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Colloid electrochemistry of conducting polymer: towards potential-induced in-situ drug release
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biosensorer och bioelektronik. Linköpings universitet, Tekniska fakulteten. Prince Songkla University, Thailand.
Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.ORCID-id: 0000-0001-8478-4663
Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Institutionen för fysik, kemi och biologi, Biosensorer och bioelektronik. Stanford University, CA 94305 USA.
Prince Songkla University, Thailand.
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2017 (engelsk)Inngår i: Electrochimica Acta, ISSN 0013-4686, E-ISSN 1873-3859, Vol. 228, s. 407-412Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Over the past decades, controlled drug delivery system remains as one of the most important area in medicine for various diseases. We have developed a new electrochemically controlled drug release system by combining colloid electrochemistry and electro-responsive microcapsules. The pulsed electrode potential modulation led to the appearance of two processes available for the time-resolved registration in colloid microenvironment: change of the electronic charge of microparticles (from 0.5 ms to 0.1 s) followed by the drug release associated with ionic equilibration (1-10 s). The dynamic electrochemical measurements allow the distinction of drug release associated With ionic relaxation and the change of electronic charge of conducting polymer colloid microparticles. The amount of released drug (methylene blue) could be controlled by modulating the applied potential. Our study demonstrated a surface-potential driven controlled drug release of dispersion of conducting polymer carrier at the electrode interfaces, while the bulk colloids dispersion away from the electrode remains as a reservoir to improve the efficiency of localized drug release. The developed new methodology creates a model platform for the investigations of surface potential-induced in-situ electrochemical drug release mechanism. (C) 2017 Elsevier Ltd. All rights reserved.

sted, utgiver, år, opplag, sider
PERGAMON-ELSEVIER SCIENCE LTD , 2017. Vol. 228, s. 407-412
Emneord [en]
colloid electrochemistry; conducting polymer; potential-modulation; microcapsules; controlled drug release
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Identifikatorer
URN: urn:nbn:se:liu:diva-136666DOI: 10.1016/j.electacta.2017.01.028ISI: 000395211600047OAI: oai:DiVA.org:liu-136666DiVA, id: diva2:1089752
Merknad

Funding Agencies|Royal Golden Jubilee Ph.D-program (RGJ) - Thailand Research Fund [3.C.PS/51/B.1]

Tilgjengelig fra: 2017-04-20 Laget: 2017-04-20 Sist oppdatert: 2018-03-27

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