liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Changes in pituitary gene expression may underlie multiple domesticated traits in chickens.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.ORCID-id: 0000-0001-5508-4465
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska fakulteten.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Heredity, ISSN 0018-067X, E-ISSN 1365-2540, Vol. 122, nr 2, s. 195-204Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Domesticated animals share a unique set of morphological and behavioral traits, jointly referred to as the domesticated phenotype. Striking similarities amongst a range of unrelated domesticated species suggest that similar regulatory mechanisms may underlie the domesticated phenotype. These include color pattern, growth, reproduction, development and stress response. Although previous studies have focused on the brain to find mechanisms underlying domestication, the potential role of the pituitary gland as a target of domestication is highly overlooked. Here, we study gene expression in the pituitary gland of the domesticated White Leghorn chicken and its wild ancestor, the Red Junglefowl. By overlapping differentially expressed genes with a previously published list of functionally important genes in the pituitary gland, we narrowed down to 34 genes. Amongst them, expression levels of genes with inhibitory function on pigmentation (ASIP), main stimulators of metabolism and sexual maturity (TSHB and DIO2), and a potential inhibitor of broodiness (PRLR), were higher in the domesticated breed. Additionally, expression of 2 key inhibitors of the stress response (NR3C1, CRHR2) was higher in the domesticated breed. We suggest that changes in the transcription of important modulatory genes in the pituitary gland can account not only for domestication of the stress response in domestic chickens, but also for changes in pigmentation, development, and reproduction. Given the pivotal role of the pituitary gland in the regulation of multiple shared domesticated traits, we suggest that similar changes in pituitary transcriptome may contribute to the domesticated phenotype in other species as well.

sted, utgiver, år, opplag, sider
London: Nature Publishing Group, 2019. Vol. 122, nr 2, s. 195-204
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-148742DOI: 10.1038/s41437-018-0092-zISI: 000455217300005OAI: oai:DiVA.org:liu-148742DiVA, id: diva2:1220276
Merknad

Funding agencies: Swedish Research Council (VR) [2015-05444]; Swedish Research Council Formas [2016-00645]; European Research Council (ERC) [322206 GENEWELL]

Tilgjengelig fra: 2018-06-18 Laget: 2018-06-18 Sist oppdatert: 2023-12-28bibliografisk kontrollert

Open Access i DiVA

fulltext(480 kB)447 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 480 kBChecksum SHA-512
e8cb288660ed3e384e21dd4dfbf3f2c3b8017c32e28e4464bccfcdc318b44acb5f90e133c24c7a4b46e482d45ed339e756780359214005d8f861c808ea166a06
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekst

Person

Fallahsharoudi, AmirLøtvedt, PiaBeltéky, JohanAltimiras, JordiJensen, Per

Søk i DiVA

Av forfatter/redaktør
Fallahsharoudi, AmirLøtvedt, PiaBeltéky, JohanAltimiras, JordiJensen, Per
Av organisasjonen
I samme tidsskrift
Heredity

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 447 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 272 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf