liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Single nucleotide polymorphisms might influence chemotherapy induced nausea in women with breast cancer
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten. Department of Oncology, Ryhov County Hospital, SE-551 85 Jönköping, Sweden.
Futurum – The Academy for Healthcare, Region Jönköping County, SE-551 85 Jönköping, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för Kirurgi, Ortopedi och Onkologi. Linköpings universitet, Medicinska fakulteten. Division of Medical Diagnostics, Region Jönköping County, SE-551 85 Jönköping, Sweden.
Regional Cancer Centre, Stockholm-Gotland, SE-10239 Stockholm, Sweden / Karolinska Institutet, Department of Learning, Informatics Management and Ethics, SE-171 77 Stockholm, Sweden.
Vise andre og tillknytning
2017 (engelsk)Inngår i: Clinical and Translational Radiation Oncology, ISSN 2405-6308, Vol. 2, s. 1-6Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background Women receiving FEC (5 fluorouracil, epirubicin and cyclophosphamide) chemotherapy (CT) for breast cancer (BC) often experience side effects such as nausea and vomiting. Individual variations of side effects occur in patients despite similar cancer therapy. The purpose of this study was to investigate a possible genetic background as a predictor for individual variations in nausea induced by CT. Methods 114 women were included in the study. All women received adjuvant CT for BC. Self-reported nausea and vomiting was recorded in a structured diary over ten days following treatment. Blood samples were collected before the treatment and used for the detection of 48 single nucleotide polymorphisms (SNPs) in 43 genes. SNPs from each individual woman were analyzed for their relation to the patient-reported frequency and intensity of nausea and vomiting. Results Eighty-four percent (n=96) of the women reported acute or delayed nausea or combined nausea and vomiting during the ten days following CT. Three out of the forty-eight SNPs in the following genes: FAS/CD95, RB1/LPAR6 and CCL2 were found to be associated with a risk of nausea. Conclusion SNPs in the FAS/CD95, RB1/LPAR6 and CCL2 genes were found to be associated with nausea among women treated with adjuvant FEC for BC. SNPs analysis is fast and cost effective and can be done prior to any cancer therapy. The association between individual SNPs and severe side effects from FEC may contribute to a more personalized care of patients with BC.

sted, utgiver, år, opplag, sider
Elsevier , 2017. Vol. 2, s. 1-6
Emneord [en]
Single nucleotide polymorphisms, Chemotherapy, Nausea, Breast cancer
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-162106DOI: 10.1016/j.ctro.2016.12.001OAI: oai:DiVA.org:liu-162106DiVA, id: diva2:1371241
Tilgjengelig fra: 2019-11-19 Laget: 2019-11-19 Sist oppdatert: 2019-11-20bibliografisk kontrollert
Inngår i avhandling
1. Prediction of side effects from anticancer treatment with the purpose of increasing quality of life
Åpne denne publikasjonen i ny fane eller vindu >>Prediction of side effects from anticancer treatment with the purpose of increasing quality of life
2019 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Cancer and its treatments can cause a variety of symptoms. Some of these symptoms are related to the disease and others are seen as a consequence of the treatment. Since patients experience side effects to different degrees despite undergoing the same treatment, it is hypothesized that there is a genetic factor. The individual variation that exists between different patients regarding nausea triggered by chemotherapy, radiotherapy induced skin reactions as well as sleep disorders associated with cancer could partly be explained by genetic differences. We have in these studies confirmed these individual differences. Previous nursing research has mainly focused on the symptoms themselves. The focus in this thesis are the following three main symptoms; nausea and vomiting related to chemotherapy, acute skin inflammation following radiotherapy and sleep problems associated with cancer diagnosis and -treatment.

The aim of this thesis was to find biological markers that can identify the risk of and/or protective factors for nausea and/or vomiting (CINV) as well as understand its heterogeneity (Study 1 and 2). It also aimed to understand the individual factors behind acute radiation skin reactions (ARSR) (Study 3) and sleeping disturbances in patients treated for cancer (Study 4), permitting a more individualized care and optimized health-related quality of life (HRQoL).

In Study 1 and 2 the patients themselves had to document in a diary their experience of nausea and vomiting and well-being. Well-being was considered as synonymous with quality of life. We found a variability and heterogeneity of those symptoms (Study 1). Three genetic markers, FAS/CD95, RB1/LPAR6 and CCL2 that could explain the individual differences and assess the risk of chemotherapy-induced nausea were found in Study 2.

Acute radiation skin reactions (ARSR) along with itching and burning sensation associated with radiotherapy (RT) was assessed by the patients themselves (Study 3) with help of the VAS- and RTOG scales, scoring for visible redness. We found two possible genetic markers, XRCC2 and IFNG. Also, individual differences in symptoms behavior were found.

Sleep disturbances were common and were reported with obvious individual differences [1]. For data collection were used a sleep questionnaire, the Medical Outcomes Study Sleep Scale (MOS), open ended questions and EORTC QLQ- C30 questionnaire of quality of life. Sleep, which is important for all primary body functions, is often affected in connection with cancer diagnosis and -treatment.

Through collaboration between nursing staff and specialists in basic science, we have found that biological markers can help in creating individualized care. Knowledge of individual variations in the severity of chemo- or radiotherapy-induced side effects is important in order to better personalize the treatment and care, improve the treatment results and alleviate or prevent the side effects of oncological treatments. By linking symptoms to biological markers, it will hopefully be able to increase the patients’ total health-related quality of life, this being the main goal of this thesis.

sted, utgiver, år, opplag, sider
Linköping: Linköping University Electronic Press, 2019. s. 93
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1716
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-162101 (URN)10.3384/diss.diva-162101 (DOI)9789179299569 (ISBN)
Disputas
2019-12-12, Originalet, Qulturum, Länssjukhuset Ryhov, Jönköping, 09:00 (svensk)
Opponent
Veileder
Tilgjengelig fra: 2019-11-19 Laget: 2019-11-19 Sist oppdatert: 2020-02-06bibliografisk kontrollert

Open Access i DiVA

Single nucleotide polymorphisms might influence chemotherapy induced nausea in women with breast cancer(294 kB)30 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 294 kBChecksum SHA-512
f06908ac5c8826d66a2fb0da8e4de80b1d986bf8452b37424661fbb192fb6194d01a60b1d79780e2dc9a168c7abc6f51ce6e3593d78e85518a3815fabe2dc5d9
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekst

Personposter BETA

Oliva, DelmyAndersson, Bengt-ÅkeLaytragoon-Lewin, Nongnit

Søk i DiVA

Av forfatter/redaktør
Oliva, DelmyAndersson, Bengt-ÅkeLaytragoon-Lewin, Nongnit
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 30 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 43 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf