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Depletion of cytotoxic (CD8+) T cells impairs implant fixation in rat cancellous bone
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Hematologiska kliniken US.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten.
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2019 (engelsk)Inngår i: Journal of Orthopaedic Research, ISSN 0736-0266, E-ISSN 1554-527X, Vol. 37, nr 4, s. 805-811Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

As cytotoxic (CD8(+)) T cells seem to impair shaft fracture healing, we hypothesized that depletion of CD8(+) cells would instead improve healing of cancellous bone. Additionally, we also tested if CD8-depletion would influence the healing of ruptured Achilles tendons. Rats received a single injection of either anti-CD8 antibodies or saline and put through surgery 24 h later. Three different surgical interventions were performed as follows: (1) a drill hole in the proximal tibia with microCT (BV/TV) to assess bone formation; (2) a screw in the proximal tibia with mechanical evaluation (pull-out force) to assess fracture healing; (3) Achilles tendon transection with mechanical evaluation (force-at-failure) to assess tendon healing. Furthermore, CD8-depletion was confirmed with flow cytometry on peripheral blood. Flow cytometric analysis confirmed depletion of CD8(+) cells (p amp;lt; 0.001). Contrary to our hypothesis, depletion of CD8(+) cells reduced the implant pull-out force by 19% (p amp;lt; 0.05) and stiffness by 34% (p amp;lt; 0.01), although the bone formation in the drill holes was the same as in the controls. Tendon healing was unaffected by CD8-depletion. Our results suggest that CD8(+) cells have an important part in cancellous bone healing.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2019. Vol. 37, nr 4, s. 805-811
Emneord [en]
bone healing; cancellous; tendon healing; cytotoxic T cells; CD8 depletion
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Identifikatorer
URN: urn:nbn:se:liu:diva-157559DOI: 10.1002/jor.24246ISI: 000467082100001PubMedID: 30737834Scopus ID: 2-s2.0-85062344231OAI: oai:DiVA.org:liu-157559DiVA, id: diva2:1328649
Merknad

Funding Agencies|Swedish Research Council [2031-47-5]; AFA insurance company EU 159 7th framework program [FP7/2007-2013, 279239]; Linkoping 160 University

Tilgjengelig fra: 2019-06-22 Laget: 2019-06-22 Sist oppdatert: 2019-06-25bibliografisk kontrollert

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Bernhardsson, MagnusDietrich, FrancieleTätting, LoveEliasson, PernillaAspenberg, Per

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