:nbn:se:liu:diva-124223 (URN)10.1186/s12870-016-0710-y (DOI)000368417000005 ()26786820 (PubMedID)
Note

Funding agencies: Lagersberg foundation; Sven och Lilly Lawskis Fond for Naturvetenskaplig Forskning; "Genomics and Evolutionary Biology" project - North Portugal Regional Operational Programme, under the National Strategic Reference Framework (NSRF), the European Regional

Available from: 2016-01-22 Created: 2016-01-22 Last updated: 2017-11-30Bibliographically approved
Videvall, E., Sletvold, N., Hagenblad, J., Ågren, J. & Hansson, B. (2016). Strong Maternal Effects on Gene Expression inArabidopsis lyrata Hybrids. Molecular Biology and Evolution, 33(4), 984-994
Open this publication in new window or tab >>Strong Maternal Effects on Gene Expression inArabidopsis lyrata Hybrids
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2016 (English)In: Molecular Biology and Evolution, ISSN 0737-4038, Vol. 33, no 4, p. 984-994Article in journal (Refereed) Published
Abstract [en]

Hybridization between populations or species can have pronounced fitness consequences. Yet little is known about howhybridization affects gene regulation. Three main models have been put forward to explain gene expression patterns inhybrids: additive, dominance, or parental effects. Here, we use high throughput RNA-sequencing to examine the extent towhich hybrid gene expression follows predictions by each of the three models. We performed a reciprocal crossingexperiment between two differentiated populations of the perennial herb Arabidopsis lyrata and sequenced RNA inrosette leaves of 12-week-old plants grown in greenhouse conditions. The two parental populations had highly differentiatedgene expression patterns. In hybrids, a majority of genes showed intermediate expression relative to that of theirparental populations (i.e., additive effects), but expression was frequently more similar to the maternal than to theirpaternal population (i.e., maternal effects). Allele-specific expression analyses showed that in the vast majority of cases,genes with pronounced maternal effect expressed both the maternal and the paternal allele. Maternal effects on hybridgene expression have rarely been documented previously and our study suggests it could be more common thanpreviously assumed. Whether the maternal effect on gene expression persists to later life-stages, and whether thevariation in gene expression is manifested in other aspects of the phenotype, remain to be elucidated. Our findingsare relevant for understanding the consequences of outbreeding and hybridization and open up several questions forfuture studies.

Place, publisher, year, edition, pages
Oxford University Press, 2016
Keywords
hybridization, gene expression, maternal effect, additive effect, Arabidopsis lyrata, RNA-Seq
National Category
Genetics
Identifiers
urn:nbn:se:liu:diva-125904 (URN)10.1093/molbev/msv342 (DOI)000374226700011 ()26685177 (PubMedID)
Available from: 2016-03-07 Created: 2016-03-07 Last updated: 2017-03-17
Forsberg, N., Russell, J., Macaulay, M., Leino, M. & Hagenblad, J. (2015). Farmers without borders-genetic structuring in century old barley (Hordeum vulgare). Heredity, 114(2), 195-206
Open this publication in new window or tab >>Farmers without borders-genetic structuring in century old barley (Hordeum vulgare)
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2015 (English)In: Heredity, ISSN 0018-067X, E-ISSN 1365-2540, Vol. 114, no 2, p. 195-206Article in journal (Refereed) Published
Abstract [en]

The geographic distribution of genetic diversity can reveal the evolutionary history of a species. For crop plants, phylogeographic patterns also indicate how seed has been exchanged and spread in agrarian communities. Such patterns are, however, easily blurred by the intense seed trade, plant improvement and even genebank conservation during the twentieth century, and discerning fine-scale phylogeographic patterns is thus particularly challenging. Using historical crop specimens, these problems are circumvented and we show here how high-throughput genotyping of historical nineteenth century crop specimens can reveal detailed geographic population structure. Thirty-one historical and nine extant accessions of North European landrace barley (Hordeum vulgare L.), in total 231 individuals, were genotyped on a 384 single nucleotide polymorphism assay. The historical material shows constant high levels of within-accession diversity, whereas the extant accessions show more varying levels of diversity and a higher degree of total genotype sharing. Structure, discriminant analysis of principal components and principal component analysis cluster the accessions in latitudinal groups across country borders in Finland, Norway and Sweden. FST statistics indicate strong differentiation between accessions from southern Fennoscandia and accessions from central or northern Fennoscandia, and less differentiation between central and northern accessions. These findings are discussed in the context of contrasting historical records on intense within-country south to north seed movement. Our results suggest that although seeds were traded long distances, long-term cultivation has instead been of locally available, possibly better adapted, genotypes.

Place, publisher, year, edition, pages
Nature Publishing Group, 2015
National Category
Biological Sciences
Identifiers
urn:nbn:se:liu:diva-110675 (URN)10.1038/hdy.2014.83 (DOI)000348071600008 ()25227257 (PubMedID)
Available from: 2014-09-18 Created: 2014-09-18 Last updated: 2017-12-05
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Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-9850-5546

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