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Exercise testing for long-term follow-up in arrhythmogenic right ventricular cardiomyopathy
Region Östergötland, Hjärt- och Medicincentrum, Fysiologiska kliniken US. Linköpings universitet, Institutionen för medicin och hälsa. Linköpings universitet, Medicinska fakulteten.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
Linköpings universitet, Institutionen för medicin och hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Hjärt- och Medicincentrum, Fysiologiska kliniken US.
Region Östergötland, Hjärt- och Medicincentrum, Fysiologiska kliniken US. Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Medicinska fakulteten.
2017 (engelsk)Inngår i: Journal of Electrocardiology, ISSN 0022-0736, E-ISSN 1532-8430, Vol. 50, nr 2, 176-183 s.Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objectives: We investigated arrhythmia, electrocardiography and physical work capacity (PWC) in the follow-up of ARVC. Design: Twenty-three patients (13 men; age 41 +/- 12 years) fulfilling diagnostic criteria were re-investigated after at least five years. Results: Ventricular arrhythmia during exercise testing (ET) was present in 14 patients (61%) and showed variation between examinations. In eleven (48%), complex ventricular ectopic activity was observed at peak exercise or immediately thereafter. Mutations known to be pathogenic in ARVC were present in 13 patients (57%) of which 11 developed complex ventricular arrhythmia at ET. PWC at baseline was 190 +/- 66 W (104 +/- 26%) decreasing to 151 +/- 61 W (91 +/- 23%, p = 0.008) after 10.7 years. Conclusion: The appearance of ventricular arrhythmia during exercise testing showed temporal variation but was.frequent in patients with relevant genetic mutation. Physical exercise capacity decreased over time in patients with ARVC in excess to the age-related deterioration and regardless of medication. (C) 2016 Elsevier Inc. All rights reserved.

sted, utgiver, år, opplag, sider
Churchill Livingstone , 2017. Vol. 50, nr 2, 176-183 s.
Emneord [en]
ARVC; Exercise testing; Arrhythmia; Follow up
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-136755DOI: 10.1016/j.jelectrocard.2016.10.011ISI: 000397368100002PubMedID: 28012557Scopus ID: 2-s2.0-85008157736OAI: oai:DiVA.org:liu-136755DiVA: diva2:1090688
Merknad

Funding Agencies|ALF Grants, Region Ostergotland, Sweden

Tilgjengelig fra: 2017-04-25 Laget: 2017-04-25 Sist oppdatert: 2017-04-28bibliografisk kontrollert

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