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Adding nanotechnology to the metastasis treatment arsenal
Columbia University Medical Center, USA.
University of Oslo, Norway.
University of Cambridge, UK.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för cellbiologi. Linköpings universitet, Medicinska fakulteten.
Vise andre og tillknytning
2019 (engelsk)Inngår i: TIPS - Trends in Pharmacological Sciences, ISSN 0165-6147, E-ISSN 1873-3735, Vol. 40, nr 6, s. 403-418Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Metastasis is a major cause of cancer-related mortality, accounting for 90% of cancer deaths. The explosive growth of cancer biology research has revealed new mechanistic network information and pathways that promote metastasis. Consequently, a large number of antitumor agents have been developed and tested for their antimetastatic efficacy. Despite their exciting cytotoxic effects on tumor cells in vitro and antitumor activities in preclinical studies in vivo, only a few have shown potent antimetastatic activities in clinical trials. In this review, we provide a brief overview of current antimetastatic strategies that show clinical efficacy and review nanotechnology-based approaches that are currently being incorporated into these therapies to mitigate challenges associated with treating cancer metastasis.

sted, utgiver, år, opplag, sider
Cambridge, Massachusets: Elsevier, 2019. Vol. 40, nr 6, s. 403-418
Emneord [en]
metastasis; nanotechnology; chemotherapy; combination therapy
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-156845DOI: 10.1016/j.tips.2019.04.002ISI: 000469437500007PubMedID: 31076247OAI: oai:DiVA.org:liu-156845DiVA, id: diva2:1315714
Merknad

Funding agencies: EU H2020 Marie Sklodowska-Curie Individual Fellowship [706694]; Wolfson College (University of Cambridge, UK); MIIC Seed Grant from Linkoping University (LiU), Sweden

Tilgjengelig fra: 2019-05-14 Laget: 2019-05-14 Sist oppdatert: 2019-09-24

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Fulltekst tilgjengelig fra 2020-05-07 12:06
Tilgjengelig fra 2020-05-07 12:06

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