liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Bacterial Infections and Osteoclastogenesis Regulators in Men and Women with Cholesteatoma
Medical University of Silesia, Poland.
Medical University of Silesia, Poland.
Medical University of Silesia, Poland.
Medical University of Silesia, Poland; George Washington University, DC USA.
Show others and affiliations
2016 (English)In: Archivum Immunologiae et Therapiae Experimentalis, ISSN 0004-069X, E-ISSN 1661-4917, Vol. 64, no 3, p. 241-247Article, review/survey (Refereed) Published
Resource type
Text
Abstract [en]

One of the most distinct features of middle ear cholesteatoma is bone destruction. Aetiology of cholesteatoma is thought to be multifactorial. Endotoxins produced by bacteria are thought to initiate the inflammation process in the middle ear leading to cholesteatoma. There are physiological differences in bone metabolism between men and women. The aim of our study was the immunohistochemical evaluation of the contents of two key components of the OPG/RANK/RANKL triad-RANKL and OPG in cholesteatoma, to analyse if there are any differences between the sexes and to evaluate the bacteria species isolated from cholesteatoma just before surgical treatment and to evaluate their plausible influence on the expression of OPG and RANKL in cholesteatoma. Twenty-one adult patients with acquired cholesteatoma who underwent surgery were analysed. There were no statistically significant differences in the expression of both regulators of osteoclastogenesis between the sexes. In 38.1 % patients cholesteatoma was not infected, whereas in 61.9 % patients various bacterial infections or mycosis were found. The most frequently isolated species was Pseudomonas aeruginosa (14.29 % infections) followed by Staphylococcus aureus (9.52 % infections). There were no statistically significant differences in expression of both OPG and RANKL between uninfected and infected cholesteatomas.

Place, publisher, year, edition, pages
SPRINGER BASEL AG , 2016. Vol. 64, no 3, p. 241-247
Keywords [en]
Cholesteatoma; Osteoprotegerin; RANKL; Bacterial infection; Sexes
National Category
Hematology
Identifiers
URN: urn:nbn:se:liu:diva-129139DOI: 10.1007/s00005-015-0373-7ISI: 000376060200005PubMedID: 26584851OAI: oai:DiVA.org:liu-129139DiVA, id: diva2:936069
Note

Funding Agencies|Medical University of Silesia in Katowice, Poland [KNW-1-096/P/2/0]

Available from: 2016-06-13 Created: 2016-06-13 Last updated: 2017-11-28

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMed

Authority records

Los, Marek Jan

Search in DiVA

By author/editor
Los, Marek Jan
By organisation
Division of Cell BiologyFaculty of Medicine and Health Sciences
In the same journal
Archivum Immunologiae et Therapiae Experimentalis
Hematology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 314 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf