liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Epidemiologisk fall-kontroll studie av reumatoid artrit: betydelsen av genotyp och omgivningsfaktorer
Linköping University, Department of Physics, Chemistry and Biology. Linköping University, The Institute of Technology.
2004 (Swedish)Independent thesis Advanced level (degree of Master (One Year)), 20 credits / 30 HE creditsStudent thesisAlternative title
Epidemiologic case-control study of rheumatoid arthritis : Significance of genotype and environmental exposures (English)
Abstract [sv]

Syftet med studien var att studera effekterna av några miljöfaktorer och genetiskt predisponerande faktorer för reumatoid artrit (RA). RA är en inflammatorisk sjukdom där immunsystemet bryter ner kroppsegen vävnad. En signifikant ökad risk för RA påvisades vid exponering för spannmålsdamm och rökning. Generna som studerades var GSTM1, GSTT1 och Fc-gamma-RII. Generna i sig var ingen predisponerande faktor för RA, men rökning visade sig vara en signifikant högre riskfaktor för de som hade en deletion av GSTM1 eller Fc-gamma-RII genen samt för de som inte hade deletion av GSTT1 genen. Exponering för spannmålsdamm visade sig vara en signifikant större riskfaktor för RA för de som inte hade deletion av GSTM1, GSTT1 eller Fc-gamma-RII genen. Vidare visade individer som inte hade en deletion av Fc-gamma-RII genen en ökad risk för RA vid exponering för stendamm.

Abstract [en]

The aim of this study was to evaluate the effects of some environmental and genetic predisposing factors of Rheumatoid Arthritis (RA). RA is an inflammatory disease where the immune system decomposes body tissue. A significant increased risk of RA was shown when exposed to grain and smoking. The genes that were studied were GSTM1, GSTT1 and Fcgamma- RII. The genes themselves were no predisposing factors of RA, but smoking showed to be a significant greater riskfactor for RA for individuals having a deletion of the GSTM1 or the Fc-gamma-RII gene, or not having a deletion of the GSTT1 gene. Exposure to grain showed to be a significant greater riskfactor for RA for individuals not having a deletion of the GSTM1, GSTT1 or the Fc-gamma-RII gene. Also individuals not having a deletion of the Fc-gamma-RII gene showed an increased risk for RA when exposed to stonedust.

Place, publisher, year, edition, pages
2004. , 37 p.
Keyword [en]
Fc-gamma-RII, genotyp, GSTT1, GSTM1, ledgångsreumatism, miljöfaktorer, reumatoid artrit
Keyword [sv]
Keywords: Fc-gamma-RII, genotyp, GSTT1, GSTM1, ledgångsreumatism, miljöfaktorer, reumatoid artrit
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:liu:diva-74265ISRN: LiU-IFM-Biol-EX-1289--SEOAI: oai:DiVA.org:liu-74265DiVA: diva2:481855
Subject / course
Biology
Uppsok
Life Earth Science
Available from: 2012-01-25 Created: 2012-01-23 Last updated: 2012-01-25Bibliographically approved

Open Access in DiVA

fulltext(212 kB)529 downloads
File information
File name FULLTEXT01.pdfFile size 212 kBChecksum SHA-512
3c90ad0188a96687a54644883e9301d9c5010c2f2d82c1740616dda0f96a56a1aaa3a9f3c5ca7c30b990c4cc72d9b595ad1068aef762d1fd48ba44b08975e039
Type fulltextMimetype application/pdf

By organisation
Department of Physics, Chemistry and BiologyThe Institute of Technology
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 529 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 535 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf