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Storage-induced change in platelet transfusion response evaluated by serial transfusions from one donor to one patient
Linköpings universitet, Institutionen för medicin och hälsa. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Regionstyrelsen, Enheten för forskningsstöd Ledningsstaben.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för mikrobiologi och molekylär medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Hematologiska kliniken US.
Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk immunologi och transfusionsmedicin.
Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Hematologiska kliniken US.
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2019 (engelsk)Inngår i: Transfusion, ISSN 0041-1132, E-ISSN 1537-2995, Vol. 59, nr 2, s. 723-728Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND

Storage of platelet concentrates (PCs) results in storage lesions with possible detrimental effects on platelet recovery after transfusion, which might affect their ability to prevent or arrest bleeding. The aim of this study was to compare the quality of PCs stored for 1 to 3 or 5 to 7 days by assessing the corrected count increment (CCI) after transfusion. To isolate the effects of storage time, we studied serial transfusions of PCs obtained from one donor and one donation, and transfused to one single recipient after storage for 1 to 3 days and 5 to 7 days.

STUDY DESIGN AND METHODS

Platelets were obtained from one donor by apheresis, divided into two units (>240 × 109platelets/unit) and stored for 1 to 3 and 5 to 7 days, respectively, before transfusion. The PCs were transfused on normal indications to patients undergoing treatment at the hematology ward. Platelet count was measured before and after transfusion.

RESULTS

Thirty patients concluded the study according to the protocol. The mean storage time was 2.4 ± 0.7 and 5.7 ± 0.8 days for platelets transfused on Days 1 to 3 and 5 to 7, respectively. Storage for 5 to 7 days decreased the 1‐hour transfusion response as compared to platelets stored 1 to 3 days, from a CCI of 17 ± 7 to 13 ± 5. Despite this decrease, 86% of the 5 to 7 days stored PCs resulted in a CCI above the cutoff value for a successful transfusion of 7.5, which was not significantly different to PCs stored for 1 to 3 days.

CONCLUSION

Storage of PCs for 5 to 7 days only slightly altered the transfusion response.

sted, utgiver, år, opplag, sider
Wiley-Blackwell Publishing Inc., 2019. Vol. 59, nr 2, s. 723-728
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-155595DOI: 10.1111/trf.15079ISI: 000459614500036PubMedID: 30548486Scopus ID: 2-s2.0-85058321870OAI: oai:DiVA.org:liu-155595DiVA, id: diva2:1298667
Merknad

Funding Agencies|Region Ostergotland

Tilgjengelig fra: 2019-03-25 Laget: 2019-03-25 Sist oppdatert: 2019-07-03bibliografisk kontrollert

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