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Postmortem MR quantification of the heart for characterization and differentiation of ischaemic myocardial lesions
University of Bern, Switzerland.
University of Bern, Switzerland.
Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Röntgenkliniken i Linköping.ORCID-id: 0000-0002-9446-6981
Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Hälsouniversitetet. Region Östergötland, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
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2015 (engelsk)Inngår i: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 25, nr 7, s. 2067-2073Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Recently, an MRI quantification sequence has been developed which can be used to acquire T1- and T2-relaxation times as well as proton density (PD) values. Those three quantitative values can be used to describe soft tissue in an objective manner. The purpose of this study was to investigate the applicability of quantitative cardiac MRI for characterization and differentiation of ischaemic myocardial lesions of different age. Fifty post-mortem short axis cardiac 3 T MR examinations have been quantified using a quantification sequence. Myocardial lesions were identified according to histology and appearance in MRI images. Ischaemic lesions were assessed for mean T1-, T2- and proton density values. Quantitative values were plotted in a 3D-coordinate system to investigate the clustering of ischaemic myocardial lesions. A total of 16 myocardial lesions detected in MRI images were histologically characterized as acute lesions (n = 8) with perifocal oedema (n = 8), subacute lesions (n = 6) and chronic lesions (n = 2). In a 3D plot comprising the combined quantitative values of T1, T2 and PD, the clusters of all investigated lesions could be well differentiated from each other. Post-mortem quantitative cardiac MRI is feasible for characterization and discrimination of different age stages of myocardial infarction. aEuro cent MR quantification is feasible for characterization of different stages of myocardial infarction. aEuro cent The results provide the base for computer-aided MRI cardiac infarction diagnosis. aEuro cent Diagnostic criteria may also be applied for living patients.

sted, utgiver, år, opplag, sider
Springer Verlag (Germany) , 2015. Vol. 25, nr 7, s. 2067-2073
Emneord [en]
Post-mortem quantitative magnetic resonance imaging; Myocardial infarction; Ischaemia; Left ventricular; Post-mortem cardiac imaging
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Identifikatorer
URN: urn:nbn:se:liu:diva-119784DOI: 10.1007/s00330-014-3582-2ISI: 000355755300026PubMedID: 25591749OAI: oai:DiVA.org:liu-119784DiVA, id: diva2:827282
Tilgjengelig fra: 2015-06-26 Laget: 2015-06-26 Sist oppdatert: 2017-12-04bibliografisk kontrollert

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