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Survival in adult acute lymphoblastic leukaemia (ALL): A report from the Swedish ALL Registry
Uppsala Univ, Sweden.
Skane Univ Hosp, Sweden.
Region Östergötland, Centrum för kirurgi, ortopedi och cancervård, Hematologiska kliniken US.
Sahlgrens Univ Hosp, Sweden.
Vise andre og tillknytning
2019 (engelsk)Inngår i: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 103, nr 2, s. 88-98Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objectives As new, effective therapies emerge for acute lymphoblastic leukaemia (ALL), the results of clinical trials need to relate to standard of care. Methods We used the population-based Swedish ALL Registry to evaluate characteristics, treatment and long-term outcome in 933 patients with diagnosis between 1997 and 2015. Results The median age was 53 years. The frequency of Philadelphia (Ph)-positive leukaemia was 34% of examined B-ALL with a peak incidence at 50-59 years. Five-year overall survival (OS) improved between 1997-2006 and 2007-2015; in patients 18-45 years from 50% (95% CI 43-57) to 65% (95% CI 58-72), 46-65 years from 25% (95% CI 18-32) to 46% (95% CI 37-55) and amp;gt;65 years from 7% (95% CI 2.6-11) to 11% (95% CI 5.9-16) (P amp;lt; 0.05). Men with Ph-neg B-ALL 46-65 years had inferior OS compared with women (P amp;lt; 0.01). Standardised mortality ratio was 5.7 (95% CI 5.0-6.3) for patients who survived 5 years from diagnosis. In multivariable analysis, Ph-positive disease was not associated with impaired prognosis but with lower risk of death in 2007-2015. Conclusions In a population-based cohort, OS has improved in adult ALL, especially for Ph-positive disease but for middle-aged men with Ph-negative B-ALL outcome was poor. Cure without late toxicity or relapse is still desired.

sted, utgiver, år, opplag, sider
WILEY , 2019. Vol. 103, nr 2, s. 88-98
Emneord [en]
acute lymphoblastic leukaemia; adult; Philadelphia-positive
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-159124DOI: 10.1111/ejh.13247ISI: 000475475200003PubMedID: 31074910OAI: oai:DiVA.org:liu-159124DiVA, id: diva2:1339677
Merknad

Funding Agencies|Lions Cancer Foundation Uppsala; Uppsala University; Uppsala County Council/Region agreement on medical training and clinical research (ALF)

Tilgjengelig fra: 2019-07-30 Laget: 2019-07-30 Sist oppdatert: 2019-11-14

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