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Successful autologous haematopoietic stem cell transplantation for refractory myasthenia gravis - a case report
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten.
Linköpings universitet, Institutionen för samhälls- och välfärdsstudier. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Hematologiska kliniken US.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Närsjukvården i centrala Östergötland, Neurologiska kliniken.
University of Uppsala Hospital, Sweden.
Vise andre og tillknytning
2017 (engelsk)Inngår i: Neuromuscular Disorders, ISSN 0960-8966, E-ISSN 1873-2364, Vol. 27, nr 1, s. 90-93Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Myasthenia gravis (MG) is an autoimmune disease, with immune reactivity against the post-synaptic endplate of the neuromuscular junction. Apart from symptomatic treatment with choline esterase blockers, many patients also require immunomodulatory treatment. Despite existing treatment options, some patients are treatment refractory. We describe a patient with severe MG refractory to corticosteroids, four oral immunosuppressants, cyclophosphamide, rituximab and bortezomib who was treated with autologous haematopoietic stem cell transplantation. Two years after this, the patient has significantly improved in objective tests and in quality of life and leads an active life. Diplopia is her only remaining symptom and she is completely free of medication for MG. We believe that autologous haematopoietic stem cell transplantation can be an effective therapeutic option for carefully selected cases of severe, treatment refractory MG. (c) 2016 Elsevier B.V. All rights reserved.

sted, utgiver, år, opplag, sider
PERGAMON-ELSEVIER SCIENCE LTD , 2017. Vol. 27, nr 1, s. 90-93
Emneord [en]
Myasthenia gravis; Autologous haematopoietic stem cell transplantation
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-135402DOI: 10.1016/j.nmd.2016.09.020ISI: 000393247400014PubMedID: 27863874OAI: oai:DiVA.org:liu-135402DiVA, id: diva2:1081490
Tilgjengelig fra: 2017-03-14 Laget: 2017-03-14 Sist oppdatert: 2017-11-29

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