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Azharuddin, Mohammad
Publications (3 of 3) Show all publications
Azharuddin, M., Zhu, G. H., Das, D., Ozgur, E., Uzun, L., Turner, A. P. F. & Patra, H. K. (2019). A repertoire of biomedical applications of noble metal nanoparticles. Chemical Communications, 55(49), 6964-6996
Open this publication in new window or tab >>A repertoire of biomedical applications of noble metal nanoparticles
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2019 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 55, no 49, p. 6964-6996Article, review/survey (Refereed) Published
Abstract [en]

Noble metals comprise any of several metallic chemical elements that are outstandingly resistant to corrosion and oxidation, even at elevated temperatures. This group is not strictly defined, but the tentative list includes ruthenium, rhodium, palladium, silver, osmium, iridium, platinum and gold, in order of atomic number. The emerging properties of noble metal nanoparticles are attracting huge interest from the translational scientific community and have led to an unprecedented expansion of research and exploration of applications in biotechnology and biomedicine. Noble metal nanomaterials can be synthesised both by top-down and bottom up approaches, as well as via organism-assisted routes, and subsequently modified appropriately for the field of use. Nanoscale analogues of gold, silver, platinum, and palladium in particular, have gained primary importance owing to their excellent intrinsic properties and diversity of applications; they offer unique functional attributes, which are quite unlike the bulk material. Modulation of noble metal nanoparticles in terms of size, shape and surface functionalisation has endowed them with unusual capabilities and manipulation at the chemical level, which can lead to changes in their electrical, chemical, optical, spectral and other intrinsic properties. Such flexibility in multi-functionalisation delivers Ockhams razor to applied biomedical science. In this feature article, we highlight recent advances in the adaptation of noble metal nanomaterials and their biomedical applications in therapeutics, diagnostics and sensing.

Place, publisher, year, edition, pages
Royal Society of Chemistry, 2019
National Category
Other Chemistry Topics
Identifiers
urn:nbn:se:liu:diva-158861 (URN)10.1039/c9cc01741k (DOI)000471721700001 ()31140997 (PubMedID)2-s2.0-85067297304 (Scopus ID)
Note

Funding Agencies|Swedish Research Council [VR 2015-04434 DIABETSENS]; Mucosal Infection and Inflammation Center (MIIC), Linkoping University, Sweden; Linkoping University, Sweden; EU H2020 Marie Sklodowska-Curie Individual Fellowship from European Commission [706694]; SERB, India [EMR/2016/000857]; UKIERI, UK [DST/INT/UK/P-119/2016]

Available from: 2019-07-16 Created: 2019-07-16 Last updated: 2019-08-29Bibliographically approved
Bandyopadhyay, S. K., Azharuddin, M., Dasgupta, A. K., Ganguli, B., SenRoy, S., Patra, H. K. & Deb, S. (2019). Probing ADP Induced Aggregation Kinetics During Platelet-Nanoparticle Interactions: Functional Dynamics Analysis to Rationalize Safety and Benefits. Frontiers in Bioengineering and Biotechnology, 7, 163
Open this publication in new window or tab >>Probing ADP Induced Aggregation Kinetics During Platelet-Nanoparticle Interactions: Functional Dynamics Analysis to Rationalize Safety and Benefits
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2019 (English)In: Frontiers in Bioengineering and Biotechnology, E-ISSN 2296-4185, Vol. 7, p. 163-Article in journal (Refereed) Published
Abstract [en]

