liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Redox-active conducting polymers modulate Salmonella biofilm formation by controlling availability of electron acceptors (vol 3, article number 19, 2017)
Department of Neuroscience, Swedish Medical Nanoscience Center, Karolinska Institutet, Sweden.
Department of Neuroscience, Swedish Medical Nanoscience Center, Karolinska Institutet, Sweden.
Department of Neuroscience, Swedish Medical Nanoscience Center, Karolinska Institutet, Sweden.
Linköping University, Department of Science and Technology, Physics and Electronics. Linköping University, Faculty of Science & Engineering.
Show others and affiliations
2018 (English)In: npj Biofilms and Microbiomes, ISSN 2055-5008, Vol. 3, article id 19Article in journal (Refereed) Published
Abstract [en]

Biofouling is a major problem caused by bacteria colonizing abiotic surfaces, such as medical devices. Biofilms are formed as the bacterial metabolism adapts to an attached growth state. We studied whether bacterial metabolism, hence biofilm formation, can be modulated in electrochemically active surfaces using the conducting conjugated polymer poly(3,4-ethylenedioxythiophene) (PEDOT). We fabricated composites of PEDOT doped with either heparin, dodecyl benzene sulfonate or chloride, and identified the fabrication parameters so that the electrochemical redox state is the main distinct factor influencing biofilm growth. PEDOT surfaces fitted into a custom-designed culturing device allowed for redox switching in Salmonella cultures, leading to oxidized or reduced electrodes. Similarly large biofilm growth was found on the oxidized anodes and on conventional polyester. In contrast, biofilm was significantly decreased (52-58%) on the reduced cathodes. Quantification of electrochromism in unswitched conducting polymer surfaces revealed a bacteria-driven electrochemical reduction of PEDOT. As a result, unswitched PEDOT acquired an analogous electrochemical state to the externally reduced cathode, explaining the similarly decreased biofilm growth on reduced cathodes and unswitched surfaces. Collectively, our findings reveal two opposing effects affecting biofilm formation. While the oxidized PEDOT anode constitutes a renewable electron sink that promotes biofilm growth, reduction of PEDOT by a power source or by bacteria largely suppresses biofilm formation. Modulating bacterial metabolism using the redox state of electroactive surfaces constitutes an unexplored method with applications spanning from antifouling coatings and microbial fuel cells to the study of the role of bacterial respiration during infection.

Place, publisher, year, edition, pages
2018. Vol. 3, article id 19
National Category
Materials Chemistry
Identifiers
URN: urn:nbn:se:liu:diva-151745DOI: 10.1038/s41522-017-0027-0ISI: 000412923600001PubMedID: 28883986OAI: oai:DiVA.org:liu-151745DiVA, id: diva2:1253165
Note

An author correction to this article was published with the DOI: 10.1038/s41522-018-0061-6 and is registered in DiVA: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-151743

Available from: 2018-10-04 Created: 2018-10-04 Last updated: 2018-12-20

Open Access in DiVA

fulltext(1983 kB)45 downloads
File information
File name FULLTEXT01.pdfFile size 1983 kBChecksum SHA-512
f1be1197353be2b027cec11f5c0ce4e44d5ea97f025555935422cf4aa738a8c9b186fa2e9c4a072dfc0043957a9cf80e2e0b4b9b49f5228f8af6437bb931ef7c
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMedLänk till correction

Authority records BETA

Persson, Kristin M.Jager, EdwinBerggren, Magnus

Search in DiVA

By author/editor
Persson, Kristin M.Jager, EdwinBerggren, Magnus
By organisation
Physics and ElectronicsFaculty of Science & EngineeringSensor and Actuator Systems
Materials Chemistry

Search outside of DiVA

GoogleGoogle Scholar
Total: 45 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 544 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf