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Modeling Suspension Cultures of Microbial and Mammalian Cells with an Adaptable Six-Compartment Model
University of Appl Science Bremen, Germany.
Linköpings universitet, Institutionen för fysik, kemi och biologi. Linköpings universitet, Tekniska fakulteten. University of Appl Science Bremen, Germany.
Hamburg University of Technology, Germany.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Teknisk biologi. Linköpings universitet, Tekniska fakulteten.ORCID-id: 0000-0001-9711-794X
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2017 (engelsk)Inngår i: Chemical Engineering & Technology, ISSN 0930-7516, E-ISSN 1521-4125, Vol. 40, nr 5, s. 956-966Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Process models can be used for model-based control strategies, but model development is a time-consuming and laborious task. To reduce the modeling effort, a new structured compartment model was developed, which may easily be adapted to different cultivation processes. The proposed six-compartment model was used to describe the time courses of cultivations of bacteria, yeast, fungi, and mammalian cell lines, namely, Escherichia coli,Lactobacillus delbrueckii, Saccharomyces cerevisiae, Cyathus striatus, and a hybridoma mammalian cell line. The model can describe the time courses of important state variables and can be adapted to the cultivation processes by parameterization. This reduces the modeling effort for a new process significantly.

sted, utgiver, år, opplag, sider
WILEY-V C H VERLAG GMBH , 2017. Vol. 40, nr 5, s. 956-966
Emneord [en]
Compartment models; Fungi; Mammalian cells; Microorganisms; Suspension cultivation
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-137594DOI: 10.1002/ceat.201600639ISI: 000399971100018OAI: oai:DiVA.org:liu-137594DiVA, id: diva2:1097376
Merknad

Funding Agencies|Bundesministerium fur Bildung und Forschung [FKZ: 031A124 A-C]; City University of Applied Sciences Bremen

Tilgjengelig fra: 2017-05-22 Laget: 2017-05-22 Sist oppdatert: 2019-01-22

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