Active cytomegalovirus replication in patients with coronary diseaseShow others and affiliations
2007 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 41, no 4, p. 230-234Article in journal (Refereed) Published
Abstract [en]
Objectives. To study the prevalence of active cytomegalovirus (CMV) infection in patients with stable and unstable conditions of coronary artery disease (CAD). Design. Forty patients with acute coronary syndrome (ACS), 50 patients with stable angina and angiographically verified CAD (SA) and 50 clinically healthy controls were included. Monocytes were isolated from peripheral blood and CMV-RNA expression was determined by a nested RT-PCR assay. CMV IgM and IgG antibodies, interleukin-(IL)-6, IL-10 and CRP were measured in serum. Results. The prevalence of active CMV infection was significantly higher in patients with ACS (15%) and in patients with SA (10%) compared with controls (2%) (p < 0.001). The presence of an active CMV infection was associated with increased serum concentrations of IL-6. Conclusions. Active CMV infection was found to a larger extent in CAD patients than in healthy controls. The data indicate that CAD patients are more susceptible to reactivation of CMV and put new focus on the role of CMV in atherosclerosis.
Place, publisher, year, edition, pages
2007. Vol. 41, no 4, p. 230-234
Keywords [en]
cytomegalovirus, monocytes, coronary artery disease, acute coronary syndrome
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-40759DOI: 10.1080/14017430701383755Local ID: 54057OAI: oai:DiVA.org:liu-40759DiVA, id: diva2:261608
2009-10-102009-10-102020-01-16