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Hypoproteinemia does not alter plasma volume expansion in response to a 0.9% saline bolus in awake sheep
University of Texas Medical Branch.
University of Texas Medical Branch.
University of Texas Medical Branch.
Karolinska Institute.
Vise andre og tillknytning
2010 (engelsk)Inngår i: CRITICAL CARE MEDICINE, ISSN 0090-3493, Vol. 38, nr 10, s. 2011-2015Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective: To test the hypothesis that hypoproteinemia reduces plasma volume expansion produced by a bolus of crystalloid solution given to awake sheep. Design: Prospective and observational. Setting: Laboratory. Subjects: Five female merino sheep (n = 5) weighing 37 +/- 3 kg were anesthetized. Interventions: Each animal was subjected to a 5-day test period: day 1: 50 mL/min 0.9% saline infusion over 20 mins. Days 2-4: daily plasmapheresis and replacement of the shed plasma with 6 L of 0.9% saline were performed in increments. Measurements and Main Results: Fractional plasma volume expansion after rapid infusion of saline on days 1 and 5 was calculated from changes in hemoglobin concentration. There was a significant reduction in total plasma protein concentration after plasmapheresis (p andlt; .05). Colloid osmotic pressures were also significantly lowered (p andlt; .05). A crystalloid infusion of 0.9% saline did not alter any of these values compared with baseline. The hemodynamic measurements did not show significant differences between the experiments. The plasma volume expansion reached approximately 20% at the end of infusion and stayed at 10-15% during the experiments. No difference was found in plasma volume expansion produced by a bolus of 50 mL/min of 0.9% in the hypoproteinemic state when compared with the euproteinemic state (p = .61). No difference in cumulative urinary output was found between the two states. Conclusions: In contrast to our hypothesis, severe acute hypoproteinemia does not reduce plasma volume expansion in response to 50 mL/min 0.9% saline infusion in nonspleenectomized sheep when compared with the resultant plasma volume expansion after a 50 mL/min of 0.9% infusion in the euproteinemic state.

sted, utgiver, år, opplag, sider
Williams and Wilkins , 2010. Vol. 38, nr 10, s. 2011-2015
Emneord [en]
anesthesia, hypoproteinemia, plasma volume expansion, crystalloids, fluid distribution
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-60253DOI: 10.1097/CCM.0b013e3181ef45e2ISI: 000282043800013OAI: oai:DiVA.org:liu-60253DiVA, id: diva2:355812
Tilgjengelig fra: 2010-10-08 Laget: 2010-10-08 Sist oppdatert: 2012-03-20

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