Platelets, one of the most sensitive blood cells, can be activated by a range of external and internal stimuli including physical, chemical, physiological, and/or non-physiological agents. Platelets need to respond promptly during injury to maintain blood hemostasis. The time profile of platelet aggregation is very complex, especially in the presence of the agonist adenosine 5′-diphosphate (ADP), and it is difficult to probe such complexity using traditional linear dose response models. In the present study, we explored functional analysis techniques to characterize the pattern of platelet aggregation over time in response to nanoparticle induced perturbations. This has obviated the need to represent the pattern of aggregation by a single summary measure and allowed us to treat the entire aggregation profile over time, as the response. The modeling was performed in a flexible manner, without any imposition of shape restrictions on the curve, allowing smooth platelet aggregation over time. The use of a probabilistic framework not only allowed statistical prediction and inference of the aggregation signatures, but also provided a novel method for the estimation of higher order derivatives of the curve, thereby allowing plausible estimation of the extent and rate of platelet aggregation kinetics over time. In the present study, we focused on the estimated first derivative of the curve, obtained from the platelet optical aggregometric profile over time and used it to discern the underlying kinetics as well as to study the effects of ADP dosage and perturbation with gold nanoparticles. In addition, our method allowed the quantification of the extent of inter-individual signature variations. Our findings indicated several hidden features and showed a mixture of zero and first order kinetics interrupted by a metastable zero order ADP dose dependent process. In addition, we showed that the two first order kinetic constants were ADP dependent. However, we were able to perturb the overall kinetic pattern using gold nanoparticles, which resulted in autocatalytic aggregation with a higher aggregate mass and which facilitated the aggregation rate.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2019
Keywords
platelet aggregation, functional data analysis, ADP, nanoparticle, Bi-stable system
National Category
Pharmaceutical Sciences
Identifiers
urn:nbn:se:liu:diva-159096 (URN)10.3389/fbioe.2019.00163 (DOI)000476955900001 ()31380358 (PubMedID)2-s2.0-85069987718 (Scopus ID)
Note

Funding agencies: SERB, India [YSS/2015/002101]; EU H2020 Marie Sklodowska-Curie Individual Fellowship [706694]; MIIC Seed Grant at Linkoping University (LiU), Sweden; Wolfson College, University of Cambridge (UK)

Available from: 2019-07-24 Created: 2019-07-24 Last updated: 2019-08-23Bibliographically approved
Patra, H. K., Azharuddin, M., Islam, M. M., Papapavlou, G., Deb, S., Osterrieth, J., . . . Slater, N. K. H. (2019). Rational Nanotoolbox with Theranostic Potential for Medicated Pro-Regenerative Corneal Implants. Advanced Functional Materials, Article ID 1903760.
Open this publication in new window or tab >>Rational Nanotoolbox with Theranostic Potential for Medicated Pro-Regenerative Corneal Implants
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2019 (English)In: Advanced Functional Materials, ISSN 1616-301X, E-ISSN 1616-3028, article id 1903760Article in journal (Refereed) Epub ahead of print
Abstract [en]

Cornea diseases are a leading cause of blindness and the disease burden is exacerbated by the increasing shortage around the world for cadaveric donor corneas. Despite the advances in the field of regenerative medicine, successful transplantation of laboratory‐made artificial corneas is not fully realized in clinical practice. The causes of failure of such artificial corneal implants are multifactorial and include latent infections from viruses and other microbes, enzyme overexpression, implant degradation, extrusion or delayed epithelial regeneration. Therefore, there is an urgent unmet need for developing customized corneal implants to suit the host environment and counter the effects of inflammation or infection, which are able to track early signs of implant failure in situ. This work reports a nanotoolbox comprising tools for protection from infection, promotion of regeneration, and noninvasive monitoring of the in situ corneal environment. These nanosystems can be incorporated within pro‐regenerative biosynthetic implants, transforming them into theranostic devices, which are able to respond to biological changes following implantation.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
herpes simplex virus type 1 (HSV-1), magnetic resonance imaging (MRI), premedicated cornea implants, pro-regeneration, theranostics
National Category
Microbiology in the medical area
Identifiers
urn:nbn:se:liu:diva-159097 (URN)10.1002/adfm.201903760 (DOI)000476281800001 ()2-s2.0-85069940064 (Scopus ID)
Note

Funding agencies: EU H2020 Marie Sklodowska-Curie Individual Fellowship [706694]; MIIC Strategic Postdoc Grant; MIIC Seed Grant at Linkoping University (LiU), Sweden

Available from: 2019-07-24 Created: 2019-07-24 Last updated: 2019-11-13Bibliographically approved
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