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Svensson, Ronald
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Nahi, H., Genell, A., Walinder, G., Uttervall, K., Juliusson, G., Karin, F., . . . Turesson, I. (2017). Incidence, characteristics, and outcome of solitary plasmacytoma and plasma cell leukemia. Population-based data from the Swedish Myeloma Register. European Journal of Haematology, 99(3), 216-222
Open this publication in new window or tab >>Incidence, characteristics, and outcome of solitary plasmacytoma and plasma cell leukemia. Population-based data from the Swedish Myeloma Register
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2017 (English)In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 99, no 3, p. 216-222Article in journal (Refereed) Published
Abstract [en]

Solitary plasmacytoma (SP) and plasma cell leukemia (PCL) are uncommon (3-6%) types of plasma cell disease. The risk of progression to symptomatic multiple myeloma (MM) is probably important for the outcome of SP. PCL is rare and has a dismal outcome. In this study, we report on incidence and survival in PCL/SP, and progression to MM in SP, using the prospective observational Swedish Multiple Myeloma Register designed to document all newly diagnosed plasma cell diseases in Sweden since 2008. Both solitary bone plasmacytoma (SBP) (n=124) and extramedullary plasmacytoma (EMP) (n=67) have better overall survival (OS) than MM (n=3549). Progression to MM was higher in SBP than in EMP (35% and 7% at 2years, respectively), but this did not translate into better survival in EMP. In spite of treatment developments, the OS of primary PCL is still dismal (median of 11months, 0% at 5years). Hence, there is a great need for diagnostic and treatment guidelines as well as prospective studies addressing the role for alternative treatment options, such as allogeneic stem cell transplantation and monoclonal antibodies in the treatment of PCL.

Place, publisher, year, edition, pages
WILEY, 2017
Keywords
multiple myeloma; plasma cell neoplasms
National Category
Hematology
Identifiers
urn:nbn:se:liu:diva-140792 (URN)10.1111/ejh.12907 (DOI)000408148200003 ()28544116 (PubMedID)
Note

Funding Agencies|Cancerfonden

Available from: 2017-09-13 Created: 2017-09-13 Last updated: 2018-04-18
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