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A Method for Evaluating the Reinforcing Properties of Ethanol in Rats without Water Deprivation, Saccharin Fading or Extended Access Training
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Centrum för social och affektiv neurovetenskap. Linköpings universitet, Medicinska fakulteten.
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, USA.
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, USA.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Centrum för social och affektiv neurovetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Närsjukvården i centrala Östergötland, Psykiatriska kliniken.
2017 (engelsk)Inngår i: Journal of Visualized Experiments, ISSN 1940-087X, E-ISSN 1940-087X, nr 119, artikkel-id e53305Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Operant oral self-administration methods are commonly used to study the reinforcing properties of ethanol in animals. However, the standard methods require saccharin/sucrose fading, water deprivation and/or extended training to initiate operant responding in rats. This paper describes a novel and efficient method to quickly initiate operant responding for ethanol that is convenient for experimenters and does not require water deprivation or saccharin/sucrose fading, thus eliminating the potential confound of using sweeteners in ethanol operant self-administration studies. With this method, Wistar rats typically acquire and maintain self-administration of a 20% ethanol solution in less than two weeks of training. Furthermore, blood ethanol concentrations and rewards are positively correlated for a 30 min self-administration session. Moreover, naltrexone, an FDA-approved medication for alcohol dependence that has been shown to suppress ethanol self-administration in rodents, dose-dependently decreases alcohol intake and motivation to consume alcohol for rats self-administering 20% ethanol, thus validating the use of this new method to study the reinforcing properties of alcohol in rats.

sted, utgiver, år, opplag, sider
JOURNAL OF VISUALIZED EXPERIMENTS , 2017. nr 119, artikkel-id e53305
Emneord [en]
Behavior; Issue 119; ethanol; self-administration; oral; reinforcement; animal model; addiction
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-136675DOI: 10.3791/53305ISI: 000397847200001PubMedID: 28190044OAI: oai:DiVA.org:liu-136675DiVA, id: diva2:1089738
Merknad

Funding Agencies|Swedish Research Council

Tilgjengelig fra: 2017-04-20 Laget: 2017-04-20 Sist oppdatert: 2018-01-13

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